Flashcards: Imidazolines

Tizanidine (trade names Zanaflex (Acorda Therapeutics), Sirdalud (Novartis), Relentus (Beximco Pharma)) is a drug that is used as a muscle relaxant.

Brimonidine is a drug used as eye drops under the brand names Alphagan and Alphagan-P to treat open-angle glaucoma or ocular hypertension, and as a gel, Mirvaso, for facial skin redness in rosacea.

Allantoin is a chemical compound with formula C4H6N4O3.

Hydantoin, or glycolylurea, is a heterocyclic organic compound with the formula CH2C(O)NHC(O)NH.

Oxymetazoline is a selective α1 adrenergic receptor agonist and α2 adrenergic receptor partial agonist.

Biotin is a water-soluble B-vitamin, also called vitamin B7 and formerly known as vitamin H or coenzyme R.

Clonidine (trade names Catapres, Kapvay, Nexiclon, Clophelin, and others) is a medication used to treat high blood pressure, attention deficit hyperactivity disorder, anxiety disorders, withdrawal (from either alcohol, opioids, or smoking), migraine, menopausal flushing, diarrhea, and certain pain conditions.

Phentolamine (Regitine) is a reversible nonselective α-adrenergic antagonist.

DBDMH is an organic compound derived from the heterocycle called dimethylhydantoin.

Moxonidine (INN) is a new-generation centrally acting antihypertensive drug licensed for the treatment of mild to moderate essential hypertension.

Naphazoline (in the hydrochloride form) is the common name for 2-(1-naphthylmethyl)-2-imidazoline hydrochloride.

Xylometazoline, also known as xylomethazoline, and marketed under many brand names, is a medication which is used as a topical nasal decongestant.

Lysidine is a derivative of 2-imidazoline derivative.

1-Bromo-3-chloro-5,5-dimethylhydantoin (BCDMH) is a chemical structurally related to hydantoin.

Imidocarb is a urea derivative used in veterinary medicine as an antiprotozoal agent for the treatment of infection with Babesia (babesiosis) and other parasites.

Tolazoline is a non-selective competitive α-adrenergic receptor antagonist.

Apraclonidine (INN), also known under the brand name Iopidine, is a sympathomimetic used in glaucoma therapy.

Imidazol-4-one-5-propionic acid is an intermediate in the metabolism of histidine.

Nutlins are cis-imidazoline analogs which inhibit the interaction between mdm2 and tumour suppressor p53, and which were discovered by screening a chemical library by Vassilev et al.

Fenoxazoline (trade name Aturgyl in Brazil) is a nasal decongestant.

Metizoline (trade name Ellsyl) is a nasal decongestant against allergic and vasomotor rhinitis.

Alinidine (ST567) is a negative chronotrope that was developed in the 1970s and 1980s.

Tiamenidine (BAN, USAN, INN, also known as thiamenidine, Hoe 440) is a imidazoline compound that shares many of the pharmacological properties of clonidine.

Antazoline is a 1st generation antihistamine with anticholinergic properties used to relieve nasal congestion and in eye drops, usually in combination with naphazoline, to relieve the symptoms of allergic conjunctivitis.

Lofexidine (sold under the brand names: BritLofex and Kai Er Ding) is an α2A adrenergic receptor agonist, historically used as an antihypertensive, but more commonly used to alleviate the physical symptoms of heroin and other types of opioid withdrawal.

Fenobam is an imidazole derivative developed by McNeil Laboratories in the late 1970s as a novel anxiolytic drug with an at-the-time-unidentified molecular target in the brain.

Imazapyr is a non-selective herbicide used for the control of a broad range of weeds including terrestrial annual and perennial grasses and broadleaved herbs, woody species, and riparian and emergent aquatic species.

2-Imidazoline (dihydroimidazoles) is one of three isomers of the nitrogen-containing heterocycle with formula C3H6N2, derived from imidazole.

Mazindol (Mazanor, Sanorex) is a stimulant drug of the tetracyclic chemical class which is used as an anorectic.

Ergothioneine is a naturally occurring amino acid and is a thiourea derivative of histidine, containing a sulfur atom on the imidazole ring.

Cibenzoline (or cifenline) is a Class Ia antiarrhythmic.

Chloroethylclonidine is an irreversible agonist for adrenergic receptors, in particular alpha1B, D, C and alpha2A/D-subtypes.

Nepicastat (INN, codenamed SYN117, RS-25560-197) is an inhibitor of dopamine beta-hydroxylase, an enzyme that catalyzes the conversion of dopamine to norepinephrine.

Tetryzoline (INN; also known as tetrahydrozoline), a derivative of imidazoline, is found in over-the-counter eye drops and nasal sprays.

Efaroxan is an α2-adrenergic receptor antagonist and antagonist of the imidazoline receptor.

Indanidine is an alpha-adrenergic agonist.

Cirazoline is a full agonist at the α1A adrenergic receptor, a partial agonist at both the α1B and α1D adrenergic receptors, and a nonselective antagonist to the α2 adrenergic receptor.

Idazoxan (INN) is a drug which is used in scientific research.

Safotibant (INN) also known by the research code LF22-0542 is a non-peptide bradykinin B1 antagonist.

Tramazoline is a chemical that is used in the form of tramazoline hydrochloride in nasal decongestant preparations.

Imidacloprid is a systemic insecticide which acts as an insect neurotoxin and belongs to a class of chemicals called the neonicotinoids which act on the central nervous system of insects, with much lower toxicity to mammals.

Enoximone (INN, trade name Perfan) is an imidazole phosphodiesterase inhibitor.

ELB-139 (LS-191,811) is an anxiolytic drug with a novel chemical structure, which is used in scientific research.

Tymazoline (trade name Thymazen in Poland) is a nasal decongestant that can be used to treat rhinitis.

Dihydroimidazol-2-ylidene is a hypothetical organic compound with formula C3H6N2.

(R)-3-Nitrobiphenyline is a drug which acts as an α2-adrenergic agonist, selective for the α2C subtype, as well as being a weak antagonist at the α2A and α2B subtypes.

BRL-44408 is a drug used in scientific research which acts as a selective antagonist for the α2A adrenoreceptor.

Tolonidine is an antihypertensive.

Imiloxan is a drug which is used in scientific research.

Fenmetozole (DH-524) is a drug which was patented as an antidepressant, but was later studied as an antagonist of the effects of ethanol, though results were poor and it even increased its effects in some cases.