Flashcards: Senescence

Bloom syndrome (often abbreviated as BS in literature), also known as Bloom-Torre-Machacek syndrome, is a rare autosomal recessive disorder characterized by short stature, predisposition to the development of cancer and genomic instability.

Calorie restriction (CR), or caloric restriction, or energy restriction, is a dietary regimen that reduces calorie intake without incurring malnutrition or a reduction in essential nutrients.

Collagen /ˈkɒlədʒᵻn/ is the main structural protein in the extracellular space in the various connective tissues in animal bodies.

Telomerase, also called terminal transferase, is a ribonucleoprotein that adds a species-dependent telomere repeat sequence to the 3' end of telomeres.

Neurodegeneration is the umbrella term for the progressive loss of structure or function of neurons, including death of neurons.

Progeria is an extremely rare genetic disorder in which symptoms resembling aspects of aging are manifested at a very early age.

A retirement home – sometimes called an old people's home or old age home, although this term can also refer to a nursing home – is a multi-residence housing facility intended for senior citizens.

The International Day of Older Persons is observed on October 1 each year.

Sirtuin or Sir2 proteins are a class of proteins that possess either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity.

Mitochondrial DNA (mtDNA or mDNA) is the DNA located in mitochondria, cellular organelles within eukaryotic cells that convert chemical energy from food into a form that cells can use, adenosine triphosphate (ATP).

Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage.

Reactive oxygen species (ROS) are chemically reactive chemical species containing oxygen.

Macular degeneration, also known as age-related macular degeneration (AMD or ARMD), is a medical condition which may result in blurred or no vision in the center of the visual field.

Biological immortality refers to a stable or decreasing rate of mortality from senescence, thus decoupling it from chronological age.

Progeroid syndromes (PS) are a group of rare genetic disorders that mimic physiological aging, making affected individuals appear to be older than they are.

RecQ helicase is a family of helicase enzymes initially found in Escherichia coli that has been shown to be important in genome maintenance.

A DNA repair-deficiency disorder is a medical condition due to reduced functionality of DNA repair.