False
Crystalline materials are more soluble than amorphous compounds. True or false?
True
For a solid solute trans-isomers are less soluble than the cis isomers. True or false?
b,d
To decrease solubility of a solid solute in water one could generally (choose all correct answers)
a. Decrease crystallinity
b. increase crystallinity
c. use cis-isomers
d. use trans-isomers
A
Which solid would give greater solubility?
a. Amorphous solid
b. Crystalline
A
Using a spray drying formulation approach a pharmaceutical scientist converted a poorly soluble crystalline cephalosporin into its amorphous form for a tablet dosage form. What could be the likely impact of this on oral bioavailability?
a. increased absorption
b. decreased absorption
B
A compound with lower melting point is likely to be _ soluble than a compound with higher melting point than a compound with a higher melting point (everything else remaining the same.
a. Less
b. More
A
Which compound is most probably going to be more soluble?
a. Theophylline anhydrous
b. Theophylline hydrate
A
Salt form is generally more soluble than non-salt form
a. True
b. False