BME 353 – Biomedical Instrumentation and Measurement
Compulsory course (2,2:3, 5 ECTS)
Prerequisites: BLM 208 – Electronic Circuits
Syllabus: Basic concepts of instrumentation. Biomedical sensors. Origins of biopotentials and electrodes.
Biopotential amplifiers and other signal processors. Electrocardiography (ECG), analog and digital
processing of ECG signals. Term project.
Textbook: Webster, J. G. (ed); "Medical Instrumentation: Application and design," 4th ed. John Wiley,
2009;
References:
1. Enderle J.D. and Bronzino J.D. Introduction to Biomedical Engineering, 3rd ed. Academic Press;
2011;
2. Carr, J.J. and Brown J.M.; "Introduction to Biomedical Equipment Technology," Prentice-Hall, 4th
ed. 2001;
3. Karagözoğlu, B. “Elektronik Ölçme ve Görüntüleme Teknikleri,” Nobel, 2015.
Goal of the Course: This course is designed to introduce the instrumentation and measurement
concepts and to illustrate their implementations in the biomedical field with examples. Eventually, it will
develop the ability of biomedical engineering students to identify components of a biomedical
instrument, from the human body to the display, and analyze principles and problems related to each
section.
Prerequisite by Topic:
1.
2.
3.
4.
Calculus, linear algebra and differential equations
Linear system theory related to signal and system descriptions
Electronic devices and circuits
Biopotential signals and physiology of cardiovascular system.
Course Learning Objectives:
By completion of the course, the students should be able to:
1.
2.
3.
4.
Recognize the basic requirements of medical instruments,
Describe the instrument functions and define terms related to electrical measurements
Identify sensors and the critical issues for sensor choice, placement, and circuit implementation,
Measure signals in medical environment and evaluate the quality of effect of measuring
instruments on the measured data,
5. Select protection schemes and devices for safe operations of electrically operated devices.
Course Schedule
Week
1
2
3
4
5
6
7
8
9
10
11
12
13
14
Subject
What is an instrument? What is special about BM instruments? Brief history of developments
Measurable medical quantities and their properties
Sensors and transducers; resistive and inductive sensors, bridge circuits
Capacitive and piezo electric displacement sensors, and temperature measurement
Power sources for medical instruments: batteries and power supplies
Biopotentials and biopotential electrodes
Biopotential amplifiers
Midterm week, biopotential amplifiers (cont.)
ECG measurements and recording
Biopotential signal processors
Blood pressure and sound
Respiratory parameters and their measurements
Clinical laboratory instrumentation
Electrical safety in the medical environment
Laboratory Schedule
Week Subject
1
Measurement principles; error, tolerance, accuracy, precision, linearity etc. instrument loading
2
Experiment design through a case study; measuring the heart rate through palpation and
comparing the results to rate meter readings
3
Obtaining characteristic of a sensor
4
Special lab session
5
Electrodes and ECG measurements
6
EMG measurements
7
Design and implementation of an ECG amplifier
8
ECG amplifier (cont.)
9
Clinical ECG
10
Special lab session
11
Blood pressure measurement
12
Respiratory measurements
13
Project
14
Project
Grading
Assessment type
Midterm exam (1 hour)
Quizzes (8 minutes)
Practical (preliminary work, lab work and report)
Lab projects
Project
Number
1
6
8
3
1
Contribution
20
12
8
12
8
Final exam (2 hours)
Bonuses
Homework and active learning
Design of new experiments
Preparing exemplary problems and solutions
1
40
100
6
9