Flashcards: All Drugs (Overview)

-inhibits dihydropteroate synthase in the

biosynthesis of folic acid

-inhibit glucan synthase, an enzyme required for

cell wall formation

-binds to ergosterol on the fungal membranes to

form pores that allow the influx of ions

-inhibits protein synthesis and also chelates

polyvalent cations

-inhibit lanosterol 14-alpha-demethylase, an

enzyme used in the synthesis of ergosterol, to

reduce production of ergosterol and increase levels

of precursors

-prodrug converted by fungal enzymes to create 5-

fluorouracil, which replaces uracil in the RNA to

act as an antimetabolite and blocks DNA synthesis

-prodrug- produces formaldehyde and ammonia in

acidic conditions

-Inhibits bacterial DNA-dependent RNA

polymerase and thus inhibits RNA transcriptions

-Inhibits phosphoenolpyruvate transferase, which

produces diphosphate-N-acetylmuramic acid, thus

inhibiting the first step in cell wall formation

-prodrug- activated by bacterial PFOR to form a

radical anion, which generates a superoxide anion,

causes damage to DNA and proteins

-Inhibits DNA gyrase and topoisomerase IV

-not an echinocandin, but this drug has the same

MOA

-inhibits squalene epoxidase, the enzyme that

breaks down squalene, to cause toxic accumulation

of squalene

-inhibits proteasomes to induce apoptosis

-prodrug activated by bacterial enzymes to generate

a superoxide anion that reacts with ribosomal

proteins, decreases synthesis of proteins, DNA,

and RNA

Tx for Polyenes?

Tx for Anasamycins?

Tx for Azoles?

Tx for Allylamines?

Tx for Echinocandins?