Flashcards: BMS1 Pharmacology

study of substances that interact with living systems through chemical processes

division of science involving using substances to prevent, diagnose, and/or treat disease

study of adverse effects of substances on living systems

a substance that affects a biological system in a potentially useful way

any substance capable of producing a harmful effect

a naturally - occurring poison

synthetic poison

the component of a cell or organism that interacts with a drug and leads to the observed effects

type of drug receptor responsible for mediating the action of endogenous chemical signals

type of drug receptor that mediates chemical reactions/structural conversions

type of drug receptor that moves things, often across membranes

type of drug receptor that provides tissue or cellular structure

ligand that binds outside the orthosteric site and subsequently increases the affinity of an agonist for that receptor

ligand that binds outside the orthosteric site and subsequently decreases the affinity of an agonist for that receptor

measure of the maximal effect produced by a drug-receptor interaction at plateau

descriptor of efficacy (measure of max effect produced at plateau)

concentration of drug required to produce an effect of a given intensity (eg EC50)

measure of the strength and probability that a drug will bind an available receptor

equilibrium dissociation constant - concentration of drug where 1/2 receptors are occupied

maximal amount of receptors bound by a drug at plateau

process tying drug binding to the end effect observed

all or none response used to indicate efficacious doses

measure or the ratio between a toxic and efficacious doses

intracellular receptors that regulate gene transcription after activation by a lipid-soluble agonist

transmembrane protein with an extracellular ligand binding domain and an intracellular domain that does not have intrinsic kinase activity, but interacts with kinases