Flashcards: Ceutics Concept Questions Test.1

ADME follows ________ kinetics.

In first order kinetics, Elimination rate constant (k), half-life (t_1/2), apparent volume of distribution (V), and clearance remain _______.

In First order kinetics, Increase in the dose causes _________ increase in plasma drug concentration and AUC_0-00.

In First order kinetics, concentrations of the drugs in plasma are below protein binding saturation, f_p remains _______.

Dose-independant

a) linear PK

b) Nonlinear PK

Dose-dependent

a) linear PK

b) Nonlinear PK

AUC_0-00 is disproportional to the dose.

a) linear PK

b) Nonlinear PK

>=1 of ADME processes is saturable.

a) linear PK

b) Nonlinear PK

Drug-plasma protein binding is _______.

Increased f_p my cause _____ in CL_H and/or CL_R

Increased f_p may cause _____ in V.

Renal Secretion and active renal reabsorption are ______ processes.

Saturated tubular secretion will lead to ______ CL_R

Saturated tubular reabsorption leads to ______ CL_R

What is Qh or hepatic blood flow?

When EH > 0.8, CLH is _______ to the change in QH.

When EH> 0.8, CLH is _______ to the change in fp or CLint.

When EH<0.2, CLH is ________ to the change in fp or CLint

When EH <0.2, CLH is _______ to the change in QH.

CLR= fp*GFR

CLR> fp* GFR

CLR< fp * GFR

Filtration occurs in the _______ of the nephron.

Secretion occurs in the ______ of the nephron.

Absorption occurs in the ______ of the nephron.

Which process is influenced by Protein binding?

a) filtration

b) secretion

c) absorption

Which process is influenced by competitive inhibitors?

a) filtration

b) secretion

c) absorption

Which process is active?

a) filtration

b) secretion

c) absorption

Which process is passive?

a) filtration

b) secretion

c) absorption

Which process is influenced by urinary pH and flow?

a) filtration

b) secretion

c) absorption

What kind of drug ionization is a characteristic of filtration?

What kind of drug ionization is a characteristic of secretion?

What kind of drug ionization is a characteristic of reabsorption?

Tubular______ and _______ are independent of plasma protein binding.

The elimination rate constant should be larger than the absorption rate constant. T/F?

The extent of oral absorption depends on____________.

a) dissolution of the dosage form

b) drug metabolism in the GI tract/liver

c) nature of the drug

d) all of the above

The oral bioavailability can be any number greater than 0. T/F?

Variability in V_max and K_m values in patients causes a narrow range in the effective doses needed to achieve therapeutic levels. T/F?

Significant first-pass metabolism means that much of the drug's metabolism occurs before its arrival at the _________.

The liver receive(s) blood from the ___________.

Renal clearance can be calculated from what ratio of rates to the drugs concentration in plasma?

Two important routes of drug excretion are _______.