Performance Enhancing Drugs Androstenedione What is it?

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General Terms

Substance Abuse: any unnecessary or improper use of a chemical substance for non-medical purposes

Illegal Drugs: a chemical substance that people of any age may not lawfully manufacture, possess, buy, or sell.

Illicit Drug Use: the use or sale of any substance that is illegal.

Overdose: a strong or sometimes fatal reaction to taking a drug.

Addiction: a physiological or psychological dependence on a drug.

Tolerance: a condition in which the body becomes accustomed to the drug and causes the user to experience a need for more of the drug to achieve the desired effect.

Psychological Dependence: a condition that develops over time and causes a person to believe that a drug is needed to function normally.

Physiological Dependence: a condition in which the user develops a chemical need for a drug.

Symptoms of withdrawal occur when the effects of the drug wear off.

Psychoactive Drugs

 Chemicals that affect the central nervous system.

 Narcotics, Stimulants, Depressants, and

Hallucinogens.

 Narcotics, Stimulants, Depressants have medical value while hallucinogens do not .

Psychoactive Drugs

 Stimulants speed up the body

 Narcotics relieve pain

 Depressants slow down the body

 Hallucinogen alter perception (time, sight, touch, smell…)

Hallucinogens

 LSD: First synthesized LSD in 1938.

 LSD is sold as tablets, capsules, and occasionally in liquid form

 Is often added to absorbent paper and divided into small decorated squares

Hallucinogens (LSD

)

 Schedule I

 Street names: Acid, micro-dots,

 Effects: alters personality, mood, and expectations. Lasts up to 12 hours. LSD users often have flashbacks. In addition, LSD users may develop long-lasting psychoses, such as schizophrenia or severe depression

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Hallucinogens

 PCP (Phencyclidine)

 Street names: PCP, Angel Dust, Supergrass, Killer

Weed.

 PCP is most commonly sold as a powder or liquid.

 Hallucinogens

 PCP (Phencyclidine)

 PCP may be snorted, smoked, injected, or swallowed

 Numbness, slurred speech, loss of coordination, rapid and involuntary eye movements

 Auditory hallucinations, image distortion, severe mood disorders, amnesia,

 PCP use is associated with a number of risks and many believe it to be one of the most dangerous drugs of abuse

Heroin

 Illegal & highly addictive drug. It is both the most abused and the most rapidly acting of the opiates.

Heroin is processed from morphine. Heroin can be injected, smoked, or sniffed/snorted

 Schedule: I

 Street names: Smack, thunder, hell dust, big H, nose drops

 Harmful effects: collapsed veins, infection of the heart lining and valves, abscesses, cellulites, and liver disease

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Predatory Drugs

Drugs used to take advantage of someone.

(Rape in most cases)

 GHB (gamma hydroxybutyric acid)

 Rohypnol

Predatory Drugs

 GHB (gamma hydroxybutyric acid)

 Street Names: Liquid Ecstasy,

Scoop, Georgia Home Boy, Liquid

X.

 An odorless, colorless liquid form

GHB

 Usually ingested in a liquid mixture; most commonly mixed with alcohol

 GHB has become popular among teens and young adults at dance clubs and "raves."

 Body builders sometimes use GHB for its alleged anabolic effects

GHB

 In lower doses, GHB causes drowsiness, dizziness, nausea, and visual disturbances.

 At higher dosages, unconsciousness, seizures, severe respiratory depression, and coma can occur.

Rohypnol

 Street Names : Mexican Valium, roophies.

 Rohypnol is usually taken orally in pill form, but can also be crushed and snorted

 Rohypnol continues to be abused among teenagers and young adults, usually at raves and nightclubs.

Rohypnol

 One of the significant

effects

of the drug is drug amnesia, a factor that strongly contributed to its inclusion in the Drug-Induced Rape

Prevention and Punishment Act of

1996. Amnesia is a condition in which events that occurred while under the influence of the drug are forgotten

.

Cocaine

Cocaine

is a powerfully addictive stimulant. Cocaine is one of the oldest known drugs.

 Street names: Blow, nose candy, snowball.

 Harmful effects: Increased heart rate, irritability, restlessness, and paranoia

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Methamphetamines

 A highly addictive drug with potent central nervous system stimulant properties

 The drug has limited medical uses for the treatment of narcolepsy, attention deficit disorders, and obesity.

 Schedule II

Methamphetamines

Street Names

: Speed, Meth, Ice,

Crystal.

Effects

: As a powerful stimulant, methamphetamine, even in small doses, can increase wakefulness and physical activity and decrease appetite.

Methamphetamines

Abusers exhibit symptoms that can include violent behavior, anxiety, confusion, and insomnia. They also can display a number of psychotic features, including paranoia, auditory hallucinations, mood disturbances, and delusions (for example, the sensation of insects creeping on the skin, which is called “formication”). The paranoia can result in homicidal as well as suicidal thoughts.

Marijuana

 Marijuana is the most commonly abused illicit drug in the United States. A dry, shredded green/brown mix of flowers, stems, seeds, and leaves of the plant Cannabis sativa, it usually is smoked as a cigarette (joint, nail), or in a pipe (bong). It also is smoked in blunts, which are cigars that have been emptied of tobacco and refilled with marijuana, often in combination with another drug. It might also be mixed in food or brewed as a tea

 Street names : Grass, pot, weed, bud, Mary

Jane, dope.

Marijuana

 Within a few minutes after inhaling marijuana smoke, an individual’s heart begins beating more rapidly

 As THC enters the brain, it causes a user to feel euphoric— or “high”—by acting in the brain’s reward system

 A marijuana user may experience pleasant sensations, colors and sounds may seem more intense, and time appears to pass very slowly

Marijuana

Occasionally, marijuana use produces anxiety, fear, distrust, or panic.

 Someone who smokes marijuana regularly may have many of the same respiratory problems that tobacco smokers do, such as daily cough and phlegm production, more frequent acute chest illnesses, a heightened risk of lung infections

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Marijuana

Cancer of the respiratory tract and lungs may also be promoted by marijuana smoke. Marijuana smoke contains 50 percent to 70 percent more carcinogenic hydrocarbons than does tobacco smoke

 Marijuana's damage to short-term memory seems to occur because THC alters the way in which information is processed by the hippocampus, a brain area responsible for memory formation.

MDMA (Ecstasy)

 MDMD is a synthetic, psychoactive drug chemically similar to the stimulant methamphetamine and the hallucinogen mescaline. MDMA is an illegal drug that acts as both a stimulant and hallucinogen, producing an energizing effect, as well as distortions in time and perception and enhanced enjoyment from tactile (touch) experiences.

MDMA (Ecstasy)

 Street Names: Ecstasy, XTC, E, X

 Schedule I

 MDMA can interfere with the body’s ability to regulate temperature. This can lead to a sharp increase in body temperature (hyperthermia), resulting in liver, kidney, and cardiovascular system failure, and death

MDMA (Ecstasy)

 Long term effects: Brain damage, as well as impaired thought, judgment and mood.

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Inhalants

•Inhalants are a diverse group of substances that include volatile solvents, gases, and nitrites that are sniffed, snorted, huffed, or bagged to produce intoxicating effects similar to alcohol.

•These substances are found in common household products like glues, lighter fluid, cleaning fluids, and paint products

Inhalants

•Affects: Use of inhalants has been associated with serious health problems. Sniffing glue and paint thinner causes kidney abnormalities, while sniffing the solvents toluene and trichloroethylene cause liver damage. Memory impairment, attention deficits, and diminished non-verbal intelligence have been related to the abuse of inhalants. Deaths resulting from heart failure, asphyxiation, or aspiration have occurred.

Inhalants

•Most inhalants act directly on the central nervous system (CNS) to produce psychoactive, or mindaltering, effects. They have short-term effects similar to anesthetics, which slow the body's functions

•Alcohol-like effects may include slurred speech, an inability to coordinate movements, euphoria, and dizziness. In addition, users may experience lightheadedness, hallucinations, and delusions.

Performance Enhancing Drugs

Androstenedione

What is it?

Androstenedione (andro) is a hormone produced by the adrenal glands, ovaries and testes. It's a hormone that's normally converted to testosterone and in both men and women.

Andro is available in prescription and nonprescription forms. The prescription version is a controlled substance.

Andro is also sold without a prescription as a nutritional supplement. Manufacturers and bodybuilding magazines tout its ability to allow athletes to train harder and recover more quickly. However, its use as a performance-enhancing drug is illegal in the United States.

Performance Enhancing Drugs

Androstenedione

Risks

Side effects of andro in men include:

Acne

Diminished sperm production

Shrinking of the testicles

Enlargement of the breasts

In women, side effects include:

Acne

Masculinization, such as deepening of the voice and male-pattern baldness

In both men and women, andro can decrease HDL cholesterol (the

"good" cholesterol), which puts you at greater risk of heart attack and stroke.

Performance Enhancing Drugs

 Human growth hormone

 What is it?

Human growth hormone, also known as gonadotropin, is a hormone that has an anabolic effect. Athletes take it to improve muscle mass and performance. However, it hasn't been shown conclusively to improve either strength or endurance. It is available only by prescription and is administered

Performance Enhancing Drugs

Human growth hormone

Risks

Adverse effects related to human growth hormone range in severity and may include:

Joint pain

Muscle weakness

Fluid retention

Carpal tunnel syndrome

Impaired glucose regulation

Cardiomyopathy

Hyperlipidemia

Performance Enhancing Drugs

Erythropoietin

What is it?

Erythropoietin is a type of hormone used to treat anemia in people with severe kidney disease. It increases production of red blood cells and hemoglobin, resulting in improved movement of oxygen to the muscles. Epoetin, a synthetic form of erythropoietin, is commonly used by endurance athletes.

Risks

Erythropoietin use among competitive cyclists was common in the 1990s and allegedly contributed to at least

18 deaths. Inappropriate use of erythropoietin may increase the risk of thrombotic events, such as stroke, heart attack and pulmonary edema.

Performance Enhancing Drugs

 Stimulants

 What are they?

Some athletes use stimulants to stimulate the central nervous system and increase heart rate and blood pressure.

Stimulants can:

Improve endurance

Reduce fatigue

Suppress appetite

Increase alertness and aggressiveness

Common stimulants include caffeine and amphetamines. Cold remedies often contain the stimulants ephedrine or pseudoephedrine hydrochloride. The street drugs cocaine and methamphetamine also are stimulants

Performance Enhancing Drugs

Stimulants

Risks

Although stimulants can boost physical performance and promote aggressiveness on the field, they have side effects that can impair athletic performance.

Nervousness and irritability make it hard to concentrate on the game.

Insomnia can prevent an athlete from getting needed sleep.

Dehydration

Heatstroke

Athletes may become psychologically addicted or develop a tolerance so that they need greater amounts to achieve the desired effect, meaning they'll take doses that are much higher than the intended medical dose.

Performance Enhancing Drugs

Stimulants

Risks

Other side effects include:

Heart palpitations

Heart rhythm abnormalities

Weight loss

Tremors

Mild hypertension

Hallucinations

Convulsions

Stroke

Heart attack and other circulatory problems

Performance Enhancing Drugs

 Creatine

 What is it?

Many athletes take nutritional supplements instead of or in addition to performance-enhancing drugs. Supplements are available over-the-counter as powders or pills.

 The most popular supplement among athletes is probably creatine monohydrate. Creatine is a naturally occurring compound produced by your body that helps your muscles release energy.

Performance Enhancing Drugs

 Creatine

 Scientific research indicates that creatine may have some athletic benefit by producing small gains in short-term bursts of power.

 There's no evidence, however, that creatine enhances performance in aerobic or endurance sports

 Your liver produces about 0.07 ounces (2 grams) of creatine each day. You also get creatine from the meat in your diet.

Creatine is stored in your muscles, and levels are relatively easily maintained. Because your kidneys remove excess creatine, the value of supplements to someone who already has adequate muscle creatine content is questionable.

Performance Enhancing Drugs

 Creatine

Risks

Supplements are considered food and not drugs by the FDA. This means supplement manufacturers are not required to conform to the same standards as drug manufacturers do. In some cases, supplements have been found to be contaminated with other substances, which may inadvertently lead to a positive test for performance-enhancing drugs.

Possible side effects of creatine that can decrease athletic performance include:

Stomach cramps

Muscle cramps

Nausea

Diarrhea

Weight gain

Performance Enhancing Drugs

 Creatine

 Weight gain is sought after by athletes who want to increase their size.

But with prolonged creatine use, weight gain is more likely the result of water retention than an increase in muscle mass. Water is drawn into your muscle tissue, away from other parts of your body. This puts you at risk of dehydration.

High-dose creatine use may potentially damage your:

Kidneys

Liver

It appears safe for adults to use creatine at the doses recommended by manufacturers. But it's unknown what kind of effect taking creatine has over the long term, especially in teens and children.

Performance Enhancing Drugs

Anabolic steroids

What are they?

Some athletes take a form of steroids — known as anabolic-androgen steroids or just anabolic steroids — to increase their muscle mass and strength. The main anabolic steroid hormone produced by your body is testosterone.

Testosterone has two main effects on your body:

Anabolic effects promote muscle building.

Androgenic effects are responsible for male traits, such as facial hair and a deeper voice.

Performance Enhancing Drugs

Anabolic steroids

Anabolic steroids come with serious physical side effects as well.

Men may develop :

Prominent breasts

Baldness

Shrunken testicles

Infertility

Women may develop :

A deeper voice

An enlarged clitoris

Increased body hair

Baldness

Performance Enhancing Drugs

Anabolic steroids

Both men and women might experience:

Severe acne

Increased risk of tendinitis and tendon rupture

Liver abnormalities and tumors

Increased low-density lipoprotein (LDL) cholesterol (the "bad" cholesterol)

Decreased high-density lipoprotein (HDL) cholesterol (the "good" cholesterol)

Hypertension

Heart and circulatory problems

Aggressive behaviors, rage or violence

Psychiatric disorders, such as depression

Infections or diseases such as HIV or hepatitis if you're injecting the drugs

Inhibited growth and development, and risk of future health problems in teenagers

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