irreversible inhibitor of COX-1 enzyme; reduces formation and release of TXA2
Aspirin MOA?
TXA2
-stimulates activation of new platelets and increases platelet aggregation
7-10 days; platelets can't make new proteins
How long does the activity of aspirin on platelet COX-1 last?
Why?
-grel suffix
How can we identify ADP pathway inhibitors?
a, b
Which are prodrugs?
a) clopidogrel
b) prasugrel
c) Ticagrelor
d) Cangrelor
-antagonize ADP-receptor P2Y12; reduce platelet aggregation
ADP pathway inhibitors moa?
a
Which has the slowest onset of action?
a) clopidogrel
b) prasugrel
c) Ticagrelor
d) Cangrelor
a
Which has the lowest platelet inhibition?
a) clopidogrel
b) prasugrel
c) Ticagrelor
d) Cangrelor
a
Which is metabolized by CYP2C19 ?
a) clopidogrel
b) prasugrel
c) Ticagrelor
d) Cangrelor
a, b
Which are irreversible inhibitors of P2Y12?
a) clopidogrel
b) prasugrel
c) Ticagrelor
d) Cangrelor
d
Which is administered via IV?
a) clopidogrel
b) prasugrel
c) Ticagrelor
d) Cangrelor
c
Which has the highest risk of intracranial bleeding?
a) clopidogrel
b) prasugrel
c) Ticagrelor
d) Cangrelor
d
Which has DDI w/ Prasugrel or Clopidogrel?
a) clopidogrel
b) prasugrel
c) Ticagrelor
d) Cangrelor
c
Which can cause dyspnea?
a) clopidogrel
b) prasugrel
c) Ticagrelor
d) Cangrelor
c
Which is orally active?
a) clopidogrel
b) prasugrel
c) Ticagrelor
d) Cangrelor
c
Which do we avoid inhibitors of CYP3A in?
a) clopidogrel
b) prasugrel
c) Ticagrelor
d) Cangrelor
c
Which can increase serum concentrations of simvastatin & lovastatin?
a) clopidogrel
b) prasugrel
c) Ticagrelor
d) Cangrelor
c
Which can interfere with Digoxin metabolism?
a) clopidogrel
b) prasugrel
c) Ticagrelor
d) Cangrelor
-antagonize glycoprotein IIb/IIIa receptors for fibrinogen, vitronectin, and vWF
glycoprotein IIb/IIIa inhibitor MOA?
abciximab, eptifibatide, tirofiban
What are the Glycoprotein IIb/IIIa inhibitors (3)
b
How are Glycoprotein IIb/IIIa inhibitors administered?
a) orally
b) IV
c) patch
d) SQ
a
Which is a chimeric monoclonal Ab?
a) Abciximab
b) Eptifibatide
c) Tirofiban
b
Which is a peptide analog?
a) Abciximab
b) Eptifibatide
c) Tirofiban
c
Which is a peptidomimetic analog?
a) Abciximab
b) Eptifibatide
c) Tirofiban
b,c
Which are competitive antagonists?
a) Abciximab
b) Eptifibatide
c) Tirofiban
Cilostazol
What is our PDE3 inhibitor?
induces vasodilation coupled with an antiplatelet effect by decreasing
synthesis of TXA2 & other platelet aggregating factors
PDE3 inhibitor MOA
treatment of PAD
What are PDE3 inhibitors used for?
f; treats pain-associated w/ walking
PDE3 inhibitors are proven to reduce the risk of CV death. T/F?