enveloped retrovirus, 2 copies of ssRNA tightly bound to nucleoproteins >

retrovirus replicate by reverse transcription of viral RNA->DNA >

within capsid;

reverse transcriptase; synthesises complementary DNA from viral RNA template, cDNA used as template for synthesis of 2nd DNA strand, forms dsDNA

integrase; enzyme integrates dsDNA into host cell's DNA

HIV protease; cleaves immature HIV polyprotein into individual functional viral proteins >

capsid surrounded by envelope formed from host's CSM >

glycoproteins(gp120, gp41) protrude thru envelope >

gp120, specific conformation, allows virus to r&b to specific receptors on host cells CSM >

gp120, gp41 association w/ host cell receptors leads to fusion of HIV envelope & host CSM

Review: H2 Biology 14 - Virus structure