Digital Unit Plan Template Unit Title: Translation (From mRNA to Protein) Name: Jessica Ly Content Area: Science (Biology) Grade Level: 9th-12th CA Content Standard(s)/Common Core Standard(s): CA Content Standard(s): HS-LS1-1: Construct an explanation based on evidence for how the structure of DNA determines the structure of proteins which carry out the essential functions of life through systems of specialized cells. Common Core Standard(s): WHST.9-12.9: Draw information from informational texts to support analysis, reflection, and research. Big Ideas: Translation, the decoding of mRNA into protein formation, takes place in the cytoplasm with 3 key components: (1) mRNA (2) ribosomes (3) tRNA. Translation occurs in 3 steps: (1) Initiation (2) Elongation (3) Termination mRNA is read according to a genetic code where codons (3 base pairs) pair to tRNA anticodons to direct protein synthesis Unit Goals and Objectives: At the end of the unit, students will be able to: 1. Identify 3 key components of translation and describe how they are functionally related to each other. 2. Name the 3 stages of translation and list the main events taking place at each stage. 3. Decode a given mRNA sequence into its tRNA and amino acid counterparts using the genetic code. Unit Summary: Throughout the particular genetic unit, students will be exposed to various learning modules and engage in various activities to demonstrate the knowledge of mRNA translation into proteins. Students will be introduced to translation through a lecture presentation and further explore the concept through hands on activities such as a webercise, class activity, and independent assignments. Students will demonstrate their knowledge and be assessed for learning through informal entry-level assessments (graphic organizer) and formal formative (crossword puzzle, timeline) and summative assessments (infographic, comic strip). By the end of the unit, students will be able to successfully accomplish the 3 objectives. Assessment Plan: Entry-Level: Formative: Summative: Anticipation Graphic Organizer: What processes/players do you think have a role in translation? Crossword Puzzle: Vocabulary Terms Quizlet: Matching genetic code mRNA codons to tRNA anticodons Infographic: The possible uses of the knowledge about the process of translation Quickwrite: Explain how the genetic code is degenerate in your own words Comic Strip: The sequence of events and key players in the process of translation Timeline: Outline the steps of initiation, elongation, termination Lesson 1 Student Learning Objective: Acceptable Evidence: 1. Identify 3 key components of translation and describe how they are functionally related to each other. Students can list 1. mRNA 2. ribosome 3. tRNA as key components of translation and explain their respective roles Instructional Strategies: ☒ Communication ☐ Collection ☐ Collaboration ☒ Presentation ☐ Organization ☐ Interaction Lesson Activities: Instructional Strategies: ☐ Communication ☒ Collection ☐ Collaboration ☐ Presentation ☐ Organization ☒ Interaction Lesson Activities: Instructional Strategies: ☐ Communication ☐ Collection Lesson Activities: Activate Prior Knowledge: Ask “What does translation mean? Can you provide an example of translation?” From a list of given vocabulary words, students will create a graphic organizer to anticipate which they think will be involved in translation. Lecture Presentation: Prezi slideshow (images, videos, definitions, etc.) presented with audio lecture. Guided notes will be provided to accompany lecture and will be due at the end of lecture. Students may also use guided notes as a study source. Lesson 2 Student Learning Objective: Acceptable Evidence: 3. Decode a given mRNA sequence into its tRNA and amino acid counterparts using the genetic code. Students can correctly pair a given codon sequence to anticodon sequence. Webercise: Students will explore internet sites and digital interactive tool to practice reading codons for translation to appropriate anticodon. Students will also practice search and retrieval methods to further their understanding of underlying concepts. Hands-On Class Manipulative: Students will personify the components of translation (mRNA, ribosomal large/small unit), tRNA, amino acids, proteins) and assemble the correct formation by following teacher instructions Lesson 3 Student Learning Objective: Acceptable Evidence: Illustration Project/Graphic Organizer 2. Name the 3 stages of translation and list the main events taking place at each stage. Students can illustrate initiation, elongation, and termination as 3 stages of translation on a flowchart. ☒ Collaboration ☐ Presentation ☒ Organization ☐ Interaction In groups of 3, students each illustrate the process of initiation, elongation, and termination. Illustrations should include major structures and list steps in a graphic organizer. Students will edit graphic organizers based on peer revision and be graded according to assessment rubric. Students will be required to present their graphic organizers and submit engaging questions to online digital interactive website. Unit Resources: Textbook: Biology by Miller & Levine: Chapter 12: DNA and RNA—Section 12.3 RNA and Protein Synthesis; pgs. 302-306 Prezi Discovery Education Puzzle Maker ReadWriteThink Timeline Generator Bitstrips Teacher Site Useful Websites: Translation Definition: Provides definition of translation and explanation of process Scitable: http://www.nature.com/scitable/definition/translation-rna-translation-173 ; http://www.nature.com/scitable/topicpage/the-information-in-dna-determines-cellular-function-6523228 ; http://www.nature.com/scitable/topicpage/translation-dna-to-mrna-to-protein-393 NCBI: http://www.ncbi.nlm.nih.gov/books/NBK9849/ Transcription and Translation Tool: Digital interactive tools to allow students to practice recognizing codon and anticodon complementary relationship Attotron: http://www.attotron.com/cybertory/analysis/trans.htm Learn.Genetics: http://learn.genetics.utah.edu/content/molecules/transcribe/ Translation Animated Videos: Videos to help students visually picture events occurring at the microscopic level Scitable: http://www.nature.com/scitable/content/translation-6656905 YouTube: http://www.youtube.com/watch?v=5bLEDd-PSTQ TeacherTube: http://www.teachertube.com/video/protein-translation-115874 Translation Step-by-Step Image: http://3.bp.blogspot.com/-W7juGeNs9aw/UNQ_xEDtpGI/AAAAAAAAAS0/IMKXXBUpo3s/s1600/translat.JPG