Flashcards: DNA-binding substances

Propidium iodide (or PI) is an intercalating agent and a fluorescent molecule with a molecular mass of 668.

Bisbenzimide is an organic compound used as a fluorescent stain for DNA in molecular biology applications.

Single-stranded binding proteins (not to be confused with the E. coli protein, Single-strand DNA-binding protein, SSB) are a class of proteins that have been identified in both viruses and organisms from bacteria to humans.

The HMG-box (High Mobility Group box) is a protein domain which is involved in DNA binding.

Netropsin (also termed congocidine or sinanomycin) is a polyamide with antibiotic and antiviral activity.

DAPI (4',6-diamidino-2-phenylindole) is a fluorescent stain that binds strongly to A-T rich regions in DNA.

A zinc finger is a small protein structural motif that is characterized by the coordination of one or more zinc ions in order to stabilize the fold.

A basic helix-loop-helix (bHLH) is a protein structural motif that characterizes a family of transcription factors.

GelRed is an intercalating nucleic acid stain used in molecular biology for agarose gel electrophoresis.

Ethidium bromide is an intercalating agent commonly used as a fluorescent tag (nucleic acid stain) in molecular biology laboratories for techniques such as agarose gel electrophoresis.

In proteins, the helix-turn-helix (HTH) is a major structural motif capable of binding DNA.

NAMI-A and KP1019 are two ruthenium anticancer agents that have entered clinical trials.

Single-strand DNA-binding protein (SSB) is a protein, 178 amino acids long, found in Escherichia coli (E. coli) bacteria, that binds to single-stranded regions of deoxyribonucleic acid (DNA).

Pentamidine (formulated as a salt, pentamidine diisethionate or dimesilate) is an antimicrobial medication given to prevent and treat pneumocystis pneumonia (PCP) caused by Pneumocystis jirovecii (formerly named Pneumocystis carinii), a severe interstitial type of pneumonia often seen in patients with human immunodeficiency virus (HIV) infection.

GelGreen is an intercalating nucleic acid stain used in molecular biology for agarose gel electrophoresis.