Useful References
Published Articles
Here are just a selection of the many published articles relating to Paget’s disease.
If you have something you would like to add to this list please contact us: helpline@paget.org.uk
2015
Rami Obaid, Sachin E. Wani, Asim Azfer, Toby Hurd, Ruth Jones, Philip Cohen, Stuart H. Ralston, Omar M.E.
Albagha, (2015), Optineurin Negatively Regulates Osteoclast Differentiation by Modulating NF-κB and
Interferon Signaling: Implications for Paget’s Disease. Cell Reports. 13, 1–7 November 10.
Maheva Vallet, Dinesh C. Soares, Sachin Wani, Antonia Sophocleous, Jon Warner, Donald M. Salter, Stuart
H. Ralston and Omar M.E. Albagha, (2015), Targeted sequencing of the Paget's disease associated 14q32
locus identifies several missense coding variants in RIN3 that predispose to Paget's disease of bone,
Human Molecular Genetics, Oxford University Press.
Rendina, D., De Filippo, G., Ralston, S. H., Merlotti, D., Gianfrancesco, F., Esposito, T., Muscariello, R., Nuti,
R., Strazzullo, P. and Gennari, L. (2015), Clinical Characteristics and Evolution of Giant Cell Tumor
Occurring in Paget's Disease of Bone. J Bone Miner Res, 30: 257–263
Zimmermann, E. A., Köhne, T., Bale, H. A., Panganiban, B., Gludovatz, B., Zustin, J., Hahn, M., Amling, M.,
Ritchie, R. O. and Busse, B. (2015), Modifications to Nano- and Microstructural Quality and the Effects on
Mechanical Integrity in Paget's Disease of Bone. J Bone Miner Res, 30: 264–273
Merashli, M., Jawad, A., (20915) Paget’s Disease of Bone among Various Ethnic Groups, Sultan Qaboos
Univ Med J. Feb; 15(1): e22–e26. Published online 2015 Jan 21.
Khan, A. A., Morrison, A., Hanley, D. A., Felsenberg, D., McCauley, L. K., O'Ryan, F., Reid, I. R., Ruggiero, S.
L., Taguchi, A., Tetradis, S., Watts, N. B., Brandi, M. L., Peters, E., Guise, T., Eastell, R., Cheung, A. M., Morin,
S. N., Masri, B., Cooper, C., Morgan, S. L., Obermayer-Pietsch, B., Langdahl, B. L., Al Dabagh, R., Davison, K.
S., Kendler, D. L., Sándor, G. K., Josse, R. G., Bhandari, M., El Rabbany, M., Pierroz, D. D., Sulimani, R.,
Saunders, D. P., Brown, J. P., Compston, J. and on behalf of the International Task Force on Osteonecrosis
of the Jaw (2015), Diagnosis and Management of Osteonecrosis of the Jaw: A Systematic Review and
International Consensus. J Bone Miner Res, 30: 3–23.
2014
Goode A, Long JE, Shaw B, Ralston SH, Visconti MR, Gianfrancesco F, Esposito T, Gennari L, Merlotti D,
Rendina D, Rea SL, Sultana M, Searle MS, Layfield R. Paget disease of bone-associated UBA domain
mutations of SQSTM1 exert distinct effects on protein structure and function. Biochim Biophys Acta.
2014;1842(7):992-1000.
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Rea SL, Majcher V, Searle MS, Layfield R. SQSTM1 mutations - bridging Paget disease of bone and
ALS/FTLD. Exp Cell Res. 2014;325(1):27-37.
Devogelaer, J., Geusens, P., Daci, E., Gielen, E., Denhaerynck, K., MacDonald, K., Hermans, C., Vancayzeele,
S., Abraham, I., Boonen, S. (2014), Remission Over 3 Years in Patients with Paget Disease of Bone Treated
with a Single Intravenous Infusion of 5 mg Zoledronic Acid. Calcified Tissue International. March, Volume
94, Issue 3, pp 311-318
M J Haddaway, M W J Davie, I W McCall, and S Howdle, (2014), Effect of age and gender on the number
and distribution of sites in Paget's disease of bone. The British Institute of Radiology, Vol 80, Issue 955.
Tan, A., Ralston, S.H., (2014), Clinical Presentation of Paget's Disease: Evaluation of a Contemporary
Cohort and Systematic Review, Calcified Tissue International, Aug 27.
Frederick R. Singer, Henry G. Bone, III, David J. Hosking, Kenneth W. Lyles, Mohammad Hassan Murad, Ian
R. Reid, and Ethel S. Siris, (2014), Paget’s Disease of Bone: An Endocrine Society Clinical Practice
Guideline, The Journal of Clinical Endocrinology & Metabolism, Vol 99, Issue 12
Shapiro, Irving; Layfield, Robert; Lotz, Martin; Settembre, Carmine; and Whitehouse, Caroline, (2014),
"Boning up on autophagy: the role of autophagy in skeletal biology." Department of Orthopaedic
Surgery Faculty Papers. Paper 69.
2013
Joanne L Welton, Matt P Morgan, Salvador Martí, Michael D Stone,Bernhard Moser, Andrew K Sewell,
Jane Turton, Matthias Eberl. Monocytes and γδ T cells control the acute phase response to intravenous
zoledronate: Insights from a phase IV safety trial. JBMR 2013 28: 464-471
Cundy, T., Bolland, M.J., (2013), Paget’s disease of bone: clinical review and update. Journal of Clinical
Pathology. Nov; 66(11): 924-7
Patel DV, Horne A, House M, Reid IR, McGhee CN. (2013), The incidence of acute anterior uveitis after
intravenous zoledronate. Ophthalmology. 120:773–776.
Ralston SH (2013) Clinical practice. Paget’s disease of bone. N Engl J Med 368:644–650
Corral-Gudino L, Garcia-Aparicio J, Sanchez-Gonzalez MD, Miron-Canelo JA, Blanco JF, Ralston SH, Del PinoMontes J. (2013) Secular changes in Paget’s disease: contrasting changes in the number of new referrals
and in disease severity in two neighboring regions of Spain. Osteoporos Int 24:443–450
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Albagha OM, Visconti MR, Alonso N, Wani S, Goodman K, Fraser WD, Gennari L, Merlotti D, Gianfrancesco
F, Esposito T, Rendina D, Di Stefano M, Isaia G, Brandi ML, Guisti F, Del Pino-Montes J, Corral-Gudino L,
Gonzalez-Sarmiento R, Ward L, Rea SL, Ratajczak T, Walsh JP, Ralston SH (2013) Common susceptibility
alleles and SQSTM1 mutations predict disease extent and severity in a multinational study of patients
with Paget’s disease. J Bone Miner Res 28:2238–2246
Corral-Gudino L, Borao-Cengotita-Bengoa M, Del Pino-Montes J, Ralston SH (2013) Epidemiology of
Paget’s disease of bone: a systematic review and meta-analysis of secular changes. Bone 55:347–352
Qureshi, A., Zahid, K. F., Ibrahim, S. I., & Burney, I. (2013). Osteosarcoma arising on a background of
Paget's disease report of an unusual case. BMJ Case Rep
Reid, I.R., Brown, J.P., Levitt, N., Román Ivorra, J.A., Bachiller-Corral, J., Ross, I.L., Su, G., Antunez-Flores, O.,
Aftring, R.P., (2013), Re-treatment of relapsed Paget’s disease of bone with zoledronic acid: results from
an open-label study. BoneKEy Reports, 2, 442. Available at www.nature.com
2012
Ian R Reid, Kenneth Lyles, Guoqin Su, Jacques P Brown, John P Walsh, Javier del Pino-Montes, Paul D
Miller, William D Fraser, Susan Cafoncelli, Christina Bucci-Rechtweg, David J Hosking (2012) A Single
Infusion of Zoledronic Acid Produces Sustained Remissions in Paget Disease: Data to 6.5 Years. Journal of
Bone Mineral Research. Sep; 26(9):2261-70.
Wark JD, Bensen W, Recknor C, et al. (2012), Treatment with acetaminophen/paracetamol or ibuprofen
alleviates post-dose symptoms related to intravenous infusion with zoledronic acid 5 mg. Osteoporos.
Int. 23:503–512.
Hocking, L. J., Whitehouse, C. and Helfrich, M. H. (2012) Autophagy: A new player in skeletal
maintenance? J Bone Miner Res, 27: 1439–1447
Peter Schwarz, Anne Qvist Rasmussen, Torben M. Kvist, Ulrik B. Andersen, et al. (2012) Paget's disease of
the bone after treatment with Denosumab: A case report Bone Vol. 50 (5), 1023-1025
How T.L., George G.H.M. (2012) Paget’s disease. Geriatric Medicine.
2011
Ian R. Reid , D.J. Hosking (2011) Bisphosphonates in Paget's disease. Bone 49, 89–94
Laëtitia Michou, Jacques P Brown. (2011) Drug Design Emerging strategies and therapies for treatment of
Paget’s disease of bone, Development and Therapy, 5 225–239
R. Graham, G. Russell. (2011), Bisphosphonates: The first 40 years, UK Bone 49, 2–19
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Calabro, T., Mavrogenis, A. F., & Ruggieri, P. (2011). Osteoblastic osteosarcoma in monostotic Paget's
disease. Musculoskelet Surg, 95(1), 37-40.
2010
Anne Sutcliffe (2010) Paget’s: The neglected bone disease. International Journal of Orthopaedic and
Trauma Nursing 14, 142–149
A Goode, R Layfield (2010) Recent advances in understanding the molecular basis of Paget disease of
bone J Clin Pathol;63:199e203.
Gennari, L., Gianfrancesco, F., Di Stefano, M., Rendina, D., Merlotti, D., Esposito, T., Gallone, S., Fusco, P.,
Rainero, I., Fenoglio, P., Mancini, M., Martini, G., Bergui, S., De Filippo, G., Isaia, G., Strazzullo, P., Nuti, R.
and Mossetti, G (2010), SQSTM1 gene analysis and gene-environment interaction in Paget's disease of
bone. J Bone Miner Res, 25: 1375–1384.
Z. Fojtik, K. Stary, L. Prochazkova, M. Obrovska (2010) Monostotic Paget's disease of the mandible Bone
Vol. 47Supplement 1, Page S226
Mays, S. (2010) Archaeological skeletons support a northwest European origin for Paget's disease of
bone. J Bone Miner Res, 25: 1839–1841
Visconti, M. R., Langston, A. L., Alonso, N., Goodman, K., Selby, P. L., Fraser, W. D. and Ralston, S. H. (2010)
Mutations of SQSTM1 are associated with severity and clinical outcome in paget disease of bone. J Bone
Miner Res, 25: 2368–2373
Langston A.L., Campbell M. K., Fraser W.D., MacLennan G.S., Selby P., Ralston S.H. 2010 Randomised trial
of intensive versus symptomatic management in Paget’s disease of bone. Journal of Bone and Mineral
Research. 25: 1 20-31
2007 – 2009
Mangham DC, MW Davie, RJ Grimer. (2009) Sarcoma arising in Paget’s disease of bone: declining
incidence and increasing age at presentation. Bone 44 (3): 431–36
Ralston S.H. (2008) Juvenile Paget's disease, familial expansile osteolysis and other genetic osteolytic
disorders. Best Practice Res Clin Rheumatol 22 (1):101–111
Langston AL, Campbell MK, Fraser WD, MacLennan G, Selby P, Ralston SH. (2007) Clinical determinants of
quality of life in Paget’s disease of bone. Calcif Tissue Int. 80:1–9.
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Singer F.R.(2009) Paget disease: when to treat and when not to treat Nature reviews. Rheumatology,
vol./is. 5/9(483-489), 1759-4804
Ralston S.H., Langston A.L., Reid I.R. (2008) Pathogenesis and management of Paget’s Disease of bone.
Lancet. 372; 155-163.
Ralston S.H. (2008) Pathogenesis of Paget's disease of bone Bone,. 43/5(819-825), 8756-3282
Deyrup, A.T., et al., (2007) Sarcomas arising in Paget disease of bone: a clinicopathologic analysis of 70
cases. Arch Pathol Lab Med, 131 (6): 942-6.
Langston, A.L., Campbell, M.K., Fraser, W.D., MacLennan, G., Selby, P., Ralston, S.H. for the PRISM Trial
Group, (2007). Clinical determinants of life in Paget’s disease of bone. Calcif. Tissue Int. 80, 1–9.
Stuart H Ralston, Anne L Langston, Ian R Reid Pathogenesis and management of Paget’s disease of bone
(2008) Lancet 372: 155–63
Tuck SP, Fordham JN. The Current Management of Paget's Disease. Prescriber March 2001; 12 (5): 97-102.
Wermers RA, Tiegs RD, Atkinson EJ, Achenbach SJ, Melton LJ. (2008) Morbidity and mortality associated
with Paget’s disease of bone: a population based study. J. Bone Miner. Res. 6:819–825
European Medicines Agency (EMA), (2009). EMEA/CHMP/292475/2009. Questions and Answers on the
Review of Bisphosphonates and the Risk of Osteonecrosis of the Jaw.
Older
Williams AE, O’Neill TW, Mercer S, Toro B, Nester CJ. Foot Pathology in Patients with Paget's Disease of
Bone. J Am Podiatr Med Assoc 2006; 96(3): 226-231.
Reid I.R., Miller P., Lyles K., et al. (2005) Comparison of a single infusion of zoledronic acid with
risedronate for Paget’s disease. New England Journal of Medicine. 353:898-908.
Tuck SP, Fordham JN. (2001), The Current Management of Paget's Disease. Prescriber, March; 12 (5): 97102.
Parvizi J, Klein GR, Sim FH.(2006) Surgical management of Paget’s disease of bone. J Bone Miner Res ; 21
Suppl 2: 75–82
Choma TJ, et al., (2004) Paget’s disease of bone in patients younger than 40 years. Clin Orthop Relat Res
418: 202–4
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Monsell, E.M., (2004) The mechanism of hearing loss in Paget’s disease of bone. Laryngoscope 114(4):
598–606
Mercer S, O’Neill TW. A brighter future for patients with Paget's disease. Professional Nurse 2002;17:36032.
van Staa TP, et al. (2002) Incidence and natural history of Paget’s disease of bone in England and Wales. J
Bone Miner Res. 17(3): 465–71
Hocking LJ, et al. (2002) Domain-specific mutations in sequestosome 1 (SQSTM1) cause familial and
sporadic Paget’s disease. Hum Mol Genet 11(22): 2735–9
Subramanian Shankar and David J Hosking (2006) Biochemical Assessment of Paget’s Disease of Bone
JOURNAL OF BONE AND MINERAL RESEARCH Volume 21, Supplement 2
Poor G, Donath J, Fornet B, Cooper C. (2006) Epidemiology of Paget’s disease in Europe: the prevalence is
decreasing. J. Bone Miner. Res. 21:1545–1549
Van Staa TP, Selby P, Leufkens HG, Lyles K, Sprafka JM, Cooper C. (2002) Incidence and natural history of
Paget’s disease of bone in England and Wales. J. Bone Miner. Res. 17:465–471
Barker DJ, Chamberlain AT, Guyer PB, Garner MJ. (1980) Paget’s disease of bone: the Lancashire focus.
BMJ. 280:1105–1107
Detheridge FM, Guyer PB, Barker DJ. (1982) European distribution of Paget’s disease of bone. Br. Med. J.
(Clin. Res. Ed.). 285:1005–1008
Paget J. (1877) A form of chronic inflammation of bones (osteitis deformans). Med. Chir. Trans.
(Lond.).;60:37–64 Tuck SP, Fordham JN. The Current Management of Paget's Disease. Prescriber March 2001; 12
(5): 97-102.
Books
The following books contain sections specifically relating to Paget’s disease.
Genetics
R.V., Whyte, M.P., Eisman, J., Igarashi, T., (Eds) (2012), Genetics of Bone Biology and Skeletal Disease
(Academic Press), Oxford: Elsevier Science Publishing Co Inc. (Chapter 19: Paget’s Disease)
Nursing
Bullock, I., Macleod Clark, J., Rycroft-Malone, J., (Eds) (2012), Adult Nursing Practice, Oxford University
Press. (Paget’s disease: p 42 – 45)
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