a
Which is IgE-mediated?
a) Type I
b) Type II
c) Type III
d) Type IV
b,c
Which is mediated by IgG or IgM?
a) Type I
b) Type II
c) Type III
d) Type IV
c
Which forms Antigen-Ab complexes in the circulation and deposits on the
basement membrane in kidneys & joints?
a) Type I
b) Type II
c) Type III
d) Type IV
d
Which is T-cell mediated?
a) Type I
b) Type II
c) Type III
d) Type IV
b
Which occurs due to blood infusion reactions?
a) Type I
b) Type II
c) Type III
d) Type IV
b
Which is Cytotoxic?
a) Type I
b) Type II
c) Type III
d) Type IV
mast; basophils
Type I reactions involve ______ cells & ______ that undergo activation
& degranulation.
airway obstruction & cardiovascular collapse
What typically occurs in Type 1: anaphylaxis? (2)
vasodilation & increased capillary permeability
Why does cardiovascular collapse occur?
laryngeal
Type I: Anaphylaxis is characterized by _________ edema.
more selective for B1; doesn't cause enough bronchodilation
Why is NE not used in Anaphylactic Shock?
antihistamines, glucocorticoids, theophylline, epinephrine
Which medications can be used for the treatment of Type I? (4)
a
Blocks the proliferation of IgE-producing clones & inhibits cytokine
production by immune cells.
a) glucocorticoids
b) theophylline
c) antihistamines
d) epinephrine
b
Reduces mediators from mast cells & induces bronchodilation.
a) glucocorticoids
b) theophylline
c) antihistamines
d) epinephrine
b
Responses are directed against cell-surface or matrix antigens.
a) Type I
b) Type II
c) Type III
d) Type IV
c
Responses are directed against soluble antigens.
a) Type I
b) Type II
c) Type III
d) Type IV
express IL-2; stimulated to proliferate and differentiate into memory TDTH cells
What do T-cells do in Type IV reactions?
TDTH; phagocytosis; lytic enzyme
Upon re-exposure, _______ cells release cytokines and activate
macrophages & neutrophils; causing _________ & ________ release.
a
Penicillins and Sulfas can cause _______ reactions.
a) Type I
b) Type II
c) Type III
d) Type IV
methimazole; clozapine
Type II reactions can be caused by which drugs? (2)
d
Usually occurs because of topical or injection-mediated drug delivery.
a) Type I
b) Type II
c) Type III
d) Type IV
a
This receptor causes bronchoconstriction.
a) H1
b) H2
b
This receptor causes the release of gastric acid.
a) H1
b) H2
b
Part of the negative feedback of the degranulation cascade.
a) H1
b) H2
a
Increases contraction & neuronal activity.
a) H1
b) H2
a
Leads to peristalsis and diarrhea.
a) H1
b) H2
b
Mediated by Mast cells.
a) Late-phase reaction
b) Immediate reaction
a
Caused by cytokines.
a) Late-phase reaction
b) Immediate reaction
a
Hyper-responsiveness occurs in this phase.
a) Late-phase reaction
b) Immediate reaction