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Copyright © Prentice Hall 2007 Chapter Fifteen Mental Retardation and Pervasive Developmental Disorders Copyright © Prentice Hall 2007 Chapter Outline • Mental Retardation • Autistic Disorder and Pervasive Developmental Disorders Copyright © Prentice Hall 2007 Overview • Mental retardation and Pervasive Developmental Disorders (PDD) involve serious disruptions in development. • Both disorders are either present at birth or begin early in life. • Both affect many areas of intellectual, social, and life functioning. • Autism is the most familiar PDD, and, in fact, professionals often use the term autistic spectrum disorders as a synonym for PDD. Copyright © Prentice Hall 2007 Overview • PDD are distinguished by dramatic, severe, and unusual symptoms. • Socially, the child not only lives in a world of his own but also in a world apart. • Many children with PDD also cannot communicate. • In addition, children with PDD are preoccupied with unusual repetitive behavior, like needing to preserve rigid routines or rocking back and forth endlessly. Copyright © Prentice Hall 2007 Overview • All people with mental retardation have impaired intellectual abilities, but they vary widely in academic ability, social functioning, and life skills. • Some people with profound retardation require total care and live their entire lives in institutions. • However, most people with mental retardation learn the self-care and vocational skills that allow them to live in the community. Copyright © Prentice Hall 2007 Mental Retardation • Much of the focus of intervention with mental retardation is on intellectual disability. • Many people with mental retardation suffer from emotional difficulties, a fact that is overlooked all too often. Copyright © Prentice Hall 2007 Mental Retardation Symptoms of Mental Retardation • The American Association on Mental Retardation (AAMR), the leading organization for professionals concerned with mental retardation, defines mental retardation somewhat differently than DSMIV-TR. Copyright © Prentice Hall 2007 Mental Retardation Symptoms of Mental Retardation (continued) • However, both definitions generally agree on the three major criteria for mental retardation: 1) significant limitations in intellectual functioning, 2) significant limitations in adaptive functioning, and 3) onset before age 18 years. Copyright © Prentice Hall 2007 Copyright © Prentice Hall 2007 Mental Retardation Symptoms of Mental Retardation (continued) • • The AAMR and DSM-IV-TR both define subaverage intellectual functioning in terms of a score on an individualized intelligence test, a standardized measure for assessing intellectual ability. Intelligence tests yield a score called the intelligence quotient, or IQ, the test’s rating of an individual’s intellectual ability. Copyright © Prentice Hall 2007 Mental Retardation Symptoms of Mental Retardation (continued) • • • Defining intelligence can be controversial, and definitions and measures of intellectual ability have changed over the years. Early versions of intelligence tests derived an IQ by dividing the individual’s “mental age” by his or her chronological age. Mental age was determined by comparing an individual’s test results with the average obtained for various age groups. Copyright © Prentice Hall 2007 Mental Retardation Symptoms of Mental Retardation (continued) • • • Contemporary intelligence tests have abandoned the concept of mental age and instead have adopted the concept of the “deviation IQ.” According to this theory, intellectual ability follows the normal distribution in the population, a bell-shaped frequency distribution. The individual’s IQ is determined based on how the person scores on an intelligence test relative to the norms for his or her age group. Copyright © Prentice Hall 2007 Copyright © Prentice Hall 2007 Mental Retardation Symptoms of Mental Retardation (continued) • • Intelligence tests are normed to have a mean (average) IQ score of 100 and a standard deviation of 15. One potential problem with the deviation IQ is that IQ scores in the normal range are rising across generations, a phenomenon known as the Flynn effect (named for James Flynn, who first noted the trend). Copyright © Prentice Hall 2007 Mental Retardation Symptoms of Mental Retardation (continued) • • • IQ tests are widely used, and they have demonstrated value for predicting performance in school. Moreover, IQ is a trait that is stable over time. Despite the value of IQ tests in predicting academic performance, a number of important questions have been raised about them. Copyright © Prentice Hall 2007 Mental Retardation Symptoms of Mental Retardation (continued) • • • One of the most controversial questions is whether intelligence tests are “culture-fair.” Culture-fair tests contain material that is equally familiar to people who differ in their ethnicity, native language, or immigrant status. Tests that are culturally biased contain language, examples, or other assumptions that favor one ethnic group, particularly members of the majority group, over another. Copyright © Prentice Hall 2007 Mental Retardation Symptoms of Mental Retardation (continued) • • • Another controversy is how well intelligence is measured among people with mental retardation. Many people with mental retardation have sensory or physical disabilities that impede their performance on standard IQ tests; thus they must take tests that are not influenced by their particular disability. Despite the difficulties, evidence indicates that, if anything, the IQ test scores of people with mental retardation are more reliable and valid than IQ scores in the normal range. Copyright © Prentice Hall 2007 Mental Retardation Symptoms of Mental Retardation (continued) • • • • The most basic concern about intelligence tests is the most important one: What is intelligence? Intelligence tests measure precisely what their original developer, Alfred Binet, intended them to measure: potential for school achievement. IQ tests predict school achievement fairly well. However, school achievement is not the same as “intelligence.” Copyright © Prentice Hall 2007 Mental Retardation Symptoms of Mental Retardation (continued) • • Common sense, social sensitivity, and “street smarts” are also part of what most of us would consider intelligence, and they are not measured by IQ tests. Both the AAMR and DSM recognize that intelligence is more than an IQ score; thus they include adaptive behavior as a part of their definitions of mental retardation. Copyright © Prentice Hall 2007 Mental Retardation Symptoms of Mental Retardation (continued) • • The AAMR suggests that adaptive behavior includes conceptual, social, and practical skills. Conceptual skills focus largely on community self-sufficiency, and incorporate communication, functional academics, self-direction, and health and safety from DSM-IV-TR. Copyright © Prentice Hall 2007 Mental Retardation Symptoms of Mental Retardation (continued) • • Social skills focus on understanding how to conduct oneself in social situations and include social skills and leisure from the DSM-IV-TR list. Practical skills focus on the tasks of daily living and include self-care, home living, community use, health and safety, and work from the DSM-IV-TR. Copyright © Prentice Hall 2007 Mental Retardation Symptoms of Mental Retardation (continued) • • Adaptive skills are difficult to quantify. As with the definition of IQ, the AAMR now defines a significant limitation in adaptive behavior as a score that is two standard deviations below the mean on a standardized measure of adaptive behavior in conceptual, social, or practical skills. Copyright © Prentice Hall 2007 Mental Retardation Symptoms of Mental Retardation (continued) • • An argument has been made for defining retardation solely on the basis of intelligence testing, because current measures of adaptive skills are imprecise. However, the adaptive skills criterion highlights the importance of assessing life functioning in borderline cases, as well as the need for services among people with mental retardation. Copyright © Prentice Hall 2007 Mental Retardation Symptoms of Mental Retardation (continued) • • • The third criterion for defining mental retardation is onset before 18 years of age. This criterion excludes people whose deficits in intellect and adaptive skills begin later in life as a result of brain injury or disease. People with mental retardation have not lost skills they once had mastered, nor have they experienced a notable change in their condition. Copyright © Prentice Hall 2007 Mental Retardation Diagnosis of Mental Retardation • • • In 1866, the British physician Langdon Down first described a subgroup of children with mental retardation who had a characteristic appearance. Down’s classification helped subsequent scientists to establish a specific etiology for what we now know as Down syndrome. The creation of IQ tests in the early twentieth century also greatly furthered the classification of mental retardation. Copyright © Prentice Hall 2007 Mental Retardation Diagnosis of Mental Retardation (continued) • • Once academic potential could be measured, controversy grew about what IQ score cutoff should define mental retardation. The AAMR has set the cutoff at two standard deviations below the mean (70). Copyright © Prentice Hall 2007 Mental Retardation Diagnosis of Mental Retardation (continued) • • • • Today, mental retardation can be classified according to two different criteria. One criterion is based on IQ scores; the other is according to known or presumed etiology. The AAMR uses a multiaxial diagnosis of mental retardation in which health, including etiological factors, is rated on a separate axis. A more controversial aspect of the AAMR subclassification is the ratings of four levels of “intensity of needed support” across nine different areas of functioning. Copyright © Prentice Hall 2007 Mental Retardation Diagnosis of Mental Retardation (continued) • • The goal in rating support intensities is to acknowledge the diversity of skills and needs among people with mental retardation both as people and for treatment planning. In adopting the support intensities approach, AAMR abandoned a long tradition still followed in the DSM-IV-TR of dividing mental retardation into four levels based primarily on IQ scores: mild, moderate, severe, and profound. Copyright © Prentice Hall 2007 Mental Retardation Diagnosis of Mental Retardation (continued) • • Mild mental retardation is the designation for those with IQ scores between 50–55 and 70. People with mild mental retardation typically have few, if any, physical impairments, generally reach the sixth-grade level in academic functioning, acquire vocational skills, and typically live in the community with or without special supports. Copyright © Prentice Hall 2007 Mental Retardation Diagnosis of Mental Retardation (continued) • • • People with moderate mental retardation have IQs between 35–40 and 50–55. They may have obvious physical abnormalities such as the features of Down syndrome. Academic achievement generally reaches second-grade level, work activities require close training and supervision, and special supervision in families or group homes is needed for living in the community. Copyright © Prentice Hall 2007 Mental Retardation Diagnosis of Mental Retardation (continued) • • Severe mental retardation is defined by IQ scores between 20–25 and 35–40. At this severity level, motor development typically is abnormal, communicative speech is sharply limited, and close supervision is needed for community living. Copyright © Prentice Hall 2007 Mental Retardation Diagnosis of Mental Retardation (continued) • • Profound mental retardation is characterized by an IQ below 20–25. Motor skills, communication, and selfcare are severely limited, and constant supervision is required in the community or in institutions. Copyright © Prentice Hall 2007 Mental Retardation Diagnosis of Mental Retardation (continued) • • • Because of the focus on intellectual difficulties, professionals can overlook emotional problems that actually are more common among people with mental retardation than the general population. In order to protect against this, mental retardation is coded along with personality disorders on Axis II in DSM-IV-TR in order to call attention to possible Axis I mental disorders. The Axis II placement also reflects the fact that significantly subaverage IQ is enduring. Copyright © Prentice Hall 2007 Mental Retardation Diagnosis of Mental Retardation (continued) • • A diagnosis of mental retardation literally might mean a difference between life and death. The United States Supreme Court recently ruled that the death penalty is “cruel and unusual punishment” for someone with mental retardation, and therefore is prohibited. Copyright © Prentice Hall 2007 Mental Retardation Diagnosis of Mental Retardation (continued) • Because of this ruling, lawyers are arguing about the precise definition of mental retardation—and psychologists are evaluating whether or not accused capital offenders have mental retardation—in close cases throughout the country. Copyright © Prentice Hall 2007 Mental Retardation Frequency of Mental Retardation • The best estimate is that only 1 percent of the population has mental retardation. • Mental retardation in the United States is more common among the poor and, as a result, among certain ethnic groups. • Mental retardation with a specific, known organic cause (for example, Down syndrome) generally has an equal prevalence among all social classes, whereas retardation of nonspecific etiology is more common among families living in poverty. Copyright © Prentice Hall 2007 Mental Retardation Causes of Mental Retardation • • • About one-half of all cases of mental retardation are caused by known biological abnormalities. The most common known biological cause of mental retardation is the chromosomal disorder Down syndrome. The cause of Down syndrome is the presence of an extra chromosome. Copyright © Prentice Hall 2007 Mental Retardation Causes of Mental Retardation (continued) • • • The incidence of Down syndrome is related to maternal age. In general, children and adults with Down syndrome function within the moderate to severe range of mental retardation. By their thirties, the majority of adults with Down syndrome develop brain pathology similar to that found in Alzheimer’s disease. Copyright © Prentice Hall 2007 Mental Retardation Causes of Mental Retardation (continued) • • • Another chromosomal abnormality, fragile-X syndrome, is the most common known genetic cause of mental retardation. Fragile-X syndrome is indicated by a weakening or break on one arm of the X sex chromosomes, and it is transmitted genetically. Not all children with the fragile-X abnormality have mental retardation. Copyright © Prentice Hall 2007 Mental Retardation Causes of Mental Retardation (continued) • • • Several other chromosomal abnormalities have been linked to mental retardation. As in fragile-X syndrome, abnormalities of the sex chromosomes are particularly notable. Mental retardation is known to be caused by several recessive gene pairings. Copyright © Prentice Hall 2007 Mental Retardation Causes of Mental Retardation (continued) • • • Phenylketonuria, or PKU, is one of these. PKU is caused by abnormally high levels of the amino acid phenylalanine, usually due to the absence of or an extreme deficiency in phenylalanine hydroxylase, an enzyme that metabolizes phenylalanine. Children with PKU have normal intelligence at birth. Copyright © Prentice Hall 2007 Mental Retardation Causes of Mental Retardation (continued) • • • • However, as they eat foods containing phenylalanine, the amino acid builds up in their system. This phenylketonuria produces brain damage that eventually results in mental retardation. Retardation typically progresses to the severe to profound range. Fortunately, PKU can be detected by blood testing in the first several days after birth. Copyright © Prentice Hall 2007 Mental Retardation Causes of Mental Retardation (continued) • • • Other relatively rare recessive-gene disorders can also cause mental retardation. Mental retardation can also be caused by various infectious diseases. Damaging infections may be contracted during pregnancy, at birth, or in infancy to early childhood. Copyright © Prentice Hall 2007 Mental Retardation Causes of Mental Retardation (continued) • • • Rubella (German measles) is a viral infection that may produce few symptoms in the mother but can cause severe mental retardation and even death in the developing fetus. The human immunodeficiency virus (HIV) can be transmitted from an infected mother to a developing fetus. The effects on the child are profound, including mental retardation, visual and language impairments, and eventual death. Copyright © Prentice Hall 2007 Mental Retardation Causes of Mental Retardation (continued) • • • Syphilis is a bacterial disease that is transmitted through sexual contact. Infected mothers can pass the disease to the fetus. If untreated, syphilis produces a number of physical and sensory handicaps in the fetus, including mental retardation. Copyright © Prentice Hall 2007 Mental Retardation Causes of Mental Retardation (continued) • • Another sexually transmitted disease, genital herpes, can be transmitted to the infant during birth and result in mental retardation. Two infectious diseases that occur after birth, encephalitis and meningitis, can cause mental retardation. Copyright © Prentice Hall 2007 Mental Retardation Causes of Mental Retardation (continued) • • • Exposure to a variety of environmental toxins can also cause mental retardation. Both legal and illegal drugs pose a risk to the developing fetus. Toxins also present a potential hazard to intellectual development after birth. Copyright © Prentice Hall 2007 Mental Retardation Causes of Mental Retardation (continued) • • • Pregnancy and birth complications also can cause mental retardation. One major complication is Rh incompatibility. Another pregnancy and birth complication that can cause intellectual deficits is premature birth. Copyright © Prentice Hall 2007 Mental Retardation Causes of Mental Retardation (continued) • Other pregnancy and birth complications that can cause mental retardation include extreme difficulties in delivery, particularly anoxia, or oxygen deprivation; severe malnutrition; and the seizure disorder epilepsy. Copyright © Prentice Hall 2007 Mental Retardation Causes of Mental Retardation (continued) • The tail of the normal IQ distribution involves cases of mental retardation of unknown etiology—what is often referred to as culturalfamilial retardation. • As the term suggests, cultural-familial retardation tends to run in families and is linked with poverty. • A controversial issue is whether this typically mild form of mental retardation is caused primarily by genes or by psychosocial disadvantage. Copyright © Prentice Hall 2007 Copyright © Prentice Hall 2007 Mental Retardation Causes of Mental Retardation (continued) • • • • Grossly abnormal environments can produce gross abnormalities in intelligence. Cultural-familial retardation is found far more frequently among the poor. Part of this is explained by the fact that lower intelligence causes lower social status. Impoverished environments lack the stimulation and responsiveness required to promote children’s intellectual and social skills throughout their development. Copyright © Prentice Hall 2007 Mental Retardation Treatment: Prevention and Normalization • • Three major categories of intervention are essential in the treatment of mental retardation. First, many cases of both organic and cultural-familial mental retardation can be prevented through adequate maternal and child health care, as well as early psychoeducational programs. Copyright © Prentice Hall 2007 Mental Retardation Treatment: Prevention and Normalization (continued) • • Second, educational, psychological, and biomedical treatments can help people with mental retardation to raise their achievement levels. Third, the lives of people with mental retardation can be normalized through mainstreaming in public schools and promoting care in the community. Copyright © Prentice Hall 2007 Mental Retardation Treatment: Prevention and Normalization (continued) • • The availability and use of good maternal and child health care is one major step toward the primary prevention of many biological causes of mental retardation. Planning for childbearing can also help prevent mental retardation. Copyright © Prentice Hall 2007 Mental Retardation Treatment: Prevention and Normalization (continued) • • A more controversial means of preventing retardation is through diagnostic testing and selective abortion. Early social and educational interventions can lead to the secondary prevention of cultural-familial retardation. Copyright © Prentice Hall 2007 Mental Retardation Treatment: Prevention and Normalization (continued) • • • The most important current secondary prevention effort is Head Start, a federal intervention program begun in 1964. Careful assessment early in life is critical to tertiary prevention. Medical screening is essential for detecting conditions like PKU. Copyright © Prentice Hall 2007 Mental Retardation Treatment: Prevention and Normalization (continued) • • Accurate detection is important, because early interventions can help. Treatment of the social and emotional needs of people with mental retardation may include teaching basic self-care skills, such as feeding, toileting, and dressing, during the younger ages and various “life-survival” skills at later ages. Copyright © Prentice Hall 2007 Mental Retardation Treatment: Prevention and Normalization (continued) • • Medical care for physical and sensory handicaps also is critical in the treatment of certain types of mental retardation. Medication is not especially helpful in treating the intellectual or socioemotional problems of people with mental retardation. Copyright © Prentice Hall 2007 Mental Retardation Treatment: Prevention and Normalization (continued) • • Normalization means that people with mental retardation are entitled to live as much as possible like other members of society. The major goals of normalization include mainstreaming children with mental retardation into public schools and promoting a role in the community for adults with mental retardation. Copyright © Prentice Hall 2007 Mental Retardation Treatment: Prevention and Normalization (continued) • • Prior to 1975, only about half of all children with mental retardation received an education at public expense. That year Congress passed the Education for All Handicapped Children Act, which affirmed that all handicapped children have a right to a free and appropriate education in the “least restrictive environment.” Copyright © Prentice Hall 2007 Mental Retardation Treatment: Prevention and Normalization (continued) • • Within the limits set by the handicapping condition, services must be provided in a setting that restricts personal liberty as little as possible. For many children with mental retardation, the least restrictive environment means mainstreaming them into regular classrooms. Copyright © Prentice Hall 2007 Mental Retardation Treatment: Prevention and Normalization (continued) • • The deinstitutionalization movement that began in mental hospitals in the 1960s also has normalized the lives of many people with mental retardation. Changing attitudes is ultimately the most effective way to normalize the lives of people with mental retardation and their families. Copyright © Prentice Hall 2007 Autistic Disorder and Pervasive Developmental Disorders • • Pervasive developmental disorders (PDDs) begin early in life and involve severe impairments in a number of areas of functioning. People with PDD exhibit profound disturbances in relationships, engage in unusual behaviors, and typically have substantial communication difficulties. Copyright © Prentice Hall 2007 Autistic Disorder and Pervasive Developmental Disorders • • Autistic disorder (autism) is characterized by profound indifference to social relationships, odd, stereotypical behaviors, and severely impaired or nonexistent communication skills. The disorder typically has a chronic, unremitting course. Copyright © Prentice Hall 2007 Autistic Disorder and Pervasive Developmental Disorders Symptoms of PDD • • Early onset is a defining feature of autism. Because babies with autism look normal, the condition may not be accurately diagnosed for a few years, as infants and toddlers fail to reach developmental milestones and social achievement. Copyright © Prentice Hall 2007 Autistic Disorder and Pervasive Developmental Disorders Symptoms of PDD (continued) • • Communication problems in PDD range from few difficulties in Asperger’s disorder to profound impairments in many cases of autism. According to field studies conducted for DSM-IV, 54 percent of patients with autism remain mute, as do 35 percent of patients with other PDD. Copyright © Prentice Hall 2007 Autistic Disorder and Pervasive Developmental Disorders Symptoms of PDD (continued) • • • Echolalia is a common problem. Those with autism or other PDD frequently repeat phrases that are spoken to them, or sometimes repeatedly echo a phrase they heard at an earlier time. Another common language problem is pronoun reversal, which involves confusing the pronoun “you” with the pronoun “I.” Copyright © Prentice Hall 2007 Autistic Disorder and Pervasive Developmental Disorders Symptoms of PDD (continued) • • The speech difficulties stem from basic disturbances in the ability to communicate and, even more basically, in the ability to imitate or reciprocate interactions. Even high-functioning people with PDD have trouble communicating or understanding abstractions. Copyright © Prentice Hall 2007 Autistic Disorder and Pervasive Developmental Disorders Symptoms of PDD (continued) • • The inability to relate to others is another central feature of autistic disorder. One view is that people with autism lack a theory of mind—that is, they fail to appreciate that other people have a point of reference that differs from their own. Copyright © Prentice Hall 2007 Autistic Disorder and Pervasive Developmental Disorders Symptoms of PDD (continued) • • Theory of mind has proved to be a useful, overarching concept for understanding social disturbances in autistic disorder, but the problems are emotional as well as cognitive. Many people with PDD appear to be missing the basic, inborn tendency to form attachments with other people. Copyright © Prentice Hall 2007 Autistic Disorder and Pervasive Developmental Disorders Symptoms of PDD (continued) • • Another defining symptom of autism is restricted, repetitive, and stereotyped patterns of behavior, interests, and activities. These odd preoccupations and rituals create social complications. Copyright © Prentice Hall 2007 Autistic Disorder and Pervasive Developmental Disorders Symptoms of PDD (continued) • • Rituals such as flapping a string or spinning a top seem to serve no other function than providing sensory feedback or self-stimulation. Although it is not a part of the diagnosis, some people with PDD respond to auditory, tactile, or visual sensations in a highly unusual and idiosyncratic manner. Copyright © Prentice Hall 2007 Autistic Disorder and Pervasive Developmental Disorders Symptoms of PDD (continued) • • Self-injurious behavior is one of the most bizarre and dangerous difficulties that can accompany PDD. One of the most intriguing characteristics of PDD is when a child occasionally shows savant performance—an exceptional ability in a highly specialized area of functioning. Copyright © Prentice Hall 2007 Autistic Disorder and Pervasive Developmental Disorders Diagnosis of Autism and PDD • • • “Early infantile autism” was first described in 1943 by the psychiatrist Leo Kanner of Johns Hopkins University. Mental health professionals only recently recognized that the Viennese psychiatrist Hans Asperger identified a very similar condition at virtually the same time as Kanner. One important difference, however, was that Asperger’s patients exhibited higher intellectual functioning. Copyright © Prentice Hall 2007 Autistic Disorder and Pervasive Developmental Disorders Diagnosis of Autism and PDD (continued) • • • The distinction between Kanner’s and Asperger’s patients was introduced into the formal diagnostic nomenclature in DSM-IV. Asperger’s disorder is now listed as a subtype of PDD. Descriptively, it is identical to autism, with the exception that the disorder involves no clinically significant delay in language. Copyright © Prentice Hall 2007 Autistic Disorder and Pervasive Developmental Disorders Diagnosis of Autism and PDD (continued) • • The new diagnosis for Asperger’s disorder refers to people who show the symptoms of autism but do not have major problems in communication and generally function higher in other areas as well. Childhood disintegrative disorder refers to a poorly understood and somewhat controversial condition characterized by severe problems in social interaction and communication, in addition to stereotyped behavior. Copyright © Prentice Hall 2007 Autistic Disorder and Pervasive Developmental Disorders Diagnosis of Autism and PDD (continued) • Rett’s disorder is a clearly distinct condition characterized by at least 5 months of normal development followed by 1) a deceleration in head growth, 2) loss of purposeful hand movements, 3) loss of social engagement, 4) poor coordination, and 5) a marked delay in language. Copyright © Prentice Hall 2007 Copyright © Prentice Hall 2007 Copyright © Prentice Hall 2007 Autistic Disorder and Pervasive Developmental Disorders Frequency of Autism and PDD • • • Upper level estimates now suggest that as many as 60 in 10,000 children suffer from autism. Three to four times as many boys as girls suffer from autism, suggesting a gender-linked etiology. Autism also is much more common among siblings of a child with autism, suggesting possible genetic causes. Copyright © Prentice Hall 2007 Autistic Disorder and Pervasive Developmental Disorders Causes of Autism • • • For many years, parents were blamed for causing autism in their children. Such bold and harmful assertions are unsupported by evidence. A number of findings indicate that biological abnormalities play an important role in the etiology of autism. Copyright © Prentice Hall 2007 Autistic Disorder and Pervasive Developmental Disorders Causes of Autism (continued) • • One epidemiological study found that over half the cases of autism were associated with various known biological difficulties or disorders. Some research suggests that genetic factors also play an important role in many cases of autism. Copyright © Prentice Hall 2007 Autistic Disorder and Pervasive Developmental Disorders Causes of Autism (continued) • The prevalence of autism is as much as 100 times higher among siblings of a proband with autism, and concordance rates are higher among MZ than DZ twins. • Different theorists argue that autism is due to deficits in various neurochemicals. Copyright © Prentice Hall 2007 Autistic Disorder and Pervasive Developmental Disorders Causes of Autism (continued) • Currently, the most promising research focuses on endorphins and neuropeptides, substances that affect the action of neurotransmitters, as mediators of symptoms of the disorder. • Other research has searched for abnormalities in brain structure, not function, among people with autism. Copyright © Prentice Hall 2007 Autistic Disorder and Pervasive Developmental Disorders Causes of Autism (continued) • Some research suggests that people with autism have abnormalities in parts of the limbic system—the area of the brain that regulates emotions—and also in areas of the cerebellum, where sensorimotor input is integrated. Copyright © Prentice Hall 2007 Autistic Disorder and Pervasive Developmental Disorders Causes of Autism (continued) • As investigators search for sites of brain damage, one thing seems clear: Any structural abnormalities are likely to be the result of abnormal brain development, not of specific damage or lesions. Copyright © Prentice Hall 2007 Autistic Disorder and Pervasive Developmental Disorders Treatment of PDD • Unfortunately, autism is a lifelong disorder. • In one study of 63 children with autism who were followed into adulthood, only one person was functioning in what could be considered the normal range. • Two developmental periods are especially important to the course of autism: the early preschool years and early adolescence. Copyright © Prentice Hall 2007 Autistic Disorder and Pervasive Developmental Disorders Treatment of PDD (continued) • A huge variety of medications have been used to treat autism, including antipsychotics, antidepressants, amphetamines, psychedelics, and megavitamins. • Unfortunately, none of these medications is an effective treatment for autism, and few show much promise. Copyright © Prentice Hall 2007 Autistic Disorder and Pervasive Developmental Disorders Treatment of PDD (continued) • Intensive behavior modification using operant conditioning techniques called Applied Behavior Analysis (ABA) is the most promising approach to treating autism. • ABA therapists focus on treating the specific symptoms of autism, including communication deficits, lack of self-care skills, and selfstimulatory or self-destructive behavior. Copyright © Prentice Hall 2007 Autistic Disorder and Pervasive Developmental Disorders Treatment of PDD (continued) • Behavior therapists have been fairly successful in teaching self-care skills and less successful in teaching social responsiveness. • Despite the fact that autism apparently is caused by neurological abnormalities, the most effective treatment for the disorder is highly structured and intensive ABA. Copyright © Prentice Hall 2007