b,d
Which class of drugs act on autoarrhythmic cells?
a) Class I
b) Class II
c) Class III
d) Class IV
a,c
Which class of drugs act on cardiomyocytes?
a) Class I
b) Class II
c) Class III
d) Class IV
a
Which phase do Class IV & Class II drugs act on?
a) Phase 0
b) Phase 1
c) Phase 2
d) Phase 3
e) Phase 4
a
Which phase do Class I drugs act on?
a) Phase 0
b) Phase 1
c) Phase 2
d) Phase 3
e) Phase 4
d
Which phase do Class III drugs act on?
a) Phase 0
b) Phase 1
c) Phase 2
d) Phase 3
e) Phase 4
procainamide
What are the Class 1A: Na+ blocking drugs? (1)
lidocaine, mexiletine
What are the Class 1B: Na+ blocking drugs? (2)
flecainide, propafenone
What are the Class 1C: Na+ blocking drugs? (2)
amiodarone, dronedarone, sotalol, defetilide, ibutilide
What are the Class III: K+ blocking drugs? (5)
dilitazem, verapamil
What are the Class IV: Ca2+ blocking drugs? (2)
slow ventricular conduction, decrease automaticity in myocytes, increase refractoriness
What are the class I effects? (3)
decrease hr, suppress abnormal pacemakers, slow ventricular response in atrial arrhythmias
What are the class II:BBs effects? (3)
1a, 2, 3
Which class increases the refractory period between action potentials?
prolongs ERP; increasing the duration of the AP without altering phase 0 or resting membrane potential
How does Class III:K+ blockers work?
nodal cells; myocytes
Class II increases refractory period in _______ while Class III increases the refractory period in _______.
c
Which class causes QTc prolongation & TdP?
a) Class I
b) Class II
c) Class III
d) Class IV
a
Which class is the most prone to causing arrhythmias?
a) Class I
b) Class II
c) Class III
d) Class IV
c
Which phase involves ca++ influx? (Nodal Cells)*
a) phase 4
b) phase 3
c) phase 0
b
Which phase involves K+ efflux; i.e. repolarization? (Nodal Cells)*
a) phase 4
b) phase 3
c) phase 0
a
Which phase involves Na+ influx? (Nodal Cells)*
a) phase 4
b) phase 3
c) phase 0
a
Class III drug with additional Class I, II, and IV effects.
a) Dronedarone
b) propafenone
c) Sotalol
d) procainamide
c
Considered class III drug, but is also a beta blocker
a) Dronedarone
b) propafenone
c) Sotalol
d) procainamide
b
Class I drug with beta blocking activity.
a) Dronedarone
b) propafenone
c) Sotalol
d) procainamide
d
Class I antiarrhythmic with additional class III effect
a) Dronedarone
b) propafenone
c) Sotalol
d) procainamide