PATHOLOGY Lecture Topics : Cell Injury Inflammation & Repair Neoplasia Hemodynamic Disorders,Thrombosis & Shock Book : Robbins Basic Pathology Labs : 2-3 Labs / topic Clinical cases for discussion Web Path Internet teaching used Exams : First , Second & Final Exams MCQ format Lab questions with pictures included in each exam Marks : 25 / 25/ 50 Make up is usually in short essay format REFERENCES REFERENCES REFERENCES REFERENCES REFERENCES INTRODUCTION Pathology: the study (logos) of suffering or disease (pathos). The study of the structural, biochemical, and functional changes in cells, tissues, and organs that are involved by disease. A bridge between the basic sciences and clinical medicine. Uses molecular, microbiologic, immunologic, and morphologic techniques trying to reach a diagnosis and explanation. INTRODUCTION General pathology: reactions of cells and tissues to abnormal stimuli. Cell injury, inflammation and repair, hemodynamic disorders, genetic disorders, immune system diseases, infectious disease and environmental diseases. Systemic pathology: alterations in specialized organs and tissues in diseased status. ASPECTS OF DISEASE Epidemiological aspects Etiology/ cause: I. Genetic: mutations II. Acquired: infectious, nutritional, chemical.. ASPECTS OF DISEASE Pathogenesis: sequence of events in the response of cells or tissues to the etiologic agent, from the initial stimulus to the ultimate expression of the disease. (mechanism). ASPECTS OF DISEASE Molecular and morphologic changes: structural alterations in cells or tissues. Molecular and immunologic aspects of the disease/tissue/organ. Pathological & clinical features including biochemical tests, radiological findings INTEGRATE ALL INFORMATION !!!!! Complications & sequelae : Events taken during the disease process that may impair full recovery Treatment Prognosis ASPECTS OF DISEASE Functional derangements and clinical manifestations: the end results of changes in cells and tissues. (functional abnormalities leading to the clinical manifestations of disease and the way it progresses). CLASSIFICATION OF PATHOLOGY Anatomical/ surgical pathology or histopathology: Gross examination and microscopic examination to reach a diagnosis. Clinical pathology: hematology, microbiology, immunology and biochemistry. ANATOMIC PATHOLOGY Histopathology. Cytopathology. Autopsy. Subspecialties: neuropathology, dermatopathology, oral pathology…… DIAGNOSIS IN HISTOPATHOLOGY Biopsies: excisional and incisional. Smears: exfoliative and fine needle aspiration.