Nutrient Absorption Disorder:

• Malabsorption/Maldigestion or Both

Pancreatic Enzyme Insufficiency

No lipase in saliva or brush border -> Fat Maldigestion

Causes:

Pancreatitis or Carcinoma;

Cystic Fibrosis

Lactase Deficiency

Defective/Absent Lactase -> Lactose Maldigestion

Causes:

(1◦) Genetic /(2◦) Intestinal Disorder

lactose accumulation -> osmotic diarrhea, painful cramps

Bile Salt Deficiency

↓ Micelle Concentration Fat Malabsorption

Causes:

Severe Liver & Ileal Disease; Gallstones; ↑ Microbiome Bile Salt Deconjugation

Vit. A: Night blindness

Vit. D: Osteoporosis

Vit. K: Clotting Issues

Review: 12. GI pathopharmacology 2