CYP2D6
Codeine---Morphine
CYP2C19
Amitriptyline ----- Nortriptyline
CYP3A4
Grapefruit juice inhibits
CYP2D6
Atomexetine (Strattera)
ADH
Ethanol------Acetyladehyde
CYP2D6
Amitriptyline--------inactive metabolite
CYP2C19
Citalopram-------inactive metabolite
CYP2D6
Tramadol
CYP2B6
Evafirenz (Sustiva)
CYP2D6
Paroxetine----- inactive metabolite
CYP2D6
Fluvoxamine (luvox)------- inactive metabolite
b, d
What statins are prodrugs?
A. Fluvastatin
B. Simvastatin
C. Rosuvastatin
D. Lovastatin
surgery, radiotherapy, cytotoxic chemo, molecularly targeted therapy, immunotherapy
What are the 5 pillars of cancer care?
CYP3A4
Tamoxifen ------> Endoxifen
prodrug; carboxylesterase; 5-fu
Capecitabine (xeloda) is a _______. It is metabolized by _________ into its active form ___________.
DPD; FUH2
5-FU is metabolized by ________ into its inactive metabolite _________.
hyperplasia, dysplasia, in situ carcinoma, invasive cancer
Development of cancer pathway?
e
Glucuronidation
A) PAPS
B) NH2
C) SH
D) SAM
E) UDP-GA
F) Acetyl CoA
a
Sulfonation
A) PAPS
B) NH2
C) SH
D) SAM
E) UDP-GA
F) Acetyl CoA
f
Acetylation
A) PAPS
B) NH2
C) SH
D) SAM
E) UDP-GA
F) Acetyl CoA
b
Amino Acid Conjugation
A) PAPS
B) NH2
C) SH
D) SAM
E) UDP-GA
F) Acetyl CoA
d
Methylation
A) PAPS
B) NH2
C) SH
D) SAM
E) UDP-GA
F) Acetyl CoA
c
Glutathione Conjugation
A) PAPS
B) NH2
C) SH
D) SAM
E) UDP-GA
F) Acetyl CoA