Blood is formed from ________ _______ ______ called ________ ________ that are suspended in ___________ _______ _______ called ______
living blood cells
formed elements
nonliving fluid matrix
plasma
The red blood cells that transport oxygen
Erythrocytes
The name for how erythrocytes make up 45% of total blood volume
Hematocrit
transport function of blood
delivers __________ from the lungs and ___________ from the digestive tract to all ________ ______
oxygen
nutrients
body cells
regulation function of blood
Maintains appropriate body ______________ by ___________ and _______________ heat throughout the body
temperature
absorbing
distributing
protection function of blood
prevents ________ ________ by _________ blood formation
blood loss
platelet
Name the three formed elements of blood
1.
2.
3.
Erythrocytes
Leukocytes
Platelets
Erythrocytes transport ___________ ______
respiratory gases
Leukocytes ________ the body from damage by ___________, __________, parasites, and tumor cells
protect
bacteria
viruses
Platelets _________ the body through the _________ ___________ process
protect
blood clotting
Process to stop bleeding if blood vessel wall breaks
Hemostasis
first step of hemostasis
________ ________ constricts the ________ to reduce ________ ________
vascular spasm
artery
blood loss
second step of hemostasis
_____________ _____ ______________
Platelet plug formation
third step of hemostasis
_________________ as _______ ________ form a ______ that traps ______ _______ ________ and ___________ forming the ________
coagulation
fibrin proteins
mesh
red blood cells
platelets
clot
Molecule markers on the external surfaces of RBC plasma membranes that the body can perceive as foreign and generate an immune response
An ____________ is a molecule marker on the ___________ surface of RBC __________ ___________ that the body can perceive as _________ and and generate an ___________ __________
antigen
external
plasma membrane
foreign
immune response
________________ cells may be clumped together and destroyed or ______________
transfused
agglutinated
RBC ____________ on the plasma membrane are also called _______________ because they cause ______________
antigens
agglutinogen
agglutination
Antigens determining ____ and __ blood groups that are improperly transfused cause __________
ABO
Rh
transfusion reactions
The 52 named Rh agglutinogens
Rh Factor
A person carrying the D antigen is ___
Rh+
A person that isn't carrying the D antigen is ____
Rh-
Destruction of RBCs
Hemolysis
If an ___ person receives ___ blood, the immune system becomes _________ and begins producing anti-Rh antibodies against the foreign antigen
_______________ does not typically occur after the first transfusion but occurs each ____________ time
Rh-
Rh+
sensitized
hemolysis
subsequent
name this part of blood composition
55% of whole blood
Least dense component
Non-living fluid matrix
plasma is _____ of whole blood and the ______ __________ component composed of a _______ __________ fluid matrix
55%
least dense
non living
name this part of blood composition
<1% of whole blood
Leukocytes and platelets
Formed elements
the buffy coat is ___ of whole blood and composed of _____________ and ______________ which are __________ ___________
<1%
leukocytes
platelets
formed elements
name this part of blood composition
45% of whole blood
Most dense component
Formed elements
erythrocytes are ____ of whole blood and the _______ _________ component composed of ____________ ___________
45%
most dense
formed elements
___________ is plasma without clotting proteins
serum
___________ is plasma with clotting proteins
Plasma
leukocytes
______________ phagocytize bacteria
Neutrophils
leukocytes
_______________ kill parasitic worms and play a complex role in allergies and asthma
Eosinophils
leukocytes
_____________ release histamine and other mediators of inflammation
Basophils
leukocytes
_________________ mount the immune response by direct cell attack or via antibodies
Lymphocytes
leukocytes
_______________ perform phagocytosis and develop into macrophages in the tissues
Monocytes
____________ __________ ______________ determines the relative proportions of individual ___________ types, it can be used as a _____________ tool, a high ____________ count may indicate parasitic infection or allergic responses
differential white count
leukocyte
diagnostic
eosinophil
_______________ are young erythrocytes
reticulocytes
the _______________ _____________ provides a rough index of RBC formation
reticulocyte count
patients who receive incompatible blood types during transfusions under go a transfusion reaction where ____________ RBCs in small blood vessels hinder _________ __________ to body __________
_______________ escapes into the bloodstream causing cell death in the ___________ _____________ which can lead to fatal kidney shutdown
clumped
blood flow
tissues
hemoglobin
kidney tubules
what are leukocytes with visible granules?
what are leukocytes with nonvisible granules?
granulocytes
agranulocytes
name the granulocytes
1.
2.
3.
neutrophils
eosinophils
basophils
name the agranulocytes
1.
2.
lymphocytes
monocytes
what blood group is a universal recipient?
why?
blood group AB
no agglutinins produced in plasma
what blood group is a universal donor?
why?
blood group O
no agglutinogens on the cell membrane
what agglutinogens are produced by blood group AB?
what agglutinins are produced by blood group AB?
what does this mean for their ability to donate blood?
AB
none
AB is a universal recipient that can only donate blood to other AB blood types
what agglutinogens are produced by blood group O?
what agglutinins are produced by blood group O?
what does this mean for their ability to donate blood?
None
anti-A
Anti-B
O is a universal donor that can only receive blood from other O types
what antigens are present on type A blood?
what plasma antibodies are present?
can they receive blood from a person with type AB blood?
A agglutinogens
anti-B agglutinins
no
what antigens are present on type B blood?
what plasma antibodies are present?
can they receive blood from a person with type AB blood?
B agglutinogens
anti-A agglutinins
no
unique to ABO blood groups is the presence in the __________ of preformed ______________ called ____________
plasma
antibodies
agglutinins
______________ ____ and __________ _______ are two vitamins required for DNA synthesis because they can jeopardize _________ dividing cell populations like developing ______________
vitamin b12
folic acid
rapidly
erythrocytes
The _________ is the RBC graveyard because old erythrocytes lose _______________ and get stuck in smaller circulatory channels
spleen
flexibility
the heme portion of hemoglobin degrades into __________
bilirubin
White blood cells can leave the bloodstream through ___________
diapedesis
______________ refers to the production of WBCs stimulated by ___________ and __________ ____________ ______
leukopoiesis
interleukins
colony stimulating factor
platelets are fragments of large cells called ___________________
megakarocytes