Flashcards: Neurosteroids

5β-Dihydroprogesterone (5β-DHP), also known as 5β-pregnan-3,20-dione, is an endogenous neurosteroid and an intermediate in the biosynthesis of pregnanolone and epipregnanolone from progesterone.

3α-Dihydroprogesterone (3α-DHP), also known as 3α-hydroxy-4-pregnen-20-one, is an endogenous neurosteroid.

Epipregnanolone, also known as 3β-Hydoxy-5β-pregnan-20-one or 3β,5β-tetrahydroprogesterone (3β,5β-THP), is an endogenous neurosteroid.

Minaxolone (CCI-12923) is a neuroactive steroid which was developed as a general anesthetic but was withdrawn before registration due to toxicity seen with long-term administration in rats, and hence was never marketed.

Pregnadienedione (PDD), or pregna-4,20-dien-3,6-dione, is a steroid and pherine, or synthetic pheromone.

17-Phenylandrostenol (17-PA), or (3α,5α)-17-phenylandrost-16-en-3-ol, is a steroid drug which binds to GABAA receptors.

Alfaxalone (INN, JAN), also known as alphaxalone or alphaxolone (BAN), is a neuroactive steroid and general anaesthetic.

Ganaxolone is a CNS-selective GABAA modulator that acts on well-characterized targets in the brain known to have anxiolytic and anticonvulsant effects.

Hydroxydione, as hydroxydione sodium succinate (INN, USAN, BAN) (brand names Viadril, Predion, and Presuren), is a neuroactive steroid which was formerly used as a general anesthetic, but was discontinued due to incidence of thrombophlebitis in patients.

Tetrahydrodeoxycorticosterone (abbreviated as THDOC; 3α,21-dihydroxy-5α-pregnan-20-one), also referred to as allotetrahydrocorticosterone, is an endogenous neurosteroid.

Cholesterol, from the Ancient Greek chole- (bile) and stereos (solid) followed by the chemical suffix -ol for an alcohol, is an organic molecule.

Progesterone (P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species.

Androstenol, also known as 5α-androst-16-en-3α-ol (shortened to 3α,5α-androstenol or 3β-androstenol), is a steroidal pheromone and neurosteroid in humans and other mammals, notably pigs.

Androsterone, or 3α-hydroxy-5α-androstan-17-one, is an endogenous steroid hormone, neurosteroid, and putative pheromone.

Androstadienone, also known as androsta-4,16,-dien-3-one, is an endogenous steroid that has been described as having potent pheromone-like activities in humans.

Androstenone (5α-androst-16-en-3-one) is a steroid-like pheromone.

Dehydroepiandrosterone/dehydroepiandrostenedione (DHEA, more correctly didehydroepiandrosterone), also known as androstenolone as well as 3β-hydroxyandrost-5-en-17-one or 5-androsten-3β-ol-17-one, is an endogenous steroid hormone.

Estratetraenol, also known as estra-1,3,5(10),16-tetraen-3-ol, is an endogenous steroid found in women that has been described as having pheromone-like activities in primates, including humans.

Pregnenolone (3β-hydroxypregn-5-en-20-one), also known as P5, is an endogenous steroid hormone.

Dehydroepiandrosterone sulfate or DHEA-S is a metabolite of dehydroepiandrosterone (DHEA).

3α-Androstanediol (often abbreviated as 3α-diol), also known as 5α-androstane-3α,17β-diol, is an endogenous inhibitory androstane neurosteroid and weak androgen, and a major metabolite of dihydrotestosterone (DHT).

Etiocholanolone, 3α-hydroxy-5β-androstan-17-one, is an endogenous 17-ketosteroid that is produced from the metabolism of testosterone.

Pregnenolone sulfate (3β-hydroxypregn-5-en-20-one sulfate; abbreviated as PS) is an endogenous excitatory neurosteroid that is synthesized from pregnenolone.

5α-Dihydroprogesterone (5α-DHP), also known as 5α-pregnan-3,20-dione, is an endogenous progestogen and neurosteroid that is synthesized from progesterone.

Alfaxolone/alfadolone (Althesin) is a short acting intravenous anaesthetic agent.

Acebrochol (INN), also known as cholesteryl acetate dibromide or 5α,6β-dibromocholestan-3β-ol acetate, is a neuroactive steroid which was described as a sedative and hypnotic but was never marketed.

Pregnanolone, also known as eltanolone (INN), as well as 3α,5β-tetrahydroprogesterone (3α,5β-THP) or 3α-hydroxy-5β-pregnan-20-one, is an endogenous neurosteroid that is biosynthesized from progesterone.

Androstadienol, or 5,16-androstadien-3β-ol, is an endogenous steroid, pheromone, and chemical intermediate to several other pheromones that is found in the sweat of both men and women.

Org 20599 is a synthetic neuroactive steroid, with sedative effects resulting from its action as a GABAA receptor positive allosteric modulator and, at higher concentrations, agonist.

Alfadolone (INN), or alphadolone is a neuroactive steroid and general anesthetic.

Org 21465 is a synthetic neuroactive steroid, with sedative effects resulting from its action as a GABAA receptor positive allosteric modulator.

Renanolone (INN), or 11-ketopregnanolone, is a semisynthetic neuroactive steroid which was described as a general anesthetic, but was never introduced for clinical use.

5α-Dihydrodeoxycorticosterone (abbreviated as DHDOC), also known as 21-hydroxy-5α-pregnan-20-one, is an endogenous progestogen and neurosteroid.

Isopregnanolone, also known as isoallopregnanolone and epiallopregnanolone, as well as sepranolone (INN), and as 3β-hydoxy-5α-pregnan-20-one or 3β,5α-tetrahydroprogesterone (3β,5α-THP), is an endogenous neurosteroid and a natural 3β-epimer of allopregnanolone.

Allopregnanolone (ALLO), also known as 3α-hydroxy-5α-pregnan-20-one or 3α,5α-tetrahydroprogesterone (3α,5α-THP), is an endogenous inhibitory pregnane neurosteroid.

5α-Dihydrocorticosterone ((5α,11β)-11,21-dihydroxypregnane-3,20-dione; abbreviated as 5α-DHC, 5α-DHB) is a naturally-occurring, endogenous glucocorticoid steroid hormone and neurosteroid.