Flashcards: Antihypertensive agents

Clonidine (trade names Catapres, Kapvay, Nexiclon, Clophelin, and others) is a medication used to treat high blood pressure, attention deficit hyperactivity disorder, anxiety disorders, withdrawal (from either alcohol, opioids, or smoking), migraine, menopausal flushing, diarrhea, and certain pain conditions.

Hydrochlorothiazide (abbreviated HCTZ, HCT, or HZT), is a diuretic medication often used to treat high blood pressure and swelling due to fluid build up.

Phentolamine (Regitine) is a reversible nonselective α-adrenergic antagonist.

Reserpine (also known by trade names Raudixin, Serpalan, Serpasil) is an indole alkaloid, antipsychotic, and antihypertensive drug that has been used for the control of high blood pressure and for the relief of psychotic symptoms, although because of the development of better drugs for these purposes and because of its numerous side-effects, it is rarely used today.

Methyldopa, sold under the brand name Aldomet among others, is a centrally acting antihypertensive agent.

Moxonidine (INN) is a new-generation centrally acting antihypertensive drug licensed for the treatment of mild to moderate essential hypertension.

Prazosin, trade names Minipress, Vasoflex, Lentopres and Hypovase, is a sympatholytic drug used to treat high blood pressure, anxiety, and posttraumatic stress disorder (PTSD).

Endralazine is an antihypertensive of the hydrazinophthalazine chemical class.

Ketanserin (INN, USAN, BAN) (brand name Sufrexal; former code name R41468) is a drug used clinically as an antihypertensive agent and in scientific research to study the serotonin system; specifically, the 5-HT2 receptor family.

Atiprosin (AY-28,228) is an antihypertensive agent which acts as a selective α1-adrenergic receptor antagonist.

Pildralazine (Atensil), also known as propyldazine or propildazine, is an antihypertensive and vasodilator.

Hydralazine (trade name Apresoline) is a direct-acting smooth muscle relaxant used to treat hypertension by acting as a vasodilator primarily in arteries and arterioles.

Tiamenidine (BAN, USAN, INN, also known as thiamenidine, Hoe 440) is a imidazoline compound that shares many of the pharmacological properties of clonidine.

Ajmalicine, also known as δ-yohimbine or raubasine, is an antihypertensive drug used in the treatment of high blood pressure.

Perindopril/indapamide (marketed as Preterax and Noliprel) is a combination drug used for the treatment of essential hypertension.

Rilmenidine is a prescription medication for the treatment of hypertension.

Rescinnamine is an angiotensin-converting enzyme inhibitor used as an antihypertensive drug.

Debrisoquine is a derivative of guanidine.

Lofexidine (sold under the brand names: BritLofex and Kai Er Ding) is an α2A adrenergic receptor agonist, historically used as an antihypertensive, but more commonly used to alleviate the physical symptoms of heroin and other types of opioid withdrawal.

Alfurolol is a beta blocker.

Arnolol is a beta blocker.

Dihydralazine is a drug with antihypertensive properties.

Adaprolol is a beta blocker.

Bucindolol is a non-selective beta blocker with additional weak alpha-blocking properties and some intrinsic sympathomimetic activity.

Isosorbide dinitrate/hydralazine is a fixed dose combination drug treatment specifically approved by the US FDA to be used to treat African Americans with congestive heart failure.

Metirosine (INN and BAN; α-Methyltyrosine, Metyrosine USAN, AMPT) is an antihypertensive drug.

Methoserpidine is an antihypertensive drug related to reserpine.

Bietaserpine (INN), or 1-diaminoethylreserpine, is a derivative of reserpine used as an antihypertensive agent.

Ciclafrine (INN) is a sympathomimetic phenethylamine and antihypertensive which does not appear to have ever been marketed.

Hydracarbazine is a pyridazine that has found use as an antihypertensive agent.

Sacubitrilat (INN; or LBQ657) is the active metabolite of the antihypertensive drug sacubitril, which is used in the treatment of heart failure.

Cryptenamine (Unitensen) is a mixture of hypotensive alkaloids extracted from Veratrum album.

Lidanserin (INN; ZK-33,839) is a drug which acts as a combined 5-HT2A and α1-adrenergic receptor antagonist.

Sacubitril (/səˈkjuːbᵻtrɪl/; INN developmental code name AHU-377) is an antihypertensive drug used in combination with valsartan.

Naftopidil (INN, marketed under the brand name Flivas) is a drug used in benign prostatic hypertrophy which acts as a selective α1-adrenergic receptor antagonist or alpha blocker.

Corynanthine, also known as rauhimbine, is an alkaloid found in the Rauwolfia and Pausinystalia (formerly known as Corynanthe) genera of plants.

Deserpidine (INN) is an antihypertensive drug related to reserpine which occurs naturally in Rauvolfia spp.

Ancarolol is a beta blocker.

Valsartan/sacubitril (brand name Entresto) is a combination drug for use in heart failure developed by Novartis.

Guanfacine (brand name Estulic, Tenex and the extended release Intuniv) is a sympatholytic drug used in the treatment of attention deficit hyperactivity disorder (ADHD), anxiety and hypertension (not to be confused with guaifenesin, an expectorant).

Guanadrel is an antihypertensive agent.

Guanoclor is a sympatholytic drug.

Pargyline (brand name Eutonyl) is an irreversible selective monoamine oxidase (MAO)-B inhibitor drug (IC50 for MAO-A is 0.01152 µmol/L and for MAO-B is 0.00820 µmol/L) It was brought to market in the US and the UK by Abbott in 1963 as an antihypertensive drug branded "Eutonyl".

Pentolinium is a ganglionic blocking agent which acts as a nicotinic acetylcholine receptor antagonist.

The combination drug olmesartan/amlodipine (trade name Azor in the US) is an oral antihypertensive medication which combines two antihypertensive agents in a film-coated tablet.

Alprenoxime is a beta blocker.

Butynamine is a tertiary (a highly hindered) aliphatic amine which has antihypertensive effects.

Xibenolol is a beta blocker.

Xipranolol is a beta blocker.

Tolonidine is an antihypertensive.

CYT006-AngQb was an investigational vaccine against angiotensin II, designed to lower blood pressure.