International J. of Healthcare and Biomedical Research, Volume: 2, Issue: 2, January 2014, Pages 157-166
Original article:
A Study of Expression of Epidermal growth factor receptor in neoplastic and nonneoplastic lesions of thyroid
1Dr.
Puja Sharma,2 Dr. Rajesh Chaurasia ,3 Dr. Satyaveer Kishore Mathur, 4Dr Pawan Singh,
5Dr Sumiti Gupta
1Associate
Professor, Department of pathology, SHKMGovt Medical College,Nalhar, Haryana, India, 122107
2Assistant
Professor, Department of Pathology, Peoples college of Medical sciences, Bhopal, Madhyapradesh, India
,462001
3Senior
Professor,Department of pathology, Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India,124001
4Assistant
5
Professor, Department of pathology, SHKM Govt Medical College, Nalhar, Haryana, India, 122107
Professor, Department of pathology, Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India,124001
Corresponding Author: Dr. Puja Sharma; Email: drpuja_sharma@yahoo.com
Abstract
Introduction: Thyroid gland is largest endocrine gland present in human body. The thyroid disease includes inflammatory, nonmalignant and malignant disorders seen in clinical practice. There are number of growth factors responsible for stimulation of
growth of thyroid tissue and cell replication.
Materials and Method: This was a retrospective study conducted at Department of pathology, Post Graduate Institute of
Medical Sciences, Rohtakduring August2001 to Dec 2003on a total of 100 cases selected randomly comprising different thyroid
lesions. Ethical clearance was taken from institutional ethics committee.For each case, both Haematoxylin and Eosin(H&E) and
immuno-histochemical staining were done.
Results: A semi-quantitative scoring on basis of number of cells showing EGFR immuno-positivity was also done which showed
that majority of malignant thyroid lesions reveal a homogenous pattern of EGFR expression as compared to heterogeneous
pattern in non-neoplastic or benign thyroid lesions.
Discussion: It may be interpreted from these findings that there is increased expression of EGFR by hyperplastic thyroid tissue
and malignant thyroid lesions. These results are also found to be consistent with studies done by Masuda et al, Lemoine et al,Van
der laan et al and Westermark et al. showing intensity of staining to be more in hyperfunctioning glands and in malignant thyroid
lesions.
Conclusion: Malignant thyroid neoplastic lesions have much more EGFR expression than benign and non-neoplastic lesions.
Key words : Epidermal growth factor receptor