Pathogenicity: Hyaluronidase and Collagenase
1.) Hyaluronidase acid is an enzyme protein (Carbohydrate acid, lipoprotein Acid)
2.) Hyaluronidase acid will cut and cleave tissues
3.)Collagenase enzymes break down the native collagen that holds animal tissues together with
4.) Collagenase enzymes can have access to deeper tissues.
5.) The neutrophil and macrophage wait to kill protein.
Name two virulence factors of hyaluronidase acid
Spyce- inhibit interlukin 8
How does gas deal with NETs?
it secrets DNA and releases STA1 from there bacteria can escape the NETs.
NETs’ release is the most dramatic stage in a cell death process called NETosis.
NETs are released during a form of pathogen-induced cell death.
DNA-histone complexes and proteins are released by activated neutrophils.
Something that allows the bacteria to evade immune response?
Virulence factors
Superantigens
Superantigens are bacterial proteins that generate a powerful immune response by binding to Major Histocompatibility Complex class II molecules on antigen-presenting cells and T cell receptors on T cells.
Superantigen secrets S. aureus.
antigen thinks it's getting IL8, 12 from T cells and damaging cells. because it's secreting S. aureus into host
Three components of tissue
Cutaneous membrane
Collagen layer
Fibrin (a tough protein substance that is arranged in long fibrous chains)