1. stimuli 2. sensation
1. constantly exposed to sensory information
2. conscious awareness to stimuli
What are sensory receptors? 2 different kinds?
-detect stimuli
•structurally complex sense organs (the eye) or simple endings of single neurons (dendritic endings in the skin)
•General senses -temperature, pain, touch, stretch, and pressure
•Special senses -gustation, olfaction, vision, equilibrium, and hearing
transducers
change one form of energy into another
•Ex: Visual receptors change light energy into electrical energy on the optic nerve
receptive fields
Receptors have this:
Areas sensitive ends distributed
adaptation, 2 kinds
constant stimulus, decrease action potential
•Tonic receptors slowly adapt (only slowly decrease firing in response to a constant stimulus)
•Phasic receptors rapidly adapt (fire only in response to changing stimuli) (hair tie)
Sensory receptor distribution kinds
General sense receptors- throughout skin and organs
-Somatic sensory receptors skin, mucous membranes lining body cavities, joints, muscles, and tendons
• texture, pressure, temperature, pain, vibration, and stretch
-Visceral sensory receptors walls of internal organs & blood vessels
•Detect stretch, changes in chemical, temperature, and pain
Special sense receptors - in complex organs in the head
•smell, taste, vision, hearing, and equilibrium
Exteroceptors
detect stimuli from external environment
• receptors in skin, body cavity linings and in special sense organs
'Stimulus origin
Interoceptors
detect stimuli in internal organs
• stretch receptors in smooth muscle
• receptors for pain, pressure, temperature, and chemical changes in viscera
'Stimulus origin
Proprioceptors
detect stimuli pertaining to body position
•Found in muscles, tendons and joints
'Stimulus origin
Chemoreceptors
Detect specific molecules dissolved in fluid
'modality of stimulus
Thermoreceptors
Detect changes in temperature
'modality of stimulus
Photoreceptors
Detect changes in intensity, color, and position of light
'modality of stimulus
1. Mechanoreceptors & 2. Baroreceptors
1. Detect touch, pressure, vibration, and stretch
2. Detect pressure changes within body structures
'modality of stimulus
Nociceptors
Detect painful stimuli
'modality of stimulus
Phantom pain & Phantom limb syndrome
-sensation associated with a part of the body that has been removed
- Excitation of a CNS neuron that was formerly excited by the amputated limb is interpreted as pain in that limb
Referred pain
impulses are perceived as originating not from the organ but in a dermatome of the skin
•Ex: Heart attack, dermatomes of T1–T5
Tactile receptors and 2 types
-most numerous type
-mechanoreceptors that react to touch, pressure, and vibration
Located in the dermis and subcutaneous layer
Two types:
•Unencapsulated: endings not wrapped in connective tissue or glial cells
•Encapsulated: endings wrapped in connective tissue or glial cells
1.Free nerve endings, 2.Root hair plexuses, 3.Tactile discs
unencapsulated tactile receptors
1: papillary layer of dermis and deep epidermis (temp, pain)
2: surround hair follicles in dermis (movement of hair)
3: associated with tactile cells in stratum basale of epidermis (light touch)
1.End bulbs, 2.Lamellated corpuscles, 3.Bulbous corpuscles, 4.Tactile corpuscles & location
encapsulated tactile receptors
1: skin and oral, nasal, vagina, and anal (light pressure/vibration)
2: in dermis, subcutaneous tissue, synovial membranes, and some viscera (course touch, deep pressure)
3: in dermis and subcutaneous layer (continuous deep pressure)
4: in dermal papillae, especially lips, palms, eyelids, nipples, and genitals (texture and shape)
1.Olfaction & 2.Odorants
1.sense of smell
2. dissolved in mucus of nasal cavity and detected
1. Olfactory epithelium 2. Olfactory receptor cells, 3. Supporting cells, 4.Basal cells
1. lining superior nasal cavity
2. detect odors
3. sustain the olfactory receptor cells
4. replace olfactory receptor
Deep to the epithelium of olfactory
lamina propria
•mucin-secreting olfactory glands
Olfactory Receptor Cells are? what is in it? bundle of them?
- bipolar neurons, primary cells in smell pathway
- a single dendrite with olfactory hairs (cilia) containing receptors for one odorant molecule
•Bundles of axons: olfactory nerves
Olfactory Discrimination
-mix air with mucus of olfactory epithelium
-eight primary odors (for example, minty)
•Secondary odors (chemicals) not recognized by all
- cells can be mitotically replaced, declines with aging
Olfactory Pathways, how do smell travel?
Axons from bipolar neurons pass through foramina of cribriform plate and enter olfactory bulbs
•Bulbs -mitral and tufted cells
• olfactory glomeruli, olfactory cells converge
Neurons within olfactory bulbs project olfactory tracts, to olfactory cortex of temporal lobe
Gustation and what cells?
-sense of taste
Gustatory cells taste receptors in taste buds
dorsal surface of the tongue in epithelial and connective tissues elevations called papillae
4 types of elevations called papillae on tongue, location and
1.Filiform papillae: Small numerous bumps lacking taste buds (middle)
2.Fungiform papillae: Mushroom shaped, tip and sides of tongue few taste buds
3.Vallate papillae: “V” back of tongue; many taste buds
4.Foliate papillae: Subtle ridges on (side) few taste buds in early childhood
Inside a taste bud are 3 cells:
•Gustatory cells detect tastants (molecules and ions) in food
-Gustatory cells are neuroepithelial cells with a dendritic gustatory microvillus (taste hair, receptive)
•taste hair extends through taste pore
•Supporting cells sustain gustatory cells
•Basal cells neural stem cells that replace gustatory cells (regeneration every 7 to 9 days)
The five taste sensations include and what elements:
•Sweet - sugars
•Salt - metal ions (Na+)
•Sour - acids
•Bitter - alkaloids
•Umami - amino acids
How do we taste?
CN VII (facial) anterior two-thirds of tongue
CN IX (glossopharyngeal)posterior one-third of tongue
thalamus then gustatory cortex
- relies heavily on sense of smell
Eyelids: 1.Tarsal glands, 2.Palpebral fissure, 3.Lacrimal caruncle
movable anterior protective coverings for eye
1. sebaceous glands ; secretion prevents overflow of tears and sticking together of eyelids
2. space between eyelids
•Medial and lateral palpebral commissures: corners of eyes
3. medial pink bump with ciliary glands that produce gritty secretion
Conjunctiva of eye different layers, what does it contain?
-lining anterior surface (ocular conjunctiva)
internal surface of eyelid (palpebral conjunctiva)
•Stratified columnar epithelium
•Space is conjunctival fornix
•blood vessels and nerves
•goblet cells: lubricate eye
•Does not cover cornea
Lacrimal Apparatus of the eye, prevent bacterial infection?
Produces, collects, and drains lacrimal fluid (tears)
lubricate
Lysozyme in tears -prevent bacterial infections
Process of lacrimal apparatus, tears
•Lacrimal gland: produces tears
•Lacrimal caruncle: contains modified sweat glands
•Lacrimal puncta: small “holes” in the caruncle
•Lacrimal canaliculus: drains lacrimal fluid into lacrimal sac
•Nasolacrimal duct: receives tears from lacrimal sac and drains to nasal cavity
What cushions eye? front and back of eye contains?
-almost spherical organ about 2.5 cm in diameter
Orbital fat cushions the eye within the socket
Anterior cavity(front of the lens)
• circulating aqueous humor
Posterior cavity (behind the lens)
•permanent vitreous humor
Fibrous tunic is composed of two regions:*
•Cornea: avascular- oxygen & nutrients from lacrimal fluid & aqueous humor
-Outer corneal epithelium is stratified squamous
-Cornea meet sclera: limbus
•Sclera: majority of fibrous tunic; white of the eye
•Made of dense irregular connective tissue
Vascular tunic 3 region*, and muscle for dilatation?
•Choroid: capillaries, nutrients & oxygen to the retina
•Ciliary body: has ciliary muscles and ciliary processes; changes lens shape
•Iris: pigmented of eye; defines pupil—controls amount of light entering eye through
-Circular sphincter pupillae
-Radial dilator pupillae
Retina? 2 layers*
-internal eye
1.Pigmented layer: (outer) attached to choroid; absorbs light passed through retina
• provides photoreceptors with vitamin A, nutrients, oxygen
2. Neural layer: photoreceptors (rod & cone)& neurons
• converts to nerve impulses
Ora serrata
jagged margin between photosensitive and nonphotosensitive (anterior) part of retina, near ciliary body
Three distinct layers form the neural layer of retina:
1.Photoreceptor cells: outermost layer
-Rods: dim light
-cones: precise vision and color
- horizontal cells between
2.Bipolar cells: synapse with photoreceptors & ganglion cells
- amacrine cells: between
3.Ganglion cells: innermost layer of the retina; axons leave and form the optic nerve (CN II)
“blind spot” on the retina
optic disc, no photoreceptors
• ganglion cell axons exit retina to form optic nerve and blood vessels enter/ exit the retina
fovea centralis, whats so special? location?
depression in retina, highest cones and no rods
• sharpest vision
•Located within the macula lutea (lateral to optic disc)
What holds the lens? what change lens shape?
behind pupil. Held by suspensory ligaments- attach outer of lens and tension changes lens’ shape
•Changes in tension are caused by contraction and relaxation of ciliary muscles of ciliary body
Accommodation of lens is? process?
making lens spherical, look at thing close
•Parasympathetic fibers excite ciliary muscle; muscle contracts and suspensory ligaments slacken; lens becomes more spherical
2 cavity of eye, and how aqueous humor flow
1.Anterior cavity: between lens and cornea; filled with aqueous humor
-The iris subdivides this into: anterior chamber and posterior chamber
•Aqueous humor is secreted into posterior chamber; flows through pupil; drained through scleral venous sinus of limbus
2.Posterior cavity: between lens and retina; filled with vitreous humor (gelatinous, permanent)
•Hyaloid canal is remnant of developmental hyaloid blood vessel
How do visual pathway go?
Retinal photoreceptors convert light to neural signals
•Stimulus is passed to bipolar and ganglion cells
Axons of ganglion cells form optic nerve
•Optic nerves converge at optic chiasm where axons from medial retina cross
•Optic tracts extend laterally, posteriorly from chiasm
-Most extend to lateral geniculate nucleus of thalamus- then primary visual cortex of the occipital lobe
stereoscopic vision (depth perception)
unite images from left and right eyes
A limited number of optic tract axons project to the midbrain
•Some go to superior colliculi to coordinate visual reflexes involving extrinsic eye muscles
•Some go to pretectal nuclei to control pupillary and accommodation reflexes
Development of the Eye
fourth week optic vesicles form
become optic cups
•Cup contains two layers connected to brain by optic stalk
•Hyaloid vessels enter cup through stalk; later regress leaving hyaloid canal
Ectoderm over optic cup forms a lens pit
•The pit indents to form lens vesicle
1.External Ear called, 2.bony tube, 3.ear drum, 4.ear wax
1.auricle: funnel-shaped, elastic cartilage structure
2. bony tube, external acoustic meatus, which ends at the 3.tympanic membrane (eardrum)
4.secretion wax like cerumen to impede growth of microorganisms
1.tympanic cavity & 2.auditory tube
1.beind tympanic membrane contains air
2.connects middle ear to nasopharynx (throat)
'middle ear
Three auditory ossicles & location
(small bones) transmit sound waves to inner ear
•Malleus between tympanic membrane and incus
•Incus is the middle ossicle
•Stapes between incus and oval window to inner ear
Two small muscles contract to restrict ossicle movement when potentially damaging loud noises occur
•Stapedius & tensor tympani
Inner ear is located
-within petrous portion of temporal bone
•bony labyrinth
-fluid-filled tubes and spaces called the membranous labyrinth (Receptors for equilibrium and hearing)
endolymph- middle
perilymph- above and under (scala vestibuli & scala tympani
Bony labyrinth has three regions:Cochlea, Vestibule, Semicircular canals and inside is
•Cochlea has cochlear duct
•Vestibule has: utricle and saccule
•Semicircular canals each has a membranous semicircular duct
Equilibrium is, what apparatus is involved? stationary vs rotation?
awareness of head position
Vestibular apparatus consists of sensory receptors:
- utricle and saccule detect static equilibrium (head position when head is stationary) and linear acceleration
- semicircular ducts detect angular acceleration (rotational movements)
maculae location, includes, and their function
- walls of utricle and saccule
- sensory epithelium lining the two maculae contains hair cells and supporting cells
Hair cells’
- 50 stiff microvilli, stereocilia
-one long cilium kinocilium
bend, change neurotransmitter released by the hair cell, changes the electrical activity sent to the brain via the vestibular nerve
(head position)
otolithic membrane is made up of, how does
location top of maculae
-otoliths and gelatin layer with Stereocilia & kinocilium
head tilts, otoliths push gelatin, bends stereocilia of the hair cells
=neurotransmitter release = changes sensory neuron activity (head position)
where is semicircular canals? and region inside it? function?
semicircular canals (Anterior, posterior, and lateral) are continuous with the utricle
with semicircular duct ending with -ampulla
detect rotational movement of the head
ampulla contains crista ampullaris, how does it detect head rotation?
ampulla - near semicircular duct
cupula- dome gelatin with stereocilia and kinocilia
-crista ampullaris inside dome, has hair cells
-head rotates, endolymph pushes against the cupula and bends the stereocilia
hair cell neurotransmitter release and the activity of the sensory neurons
ear Vestibular Pathway, nerve pathway
- hair cells in vestibule or semicircular canal change their transmitter release, impulses initiated on vestibulocochlear nerve (CN VIII)
-Vestibular axons project to vestibular nuclei in the medulla oblongata or to cerebellum
•Vestibular nuclei: reflexive eye movements
•Cerebellum: coordinate balance
relayed to thalamus and cerebral cortex for awareness of body position
Structures for Hearing, 1.cochlea, 2.modiolus,3.cochlear duct. 4 above and below the cochlear duct:
1: inner ear organ of hearing
2 Snail shaped with bony axis
3 Membranous labyrinth(fluid) inside cochlea (endolymph)
4.•Scala vestibule (perilymph)
•Scala tympani (perilymph)
Spiral organ location, includes hair, and project into? base of those hair?
-of cochlea is a thick sensory epithelium with hair cells and supporting cells on the basilar membrane
• row of inner hair cells (hearing)
•3 rows of outer hair cells (help tune spiral organ response to sounds)
The stereocilia and kinocilium of each hair cell project into gelatinous mass tectorial membrane
base of hair cells are sensory neurons that have their cell bodies in spiral ganglia
Process of Hearing
- auricle into external acoustic meatus
-Tympanic membrane vibrates = move ossicles
-Stapes moves oval window, transmitting sound to inner ear
-Pressure waves in perilymph of scala vestibuli deform cochlear duct
•Region of basilar membrane that matches sound frequency is displaced
-Stereocilia of hair cells bent = impulses in cochlear branch of vestibulocochlear nerve
Frequency of sound
# of waves per unit of time
• hertz (Hz); pitch of a sound
•Influences which part of spiral organ is stimulated
High frequency near oval window; low far
Nerve pathway for hearing
-Bending of stereocilia = impulses on cochlear nerve
-Sensory axons of cochlear nerve terminate in cochlear nuclei of brainstem and synapse with secondary neurons
-Secondary axons travel to either superior olivary nuclei ( sound localization) or inferior colliculi
-From inferior colliculus, nerve impulses travel to medial geniculate nucleus of thalamus and then to primary auditory cortex of temporal lobe
Development of the Ear
fourth week
External acoustic meatus forms from first pharyngeal cleft
Tympanic cavity and auditory tube form from first pharyngeal pouch
•Pouch first grows into tubotympanic recess
Tympanic membrane forms from first pharyngeal membrane
Inner ear forms from otic placode
•Placode invaginates forming otic pit
•Otic pit closes to become otocyst—primitive precursor to inner ear
Cochlear Implants
Sound waves are detected by the receiver and turned into electrical impulses, which travel through the transmitter.
stimulatecochlear nerve, which then transmits nerve impulses to the brain.
loudness of sound
-measured in decibels dB
-louder sound stimulate more hair cell = higher rate of nerve impulse on cochlear nerve