Infliximab, Certolizumab, Adalimumab, Golimumab
What are the TNFa inhibitors? (4)
Remicade
Infliximab =
Humira
Adalimumab =
Cimzia
Certolizumab =
Simponi
Golimumab =
a
What is the preferred treatment for moderate-severe UC?
a) Anti-TNFa
b) Ustekinumab
c) Mirikizumab
d) JAK inhibitors
e) Natalizumab
f) Vedolizumab
d
Which agent has a BBW for serious infections?
a) Anti-TNFa
b) Ustekinumab
c) Mirikizumab
d) JAK inhibitors
e) Natalizumab
f) Vedolizumab
e
Which has a REMS program for PML?
a) Anti-TNFa
b) Ustekinumab
c) Mirikizumab
d) JAK inhibitors
e) Natalizumab
f) Vedolizumab
Tysabri
Natalizumab =
moderate-severe UC who failed: immunomodulators, anti-TNFa
What is the indication for Ustekinumab? (3)
Stelara
Ustekinumab =
f
Which is indicated ONLY for refractory disease?
a) Anti-TNFa
b) Ustekinumab
c) Mirikizumab
d) JAK inhibitors
e) Natalizumab
f) Vedolizumab
Entyvio
Vedolizumab =
c
Which TNFas is the ONLY one available via IV?
a) Adalimumab
b) Golimumab
c) Infliximab
d) Certolizumab
infliximab, vedolizumab, ustekinumab
Which biologics are available via IV? (3)
adalimumab, golimumab
Which biologics are available in pre-filled pens? (2)
f
Which can cause nasopharyngitis?
a) Anti-TNFa
b) Ustekinumab
c) Mirikizumab
d) JAK inhibitors
e) Natalizumab
f) Vedolizumab
a
Which is administered every 2 weeks?
a) Adalimumab
b) Golimumab
c) Infliximab
d) Certolizumab
b,d
Which is administered every 4 weeks?
a) Adalimumab
b) Golimumab
c) Infliximab
d) Certolizumab
serious infections, cancer, CV events
What are the BWs for JAK inhibitors? (3)
Xeljanz
Tofacitinib =
Rinvoq
Upadacitinib =
mesalamine
Which drugs are considered maintenance medication for Mild disease?
Anti-TNFa, thiopurine, cyclosporine, Ustekinumab, JAKs
Which drugs are considered maintenance medication for Moderate-Severe Disease? (5)
Vedolizumab
Which drug is for Refractory disease?
mesalamine +/- steroid, Anti-TNF, ustekinumab, Tofacitinib, Vedolizumab, IV cyclosporine
Which drugs can induce remission? (6)
arthralgia, nasopharyngitis, HA/fatigue
Vedolizumab AE's? (3)
TNFa, JAK, Natalizumab
Which immunomodulators have a BW? (3)
d
Which has a REMS program for CV events?
a) Anti-TNFa
b) Ustekinumab
c) Mirikizumab
d) JAK inhibitors
e) Natalizumab
f) Vedolizumab