PATHOLOGY
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Lecture Topics :
Cell Injury
 Inflammation & Repair
 Neoplasia
 Hemodynamic Disorders,Thrombosis &
Shock
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Book :
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Robbins Basic Pathology
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Labs :
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2-3 Labs / topic
Clinical cases for discussion
Web Path Internet teaching used
Exams :
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First , Second & Final Exams
MCQ format
Lab questions with pictures included in
each exam
Marks : 25 / 25/ 50
Make up is usually in short essay format
REFERENCES
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REFERENCES
INTRODUCTION
Pathology: the study (logos) of suffering or
disease (pathos).
 The study of the structural, biochemical, and
functional changes in cells, tissues, and organs
that are involved by disease.
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A bridge between the basic sciences and clinical
medicine.
 Uses molecular, microbiologic, immunologic, and
morphologic techniques trying to reach a
diagnosis and explanation.
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INTRODUCTION
General pathology: reactions of cells and
tissues to abnormal stimuli. Cell injury,
inflammation and repair, hemodynamic
disorders, genetic disorders, immune system
diseases, infectious disease and environmental
diseases.
 Systemic pathology: alterations in specialized
organs and tissues in diseased status.
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ASPECTS OF DISEASE
Epidemiological aspects
 Etiology/ cause:
I.
Genetic: mutations
II.
Acquired: infectious, nutritional, chemical..
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ASPECTS OF DISEASE
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Pathogenesis: sequence of events in the response
of cells or tissues to the etiologic agent, from the
initial stimulus to the ultimate expression of the
disease. (mechanism).
ASPECTS OF DISEASE
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Molecular and morphologic changes: structural
alterations in cells or tissues. Molecular and
immunologic aspects of the disease/tissue/organ.
Pathological & clinical features including biochemical
tests, radiological findings
INTEGRATE ALL INFORMATION !!!!!
Complications & sequelae :
Events taken during the disease process that may
impair full recovery
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Treatment
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Prognosis
ASPECTS OF DISEASE
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Functional derangements and clinical
manifestations: the end results of changes in cells
and tissues. (functional abnormalities leading to
the clinical manifestations of disease and the way
it progresses).
CLASSIFICATION OF PATHOLOGY
Anatomical/ surgical pathology or histopathology:
Gross examination and microscopic examination
to reach a diagnosis.
 Clinical pathology: hematology, microbiology,
immunology and biochemistry.
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ANATOMIC PATHOLOGY
Histopathology.
 Cytopathology.
 Autopsy.
 Subspecialties: neuropathology,
dermatopathology, oral pathology……
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DIAGNOSIS IN HISTOPATHOLOGY
Biopsies: excisional and incisional.
 Smears: exfoliative and fine needle aspiration.
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