Epitope
-the part of the antigen that interacts with antibody---- usually a small peptide sequence
vaccines, pathogens, tumor cell, allergens
Antigens are proteins that can be found in:
mAb
-are identical immunoglobulins, generated from a single B-cell clone.
b
Which Immunoglobulin is primarily expressed in the secondary response?
a) IgM
b) IgG
a
Which Immunoglobulin is primarily expressed in the primary response?
a) IgM
b) IgG
measles
Which virus can destroy immune memory from past infections?
bone marrow, spleen, lymph nodes
Where does B-cell development take place?
CD4+; II
B-cell talk to _________ helper T-cell via MHC class _______.
non-covalent
The binding of Fab & the epitope is through _________ means.
1 Fab piece & Fc portion shred into into peptides
Pepsin cleavage =
2 Fab pieces and Fc piece
Papain cleavage =
Biologics Price Competition and Innovation Act
biological products that are demonstrated to be biosimilar to or interchangeable with an FDA-approved biological product
chimeric; 50-75% human
ximab=
humanized; less than 90% human
zumab=
mouse; 0% human
omab=
L, M, N, or S, before u
How can we tell human biologics?
cardiovascular; chimeric
abciximab; target & species?
interleukin; human
Ustekinumab; target & species?
immunomodulating; humanized
Vedolizumab; target & species?