converting a protein amino acid side from arginine to citrulline
What is Citrullination?
genetically predisposed; environmental
Rheumatoid arthritis is considered to occur when ___________ individuals are exposed to specific ___________ risk factors.
Anti-citrullinated protein antibodies
-autoantibodies produced by B-cells that are directed against self-proteins that are citrullinated.
number of tender joints, global activity of symptoms, ESR
What does the Disease Activity Score measure?
Erythrocyte sedimentation rate
-measures the degree of inflammation in the joints by taking out blood and placing it in a small, thin tube and the distance the RBCs settle in one hour is measure. mm/hr
remission
-defined as the absence of signs and symptoms of inflammatory disease activity; or low disease activity as a goal.
slowing of disease progression & maintaining function
The goal(s) for RA patients is what?
JAK inhibitors & PDE4 inhibitors
What are our tsDMARD's?
methotrexate
What is our csDMARD?
AICAR transformylase; adenosine deaminase; inhibit neutrophils
Methotrexate inhibits __________ leading to the accumulation of AICAR. AICAR inhibits ____________. This leads to increased production of adenosine which will ___________.
citinib
How can we tell if a drug is a JAK inhibitor? What suffix?
milast
How can we tell if a drug is PDE4 inhibitor? What suffix
cAMP
Elevated levels of ______ leads to reduction of pro-inflammatory cytokines.
d
Which drug should you carefully weigh the risks & benefits of treating when the patient has depression?
a) Barcitinib
b)Tofacitinib
c) Methotrexate
d) Apremilast
d
Which drug requires prescribers to monitor weight regularly?
a) Barcitinib
b)Tofacitinib
c) Methotrexate
d) Apremilast
false; patients do not respond well
When it comes to treating ACPA+ patients, MTX monotherapy is sufficient. True or false?
prevent inflammatory cytokine signaling by blocking phosphorylation of STAT
How do JAK inhibitors work?
Ulcerative colitis, PsA
What are other indications for Tofacitinib (XELJANZ)?
opportunistic infection & cardiovascular disease
What are Box warnings associated with JAK inhibitors?
CYP3A4; CYP2C19
Tofacitnib is metabolized by what enzymes?
a
Which drug is selective for JAK1/JAK2?
a) Barcitinib
b)Tofacitinib
c) Methotrexate
d) Apremilast
b
Which drug is a Pan-inhibitor (non-selective) JAK?
a) Barcitinib
b)Tofacitinib
c) Methotrexate
d) Apremilast
b
Which drug was found to increase risk of lung blood clots and had a dose reduction from 10 mg twice daily to 5mg twice daily?
a) Barcitinib
b)Tofacitinib
c) Methotrexate
d) Apremilast
a
Which drug has been approved as the first systemic treatment of Alopecia?
a) Barcitinib
b)Tofacitinib
c) Methotrexate
d) Apremilast