Osteoarthritis
•
A notable characteristic is
Heberden’s nodes on the outermost finger joints.
•
This condition is considered primarily a wear and tear disease.
• A number of nutrients improve the body’s repair processes.

Rheumatoid Arthritis
•
Joints make a sound like crinkling cellophane.
•
Almost universal redness, warmth, and swelling of the joints on both sides of the body.
•
A feeling of sickness and fatigue.

Osteoarthritis Defined
• Most common form of arthritis.
• Wear and tear disease characterized by degeneration of the joint cartilage resulting in pain, stiffness, and decreased range of motion.
• Reparative processes can not keep up with the deterioration processes.
•
Primary: result of aging
• Secondary: trauma, repetitive joint motion, developmental defects, metabolic disorders, and obesity.

Osteoarthritis Treatment
• Long thought irreversible.
• Now considered reversible in early stages.
• Conventional treatment NSAIDS even though they are known to accelerate joint destruction.
•
NSAIDS cause other side-effects: bleeding, peptic ulcer, liver damage (esp. acetaminophen), renal failure.
• Nutritional treatments: often slow progression and reduce pain without these side-effects.

Osteoarthritis: Lifestyle Factors
• Weight loss: knee and hip deterioration is often associated with excess weight. Modest weight loss: significant improvement.
• 20-30% of sufferers have food allergies with other symptoms including migraines, mouth ulcers, runny nose, increased pulse rate. Allergies impair reparative processes. Consider digestive aids.
• Norman Childers found that many arthritics improved after avoiding nightshade plants for anywhere from a few days to 9 months.

Norman Childers
In his 50’s Childers suffered arthritis so debilitating that he couldn’t even walk. After discovering the link between nightshades and arthritis, he recovered and has spent many years helping others with their arthritis issues.
//noarthritis.com/94thBirthday.htm
Childers, N.F., and Margoles, M.S., An apparent relation of nightshades (Solanaceae) to arthritis, Journal of Neurological and
Orthopedic Medical Surgery (1993) 12:227-231.
Childers, Norman F., Arthritis , Gainesville, FL.: Horticultural
Publications, 1986.

Osteoarthritis: Nightshades
• “ I for one would be in a wheelchair and likely would be a drug addict and in a mental institute because I had such severe incapacitating pains from the nightshades foods. They swelled up all my MP and IP joints to the point where I could barely walk or use my hands. They flared up my damaged back discs so badly that for days and weeks I would be "mysteriously" bedridden and had to be carried to the bathroom while screaming in pain.
At one time I was strapped in a fiberglass cast daily for six years and offered to have my back fused with a piece of my hip. Being an M.D., I tried every known medicine and top specialist. I was ruined.”

Osteoarthritis: Nightshades
• Now, I'm pain-free. Your work saved my life and sanity for many pain-free productive years. Now I avoid those foods like the plague. I'm totally healthful. I can carry a hundred pound sack of oats, play golf and singles tennis, and water skiing backwards. In my 27 years of medical practice,
I've never seen anything as powerful as your No-
Nightshades Diet. It's right up there with the best ways to heal the impossible. I can trace every single "mysterious" catastrophic painful episode in the past and present to the nightshades and turn the pain off and on like a switch. It takes two months to get them out of my system.

Osteoarthritis: Nightshades
• I personally thank you from the bottom of my heart and on behalf of my many patients who have benefited from it. You are certainly one of God's gifts to me and my patients. I am reminded of 1 Corinthians 1, "Has God not made foolish the things of this world?" For after all the high-tech medicine could offer had failed me, a simple Diet gave me power over my pain.
With deep appreciation and admiration.
Dr. Sherry A. Rogers, M.D.
Sarasota, FL
• Dr. Sherry Rogers is a specialist in Environmental Medicine, certified by The American Board of Family Practice, The
American Board of Environmental Medicine and a fellow in the American College of Allergy and Immunology.

B Complex: B3 & Reparative Process
• William Kauffman in the 1940’s and 1950’s found that vitamin B3 improved objective measurements of joint motion as well as subjective sensations of joint pain, inflammation and discomfort.
• Improvement could be observed within a month and continued for up to 3 years. Some patients experienced improvement for 20 years.
• Cessation of supplementation resulted in slow deterioration.
•
Multiple small doses worked more effectively than less frequent larger doses. This is probably due to a short half-life for the activity of the vitamin. Value of Threshold Control
• Wide range of benefits beyond improvement in joint function making this a first line approach.

William Kaufman
•
Researcher on niacinamide deficiency disease and joint dysfunction.
• Kaufman, William, “Niacinamide: A Most
Neglected Vitamin,”
Journal of the
International Academy of Preventive
Medicine ,Winter, 1983.
• Kaufman, William, The Common Form of
Joint Dysfunction: Its Incidence and
Treatment , Brattleboro, Vermont: E.L.
Hildreth & Company, 1949.

Joint Mobility
• “…adequate niacinamide therapy can ameliorate impaired joint mobility in persons of all ages with or without visible arthritic deformities provided they also ingest adequate protein and calories…”
• Kaufman, William, “Niacinamide: A Most
Neglected Vitamin,”
Journal of the
International Academy of Preventive
Medicine ,Winter, 1983, p. 13.

B Complex: B3 & Reparative Process
• A study in 1996 confirmed Kauffman’s observations. After 3 months patients receiving niacinamide (3,000 mg) improved 29% while those on placebo worsened by 10%. Maximum benefit took
1-3 years.
•
Jonas, W. B., et al, The Effect of Niacinamide on Osteoarthritis: A Pilot Study, Inflammation Research, 1996;45:330-
334.

Other B Vitamins
• Pantothenic Acid (B5): Rats fed a diet deficient in this nutrient develop osteoarthritis.
Folic Acid and Vitamin B12: Increases the osteocalcin involved in building bone. Patients using a combination of the two reduced the use of pain medication. These nutrients were as effective as
NSAIDS when used at high levels. 20 mcg B12, 6400 mcg folic acid.

Why GNLD Super B

Exclusive biologically-bound yeast from whole food sources provides B vitamins in naturally-occurring ratios.

Complete

High potency

Natural protein glaze to protect potency.
 Contains beta-glucan, a potent immune booster .

Biologically Bound Yeast: The body is best designed to extract the value from nutrient complexes as we find in living things. Synthetic vitamins and processed foods are not well utilized: both fail to provide optimal nutrition.
“Unless both enzyme and co-enzyme are present no catalysis takes place.
Synthetic and pure chemical forms of vitamins lack these vital enzymes and co-enzymes. Hence, not only are their primary biochemical and physiological activities suppressed but their nutritional value determined on the basis of old nutritional concepts must be carefully reassessed.”
Yanick, Paul Jr., Assessing the Physiological-Chemical Response, Clinical Chemistry & Nutrition Guidebook: A
Physician’s Desk Reference ed. Paul Yanick, Jr. and Russell Jaffe, T & H Publishing, 1988, 394.

“There is no evidence that the body is able to convert excessive quantities of synthetic vitamins into the co-enzyme form and thus elevate the intracellular activity.”
“A closer study of the molecular and biological processes that underlie the enzymatic patterns found in the natural and organic vitamin complex will convince the advanced clinical nutritionist or physician that the physiological function of these nutrients do not in any way correspond to that of isolated synthetic vitamins. When vitamins were discovered, it was the initial absence of knowledge of this complex chemical structure that led to a letter system of designation with units of measurement being defined in relation to its effect on the animal.”
Yanick, Paul Jr., Assessing the Physiological-Chemical Response, Clinical Chemistry & Nutrition Guidebook: A
Physician’s Desk Reference ed. Paul Yanick, Jr. and Russell Jaffe, T & H Publishing, 1988, 394-5.

Beta Glucan
• “Beta glucan is a scientifically proven biological defense modifier (BDM) that nutritionally potentiates and modulates the immune response.” It is found in the cell walls of yeast and first identified in the 1960’s by Nicholas DiLuzio,
Ph.D.
• http://www.betaglucan.org/
• The cell walls of Saccharomyces cerevisiae yeast are an important source of this polysaccharide.
• Beta-D-Glucan “has bioactive and medicinal properties, which include immune stimulation, being anti-inflammatory, anti-microbial, anti-infective, anti-viral, anti-tumoral, cholesterol lowering, radioprotective and wound healing.”
• “the 1,3-beta-D-glucans lentinan and schizophyllan have been used clinically as adjuncts in cancer therapy.”
•
Freimund S, Sauter M, et al, A New Non-Degrading Isolation Process for 1,3-
�
-D-glucan of High Purity From Baker's
Yeast Saccharomyces cerevisia, Carbohydr Polymers , 2003;54:159-171.

Osteoarthritis: Vitamin C
•
Guinea pigs like humans do not synthesize their own vitamin C. Diets low in vitamin C lead to every indication of advanced osteoarthritis in guinea pigs.
• Schwartz, E.R., “The modulation of osteoarthritic development by vitamins C and
E,” Int J Vit Nutr Res Suppl 26, 141-6, 1984.

Antioxidants
•
Vitamin C
Synthesis of collagen and proteoglycans.
• Decreases risk of cartilage loss and significantly improve pain.
• Guinea pigs which cannot synthesize vitamin C develop osteoarthritis when supplied with inadequate vitamin C as they age.
• Participants in one study who reported supplementing with vitamin C had an 11% reduced risk of developing knee osteoarthritis.
• Vitamin E:
•
Vitamin E provided as much benefit as glucosamine when used for 6 months among those with osteoarthritis of the knee. The dose used was
400 IU a day.

Allium, Fruits and Vegetables
•
A large study of twins found that a high intake of non-citrus fruit and vegetables
(particularly alliums with diallyl disulphide) repressed the expression of matrix-degrading proteases in chondrocyte-like cells. They concluded that alliums like garlic may benefit patients with osteoarthritis of the hip.
• Williams FM, Skinner J, et al, Dietary garlic and hip osteoarthritis: evidence of a protective effect and putative mechanism of action, BMC
Musculoskelet Disord, 2010 Dec 8; 11(1): 280, [Epub ahead of print].

Vitamin K
•
Decreased levels of vitamin K were found to be associated with increased risk of osteoarthritis of the hand and knee.
• Vitamin K is a natural component of green leafy foods and is also synthesized by beneficial bacteria in the digestive tract.
• Neogi T, Booth SL, et al, Low vitamin K status is associated with osteoarthritis in the hand and knee, Arthritis
Rheum , 2006; 54(4): 1255-61.

Tumeric
• Kuptniratsaikul V, Thamlikitkul V, et al, Efficacy and safety of
Curcuma domestica extracts in patients with knee osteoarthritis , J
Altern Complement Med , 2009; 15(8): 891-7.

Fatty Acids and Vitamin D
• Tre-en-en: The portion of oil from avocado and soybeans which cannot be made into soap (unsaponifiable) stimulates collagen synthesis in joint cartilage.
• Cod Liver Oil: Few studies have been done. This oil has antiinflammatory fats, vitamin D and vitamin A. Hip degeneration
• Vitamin D
Deficiency has been shown to speed the progression of osteoarthritis.
• Supplementation enhances bone mineral density in knee osteoarthritis.
Vitamin D deficiency leads to progression of knee osteoarthritis.
•
Vitamin D deficiency appears to increase the risk of hip degeneration.
• Omega-3 fatty acids: May improve the utilization of vitamin B-3.
Donald Rudin. Flax oil has been shown to improve osteoarthritis.

Minerals: Calcium and Magnesium
• Supplementation with seaweed rich in calcium, magnesium and other minerals provided significant improvement in pain over a period of 12 weeks.
•
Frestedt, Joy, A Natural Mineral Supplement Provides Relief from Knee Osteoarthritis Symptoms:A
Randomized Controlled Pilot Trial, Nutr J , 2008; 7(1): 9.
•
Flotation spa therapy for 6 weeks improved all patients. Patients were floated in a magnesium sulfate (Epsom salt) solution so thick floating takes no effort.
• Hill S, Eckett MJH, Paterson C, Harkness EF, A Pilot Study to Evaluate the Effects of Flotation Spa
Treatment on Patients With Osteoarthritis, Complementary Therapies in Medicine , 1999;7:235-238.
• Magnesium is involved in many of the energy production processes in the body and should promote the reparative process.
•
Note: Corticosteroids deplete calcium and cause bone loss.

Cod Liver Oil Testimony
• I have tried everything for arthritis. Nothing that the doctors had given me even eased the pain. Then I saw information on Salmon
Oil and decided to try it. I bought three bottles. When I reordered,
I talked to my son and my grandson and they both said that Cod
Liver Oil did more good for them. I bought Cod Liver Oil.
• The ache—constant ache in my joints is gone. There is some soreness yet. I am hoping it goes too. I am hoping it goes too. The
Cod Liver Oil helped me more than the Salmon Oil did. I think that if people don’t get the results they want from Salmon Oil they ought to try Cod Liver Oil and not give up. I was about ready to give up, but am glad I gave the Cod Liver Oil a try. —Dorothy

Cod liver Oil/ Cal Mag Testimony
•
It was mid-September when my fingers and toes both started to feel like electric wires were turned on, and sometimes like a toothache. I could hardly wear any shoes! I tried different kinds of socks and they didn’t help. I must say I went to the doctor and he gave me
Trilisate, and after taking that two months it was worse. I started taking Cod Liver Oil and Cal-Mag. By the second week I began to feel some relief and it got better and better. I could hardly believe it. I am so happy to be able to wear whatever shoes I want and not have that pain in either fingers or toes. I can’t say enough for Cod Liver Oil and the Cal-Mag. —
Florence

Glucosamine (Glucose + Amine)
•
Precursor to the bricks (proteoglycans) the body uses to make cartilage.
•
1500 mg. shown to benefit knee pain is most studies.
•
Works at least as effectively as NSAIDS for pain relief according to some researchers.
•
Not associated with dangerous side-effects.
•
Noticeable benefits after 4 weeks. 3 year study showed a slowing of progression of disease. Benefits continue for 60 days after ceasing supplementation.
•
Less helpful for back pain than for knees and other joints.

Glucosamine hydrochloride vs Sulfate
•
Less allergenic potential than glucosamine sulfate: sulfite sensitivity.
•
More concentrated making tablets smaller and easier to swallow.
•
Easier on the digestive tract for those with digestive difficulties.

Glucosamine vs. Chondroitin
•
Glucosamine is well-absorbed.
•
Chondroitin is poorly absorbed.
•
Most of the benefits of combination formulas come from the glucosamine.
•
The biggest drawback to compliance is that pills are too large and difficult to swallow.

GNLD Full Motion

Glucosamine Hydrochloride:
Pharmaceutically pure minimizing risk of allergic reactions to shellfish.
 Herbal Comfort Complex to boost body’s natural anti-inflammatory capacity.

Bromelain

White willow

Boswellia
 Regenerative Mineral Complex: minerals essential for cartilage formation and repair.

Boron

Silica

Zinc

Willow Bark Extract
• 39 subjects who received willow bark extract experienced a statistically significant 14% reduction in the WOMAC Osteoarthritis
Index pain score.
• Schmid B, Ludtke R, et al, Efficacy and
Tolerability of a Standardized Willow Bark
Extract in Patients With Osteoarthritis:
Randomized, Placebo-Controlled, Double
Blind Clinical Trial, Z Rheumatol ,
2000;59:314-320.

Boswellia
•
A boswellia extract reduced pain and improved functional ability in as little as 7 days from baseline. It was concluded boswellia may reduce enzymatic degradation of cartilage.
•
Sengupta K, Raychaudhuri SP, et al, A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin(R) for treatment of osteoarthritis of the knee, Arthritis Res Ther , 2008 Jul 30; [Epub ahead of print].

Bromelain
•
An oral enzyme formulation containing bromelain was found to be an effective and safe alternative to NSAIDS in knee osteoarthritis.
•
Singer F, Singer C, Oberleitner H,
Phlogenzym® Versus Diclofenac in the
Treatment of Activated Osteoarthritis of the
Knee. A Double-Blind Prospective
Randomized Study, Int J Immunother ,
2001;17(2/3/4):135-141.

Boron
• A double blind trial compared boron to placebo.
The boron had significant benefit in severe osteoarthritis with 5 of 10 patients improving while only 1 in the placebo group did.
•
Travers, Richard L., M.D., et al, Boron and
Arthritis: The Results of a Double-Blind Pilot
Study, Journal of Nutritional Medicine ,
1990;1:127-132.

Silicon
• Carlisle, Edith M., In vivo requirement for silicon in articular cartilage and connective tissue formation in the chick, J. Nutr . 106;
478-484, 1976.

Zinc
•
Zinc is an important component of matrix metalloproteases and is required for binding of collagen and procollagens by matrix proteins.
•
Mobasheri, A., Nutraceutical Therapies For
Degenerative Joint Diseases: A Critical Review,”
Crit Rev Food Sci Nutr . 2005;45(3):145-64.

Nutritional Support for Osetoarthritis
•
Full Motion 3 a day
•
B Complex: One per meal minimum
•
Super C: 2 tablets 3 times a day
•
Cod Liver Oil: 2-4 a day
•
Chelated Cal-Mag: 3-6 a day [Chelated Multi-Min]
•
Vitamin E: 2 a day
•
Dietary: A trial of avoiding nightshade plants and other allergens
•
Allium Complex