Biodefense-related Research
UMDNJ-New Jersey Medical
School
Nancy Connell, Ph.D.
Director, UMDNJ Center for Biodefense
Vice-chair for Research
Department of Medicine
MOU
With NYC
Renew MOU
With NYC
Newark:
MMRS
Member:Domestic
Preparedness
Task Force - NJ
WMD firstResponder training
UH-EMS
9-11
Center for
Biodefense
Incident Support
And Operational
Planning (2002)
BT annex Univ.
Hospital plan:
State model
Anthrax
attacks
Mobilization
of expertise
“Public Health
War College”
MOU
NJDoH
ICPH
(PHRI)
Emerging
Pathogens
1999
DoD
funding
2000
DoD
funding
2001
NIH- Regional Center
of Excellence
in Biodefense
DoD
funding
2002,2003
INFORM
HRSA
Funding
2003
HHS funding
(NJDoHSS)
2002, 2003
Regional
Biocontainment
Laboratory
Biological Agent Research
Capacity in Newark
• Center for Emerging
and Re-emerging
Pathogens (NJMS)
•International Center
for Public Health
–NJMS Microbiology
–NJMS Nat’l TB Center
–Public Health Research Inst
Biological agents
• Bacillus anthracis
• Yersinia pestis
• Burkholderia
mallei
• Francisella
tularensis
• Mycobacterium
tuberculosis
•
•
•
•
•
Hantaan virus
Dengue virus
Monkeypox
Influenza virus
SARS
Biological research areas
• Diagnostics
– DNA microarrays
– Molecular beacons
• Host response
– Testing vaccine response (smallpox vaccine)
– Infection models
– Antibiotic resistance
DNA microarrays
• Infection by different organisms will turn
on and off different patterns of genes in
the host.
• Can we determine these patterns and use
them for early diagnosis of infection?
avirulent vs virulent
uninfected vs virulent
Up 1 A-V 3+ P
37
37
Up 1 U-A 3+ P
0
0
NJMS/NJDS:
Gallagher
Alland
Raveche
Schutzer
80
80
0
DNA microarray
analysis
of the host response
to infection
0
3
CBD:
Jessica Mann
Paula Trzop
Carolina Sofer
18
3
18
61
61
44561
Total genes
44,561
all genes
CAG (PHRI)
Pat Soteropoulos
Anthony Galante
Up 1 U-V 3+ P
uninfected vs virulent
NJIT
Michael Recce
Virginie Airis
NIH Regional Center of Excellence in
Biodefense and Emerging Pathogens
•
•
•
•
•
•
Northeast Biodefense Center (among 8 of 14 applied)
Consortium of 30 institutions: NY, NJ, CT
200 + investigators (P.I., Ian Lipkin [Columbia])
Commissioner Lacy: advisory board
3 New Jersey investigators on executive committee
$45 million total award (5 yrs): $ 2 million to
PHRI’s David Perlin as animal core director
• Vaccines, therapeutics, diagnostics, training
• Strong emphasis on global emerging infections
(SARS, West Nile)
NIH Regional Biocontainment
Laboratory
•
•
•
•
•
•
Joint effort of NJMS and PHRI
$21 million award with 1/3 match by UMDNJ
40,000 sq ft building adjacent to ICPH
University Heights Science Park
Jeannette Brummel, community liason
Brings total Newark BSL space to 22,000 sq ft
NIH biodefense
research priorities
Northeast
Biodefense Center
CAG (PHRI)
Keck Center (Rutgers)
Beacons (NJMS, PHRI)
Arrays (NJMS)
PHRI
The RBL:
NJMS, PHRI