TBI Programs and Resources in the US Military 30 April 2010 Kathy Helmick MS, CRNP, CNRN Interim Senior Executive Director, TBI 27 October 2009 Defense Centers of Excellence for Psychological Health and Traumatic Brain Injury Version 1.0 Agenda • • • • • • • • • DoD definition of TBI Severity of injury Mechanisms of injury Recent research findings DoD enterprise wide initiatives TBI management continuum Resources – patient, family, provider Research The way ahead 2 High-level Attention Task Force on Returning Global War on Terror Heroes Independent Review Group (IRG) Commission on Care for America’s Returning Wounded Warriors DoDIG Review of DoD/VA Interagency Care Transition Mental Health Task Force Veterans Disability Benefits Commission (www.vetscommission.org ) 3 What is DCoE? – DCoE is a DoD organization that, in close partnership with the Department of Veterans Affairs, leads a national and international collaborative network of other governmental organizations, military and civilian agencies, community leaders, advocacy groups, clinical experts and academic institutions in helping service members with psychological health and traumatic brain injury issues. – DCoE’s work focuses on assessing, validating, overseeing and facilitating programs which aid service members with resilience, recovery and reintegration for psychological health and traumatic brain injury issues. Our core messages – You are not alone – Treatment works. The earlier the intervention, the better – Reaching out is an act of courage and strength 4 Who We Support • Service members – Guard and Reserve • • • • • • • • Veterans Families Military leaders Healthcare providers Researchers Employers Caregivers Chaplains 5 DoD TBI Definition (Oct 07) • Traumatically induced structural injury or physiological disruption of brain function as a result of external force to the head • New or worsening of at least one of the following clinical signs – – – – – Loss of consciousness or decreased consciousness Loss of memory immediately before or after injury Alteration in mental status (confused, disoriented, slow thinking) Neurological deficits Intracranial lesion • DoD definition parallels standard medical definition – CDC, WHO, AAN, ACRM 6 Severity Rating for TBI Traumatic Brain Injury Description Severity GCS AOC LOC PTA Mild 13-15 ≤24 hrs 0-30 min ≤24 hrs Moderate 9-12 >24 hrs >30min <24 hrs >24hrs <7 days Severe 3-8 >24hrs ≥24 hrs ≥7 days GCS- Glasgow Coma Score AOC- Alteration in consciousness LOC -Loss of consciousness PTA- Post-traumatic amnesia 7 TBI Clinical Standards: Severity, Stages, Environment Types of TBI TBI Post-Injury Stages Levels of TBI Care Mild Acute In-theater Moderate Sub-Acute CONUS Severe Chronic In-patient Penetrating Outpatient Community 8 Tracking: DoD Totals Number of TBI Cases 30000 25000 20000 15000 10000 5000 0 2000 Data Source: www.DVBIC.org 2002 2004 2006 2008 *2009 data does not include Oct - Dec 9 TBI Tracking: Severity Data 90 Percentage 80 70 Severe/Penetrating 60 50 Moderate 40 Mild 30 20 Not Classified 10 0 2000 2002 Data Source: www.DVBIC.org 2004 2006 2008 *2009 data does not include Oct - Dec 10 Tracking: TBI ICD 9 Code Surveillance 310.2 Post concussion syndrome 803.4 851.2 800.0 Fracture of the vault of the skull 803.5 851.3 800.1 803.6 851.4 800.2 803.7 851.5 800.3 803.8 851.6 800.4 803.9 851.7 800.5 804.0 800.6 804.1 851.9 800.7 804.2 852.0 800.8 804.3 852.1 800.9 804.4 852.2 804.5 852.3 801.1 804.6 852.4 801.2 804.7 852.5 801.3 804.8 853.0 801.4 804.9 801.5 850.0 801.6 850.1 854.1 801.7 850.2 950.1 801.8 850.3 950.2 801.9 850.4 950.3 850.5 959.01 Other and unspecified injury to head face and neck 803.1 850.9 995.55 Shaken baby syndrome 803.2 851.0 V15.5+Ext GWOT TBI codes 803.3 851.1 801.0 803.0 Fracture of the base of the skull Other closed skull fracture w/o mention of intracranial injury Closed fractures involving the skull or face with other bones w/o mention of intracranial injury 851.8 Subarachnoid hemorrhage following injury w/o mention of open intracranial wound 853.1 Concussion w/ no loss of consciousness Cortex (cerebral) contusion w/o mention of open intracranial wound 854.0 Injury to optic chiasm 11 Mechanisms of Injury • Acceleration-deceleration – Combination due to rapid velocity changes of the brain 12 Blast Injury Primary: Direct exposure to over pressurization wave 13 Impact Vice Blast Vice Blast “plus” • Understanding differences in mechanism of injury • Differences in DTI between blast and impact TBI • Inflammatory markers in animal studies • Computer modeling of blast injury • Physiological, Histological, and/or behavioral differences between blast and non-blast in shock tubes with rodents 14 Cause for Concern CONCUSSIVE EFFECTS/TBI • A study commissioned by the NFL reports that Alzheimer’s like memory- related diseases appear to have been diagnosed in the league’s former players vastly more often than in the national population – including a rate of 19 times the normal rate for men ages 30 through 49. - Study conducted by University of Michigan’s Institute for Social Research 15 Chronic Traumatic Encephalopathy (CTE) Center for the Study of Traumatic Encephalopathy (CSTE) at BU School of Medicine • “a distinct disease with a distinct cause, namely repetitive head trauma” (Ann McKee, MD, CSTE co-director and neuropathologist) • CTE diagnosed in 6 former NFL players since 2002, including: – Pittsburgh Steelers - Mike Webster, Terry Long and Justin Strzelczyk – Tampa Bay Buccaneer Tom McHale, died at age 45 • Youngest case to date: 18-year-old boy who suffered multiple concussions in high school football 16 Sports Legacy Project Christopher Nowinski and the Sports Legacy Institute Top: Slide detailing x600 magnification of immunostained neocortex in a non-CTE damaged brain. Chris Benoit, Professional Wrestler Bottom: Slide detailing x600 magnification of Chris Benoit's tau-immunostained neocortex showing neurofibrillary tangles, neuritic threads, and several ghost tangles indicating CTE. Source: http://www.sciencedaily.com/releases/20 07/09/070905224343.htm Image courtesy of Sports Legacy Institute 17 Progressive Tauopathy in an athlete with Chronic Traumatic Encephalopathy Tau-immunoreactive neurofibrillary tangles in the superficial cortical layers of the frontal, subcallosal, insular, temporal, and parietal cortices and the medial temporal lobe; marked accumulation of tau-immunoreactive astrocytes Accumulation of abnormal Tau protein in the form of NFTs and NTs in the brain has been confirmed to cause neurodegeneration, cognitive impairment and dementia. Coronal sections immunostained for tau with monoclonal antibody AT8 and counterstained with cresyl violet McKee AC, Cantu RC, Nowinski CJ, et al, J Neuropathol Exp Neurol Volume 68, Number 7, July 2009 18 Clinical Sequelae of Chronic Traumatic Encephalopatby Symptoms can Include; – – – – – – Memory disturbances Behavioral changes Personality changes Parkinsonism Speech abnormalities Gait abnormalities 19 Cultural Change Emerging science supports acute management to include concerns of safety to encourage acute management and evaluation to prevent recurrent concussions before full recovery from prior injury State Laws: Washington – First state legislation Oregon, Texas Under consideration: ME, CA, MA, NJ, NY 20 Post Concussive Symptoms Physical Emotional Cognitive • Headache • Anxiety • Slowed processing • Dizziness • Depression • Decreased attention • Balance problems • Irritability • Poor Concentration • Mood lability • Memory Problems • Nausea/Vomiting • Fatigue • Visual disturbances • Verbal dysfluency • Word-finding • Abstract reasoning • Sensitivity to light/noise • Ringing in the ears 21 Possible Effects of mTBI • Acute – Poor marksmanship – Slower reaction time – Decreased concentration • Chronic – – – – Reduced work quality Behavioral problems Emotional problems “Unexplained“ symptoms TBI-related impairments increase vulnerability to subsequent injury until full recovery occurs 22 DoD Wide Initiatives • • • • TBI Screening (PDHA/PDHRA) TBI Surveillance NCAT (Neuro Cognitive Assessment Tool) pre deployment program Clinical guidance packages – – – – Cog rehab Driving assessments after TBI mTBI/PTSD mTBI and co occurring conditions • 4th Annual TBI military training conference ( 30-31 Aug 10) • TBI Family Caregiver Guide • TBI Care Coordination • CDMRP bolus of research funds 23 TBI Management Continuum GOAL: A cultural change in fighter management after concussive events: identification and treatment close to point of injury, documentation of the incident, and expectation of recovery with early treatment. VISION: Every Warrior trained to: – Recognize the signs/symptoms – Reduce the effects And in the event of an injury – – Treat early to minimize the impact and maximize recovery from TBI. MISSION: Produce an educated force trained and prepared to provide early recognition, treatment, tracking & documentation of TBI in order to protect Warrior health. Education & Prevention Rehabilitation, Recovery, Reintegration & Research Early Detection Treatment & Tracking Educate – Train – Treat – Track 24 Education & Prevention 25 Early Detection: Why Screen for TBI? Studies suggest TBI is a common injury in OEF/OIF • 16% of returning Army Soldiers screened positive1 • 15% of returning Army Soldiers screened positive2 • 19% of OIF/OEF Veterans screened positive3 • 23% of returning Army Soldiers screened positive4 • 18.5% of Veterans at VA medical centers screened positive5 1.Schwab KA, Ivins B, Cramer G, Johnson W, Sluss-Tiller M, Kiley K, Lux W, Warden B. Screening for traumatic brain injury in troops returning from deployment in Afghanistan and Iraq: Initial investigation of the usefulness of a short screening tool for traumatic brain injury. J Head Trauma Rehabil 2007; 22(6): 377-389. 2.Hoge CW, McGuirk D, Thomas JL, Cox AL, Engel CC, Castro CA. Mild traumatic brain injury in US soldiers returning from Iraq. N Engl J Med 2008; 358(5): 453-463. 3.Schell TL, Marshall GN. Chapter 4, Survey of individuals previously deployed for OIF/OEF. In Tanielian T and Jaycox LH (eds.) Invisible Wounds: Mental Health and Cognitive Care Needs of America’s Returning Veterans. Santa Monica, CA: The RAND Corporation; 2008. 4.Terrio H, Brenner LA, Ivins BJ, Cho JM. Helmick K, Schwab K, Scally K, Bretthauer R, Warden D. Traumatic brain injury screening: Preliminary findings in a US Army brigade combat team. J Head Trauma Rehabil 2009; 24, 14-23. 5.Unpublished data. UNCLASSIFIED 26 Early Detection: Why Screen for TBI? (cont’d) Most TBIs are mild (mTBI) 76% of current military TBIs are mTBI1 (recent surveillance program trying to better define “scope of the problem”) 75% of civilian TBIs are mTBI2 MTBI is often untreated and undocumented As many as 25% of those with mTBI do not seek medical attention3 Many individuals with mTBI who receive medical attention do not have a TBI diagnosis recorded, especially those with multiple trauma4 1.DVBIC, unpublished data. UNCLASSIFIED 2.National Center for Injury Prevention and Control. Report to Congress on Mild Traumatic Brain Injury in the United States: Steps to Prevent a Serious Public Health Problem. Atlanta, GA: Centers for Disease Control and Prevention; 2003. 3.Sosin DM, Sniezek JE, Thurman DJ. The incidence of mild and moderate brain injury in the United States, 1991. Brain Inj 1996; 10: 47-54. 4.Moss NEG, Wade DT. Admission after head injury: How many occur and how many are recorded. Inj 1996; 27: 159-161. 27 Locations Where TBI Screening Occurs • In-theater • Landstuhl Regional Medical Center (LRMC) • CONUS, during Post Deployment Health Assessment (PDHA) and Post Deployment Health ReAssessment (PDHRA) • VA Medical Centers Numerous screening safety nets to ensure capture of Service members requiring intervention Diagnosis is confirmed through clinical interview 28 Post-Deployment Health Assessment/ Reassessment 9.a. During this deployment, did you experience any of the following events? (Mark all that apply) (1) Blast or explosion (IED, RPG, land mine, grenade, etc.) (2) Vehicular accident/crash (any vehicle, including aircraft) (3) Fragment wound or bullet wound above your shoulders (4) Fall (5) Other event (for example, a sports injury to your head). Describe: 9.b. Did any of the following happen to you, or were you told happened to you, IMMEDIATELY after any of the event(s) you just noted in question 9.a.? (Mark all that apply) (1) Lost consciousness or got “knocked out” (2) Felt dazed, confused, or “saw stars” (3) Didn’t remember the event (4) Had a concussion (5) Had a head injury 9.c. Did any of the following problems begin or get worse after the event(s) you noted in question 9.a.? (Mark all that apply) (1) Memory problems or lapses (2) Balance problems or dizziness (3) Ringing in the ears (4) Sensitivity to bright light (5) Irritability (6) Headaches (7) Sleep problems 9.d. In the past week, have you had any of the symptoms you indicated in 9.c.? (Mark all that apply) (1) Memory problems or lapses (2) Balance problems or dizziness (3) Ringing in the ears (4) Sensitivity to bright light (5) Irritability (6) Headaches (7) Sleep problems Positive screen = concurrence to all four questions Positive screen ≠ concussion diagnosis Need clinician confirmation to diagnose concussion 29 Warrior mTBI Management Goal: A cultural change that focuses on leadership, service member and medical personnel mutual responsibilities after concussive events Vision: Every Warrior treated appropriately to minimize concussive injury and maximize recovery Mission: Produce an educated force trained and prepared to provide early recognition, treatment & tracking of concussive injuries in order to protect Warrior health. Educate - Train - Treat - Track As of: 27 October 2009 Slide 30 of 25 30 Early Detection In-theater Clinical Practice Guidelines SCENARIOS REQUIRING MANDATORY MEDICAL SCREENING • Mounted: All personnel in any damaged vehicle (e.g. blast, accident, rollover, etc) • Dismounted: All within 50m of a blast; All within a structure hit by an explosive device • Anyone who sustains a direct blow to the head or loss of consciousness • Command Directed – NOT limited to repeated exposures Currently Being Codified in Directive Type Memorandum (DTM) 31 Early Detection In-theater Clinical Practice Guidelines MEDICAL SCREENING REQUIREMENTS • ALL RECEIVE – – – – Medic/corpsman evaluation (MACE) Minimum 24 hrs downtime Medical re-evaluation pre-RTD Event capture/tracking • mTBI/concussive event – Medical evaluation above with physician, PA or NP oversight • Witnessed loss of consciousness – Neurological evaluation by physician, PA or nurse practitioner – Loss of consciousness greater than 5 minutes requires evacuation to Level III facility 32 MACE: Military Acute Concussion Evaluation • • • Developed by DVBIC and released in Aug 2006 Performed by medical personnel 3-Part Screening Tool – “CNS” – – – • • • Cognition Neurological Exam Symptoms Alternate versions available Upcoming revision will include recurrent concussion questions Can be used during exertional testing to ensure that cognitive function remains intact 33 Treatment MILD TBI • Primary Care • Referral to TBI specialist after initial management failure • Core TBI interventions (if required) may include: – – – – – – – – – Cognitive rehabilitation Vestibular/balance therapy Medication management Vision therapy Driving rehabilitation Assistive technology Tinnitus management Headache Management Complementary and alternative medicine interventions MODERATE / SEVERE / PENETRATING • In-theater Acute Field Management • First Responder actions (Combat Lifesaver) • Neurosurgical theater presence • Continuing evolution of air transport capabilities • DoD TBI centers, VA Polytrauma Rehabilitation Centers, Civilian Rehabilitation Programs 34 Treatment: Headache Chronic Daily Headache Episodic Headache •> 15 HA days per month •Analgesic rebound •Prophylaxis is key •Characterize type •Abortive therapy •Maximum 6 doses/week Avoid Narcotics & Benzodiazipines Prophylaxis Abortive NSAIDs •GI side effects Ibuprofen Naproxen Sodium Acetaminophen Aspirin Triptans •Contraindicated in patients with CAD Onset of action ~ 4 wks Combination Medications Alternatives Promethazine Metoclopramide •Cognitive side effects Prochloroperazine •Risk of W/D Tizanidine Non-medication Fioricet Trigger point injection Fiorinal Occipital nerve block Midrin Physical therapy Anti-depressants Anti-epileptics Beta-blockers •May improve mood •Improves sleep Nortriptylline Amitryptilline Paroxetine Fluoxetine •Neuropathic pain gabapentin •Mood lability valproic acid topirimate •Non-selective may have benefit on autonomic effects of PTSD Propranolol 35 Treatment: Cognitive Deficits DVBIC/DCoE MAR08 Cognition Memory loss or lapse Forgetfulness Poor concentration Decreased attention Slowed thinking Executive dysfunction Concussion Management Grid Administer: MACE if injury within 24 hours, Other neurocognitive testing as available (eg ANAM or other neuropsychological testing) Gather: Collateral information from family, command and others Table 1 Normalize sleep & nutrition Pain control Refer: Speech/language pathology Occupational therapy Neuropsychology 36 Treatment: Cognitive Rehabilitation in mTBI • Accelerating but still small body of scientific literature supporting cognitive rehabilitation in mTBI • DoD Programs (inventory of current programs) • Outsourced care vs MTF provided • DCoE/DVBIC Consensus Conference – April 2009 – – – – 2-day; 50 members DoD (Quad Service)/DVA representation SOCOM/Reserve Affairs representation Civilian Subject Matter Experts 37 Treatment: Cognitive Rehabilitation (cont’d) • Cognitive domains affected after TBI – Attention • Foundation for other cognitive functions/goal-directed behavior • Efficacy of attention training established – Memory • True memory impairment vs poor memory performance from inattention • Evidence to support development of memory strategies and training in use of assistive devices (‘memory prosthetics’) – Social/Emotional • Evidence to support group sessions in conjunction with individual goal setting – Executive Function • Evidence to support training use of multiple step strategies, strategic thinking and/or multitasking • Compensatory vs restorative therapy 38 TBI and Co-occurring Conditions • • • • • • • PTSD Pain Substance Use Disorders Dual Sensory Impairments Depression Anxiety Suicide 39 39 Prevalence of PTSD, mTBI and Pain Chronic Pain N=277 81.5% 16.5% 10.3% 2.9% PTSD N=232 68.2% 42.1% 12.6% 6.8% 5.3% TBI N=227 66.8% 340 OEF/OIF Veterans evaluated at VA Boston Polytrauma site, Lew et al, In press 40 Toolkit Development 41 Toolkit Development • Layout – Importance of assessment • Understanding the potential diagnoses behind the symptoms – First appointment tips • Requested by primary care – Primary symptoms • Sleep • Mood • Attention • Chronic Pain – Medication Appendix • Cross-walk table • Reference list of medications – Patient Resources – Provider Resources • Websites • Outcome measures and recommended assessment/re-assessment tools 42 Functional Imaging Concussion Severe TBI • Assessment of Neuronal/Metabolic Function • Informing DoD policy -Undiagnosed concussion can result in: – Symptoms affecting operational readiness – Risk of recurrent concussion during the healing period Normal High Activity Low Activity Bergsneider et al., J Neurotrauma 17:2000 43 Imaging: mTBI and Depression An fMRI Study of Male Athletes • Athletes with symptoms of depression with onset after concussion showed reduced activation in the dorsolateral prefrontal cortex and striatum, and attenuated deactivation in medial frontal and temporal regions. • The severity of symptoms of depression correlated with neural responses in brain areas that are implicated in major depression. • Voxel-based morphometry confirmed gray matter loss in these areas. • Conclusion: Depressed mood following a concussion may reflect an underlying pathophysiology consistent with a limbic-frontal model of depression. Neural substrates of symptoms of depression following concussion in male athletes with persisting postconcussion symptoms. Chen JK, et al. Arch Gen Psychiatry. 2008 Jan;65(1):81-9. 44 TBI Research: Novel/Innovative Areas of Inquiry • Illustrative Examples: – – – – – Omega-3 fatty acids Progesterone Transcranial laser therapy Transcranial magnetic stimulation Neurofeedback (EEG biofeedback/neurotherapy) – Hyperbaric oxygen 45 Treatment: Return to Duty Determination • Objective: better inform return to duty determinations in the field following TBI beyond exertional testing and MACE • NCAT – Over 500K baselines – Army ANAM Ops • Vestibular Balance Plate Testing – Under development • Nystagmus Detection – Under development 46 Neurocognitive Assessment Tool (NCAT)/Automated Neuropsychological Assessment Metrics (ANAM) • Computerized neurocognitive assessment tool • Purpose: – Establish an accurate assessment of pre-injury cognitive performance for comparison in post-injury return to duty (RTD) decisions • One piece of clinical picture • Selective use for those with more clinically challenging cases • Takes 20 minutes to complete • Current policy (May 08): – All pre-deployers receive baseline cognitive testing with ANAM within one year of deployment • Other tools being studied head-to-head • Better assessment if injured SM is compared to their baseline scores as opposed to a normative databank 47 47 Patient, Family and Caregiver Education Office of the Surgeon General/Army Medical Department Health Policy & Services Proponency Office for Rehabilitation & Reintegration Curriculum for Traumatic Brain Injury 48 Family Caregiver Curricula • 4 Modules: – – – – Module 1: Introduction to TBI (learning about the brain, acute care issues, complications) Module 2: Understanding Effects of T BI and What You Can do to Help (physical , cognitive, communication, behavioral, emotional) Module 3: Becoming a Family Caregiver for a Service Member/Veteran with TBI (starting the journey, caring for SM and yourself, finding meaning in caregiving) Module 4: Navigating the system (recovery care, eligibility for compensation and benefits) • Due to be released by Summer 2010 49 49 Provider Resources • DCoE : www.dcoe.health.mil – Outreach Center: 866.966.1020 – Monthly video teleconferences • DVBIC: www.dvbic.org – Annual TBI Military Training Conference – Education coordinators – TBI.consult: tbi.consult@us.army.mil • VA/DoD mTBI/Concussion CPG Fact Sheet • ICD-9 DoD TBI Coding Fact Sheet • Service TBI POC 50 Public Service Announcements • NFL: Take Head Injuries out of Play http://www.nfl.com/videos/nfl-network-aroundtheleague/09000d5d814d2543/Concussion-safety • DoD: Protect your most valuable weapon – your head! http://www.facebook.com/video/video.php?v=104 824466213664 51 Regional Care Coordination Program launched Nov 2007 • Provide 100% follow-up to identified Service Members with Traumatic Brain Injury (mild, moderate, severe and penetrating) from 13 regional catchment areas across the US • Monitor the care continuum for traumatic brain injury to include potential rehabilitation needs, education, advocacy and support to Service Members with TBI and their families from injury to return to duty and/or re-entry into the community • Identify and connect Service Members to available TBI resources within DoD, VA and civilian communities • Provide education and support-serving as a TBI subject matter expert to all involved in the care and support of the Service Member and family. • Identify barriers and/or gaps in service delivery for TBI Service Members as they transition between systems and settings • Functional outcomes picture to look at quality of life issues related to home, work and social environments 52 Rehabilitation, Recovery, Reintegration DoD TBI Programs Draft53 DVBIC Virtual TBI Clinic • TBI screening, assessment, consultation & care to: – – • • • Direct specialty care via VTC Local PCPs provide on-site testing and therapy Multiple specialties – • Patients at remote military medical centers Troop intensive sites where demand fluctuates with mass mobilizations Neurology, neuropsychology, pain management, rehabilitation Contact DVBIC if interested in establishing dedicated connection to Tele-TBI Clinic – 800.870.9244 54 Research & Development Treatment & Clinical Improvement (e.g. Hyperbaric Oxygen Therapy, Cognitive Rehab) Blast Physics/ Blast Dosimetry Rehabilitation & Reintegration: Long Term Effects of TBI Complementary Alternative Medicine Neuroprotection & Repair Strategies: Brain Injury Prevention Field Epidemiological Studies (mTBI) Force Protection Testing & Fielding Concussion: Rapid field Assessment (e.g., Biomarkers/ Eye Tracking 55 Research & Development CDMRP Funded Studies Funded TBI Investigators TBI Drugs TBI Other Interventions PI Funded in Hawaii Awards range from $150K over 18 months to $4M over 4 years 201 Proposals selected from a pool of 2110 applicants TBI Research Gaps Treatment and Clinical Management Neuroprotection and Repair Rehabilitation/Reintegration Field Epidemiology Physics of Blast 56 Way Forward • Fast tracking of medical research projects to translate findings to Service members in the field • TBI & Co-occurring disorders – – – PTSD Dual Sensory Impairments: Visual and Auditory CPG’s addressing these • Directive-type memorandum (DTM) – Early detection and Early treatment • In theater based care – Role II centers • Ongoing efforts to promote the linkage of blast tracking with medical data/science • Training and Education efforts 57 Questions? 58