Flashcards: Antiparkinsonian agents

Benzatropine (INN), also known as benztropine (USAN, BAN), is an anticholinergic marketed under the trade name Cogentin which is used in the treatment of Parkinson's disease, Parkinsonism, and dystonia.

Trihexyphenidyl (Artane, Apo-Trihex, Parkin, Pacitane), also known as benzhexol and trihex, is an antiparkinsonian agent of the antimuscarinic class.

Amantadine (trade name Symmetrel, by Endo Pharmaceuticals) is a drug that has U.

Benserazide (also called Serazide or Ro 4-4602) is a peripherally-acting aromatic L-amino acid decarboxylase (AADC) or DOPA decarboxylase inhibitor, which is unable to cross the blood–brain barrier.

Budipine (brand name Parkinsan) is an antiparkinson agent marketed for the treatment of Parkinson's disease.

Bromocriptine (INN; trade names Parlodel, Cycloset, Brotin (Pakistan)), an ergoline derivative, is a dopamine agonist that is used in the treatment of pituitary tumors, Parkinson's disease (PD), hyperprolactinaemia, neuroleptic malignant syndrome, and type 2 diabetes.

L-DOPA (/ˌɛlˈdoʊpə/ or levodopa /ˌlɛvoʊˈdoʊpə/) (alt., L-3,4-dihydroxyphenylalanine) is a chemical that is made and used as part of the normal biology of humans, some animals and plants.

Rasagiline (Azilect, TVP-1012, N-propargyl-1(R)-aminoindan) is an irreversible inhibitor of monoamine oxidase-B used as a monotherapy to treat symptoms in early Parkinson's disease or as an adjunct therapy in more advanced cases.

Selegiline, also known as L-deprenyl, is a substituted phenethylamine.

Memantine is the first in a novel class of Alzheimer's disease medications acting on the glutamatergic system by blocking NMDA receptors.

Carbidopa (Lodosyn) is a drug given to people with Parkinson's disease in order to inhibit peripheral metabolism of levodopa.

Mofegiline (MDL-72,974) is a selective, irreversible inhibitor of monoamine oxidase B (MAO-B) and semicarbazide-sensitive amine oxidase (SSAO) which was under investigation for the treatment of Parkinson's disease and Alzheimer's disease, but was never marketed.

Biperiden, sold under the brandname Akineton among others, is a medication used to treat Parkinson disease.

Etybenzatropine (INN), also known as ethybenztropine (USAN, BAN) and tropethydrylin, is an anticholinergic/antihistamine marketed under the trade names Panolid, Ponalid, and Ponalide, which is used as an antiparkinsonian agent.

Pridinol is a muscle relaxant that is used as an antiparkinsonian and anticholinergic drug.

Metixene (brand names Methixart, CholinFall, Tremonil, Trest), also known as methixene, is an anticholinergic used as an antiparkinsonian agent.

Cycrimine (trade name Pagitane) is a central anticholinergic drug designed to reduce the levels of acetylcholine in the treatment of Parkinson's disease.

Carbidopa/levodopa, also known as levocarb and co-careldopa, is the combination of the two medications carbidopa and levodopa.

Carbidopa/levodopa/entacapone, sold under the brand name Stalevo, is an anti-parkinsonian dopaminergic combination medication that contains carbidopa, levodopa, and entacapone for the treatment of Parkinson's disease.

Piroheptine (brand name Trimol) is an anticholinergic and antihistamine used as an antiparkinsonian agent.

Etanautine, also known as diphenhydramine monoacefyllinate, is an anticholinergic used as an antiparkinsonian agent.

Mazaticol (Pentona) is an anticholinergic used as an antiparkinsonian agent in Japan.

Bornaprine (brand name Sormodren) is an anticholinergic used as an antiparkinsonian agent.

Traxoprodil (CP-101,606) is a drug developed by Pfizer which acts as an NMDA antagonist, selective for the NR2B subunit.

Tremorine is a drug which is used in scientific research to produce tremor in animals.