Flashcards: Nitrogen mustards

Melphalan (trade name Alkeran, in former USSR also known as Sarcolysin) is a chemotherapy drug belonging to the class of nitrogen mustard alkylating agents.

Uramustine (INN) or uracil mustard is a chemotherapy drug which belongs to the class of alkylating agents.

Bendamustine (INN, trade names Treakisym, Ribomustin, Levact and Treanda; also known as SDX-105) is a nitrogen mustard used in the treatment of chronic lymphocytic leukemia and lymphomas.

Trofosfamide (INN) is a nitrogen mustard alkylating agent.

Chlormethine (INN, BAN), mechlorethamine (widely used in the US, not the USAN, however) also known as mustine and HN2 and in former USSR known as Embichin is a nitrogen mustard sold under the brand name Mustargen.

Mafosfamide (INN) is an oxazaphosphorine (cyclophosphamide-like) alkylating agent under investigation as a chemotherapeutic.

Carboxycyclophosphamide is an inactive metabolite of the cytotoxic antineoplastic drug cyclophosphamide.

Bis(2-chloroethyl)ethylamine is the organic compound with the formula C2H5N(CH2CH2Cl)2.

Glufosfamide, also known as glucophosphamide, D-glucose isophosphoramide mustard, D-19575 is an experimental cytotoxic chemotherapeutic agent for treatment of malignancies.

Mannomustine (INN), also known as mannitol nitrogen mustard, tradename Degranol is an old alkylating antineoplastic agent from the group of nitrogen mustards.

Prednimustine is a drug used in chemotherapy.

Prospidium chloride is a spiro compound.

Chlorambucil (marketed as Leukeran by GlaxoSmithKline) is a chemotherapy drug that has been mainly used in the treatment of chronic lymphocytic leukemia.

Cyclophosphamide (INN), also known as cytophosphane, is a medication mainly used in chemotherapy.

Ifosfamide (also marketed as Ifex) is a nitrogen mustard alkylating agent used in the treatment of cancer.

Perfosfamide, or 4-hydroperoxycyclophosphamide (trade name Pergamid) was an experimental drug candidate for blood cancers that was rejected by the FDA in 1993 and never reached the market.

Estramustine (INN, USAN, BAN) (brand names Emcyt, Estracit), in salt form as estramustine phosphate sodium (USAN) (or estramustine sodium phosphate (BAN)) or estramustine phosphate meglumine, is an alkylating antineoplastic agent (that is, a chemotherapeutic) that is used in the treatment of prostate cancer throughout the world.

Tris(2-chloroethyl)amine is the organic compound with the formula N(CH2CH2Cl)3.

4-Hydroxycyclophosphamide is in the class of oxazaphosphorine compounds, and is the main, active metabolite of cyclophosphamide and of mafosfamide after they partially metabolized by cytochrome P450.

Chlornaphazine, a derivative of 2-naphthylamine, is a nitrogen mustard that was developed in the 1950s for the treatment of polycythemia and Hodgkin's disease.

Evofosfamide (INN, USAN; formerly known as TH-302) is an investigational hypoxia-activated prodrug that is in clinical development for cancer treatment.

PR-104 is a drug from the class of hypoxia-activated prodrugs (HAPs), which is being researched as a potential anti-cancer therapeutic agent.

Atrimustine (INN) (developmental code name KM-2210), also known as bestrabucil or busramustine, is a nitrogen mustard alkylating antineoplastic drug that was under development in Japan by Kureha Chemicals (now Kureha Corporation) for the treatment of breast cancer and non-Hodgkin's lymphoma as well as for the prevention of graft-versus-host disease in bone marrow transplant recipients.

Alestramustine (INN), also known as estradiol 3-(bis(2-chloroethyl)carbamate), 17-ester with L-alanine, is a nitrogen mustard alkylating antineoplastic drug that was never marketed.

Estromustine (developmental code name Leo 271 f), also known as estrone 17β-3-N-bis(2-chloroethyl)carbamate or estrone-cytostatic complex, is both the main metabolite and an important active metabolite of the cystotatic estrogen and nitrogen mustard alkylating antineoplastic agent estramustine, a drug used in the treatment of prostate cancer.

Estradiol mustard (developmental code name NSC-112259), also known as chlorphenacyl estradiol diester, as well as estradiol 3,17β-bis(4-(bis(2-chloroethyl)amino)phenyl)acetate, is a synthetic, steroidal estrogen and alkylating antineoplastic agent and a nitrogen mustard-coupled estrogen ester that was never marketed.

ICI-85966 (former tentative brand name Stilbostat), also known as diethylstilbestrol bis(di(2-chloroethyl)carbamate), is a synthetic, non-steroidal estrogen and alkylating antineoplastic agent of the stilbestrol group and a cytostatic nitrogen mustard ester of diethylstilbestrol (DES) that was developed for the treatment of breast cancer and prostate cancer but was never marketed.

Phenestrol (developmental code name NSC-183736), or fenestrol, also known as hexestrol bis[4-[bis(2-chloroethyl)amino]phenylacetate, is a synthetic, non-steroidal estrogen and alkylating antineoplastic agent and a nitrogen mustard ester of hexestrol that was developed in the early 1960s but was never marketed.