CARBOHYDRATE FAMILY CARBOHYDRATES • • • • • Hydrated Carbon atoms Organic Compounds Ratio (C H2 O) Hexoses = 6 Carbon sugars*** Bonds Monosaccharides = 1 Disaccharides = 2 Oligosaccharides = 3-10 Polysaccharides = 10 - thousands MONOSACCHARIDES • GLUCOSE • part of every disaccharide • main component of polysaccharide • body’s final form of fuel • GALACTOSE – rarely free in nature • FRUCTOSE • sweetest sugar • converted to glucose in small intestine/liver • requires insulin MONOSACCHARIDE STRUCTURES CONDENSATION OF MONOSACCHARIDES DISACCHARIDES • MALTOSE 2 Glucose units Malt sugar Intermediate product of starch digestion • LACTOSE Glucose + Galactose Milk sugar • SUCROSE Glucose + Fructose Table sugar SWEETNESS OF SUGARS • • • • • • FRUCTOSE …………...170 SUCROSE……………...100 GLUCOSE………………70 MALTOSE……………...46 LACTOSE………………35 GALACTOSE…………..32 OLIGOSACCHARIDES • OLIGO = Scent • 3-10 single glucose units • Raffinose and Stachycose beans, legumes • No digestive enzymes large intestinegas COMPLEX CARBOHYDRATES POLYSACCHARIDES GLYCOGEN • • • • Storage form of energy for animals Not found in plants Humans store glucose as glycogen Released with hormone signal STARCH • Storage form of glucose for plants • Found in grains, legumes, tubers • Long, branched or unbranched chains (amlyopectin or amylose) • Hydrolyze starch glucose energy FIBER • • • • • • • Structural part of plants Polysaccharide but not starch Not digested by human enzymes Contribute little or not energy Nonstarch polysaccharides Nonpolysaccharides Resistant starches – starches classified as fiber, resist digestion FIBER BY SOURCE • Dietary fibers – found naturally intact in plants • Functional fibers – extracted from plant or manufactured, beneficial health effects • Total fiber – sum of dietary fiber and functional fiber PHYSICAL CHARACTERISTICS SOLUBILITY SOLUBLE FIBERS • Form gels – viscous, hold water • Fermentable- bacteria in colon • Protect against heart disease by lowering blood cholesterol levels – traps bile which is then excreted • Protect against diabetes by lowering blood glucose levels • Delays transit time and stomach emptying • Provides feeling of fullness EXAMPLES • • • • • • Gums and Mucilages Guar gum Psyllium Carrageenan Barley Oats • Used as stabilizers in food industry • • • • • Pectins Apples Citrus fruits Strawberries Carrots • Used in food industry as thickeners, control texture and consistency WATER INSOLUBLE FIBER • Do not form gels • Less readily fermented • Promote bowel movements and prevent constipation • Provide feeling of fullness and satiety • Delays gastric emptying EXAMPLES • Cellulose from fruits, vegetables, legumes, bran • Hemicellulose-main part of plant fiber, bran and whole grains • Lignin • Found in fruits with edible seeds (strawberries, tomatoes) • Woody structure of plants DIGESTION Mouth SALIVARY AMYLASE Some starch digestion, chewing high fiber foods Stomach ACIDS – NO ENZYMES Chyme – NO starch digestion Small Intestine PANCREATIC AMYLASE Most starch digestion Dextrins and Disaccharides (Maltose) Intestinal Mucosa (Villi) – fibers attract water to soften stool Bacteria in large intestine ferment fibers Sugars and most starches digested within 1-4 hours HYDROLYSIS ABSORPTION Nutrient absorption in small intestine Blood from intestines circulates through liver Liver Converts sugars to glucose to cells for fuel or storage Storage – liver, muscle, adipose tissue Heart, kidney, brain, liver – No insulin Muscle, adipose tissue – Insulin required DIGESTION AND ABSORPTION METABOLISM • Glucose – major in metabolism • Stored as glycogen in liver – about 1/3 of body’s supply • 2/3 stored in muscles • Glycogen made when blood glucose is high • Glycogen dismantled when blood glucose is low – from liver • Muscle glycogen used for muscle usage • Glycogen is bulky because of water – limits storage GLUCOSE FOR ENERGY • • • • Fuels most of body activities; energy for brain and CNS Frequent replenishing due to low storage amounts Gluconeogenesis-Carbohydrates are protein sparing Fat for energy – need carbohydrates to release energy Fat + glucose energy + CO2 + H2O Fat + fat Ketones (ketosis) upsets acid/base balance • Glucose fat; excess glucose stored as fat after glycogen stores are filled BLOOD GLUCOSE LEVELS • Normal blood glucose level = 80-120 mg/dl (FBS) • INSULIN – Beta cells of the Pancreas respond to HIGH blood glucose levels • GLUCAGON – Alpha cells of pancreas respond to LOW blood glucose levels • EPINEPHRINE – Adrenal glands “flight” or “fright” – glucose released from glycogen REGULATION OF BLOOD GLUCOSE GLYCEMIC RESPONSE • Glycemic response – how fast glucose is absorbed after a person eats, how high blood sugar rises, how fast returns to normal • Glycemic index – classifies food according to their potential to raise blood sugar levels • May help control diabetes, heart disease and weight management • Not many foods have been analyzed, values vary greatly, eat foods in combination DIABETES • Normal blood sugar 80-120 mg/dL • Type 1 diabetes – pancreas doesn’t make insulin – unsure why • Type 2 diabetes – cells not reacting to insulin due to age, obesity • Type 2 epidemic in children and adolescents in US • Type 2 most common form of diabetes ORAL GLUCOSE TOLERANCE TEST • Nothing by mouth for at least 12 hours before test • Administer CHO load 75-100 gms CHO • Blood draws: Normal range Fasting <140 mg/dl 30, 60 minutes <115 mg/dl 120 minutes <200 mg/dl 180 minutes <140 mg/dl • If two high values – one must be at the 2 hour interval > 200 mg/dL diagnose DM • 2 hours post prandial (pp) =138-205 mg/dl is normal NORMAL HORMONE BALANCE GLYCOSYLATED HEMOGLOBIN (HbA1C) Provides accurate, long term index of average blood glucose levels With high blood glucose levels certain Hemoglobins become glycosylated-glucose attaches to hemoglobinsugar coated Irreversible average blood sugar level 100120 days prior to test Adult/elderly…………..2.2-4.8% Good Diabetic control….2.5-6% Fair Diabetic control……6.1-8% Poor Diabetic control…..>8% HYPOGLYCEMIA • Normal blood sugar rises after eating then returns to normal • Hypoglycemia – blood sugar drops quickly – below normal • Caused by too much insulin, strenuous physical activity, illness, inadequate food intake • Some people do have hypoglycemia and must regulate carbohydrate intake HYPOGLYCEMIA LACTOSE INTOLERANCE • • • • Missing adequate amount of lactase Lactase Glucose + Galactose Amount produced decreases as we age Deficiency due to intestinal villi are damaged (disease, medication, malnutrition, surgery) • May be temporary • May be genetically determined TREATMENT • Limit – not necessarily avoid milk and milk products • Read labels for milk, milk solids, whey, casein, lactose in medications as filler • Symptoms – diarrhea, gas, abdominal discomfort • Can use lactaid pills or “milk”, acidophilus milk, yogurt TESTING • Give lactose load – 50-100mg of lactose • Blood draws to check glucose levels at 1 min., 15 min., 30, 60, 120 min. • Watch for 20-30mg/dl ^ in blood glucose levels • No increase in glucose levels and positive symptoms lactase deficient • Second method is Breath H test-Check hydrogen level in breath after lactose challenge HEALTH EFFECTS OF SUGAR • • • • • • Nutrient deficiencies Dental caries Causes obesity Causes heart disease Causes behavior problems Causes cravings and addictions RECOMMENDED INTAKE • Carbohydrate = 130 gms/day (45-65% of calories) • Daily value = 300 gms/day (60% of 2000 cal) • Added sugar = empty calories • Discretionary calories • Hard to distinguish between naturally occurring or added • Read label – HFCS, sugar, lactose, glucose, honey, corn syrup, corn sweetener HEALTH EFFECTS OF FIBER • • • • • • • Heart disease Diabetes GI health Cancer Weight management Causes abdominal discomfort Nutrient bioavailability may be affected FIBER FORM DIVERTICULA RECOMMENDATIONS FOR FIBER • Intake of 25-35 Grams /Day (14 gms/1000 calories) • Using fiber rich foods – not supplements • Use fruits, vegetables, legumes, whole grains • Increase gradually over several weeks to give GI tract time to adapt • Drink adequate fluids FIBER EXCHANGE LISTS • Introduced in 1950 by American Diabetes Association and American Dietetic Association • 3 groups based on the macronutrients • Carbohydrate group (CHO) • Meat and meat substitute group (protein) • Fat • Portion sizes adjusted so that CHO, Fat, Protein and Kcals are approximately equal • Does not consider micronutrients MEMORIZE GOOD DIABETIC CONTROL • • • • • • • DIET MEDICATION SKIN AND FOOT CARE VISIT DOCTOR REGULARLY BLOOD/URINE TESTING EXERCISE EDUCATION INSULIN ACTIVITY DIABETES CONTROL AND COMPLICATIONS TRIAL • • • • FOOD PYRAMID EXCHANGE LISTS CHO COUNTING TAG SYSTEM (TOTAL AVAILABLE GLUCOSE • TO INCREASE COMPLIANCE MUST INDIVIDUALIZE CARBOHYDRATE COUNTING Need to identify the carbohydrate to insulin ratio: Insulin through CSII (Continuous subcutaneous insulin infusion) Most closely resembles body Need to count grams of carbohydrate in food items Builds on knowledge of food exchange lists and portion sizes Multiple daily injections ESTIMATED INSULIN-TOCARBOHYDRATE RATIO WEIGHT (LB) 100-109 110-129 130-139 140-149 150-169 170-179 180-189 190-199 200+ RATIO INSULIN TO CHO 1:16 1:15 1:14 1:13 1:12 1:11 1:10 1:9 1:8 ARTIFICIAL SWEETNERS • • • • • • • • • Non-nutritive – no energy Saccharin – oldest, no more warning label Aspartame – amino acids, PKU Acesulfame-K – tumors and rat studies Sucralose – changed structure of sugar, used in cooking, not digested Neotame – newest Tagatose – fructose related Alitame and Cyclamate – approval pending Stevia – herbal, no FDA approval needed SWEETENERS • Acceptable daily intakes – amount considered safe if stable throughout lifetime • Weight control – confusing studies SUGAR ALCOHOLS • Sugar relatives – sugar replacers, nutritive sweeteners • Yield energy – less than glucose • Low glycemic response • Used extensively in food processing – provide bulk and sweetness • Examples: Mannitol Sorbitol (diarrhea) Xylitol lactitol isomalt