2015 - 2016 PEDIATRIC FACULTY RESEARCH INTERESTS SELECTING YOUR MENTOR AND RESEARCH IDEAS (Updated and compiled by M. Evinger 08.25.15) Research Interests - Key Words describe faculty member’s research topics and areas of clinical expertise Project Category – Abbreviations describe the project based on Scholarly Activity Categories Project Category HE Prospective Research. - Pt. /Community Health or Education HP - Health Policy ID - Instructional Design w/ Assessment BR - Basic Research Cl. Res. - Clinical Research Ch. Rev. - Chart Review w/ Formal Hypothesis QM Quality Management – QA or QI Rev. Art. Review Article or Chapter for Submission Oth. Other (Approved by Residency Research Director, Dr. Woroniecki) Project Status –Abbreviations indicate current status of the Project or Mentor’s availability. Abbr. STATUS Act. Active (In Progress) Pend. Pending (Awaiting IRB or other approval) Pot’l Potential (Needs to get approval/ funding before starting) N/A Mentor Not Available to Take Advisees at This Time Project describes ongoing or planned research (basic or clinical) projects DIVISION OF ADOLESCENT MEDICINE Faculty Member Allison Eliscu, MD Zachary Jacobs, DO Research Interests Project Category Reproductive health, STIs and eating disorders Sexual and reproductive health counseling/education from physicians to youth, Understanding sexual and reproductive health of youth with chronic illnesses Psychosocial topics (other than sexual and reproductive health) in youth with chronic illnesses QM Cl. Res. Project Status Project Title Pot’l DIVISION OF ALLERGY/ IMMUNOLOGY Faculty Member Susan Schuval, MD Kalpana Patel, MD Research Interests Resident educationanaphylaxis, Eosinophilic Esophagitis Primary Immunodeficiency disorders Project Category Project Status HE Act “Knowledge, Attitudes and Behaviors of Internal Medicine and Pediatric Residents Regarding Anaphylaxis diagnosis and Management” Cl Res Cl. Res. Pending Pending Eosinophilic Esophagitis in Infants and Toddlers A Registry of Patients with Primary Immunodeficiency Disorders Project Title No ongoing research projects at this time DIVISION OF PEDIATRIC CARDIOLOGY Faculty Member James Nielsen, MD Laurie Panesar, MD James Nielsen, MD Laurie Panesar, MD James Nielsen, MD Research Interests Non-invasive imaging of congenital and acquired pediatric heart disease Non-invasive imaging of congenital and acquired pediatric heart disease Clinical Cardiology Project Category Project Status Project Title Rev. Art. N/A Revising book chapter (second addition) on Echo assessment of MV and left atrial anomalies. Dr. Panesar and I are co-authors. Cl.Res. Ch. Rev. N/A Research Question: Serial comparison of left ventricular (LV) mass by m-mode echocardiography (ECHO) compared to cardiac MR (CMR) in growing children. Design: Retrospective analysis of echocardiographic and CMR imaging data. Currently working with Drs. Laurie Panesar and Kat Supe-Markovina. QM Pot’l Improve preliminary ECG interpretation by Residents and Attendings in the ED, outpatient and inpatient settings Non-invasive imaging of congenital and acquired pediatric heart disease Clinical Cardiology QM Pot’l Evidence based approach to define normal cardiovascular structure size in pediatric Echocardiography reporting. QM N/A Improve screening for dangerous cardiac disease in the community. Non-invasive imaging of congenital and acquired pediatric heart disease Non-invasive imaging of congenital and acquired Cl.Res. Ch. Rev. Pot’l Research Question: Normal LV size in premature newborns is incompletely characterized. Laurie Panesar, MD James Nielsen, MD Laurie Panesar, MD James Nielsen, MD Laurie Panesar, MD James Nielsen, MD Laurie Panesar, MD James Nielsen, MD Carl Kaplan, MD Design: Retrospective analysis of echocardiographic and CMR imaging data. Utilize bullet LV to report normal values for premature newborns. Cl.Res. Ch. Rev. N/A Research Question: Can targeted ECHO in the pediatric emergency room accurately diagnose pericardial effusion and depressed left ventricular function? Design: Retrospective analysis of ECHO from ED compared to a full ECHO study to examine the accuracy. James Nielsen, MD Dennis Davidson, MD James Nielsen, MD James Nielsen, MD Stuart Holzer, MD Kathleen Walsh, MD Christy Beneri, DO pediatric heart disease Non-invasive imaging of congenital and acquired pediatric heart disease Non-invasive imaging of congenital and acquired pediatric heart disease Non-invasive imaging of congenital and acquired pediatric heart disease Clinical Cardiology Clinical Cardiology/ ID Cl. Res. Ch. Rev. N/A Research Question: Standard CXR determination of umbilical catheter position in preterm (<1500gram) newborn is inaccurate compared to ECHO assessment of catheter position. Design: Prospective ECHO versus CXR clinical study. Cl. Res. Ch. Rev. N/A Research Question: Is OPEN cardiac MRI more patient friendly? Design: Survey of families and patients who have undergone OPEN cardiac MRI. Cl.Res. Ch. Rev. N/A Research Question: Is OPEN cardiac MRI as accurate as standard cardiac MRI? Design: Retrospective analysis of CMR data from Univ. Michigan and Stony Brook examining clinical and imaging data. Cl Res. Ch. Rev Cl. Res. Pot’l Active Retrospective chart review of Kawasaki disease patients- predictors of refractory disease (Potentially have a resident to do the IRB already) Revision stage of paper- "Mid-term outcomes of TGA and bicuspid pulmonary valve" DIVISION OF CHILD ADVOCACY Faculty Member Research Interests Project Category Leslie Quinn, MD Child maltreatment and prevention including resident education in this area, primary pediatric preventive care ID Project Status Act Cl. Res QM Potential Project Title GUIDES: A Template to educate and enhance assessment of risk factors for childhood injury. This is an IRB approved project already in progress. It aims to educate residents on the risk factors for child maltreatment and teaches them a method to use to identify patients/ families at risk in their continuity care clinics. Pediatric ED use of Guidelines for Suspicion of Child Maltreatment (created by Dr L. Quinn). There is currently a wide variation in the documentation by nurses and physicians in the peds ED when a child presents with an injury. In order to try and evaluate whether faculty are even thinking about/ or considered the possibility of child maltreatment in their differential and if they used the guidelines or not, I have created a 5 question (Yes/No) document to be completed on children (still deciding on age cut off) who present with any injury to our peds ED. I am working on this project with Dr. C. Kaplan. We are currently trying to work with EMR/IT people to figure out the logistics. The project will include a chart review looking at pre-questionnaire documentation. This will be a formal QI project. Cl.Res HE Potential Cl. Res Burn Injury Prevention QM Active Breast feeding education project for residents and the effect on promoting exclusive breast feeding in the NBN and beyond. Based on prior research done at SBUH by Dr. Apruzzese and Dr. Connolly, they concluded that the educational interventions to promote exclusive breast feeding in post partum mothers may be more effective if given independent from the large amount of post-partum information mothers already receive. This project aims to provide an educational intervention before delivery in an effort to promote exclusive breast feeding. Interested primip women in their third trimester who are followed by UHSB OB and midwives will be contacted by phone by the pediatric resident on Community Rotation who will give "scripted" information about breastfeeding and address any questions the mother-to-be might have regarding breast feeding. Follow-up will be at delivery in the NBN and one month later (by phone) . I have already received permission from the Department of OB/Gyn at Stony Brook. I will be working with Dr. M. Connolly on this project. We do plan to get IRB approval. We are currently working on the educational piece for the residents. In conjunction with Stony Brook Injury Prevention Educator / Coordinator and the Trauma Service Nurse for Pediatrics, this project is a requirement for all residents; each will have a role in the development and creation of the program. DIVISION OF CRITICAL CARE MEDICINE Faculty Member Margaret Parker, MD Laura Czulada, DO Kimberly Fenton, MD Research Interests Safety of endotracheal intubation in children Ventilator-associated infections QI, especially in regard to end of life discussions, daily communication in the PICU, and standardization of rounding procedures 1.Trauma outcomes including timing of tracheostomy in pediatric trauma Project Category QM Project Status Act Project Title Multicenter study of intubation events in children Cl. Res. Act. Multicenter point prevalence study Cl Res Active National Palliave Care Survey QI Pot'l Improving difficult conversations with Families using Simulation QM Pot’l Improving daily communiation in the ICU with families QM Cl. Res. Pot’l Act. Developing a pathway for End of life care in the ICU Physician Opinion related to Timing of Tracheostomy in Trauma (POETT) Study 2. Evaluation of Resident SBAR Handoff in the Simulation Lab QM Act 3.Improving patient outcomes via improved communication in the inpatient setting QM Pot 4.Outcome of adolescents and young adults hospitalized in the PICU vs MICU Clin. Res. Act Ilana Harwayne-Gidansky, MD Laura Monahan, MD Rahul Panesar, MD Daniel Sloniewsky, MD 1.Quality Improvement, Mentor on resident project (in development 2. Quality improvement: resident director for QI curriculum 3. Global Health QM Act. QM Act. Cl. Res Pot’l Quality Improvement, Electronic Medical Documentation, Pediatric Simulation Education QM Act. 1. The relationship between transfusion and infection 2. Quality improvement Just arrived 7/2015. Check with about potential projects. Working on a QI project to evaluate resident handbook effectiveness Working on a QI project to improve resident handoff Advise and review resident QI projects Cl. Res Act. Act. Pot'l Development of sustainable education programs for residents involved in international pediatric rotations 1. PECARN Head Trauma Simulation Study 2. Evaluation of Simulated Hand-Offs from Pediatric Residents to Faculty using SBAR—Curriculum Development 3. Evaluation of Pediatric Resuscitation Team Performance in High-Fidelity Simulations using a Validated Assessment Tool 4. Telemetry Bed Initiative – QA/QI project 1 Correlation of transfusion with fevers in children with neutropenia QM Pot'l 2. Can a pediatric transport clinical scoring system improve outcomes? Act. DIVISION OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS (See also Pediatric Neurology) Faculty Member Janet Fischel, PhD Research Interests Language disorders, early literacy skill development in children from low income families; disparities in child health care across socioeconomic levels Project Category Project Status Project Title HE/HP/Cl. Re.s Pend. HE Pot’l -Disparities in health care and their relation to developmental and behavioral skill acquisition; -Children's book distribution impact on family literacy; shared reading, dialogic reading and children's oral language and early literacy skills Rev Art N/A Cl Res Potential Active Potential -Update on nomenclature and evidence-based outcomes research on children with disorders of elimination --Parental perceived needs from the health care system at medical visits for children with ASDs (already working w/ a resident) perceived needs from the health care system at medical visits for children with ADHD (potential) perceived needs from the health care system at medical visits for children with ASDs (active) -- a follow up to prior resident scholarly project with me) Trainee education in empathy and compassionate care (potential - a follow up to prior resident scholarly project with me) Patricia Bigini-Quinn, MD Developmental disorders of childhood; Predominantly autistic spectrum disorders, anxiety disorders, and attentional disorders QM/chart review Potential Ch rev/QM Potential Screening for anxiety / Depression in children 12- 18 years of age in general pediatric clinics. Is it occurring? ADHD initial visit patients Are they being screened with appropriate questionnaires, scheduled for a followup visit within 6-8 weeks provided with educational materials on ADHD Do pediatricians address future beyond high school plans Pending/Active Clinical for education or training or career at health care visits? Do research/questionnaire parents expect pediatricians to do this and does it have an use impact? Does having multiple co morbidities contribute to increasing the number of clinic visits and /or telephone contacts between family and doctor in Developmental Behavioral Pediatric Clinics and psychology clinics in the Dept of Pediatrics. Dr. Fischel and Dr. Keluskar will also be involved in this study along with Dr. Quinn and Dr. Chung. Jaeah Chung, MD Alfred Scherzer, MD ADHD, premature infant follow up Global health policy and practice; Developmental health and trajectories for children in developing countries Cl. Res. Cl. Res Cl. Res.. Act HE; Hp Act. Rev. Art. Act Management of ADHD in Preschool Children: Specialists’ Adherence to Treatment Guidelines and Clinical Criteria Used for Initiating Pharmacotherapy Early Introduction of Solid Foods to Premature Infants and Impact on Feeding Behaviors Failure to Adjust for Gestational Age When Plotting Premature Infant Growth and Its Impact on Parental Satisfaction studies of developmental health trajectories for children in developing countries; policy and position reports to impact global child health facilitation Act Act DIVISION OF PEDIATRIC EMERGENCY MEDICINE Faculty Member Sergey Kunkov, MD Research Interests Asthma, pain control Project Category Cl Res Project Status Pot'l Project Title Comparison of analgesic properties of Buzzy analgesic device and Liposomal Lidocaine Cream in reducing pain during pediatric phlebotomy Pending Co Comparison of oral sucrose versus topical LMX for analgesia in neonatal lumbar Richard Bruckner, MD Pediatric Pain Control, Pediatric Emergency Preparedness, Pediatric Resident Education Assessment Jeffrey N. Chen, MD Pain management Recent arrival. No current ongoing projects. Clin. Res. Pot’l Use of Intranasal Fentanyl for Sickle Cell Pain in the Pediatric Emergency Department Sickle cell disease Henry Chicaiza, MD 1) Bedside Ultrasound 2) Newborn Hematemesis 1)BR 2) Clin.Res 1&2 Potential/ pending Utilization of a computer-based cardiac ultrasound trainer to aid in the visualization and conceptualization of structures viewed in a 2D ultrasound Application of a bedside version of apt test to aid in the diagnosis of maternal swallowed blood in pts presenting with newborn hematemesis Not involved in research Simulation, Emergency Medical Services HE Active Simulation-based mastery learning with just-in-time refreshers improves physicians’ infant lumbar puncture performance. Clin. Res. Active Simulation Strategies to teach Clinical Reasoning to Interns QM Improving Lumbar Puncture Clinical Outcomes among Trainees Cl. Res. Active Diagnostic testing for intussusception Cl. Pot’l Diagnostic testing for foreign body in lungs Cl Pot’l GIS-resource utilization of ED patient Kathleen Doobinin, MD Devin Grossman, MD Jeffrey Hom, MD, MPH Evidence-based medicine Trauma (Please note that Dr. Hom is already mentoring several residents so not eligible to take additional trainees at this time.) Carl Kaplan, MD Katherine Morgera-Clores, DO Analgesia Resident Education Cl res Pending Improving asthma care from the pediatric emergency department Cl. Res Active Intranasal Midazolam in the PED Recent arrival – No ongoing projects but willing to discuss potential ideas DIVISION OF PEDIATRIC ENDOCRINOLOGY Faculty Member Thomas Wilson, MD Project Category Research Interests Project Status Project Title Depression, Quality of Life and Transgender Cl Act, Depression, Quality of Life and Transgender: Does treatment with GnRH analogues, Progesterone, Anti androgens or cross sex steroids help? EMR in a consultative service QA, Pot’l Perceptions and Receptiveness to EMR by Referring Physicians Diabetes Insipidus RA Adrenal Insufficiency Rev Art. Act. Act. Review article on Diabetes Insipidus for NORD (National Organization of Rare Diseases) Chapter for Manual of Endocrinology and Metabolism Adrenal Excess Act. Chapter for Manual of Endocrinology and Metabolism Rev. Art. Andrew Lane, MD Jennifer Osipoff, MD All aspects of endocrinology Type 1 diabetes mellitus (T1DM), prospective memory, adherence/compliance with treatment regimens, adolescents, disordered eating in T1DM, CGM use in DKA, antipsychotics and prevention of insulin resistance, autoimmune diabetes insipidus Cl. Res. Act. Measurement of phallus size in SGA infants to create standardized references. Does birth weight influence phallus size? Ch. Rev. Act. Timing of peak GH during a combined stimulation test Potential for Cl.REs., All potential- ideas are - need time/funding to get them started Potential ideas include: 1) Prospective memory in adolescents with type 1 diabetes mellitus using a revised scale Ch.Rev., Rev.Art. 2) Randomized, blinded control trial of using metformin at the onset of atypical antipsychotic use and its effect on weight gain and insulin resistance 3) Development of a survey/questionnaire screening for disordered eating in our population of type 1 diabetics 4) Case series of patients being treated by our team for autoimmune diabetes insipidus and review of the literature 5) Using the protocol developed by Drs. Lane and Skaria but using the IPRO2 CGM device to determine reliability of its readings during DKA 6) Investigating ways to increase school nurses knowledge about managing children with diabetes-- recently completed a survey looking at school nurses knowledge/comfort so could build off of that Kimberly, Tafuri, DO Type 1 diabetes mellitus (T1DM), obesity, vitamin D deficiency Cl. Res, Ch. Rev, QM 7) Language development in children with diabetes Controversy regarding management of relative hypoglycemia during the treatment of diabetic ketoacidosis. Prospective randomized blinded control trial. Protocol already written. Pot’l Act. Medtronic sponsored trial Multicenter, Prospective, Observational Study of the TS (Threshold Suspend) Feature with a Sensoraugmented Pump System in Pediatric Patients with Type 1 Diabetes Act. Measurement of phallus size in SGA infants to create standardized references. Does birth weight influence phallus size? (Fellow project) Pot’l Vitamin D status in new onset type 1 diabetes DIVISION OF PEDIATRIC GASTROENTEROLOGY Faculty Member Research Interests Project Category Project Status Anupama Chawla, MD Celiac Disease Eosinophilic esophagitis Obesity Cl.Res. Cl. Res. Cl. Res Act. Act. Act. Grace Gathungu, MD Inflammatory Bowel Disease (IBD) B.R. Act. GM-CSF autoantibodies in Crohn's disease Act. Act. Project Title Jeffrey Morgenstern, MD Michelle Tobin,MD Detection of Invasive bacteria in IBD Role of food additives in intestinal inflammation Act. Inflammatory Bowel Disease Non-alcoholic Liver Disease Inflammatory Bowel Disease Cl.Res. Cl. Res. Act. Act. Also industry-based registry B.R. Act. Food additives and intestinal inflammation- working with Dr Gathungu Eosinophilic Esophagitis Ch. Rev. Act. Cl. Res. Pot. EoE and Epidemiology -in collaboration with Dr Schuval and resident EoE and Treatment - in collaboration with Dr Schuval QI Act. Assessment of Independence in CF patients 12years and older in collaboration with CF center Cl. Res. Act. Omegaven for patients with PNALD Potential Clinical interest in liver, but no current research projects as of yet CF Liver DIVISION OF PEDIATRIC GENETICS Faculty Member Patricia Galvin-Parton, MD Margaret McGovern, MD, PhD Research Interests Project Category Project Status Project Title Berrin Monteleone, MD Cancer genetics Cl.res Peds genetics Ch.Rev. BR Act. 1. Characteristics of patients with rearrangement at Xq28: report of two cases and review of literature (Act) Current 2. Pancreatic cancer screening for high risk patients(Pot’l) 3. Lobular type breast carcinoma and association with melanoma: mRNA study(pot’l) 4. Characteristics of triple negative breast cancer patients(Act) 5. PAX 8 expression in Fallopian tube tumors and association with BRCA mutations (pot’l) 6. A case report of homozygous PMS2 mutation in a patient with ureter cancer and review of literature(act) DIVISION OF HOSPITALIST MEDICINE Faculty Member Research Interests Project Category Project Status Project Title Carolyn Milana, MD Josette Bianchi-Hayes, MD Rachel Boykan, MD Obesity, Healthcare technology, mobile health Tobacco Cessation/Physicians Tobacco Cessation/Quitline Collaboration Asthma/Depression Maribeth Chitkara, MD Evidence Based Medicine Clin.Res. Act. Development of a multimodal intervention for adolescent obesity Clinical Research Active; N/A Physicians’ Perceptions Regarding Third-hand Smoke Clinical Research/HM Active Clinical Research Active A Comparison of Parents/Caregivers of Healthy vs. Sick Neonates: Is there a difference in readiness and/or Quitting Smoking? Correlation between depression screening and length of stay in adolescents admitted to a hospital for asthma exacerbation ID Act. An Integrated Practical Evidence Based Medicine Curriculum for Pediatric Residents Medical Education Quality Improvement Professionalism QM Act. Professionalism in the Pediatric Workplace: A Qualitative Analysis ID Act Does an Advanced Clinical Experience (ACE) Course in Pediatrics Improve Senior Residents’ Self-Directed Learning Behaviors and SelfEfficacy Ratings on Key Clinical Internship Skills? Principal Investigator . Margaret Connolly, MD Exclusive breastfeeding, Standardization to improve medical care, Quality improvement, Care of the medically complex child/child with special health care needs Traci Downs, MD Asthma, Breastfeeding, Global health Lisa Wilks-Gallo, MD Communication in medicine; Newborn Nursery Medicine including breastfeeding; Inpatient Pediatric Medicine topics 1) 2) HE HE 1) Active 2) Pending 3) QM 3) Active 4) QM 4) Active 1) Breastfeeding Knowledge, Attitudes and Beliefs Among Pediatric Resident Physicians 2) Effect of Prenatal Breastfeeding Counseling on Exclusive Breastfeeding Rates among Primiparous Women 3) An Evaluation of the Implementation of a Neonatal Sepsis Powerplan in a Pediatric Emergency Department 4) QI Project to improve medication reconcilliation during hospital transfers Currently doing an Asthma QI project to improve asthma control and improve provider documentation and compliance with Asthma EPR guidelines. Currently no other research projects, but would love to do one if there is mentoring and support for those of us with full-time clinical duties. No ongoing projects as prior studies have now been completed. Interested in beginning a new project. Approach with ideas/suggestions for potential studies that are relevant to inpatient medicine and/or communication issues in medicine. DIVISION OF PEDIATRIC HEMATOLOGY/ONCOLOGY Faculty Member Research Interests Robert Parker, MD Edward Chan, MD Laura Hogan, MD Tyrosine kinases as biomarkers and therapeutic targets; Personalized molecular target therapy Project Category Project Title BR/Cl.Res. Pot’l Cl.Res. Cl.Res. Pot’l Pot’l BR Pot’l Cl.Res. Pot’l BR Pot’l BR Act. BR Act Uses of hyper-thrombocytosis in children effect of estrogen-impregnated contraceptive devices on von Willebrand factor parameters (p,L/c) predictors of bacteremia in febrile neutropenic patients (p,c) Assessment of the need for hospitalization for patients with newly diagnosed ITP (p,c) Assessment of immune response recovery following completion of cancer chemotherapy (p, L) NIRS as a tool to assess response to therapy in Sickle Cell acute vaso-occlusive crisis (p, c) Molecular analysis of patients with Noonan syndrome and fibrinolytic abnormalities (p, L) BR Act BR Pot'l BR Pot'l Defining the role of EGFR extracellular mutants, EGFR471, 660 and a EGFR kinase missense mutation, P733S BR Act. Identifying targeted therapy for relapsed pediatric ALL Cl.R Act. Bone density loss in survivors of childhood cancer Act. Markers of Renal and Cardiovascular Dysfunction in Childhood Cancer Survivors. Ron as a therapeutic target for head and neck squamous cell carcinomas Defining the biological role of EGFR768 in neuroblastoma Cl.R Joseph Laver, MD Project Status HP, HE, QM Validating the prognostic value of EGFR768 in neuroblastoma Identifying and validating a Ron antibody for translational research studies Rina Meyer, MD Supportive care of pediatric oncology patients Cl. Res. Act. Biomarkers of sepsis in febrile neutropenia Cl. Res. Act. Pediatric palliative care practices Cl. Res./Ch. Review Act./Pend./Pot’l Reducing oral complications in pediatric oncology patients (multi-part research with chart review, QA and clinical trial components) Cl. Res. Pot’ Psychosocial assessment and intervention in pediatric oncology patients and their parents Cl. Res. Pend. Assessment of neuropathy in pediatric cancer patients - Devina Prakash, MD Patient attitudes to neutropenic diets Pediatrician anticipatory guidance regarding feeding and iron def. anemia DIVISION OF PEDIATRIC INFECTIOUS DISEASES Project Status Faculty Member Research Interests Project Category Project Title Sharon Nachman, MD HIV Cl. Res. Active Lyme Cl. Res Pot’l TB Cl. Res. Active Evaluate novel approaches for tuberculosis (TB) prevention, treatment and diagnosis in HIV-infected children, adolescents, and pregnant women. Antibiotics Cl. Res. ActivePharma sponsors Open studies in C.diff; Cellulitis IMPAACT network (HIV treatment, HIV Cure, TB, Hepatitis B and C, Vaccines in HIV+ and HIV exposed infants and children) http://impaactnetwork.org/index.htm Sumita Bhaduri-McIntosh, MD, PhD EBV-related diseases; EBV persistence and mechanisms underlying reactivation; Mechanisms of DNA damage response suppression; Immunocompromise associated cancers Christy Beneri, DO TB, Tick-borne infections, antibiotic protocol guidelines/ infection control, transplant medicine Saul Hymes, MD Anti-microbial stewardship infection control and prevention Social media and its role in medicine Active Studies of host cell factors that determine susceptibility to EBVtumorigenesis and EBV lytic reactivation; immune responses to EBV in different diseases Act Cl. Res. TB therapeutics, TB diagnostics Act Cl. Res. Epidemiology ticks in Suffolk county Act Cl.Res./QM Infection control Act QM Transplant medicine (renal transplants) Pot’l Cl.Res./QM Travel medicine Pend 1. Review of appropriate antibiotic use in appendicitis—fellow project BR Cl Res Active Pend Pend Pot’l Pot'l 2. Survey of COG (pediatric oncology) institutions on 1. neutropenic diet and 2. antibiotic practices (2 projects) 3. Survey of Stony Brook outpatient antibiotic use knowledge, attitudes, and practices—existing resident project 4. Relation of vaccination rates and outbreaks of vaccine-preventable diseases to pro- and anti-vaccine thought on Twitter 5. Prospective study of nephrotoxicity/renal dosing of Zosyn and/or other antimicrobials in the NICU 6. Survey of social media use among infectious disease physicians, pediatricians or other groups DIVISION OF MOLECULAR NEUROSCIENCE Faculty Member Research Interests Project Category Marian Evinger, Ph.D. Transcriptional regulation of gene expression. All BR Cell signaling via nicotinic cholinergic receptors Project Status Project Title Pot’l Molecular Profile of Developmental Factors in Medulloblastoma Act. Hypoxia Influence on Neural Production and Release of Cytokines Act. Act. Hypoxia Influence on Production and Release of Opioids and Opioid Peptides in Neural Cells Nicotine-Mediated Regulation of Adrenergic Gene Expression Act. Effects of Nicotine Exposure on Mammary Tumor Development DIVISION OF NEONATOLOGY Faculty Member Shanthy Sridhar, MD Research Interests Project Category Multicenter Clinical Trials NIH-U54 Funded NICU study /Follow up study Prospective study Multicenter Trial Retrospective Quality Improvement NYS Sate Collaborative Project Status Project Title IRB pending Synergistic Pharmacologic Intervention for Prevention of Retinopathy of Prematurity.Phase III trial Funding and IRB is work in progress Long term follow up of renal and cognitive function in young children who graduated from Neonatal Intensive Care Unit (NICU Colloboration with PEds Neorology (Dr Worniecki/Dr Fine ) IRB approved; Active AWAKEN Study-Multicenter trial All World wide assement of Acute Kidney Injury and Epidemiology in Neonates. Data collection in Progress Neonatal Nutritional project – Completed; published. QI CLABSI project NICHQ/RPC Collaborative – Completed; published Safe Sleep Practices Project NYS Collaboration-starting in Fall Antenatal Steroind( 32-34 weeks ) exposure improves Respiratory and comorbidities in LAte pretermPreterm Infant - IRB Approved Culture Negative Sepsis and PLacental Pathology Usefulness of Hematological Indices- Awaiting IRB approval Pending Looking for a resident/Fellow in PBLI/SBP projects 1.Role of Anesthesia in Neonatal MRI. 2. Myths and Challenges in improving Birthing dose of NYS Hepatitis B Vaccine rates 3. Use of Donor Milk Program in NICU Dennis Davidson, MD Umbilical Venous Line Placement Cl Res Caffeine Pharmacokinetics Cl Res Efficacy of Nasal IMV Brain O2 extraction via NIRS during Umbilical Artery Sampling Joseph DeCristofaro, MD 1) Apnea of Prematurity days off caffeine for safe discharge Cl Res Active:Nearly complete Fellow Project Comparing proper placement of UV catheter in VLBW infants: Xray vs ECHO Active: Fellow manuscript in review process Is seven days off caffeine safe for discharge Pending:New Fellow Project in IRB review process Using TcCO2 monitoring to optimize ventilation for preterm infants on NIMV Collaborating investigator with Dr. Mintzer Cl Res Cl Res Active Active Is seven days off caffeine safe for discharge? 2)Medication Safety 3)NICU quality Improvement- reducing BPD by early INSURE and non-invasive ventilation QI Potential Can focus on non invasive ventilation in VLBW infants decrease BPD? Active Can we keep the O2 saturation in VLBW infants within the prescribed limits? 4) NICU QI- O2 sats in goal QI Active QI Potential Cl Res Active Cl Res Active 1. The use of umbilical cord blood Cl. Res., Active/Funded 1. Umbilical cord blood as an alternative for late preterm admission complete blood count-prospective study 2. Stannsoporfin use in Neonatal hemolytic jaundice(64,185-204) Cl. Res., Active/Funded 2. A phase 2b multicenter, single dose, randomized, double blind, placebo controlled, parallel group study evaluating the safety and efficacy of two doses of stannsoporfin in combination with phototherapy in neonates 5) Patient Safety 6) Pharyngeal reflux in preterms infants 7) TCOM vs ETCO2 during operative procedures Echezona Maduekwe, MD 3. Follow up study on Stannsoporfin(64,185-205) 4. Endotracheal tube insertion depth Cl. Res., QI QI Active/Funded Active Active How common is pharyngeal reflux in preterm infants and is there any relationship to apnea Comparison of transcutaneous CO2 monitoring vs End Tidal CO2 in VLBW infants pCO2 levels on blood gas monitoring in the operating room. 3. A four year blinded outcomes follow up study of patients having received stannsoporfin or placebo in clinical trial 64,185-204) 4. Predicting the optimal insertion depth of endotracheal tube in neonates 5. Decreasing the incidence of severe retinopathy of prematurity in the neonatal intensive care unit using educational interventions 5. Retinopathy of prematurity Potential Optimizing the management of seizures in neonatal intensive care unit patients with Hypoxic ischemic encephalopathy QI 6. Seizure management in HIE Jonathan Mintzer, MD 1) Cerebral Hypoperfusion with Umbilical Arterial Blood Sampling 1) Cl. Res. 1) Active (funded) 1) Evaluating the effects of umbilical arterial blood sampling on cerebral tissue oxygenation 2) Analysis of Fractional Tissue Oxygen Extraction as a Clinical Support Tool in the Management of Neonatal Presumed Sepsis 2) Cl. Res 2) Pot’l (applied for funding) 2) Evaluating the use of NIRS-derived fractional tissue oxygenation trending in the management of presumed sepsis in full-term neonates 3) Multi-site Oxygenation Monitoring During Neonatal Hypothermia 3) Cl. Res 3) Pot’l 3) Evaluating the use of multi-organ NIRS monitoring before, during, and following therapeutic hypothermia in hypoxicischemic encephalopathy 4) Prevention of Transfusion Related Acute Gut Injury (TRAGI) in ELGAN Neonates Using iNO - Proof of Concept Pilot: The NO-TRAGI Trial 4) Cl. Res 4) Pend (industry-funded) 4) Multicenter randomized pilot examining the effects of iNO for prevention of Transfusion Related Acute Gut Injury; utilizes NIRS for splanchnic fractional tissue oxygen extraction determination 5) Multicenter Study of Saturation Targeting by Automated vs. Manual Adjustment of Inspired Oxygen in Neonates and Infants 5) Cl. Res. 5) Pend (industry-funded pending) 5) Multicenter crossover trial examining the use of automated versus manual FiO2 adjustment with outcome of time spent in desired 6) Automatic Adjustment of Inspired Oxygen for ROP and BPD Prevention in Preterm Infants 6) Cl. Res. 6) Pot’l (applied for NIH funding) 6) Multicenter trial examining the use of automated FiO2 adjustment on ROP and BPD outcomes 7) Measurement of Intraoperative CO2 in 7) Cl. Res. 7) Active (funded) 7) Anesthesia study comparing the use of end-tidal with transcutaneous CO2 monitoring Neonates and Infants by Two Methods 8) Is Excess Fluid Administration Shortly Following Birth in Very Low Birth Weight Neonates Associated With an Increased Rate of Patent Ductus Arteriosus Requiring Treatment? 8) Ch. Rev. 8) Active 8) Retrospective chart review evaluating fluid management in the first postnatal day and effects on PDA requiring medical or surgical treatment (resident project) 9) Effects of indomethacin dosing strategy on closure of patent ductus arteriosus (PDA) in very low birth weight (VLBW) neonates 9) Ch. Rev. 9) Active 9) Retrospective chart review evaluating q12h versus q24h indomethacin dosing regimens on PDA closure and other neonatal outcomes 10) ID 10) (On Hold) 10) A novel online system for education regarding NICUrelated mathematic concepts QI 1. presented at PAS (in process of writing) 1."NICU QA project: Needs assessment for Neonatal intubation" 10) An Online, Interactive, Modular Educational System for the Mastery of Mathematic Concepts in the NICU Aruna Parekh, MD 1. NICU QA projects: (2) "Structured intervention for improving skills at neonatal intubation " 2. Pulmonary and neurologic follow up 2 Ongoing 2. Trial of Late Surfactant to Prevent Bronchopulmonary Dysplasia (TOLSURF) study: Long term pulmonary and neurodevelopmental out comes 3. Synchronization study using SIPAP and CPAP using grasbey capsule 3. Under active data collection phase 3. A randomized, pilot study of the short term respiratory effects of synchronized bi-level nasal continuous positive airway pressure (CPAP) vs standard bi-level CPAP in very low birth weight infants Jennifer Pynn, MD 1. QI Project QM Ch. Rev. Active 1. Minimizing Days of Invasive Ventilation/Maintaining Successful Extubation Rates HE Active 2. Validity of Tracheal Aspirates for Pneumonia in Very Low Birthweight Neonates 3. Medical Student Scholarly Concentrations Program 4. Fellow Education HE Pend 3. How do religious beliefs/spirituality affect clinical decision making HE Active 4. Utilization of a Learner Centered Teaching Model & an Audience Response System in Fellowship Training immune response and anti-inflammatory agents to regulate the innate neonatal immunity BR Active BR Active QI Active 1) Pharmacological strategies to enhance the neonatal antiinflammmatory defense 2) Regulation of inflammatory immune responses in term and preterm neonates 3) Improving respiratory outcome and reducing unplanned extubations in the NICU 2. Pediatric Resident Scholarly Activity Esther Speer, MD DIVISION OF PEDIATRIC NEUROLOGY Faculty Member Research Interests Project Category Thomas Preston, Ph.D. Memory and Executive Functions in Children with Medical and Psychiatric Disorders Cl Res Project Status Active, Pending, and Potential Project Title “Prospective Memory Functions in Children with Acquired Brain Injury” “Memory and Executive Functions in Children with Epilepsy” “Cognitive Screening for Children with Cancer” DIVISION OF PEDIATRIC NEPHROLOGY Faculty Member Research Interests Project Category Robert Woroniecki, MD Nephrotic syndrome, Hypertension, Acute kidney injury ChRev Completed Microbiologic Agents in Sepsis-Induced Acute Kidney Injury (sAKI). Clin.Res Active Association of Apolipoprotein L1 (APOL1) Genetic Variants with Cardiovascular Morbidity and Renal Disease Progression in African Americans. Clin. Res Completed Assessment of Worldwide Acute Kidney Injury (AKI), Renal Angina and Epidemiology (The AWARE Study). Clin.Res Active Evaluation of diagnostic tests in management of hypertension in children. Clin.Res Active Markers of Renal and Cardiovascular Dysfunction in Childhood Cancer Survivors Clin. Res. Active Efficacy and safety of RE-021 in patients with Focal Segmanetal Glomerulosclerosis: a randomized, double-blind, active-control, dose escalation study. Clin. Res. Active Eculizumab use in Pediatric Practice Clin. Res. Active Clin. Res. Active Clin. Res. Active Project Status Project Title Kidney size and cardiovascular risks in children with hypertension Childhood Nephrotic Syndrome Observational Study Additional research-related info provided by Dr. Woroniecki: # mentees =1 # publications =2 # abstracts =8 # approved and active IRB projects (with you as PI)= 10 # active grants =1 Richard Fine, MD Renal disease; renal transplantation Cl. Res. Pot’l "Incidence of microalbuminuria in infants, children and adolescence with a single kidney" Katarina Supe-Markovina, ME Pediatric renal transplantation Cl.Res. Active Assessment of left ventricular mass by cardiovascular magnetic resonance DIVISION OF PRIMARY CARE MEDICINE Faculty Member Research Interests Project Category Project Status Susmita Pati, MD, MPH Child health services research, disparities, pediatric preventive care HP HE/HP/ClRes/ChRev Act. Robyn Blair, MD Residency education curriculum, Handoffs, Resident continuity, Breastfeeding, Immunizations, Patient anticipatory guidance, Systems error analysis, Patient Safety.. HE, ID, QM Active Act. Project Title 1. Health Insurance Improvement Project: aims to develop sustainable methods to promote child health insurance retention 2. Tailoring pediatric preventive care to individual family needs: aims to customize the one-size-fits-all approach to better meet the needs of children at varying psychosocial risk 1. Resident- Patient communication through white boards on the inpatient unit- a study of patient satisfaction and physician communication. Active 2. Resident Communication: Interdepartmental study of the implementation of a resident handoff tool Resident decision-making in a high acuity ICU setting Active 3. Resident continuity in the outpatient continuity clinic. Active 4. Newborn screen tracking ad documentation in the outpatient continuity clinic Active 5. Medication Reconciliation- Improvement of resident completion rates in the outpatient continuity clinic Active 6. Transitions of care for outpatient continuity clinic patients at the end of residency- a study on the improvement of communication and quality of care Please check in for these and other project ideas Rosa Cataldo, DO Childhood obesity research and pediatric preventive care Cl.Res. N/A at this time Early Childhood Longitudinal Study Data Analysis: The Effects of High BMI on Development in Infants and Young Children Latha Chandran, MD Curricular Innovations in Medicine ID Active Does the LEARN curriculum enhance student life long learning skills, self-direction and motivation? Educational Scholarship Student Mistreatment in the Learning Environment: A case study. No Research Interested-Clinical Pediatrics No Research Cathy Coleman, MD Jill Creighton, MD Health Call Education Clinical Administration Roosjie De Grauw, MD Tobacco Cessation Megan Kasnicki, MD Quality Improvement Initiatives in our primary care offices, clinical pediatrics, residency curriculum No projects currently active. Second Hand Smoke QM No Research No Current Projects Jennifer Klingenberger-Beyer, MD No Current Projects Robyn LaBarca, MD No Research Projects Lycia Ryder, DO No Research Projects No Research Projects Rizwana Shams, MD Jonathan Tolentino, MD Susan Walker, MD Resident education, Transition from pediatric to adult care, quality/performance improvement, Reach Out and Read/Literacy Resident education in pediatric primary care QM ID Act ID Pend. 1. Calling the shots- improving resident ability to discuss parental vaccine concerns 2. Implementation and evaluation of a resident curriculum in child health supervision DIVISION OF PEDIATRIC PULMONOLOGY/ CYSTIC FIBROSIS Faculty Member Catherine Kier, MD Barry Diener, MD Mathew Ednick, DO Research Interests Pediatric sleep, asthma education, asthma and obesity, cystic fibrosis Quality improvement Implementation of clinical pathways Severe asthma Cystic fibrosis Lung function testing Pediatric Sleep Medicine Quality Improvement Project Category Clin.Res. Clin. Res. Ch.Rev./Clin.Res. Clin. Res. Clin. Res. Intervention (pre and post algorithm change) QI Project Status Active Active Pot’l Active Project Title Pediatric Sleepiness Scale; Asthma and Obesity; Correlation of Sleep symptoms with polysomnography (sleep study); Asthma and Quality of Life; Predictors of CF related Diabetes; CF and the CF Newborn Screening Program Reassessment and Implementation of new inpatient asthma protocol Reassessment and Implementation of new CF protocol PFT lab quality improvement initiative – having orders for tests, implementing and electronic program for interpretation Asthma valve-holding chamber program in outpatient setting. QI Active Increase the number of patients with CF at Stony Brook Children’s Hospital that are on, or at least offered, those chronic respiratory medications as recommended by the CF Foundation Clin. Res P Peds Sleepiness Scale (with Dr Kier) Katharine Kevill, MD Asthma program QI Active Impact of Keeping Families Healthy Program CHW visits on asthma outcomes and asthma health literacy Health Services Delivery Pot’l Electronic Monitoring of Adherence to Asthma Control Medicines as part of the Suffolk Care Collaborative Promoting Asthma Self-Management Project, which is part of DSRIP Implementation of a customized, interactive, web-based asthma self management plan within the DSRIP asthma project. QI Active Implementation of the pediatric asthma family guide for inpatient hospital admissions. Tracheostomy care and discharge planning for Stony Brook Children’s DIVISION OF PEDIATRIC RHEUMATOLOGY Faculty Member Research Interests Project Category Julie Cherian, MD Lupus JIA CRMO CNS Vasculitis Lupus JIA CRMO CNS Vasculitis Cl. Res. Potential Cl. Rev. Pending Cl. Res. Potential Cl. Rev. Pending Maria Yee, MD Project Status Project Title CRMO (chronic recurrent multifocal osteomyelitis )and Radiologic findings Brain Works: CNS Vasculitis Registry CRMO (chronic recurrent multifocal osteomyelitis) and Radiologic findings Brain Works: CNS Vasculitis Registry