bind inflammatory cytokine antigens or receptors; block signaling
How do bDMARDs work?
block cytokine that is overproduced in chronic inflammatory disease
TNF-a blocker MOA?
lower patient ability to fight infections, must test for TB prior to start, no live vaccines
What are BBW associated with TNF-a blockers?
active infections, malignancies, hypersensitivity
What are Contraindications associated with TNF-a blockers?
b
Which TNF-a blocker has a citrate free formulation to reduce injection site pain?
a) Enbrel
b)Humira
c) CIMZA
d) SIMPONI
a
Which TNF-a blocker is a fusion protein?
a) Enbrel
b)Humira
c) CIMZA
d) SIMPONI
c
Which TNF-a blocker has an extended half-life, bioavailability, and stability?
a) Enbrel
b)Humira
c) CIMZA
d) SIMPONI
b
Which TNF-a blocker is administered every 2 weeks?
a) Enbrel
b)Humira
c) CIMZA
d) SIMPONI
a
Which TNF-a blocker has several different injection platforms/mechanisms?
a) Enbrel
b)Humira
c) CIMZA
d) SIMPONI
c
Which TNF-a blocker has no Fc region in its antibody structure?
a) Enbrel
b)Humira
c) CIMZA
d) SIMPONI
d
Which TNF-a blocker is the first to only require one dose per month?
a) Enbrel
b)Humira
c) CIMZA
d) SIMPONI
c
Which TNF-a blocker has a low transfer in breast milk and across the placenta?
a) Enbrel
b)Humira
c) CIMZA
d) SIMPONI
enbrel, humira, cimza, simponi
What are our TNF-a blockers?
plaque psoriasis
What was the original indication for our IL blockers?
stelara, cosentyx
What are our IL blockers?
actemra, siliq
What are our IL-receptor blockers?
d
Which IL-medication is a first in class IL-12/IL-13 blocker?
a) Cosentyx
b) Actemra
c) Siliq
d) Stelara
a
Which IL-medication is a first-in-class IL-17A blocker?
a) Cosentyx
b) Actemra
c) Siliq
d) Stelara
c
Which IL-medication is a IL-17A receptor blocker?
a) Cosentyx
b) Actemra
c) Siliq
d) Stelara
c
Which IL-medication is contraindicated for Crohn's disease?
a) Cosentyx
b) Actemra
c) Siliq
d) Stelara
b,c
Which IL-medications can lower ability to fight off infections and require TB testing?
a) Cosentyx
b) Actemra
c) Siliq
d) Stelara
b
Which IL-medication is an IL-6 receptor blocker?
a) Cosentyx
b) Actemra
c) Siliq
d) Stelara
c
Which IL-medication has a BBW for suicidal ideation?
a) Cosentyx
b) Actemra
c) Siliq
d) Stelara
b
Which IL-medication can also be used to treat COVID-19 patients with severe disease?
a) Cosentyx
b) Actemra
c) Siliq
d) Stelara
entyvio
What is our T-cell communication antagonist?
c,d
What conditions is Entyvio used to treat?
a) RA
b) Plaque Psoriasis
c) Ulcerative colitis
d) Crohn's disease
denosumab; xgeva, prolia
What are our RANKL inhibitors?
a
Which RANKL inhibitor is used to prevent Skeletal-related events in bone cancer?
a) XGEVA
b)PROLIA
b
Which RANKL inhibitor is used to treat Osteoperosis in post-menopausal women?
a) XGEVA
b) PROLIA
binds to RANKL; inhibits osteoclastic bone resorption
Denosumab MOA?
inhibits T-lymphocytes that migrate into inflamed GI tissue
ENTYVIO MOA?
rheumatoid arthritis
RANKL inhibitors are not for _______.
cytokine storm
-a condition where IL-6 production gets stuck in a positive feedback loop causing the immune system to ramp up higher and higher until it attacks patient's own cells.
b
Which IL medication is used in patients refractory to standard anti-TNFa therapy?
a) Cosentyx
b) Actemra
c) Siliq
d) Stelara
a
Which immunoglobulin does Enbrel use on its Fc portion?
a) IgG
b)IgE
c)IgA
d)IgM
integrin receptor antagonist
What is another drug classification for ENTYVIO?