實現非接觸主動式電極以量測心律之研究 Study of Implementing Non-contact Active Electrodes to Measure the Heart Rate Adviser: Huang Ji-Jer Presenter:Chou Hou-Yu Date:2014/10/22 OUTLINE 1. Introduction 1. 2. 2. 3. Paper Review Materials and Methods 1. 4. Analog circuits Results 1. 5. Brief introduction ECG, PPG ,FET background and principles Analog circuit analysis and measurement Conclusions and Future Work 1. Introduction Demographic analysis 表一、戶籍登記現住人口數按年齡分 年齡結構百分比 (%) 戶籍人口登記數 年底別 民國92年底 民國93年底 民國94年底 民國95年底 民國96年底 民國97年底 民國98年底 民國99年底 民國100年底 民國101年底 民國102年底 較101年底 增減率(%) 總增加 自然增 社會增 0-14歲 率(‰) 加率(‰) 加率(‰) 22,604,550 3.71 4.27 -0.55 19.83 人數 22,689,122 22,770,383 22,876,527 22,958,360 23,037,031 23,119,772 23,162,123 23,224,912 23,315,822 23,373,517 3.73 3.58 4.65 3.57 3.42 3.59 1.83 2.71 3.91 2.47 3.59 2.92 3.01 2.76 2.40 2.07 0.91 1.88 3.23 1.85 0.25 ②-1.44 ②-1.38 0.14 0.65 1.64 0.81 1.02 1.52 0.92 0.82 0.67 0.62 ②-0.05 性別比例 扶養比 15-64歲 65歲以上 (女=100) (%) 扶幼比 扶老比 老化 指數 (%) 70.94 9.24 103.84 40.97 27.95 13.02 46.58 71.19 71.56 71.88 72.24 72.62 73.03 73.61 74.04 74.22 74.15 9.48 9.74 10.00 10.21 10.43 10.63 10.74 10.89 11.15 11.53 103.53 103.16 102.72 102.28 101.89 101.34 100.94 100.57 100.26 99.96 40.48 39.74 39.12 38.43 37.70 36.93 35.85 35.07 34.74 34.85 27.16 26.14 25.21 24.30 23.34 22.38 21.26 20.37 19.72 19.31 13.31 13.60 13.91 14.13 14.36 14.56 14.59 14.70 15.03 15.55 49.02 52.05 55.17 58.13 61.51 65.05 68.64 72.20 76.21 80.51 ①-0.31 ①-0.07 ①0.38 19.34 18.70 18.12 17.56 16.95 16.34 15.65 15.08 14.63 14.32 ①-0.30 ①0.11 ①-0.41 ①0.52 ①4.30 資料來源:本部戶政司。 說 明:1.自然增加率=(出生人數-死亡人數)÷年中人口數×1,000。 2.社會增加率=(遷入人口數-遷出人口數)÷年中人口數×1,000。 3.總增加率=自然增加率+社會增加率。 4.性別比例=(男性人口數/女性人口數)*100。 5.扶養比=(0-14歲人口+65歲以上人口)/(15-64歲人口)*100。 6.扶幼比=(0-14歲人口)/(15-64歲人口)*100。 7.扶老比=(65歲以上人口)/(15-64歲人口)*100。 8.老化指數=(65歲以上人口)/(0-14歲人口)*100。 備 註:①係指增減百分點。 ②係指增減千分點。 內政部統計處 http://www.moi.gov.tw/stat/news_content.aspx?sn=8057 103/10/13 1. Introduction • 2013 statistical results on causes of death in Taiwan 順 位 1 2 合 ICD-10 國際死因 分類號碼 計 死亡 死 亡 原 因 人數 A00-Y98 所有死亡原因 C00-C97 惡性腫瘤 I01-I02.0, I05-I09, 心臟疾病(高血壓性疾病除外) I20-I25, I27, I30-I52 每十萬人口 標準化 死亡率 死亡率 死亡 百分比 % 154,374 661.3 435.3 100.0 44,791 191.9 130.4 29.0 17,694 75.8 47.7 11.5 11,313 48.5 30.3 7.3 3 I60-I69 腦血管疾病 4 E10-E14 糖尿病 9,438 40.4 25.8 6.1 5 J12-J18 肺炎 9,042 38.7 22.5 5.9 6,619 28.4 22.4 4.3 6 V01-X59, Y85-Y86 事故傷害 7 J40-J47 慢性下呼吸道疾病 5,959 25.5 14.9 3.9 8 I10-I15 高血壓性疾病 5,033 21.6 12.9 3.3 9 K70, K73-K74 慢性肝病及肝硬化 4,843 20.7 14.8 3.1 4,489 19.2 11.9 2.9 35,153 150.6 101.8 22.8 10 N00-N07, N17-N19, 腎炎、腎病症候群及腎病變 N25-N27 其他 衛生福利部 http://www.mohw.gov.tw/cht/Ministry/DM2_P.aspx?f_list_no=7&fod_list_no=4558&doc_no=45347 103/10/13 1. Introduction • ECG background and principles ◦ ECG records the heart in nerve conduction arising from potential changes graphics Photo Source : http://www.bostonscientific.com/lifebeat-online/heart-smart/electrical-system.html 1. Introduction ECG: Advantages: Better signals Disadvantages: 1. Skin irritations 2. Specific preparation before measurements 3. Limitations related to the connecting cables http://140.134.32.60:83/news/test/biotech/bei/bei.html 102/12/9 1. Introduction Capacitive ECG : Advantages: 1. Does not need contact 2. Make continuous for long time monitor 3. An office chair, a bed, a toilet seat , automobile Disadvantages: 1. Still suffer from strong artifacts 2.Paper Review • A Wireless Wearable ECG Sensor for Long-Term Applications IEEE Communications Magazine • January 2012 Ebrahim Nemati, M. Jamal Deen, and Tapas Mondal, McMaster University 2.Paper Review Schematic representation of the ECG system architecture 2.Paper Review Photograph of the designed PCBs Frequency spectrum of the sensor 2.Paper Review Reference Technologies used Implemen Advantages tation Limitation s Y.Yama Capacitive sensing Integrated on cloth Flexible electrodes — 24 mm × 41.7 mm Large FM inconvenient transmitter electrode at 315 MHz S. Fuhrhop Capacitive sensing Integrated on a belt Flexible electrodes Poor integrated into filtering garment Bluetooth A.Aleksand rowicz Capacitive sensing Integrated on chair Un-noticeable onchair electrodes – 4 cm × 8 cm Not for ambulatory applications Zebra Zigbee module Integrated on chair Integrated onchair electrodes – 4 cm × 4 cm Not for ambulatory applications, — Y. G. Lim, K. Capacitive K. Kim sensing, Active shielding Wireless technology 2.Paper Review Referen ce Technologie s used Implementa Advantages tion Limitation s C. Park Capacitive sensing Integrated on cloth and belt Fairly small electrodes (15 mm diameter) Extremely Wireless low-capacity module 2.4 battery GHz E. M. Spinelli Dry-electrode Integrated on sensing, Cloth Active shielding Small electrodes (down to 8 mm diameter) Low signal quality BluesenseAD module Lowest power, relatively small sensor size, ultra-thin electrodes (2 mm) Rigid Electrodes ANT module, extremely low power — 1 mA Proposed Capacitive sensor sensing Integrated on a stretchable cloth Wireless technology 2.Paper Review • Designing Sensitive Wearable Capacitive Sensors for Activity Recognition IEEE Sensors Journal, VOL. 13, NO. 10, OCTOBER 2013 Jingyuan Cheng, Oliver Amft, Gernot Bahle, and Paul Lukowicz 2.Paper Review Analog circuitry of our wearable capacitance measuring approach 2.Paper Review Simplified model of sensor and the human body ◦ Sensor pads (blue) , clothes (green), skin (yellow), muscle (red) ◦ Use SEMCAD X (a) Side view (b) Top view (c) E-density distribution 2.Paper Review Energy density alone the line crossing the center of one pad,with E-field at 10 MHz and different clothes thickness 2.Paper Review • Thin and flexible active electrodes with shield for capacitive electrocardiogram measurement International Federation for Medical and Biological Engineering 2010 Med Biol Eng Comput (2010) 48:447–457 Seung Min Lee , Kyo Sik Sim ,Ko Keun Kim ,Yong Gyu Lim ,Kwang Suk Park 2.Paper Review (a)Cross-sectional view of electrode,(b) Diagram of active electrode with feedback gain to reduce stray capacitance,(c) Top view of electrode,(d) Electrode fixed onto two fingers 2.Paper Review The equivalent circuit Transfer function 2.Paper Review The equivalent circuit Positive feedback can make the amplifier unstable and cause oscillation, which can be reduced by decreasing feedback gain 2.Paper Review Shielding plate with guarding feedback 2.Paper Review Effect of cloth thickness ◦ Cotton cloths, electrode were set to 45 cm² C : The capacitance A : The area of overlap of the two plates εr : Dielectric constant( εr = 1 ,almost air) ε0 : The electric constant (ε0 ≈ 8.854×10−12 F m–1 2.Paper Review Effect of electrode area 2.Paper Review Effect of contact pressure 2.Paper Review ECG measurements 3.Materials and Methods Capacitive coupling electrode —To capture the weak charge with the capacitive coupling electrode must place high impedance and low noise opamp,the induced charge via the resistor (𝑅𝐵) ,converted into a voltage signal output 3.Materials and Methods The equivalent circuit Explanation of terms —𝐶𝑔:The stray capacitance between the human and the ground —𝐶𝑚:The stray capacitance between the instrument and the ground —Cs: The shielding plate stray capacitance —Rsk:Skin impedance —Rc,CC: Active electrode impedance —Rin,Cin:OP impedance 3.Materials and Methods 2 1 1 ) // //( Rin // ) sCm sCs sCin Vo Vs 2 1 2 1 1 //{Rsk Rc //( ) [( Rb ) // //( Rin // )]} sCg sCc sCm sCs sCin 2 1 2 1 [ // Rsk ( Rc // )] //( Rb ) //( Rin // ) sCg sCc sCm sCin AVo 1 2 1 2 1 //{[ Rsk ( Rc // )] //( Rb ) //( Rin // )} sCs sCg sCc sCm sCin ( Rb ∵ 2 𝑆𝐶𝑔 ≫ 𝑅𝑠𝑘 + 𝑅𝑐// 1 𝑆𝐶𝑐 + 𝑅𝑏 + 2 𝑆𝐶𝑚 // 1 𝑆𝐶𝑠 // 𝑅𝑖𝑛// 1 𝑆𝐶𝑖𝑛 3.Materials and Methods Cg Óscas Casas ,2007 [1] Cc Cm Cs l h 20 pF Tobias Wartzek , 2011 [2] 200 pF 21 pF Ko Keun Kim and Kwang Suk Park , 2008 [3] 200 pF 33 pF Emad Alnasser , 2014 [4] 300 Pf Ko Keun Kim , 2005 [5] Seung Min Lee, 2010 [6] Cin Rb Ri n 500 pF 200 pF 500 pf 33 pF 18 40 pF 50 G Ω 18 pF 1.6 G Ω 18 Pf 1.6 G Ω 5 3.Materials and Methods ∴ ⇒ 1 // Rb ) sCc Vo Vs AVo 1 1 1 1 ( Rc // ) ( Rb // ) ( Rc // // Rb ) sCc sCs sCs sCc ( Rb // 1 ) sCs ( Rc // Vo Rb (1 sRcCc ) Vs Rb Rc sRbRc (1 A)Cs Cc 3.Materials and Methods Electrode Gain(As) As gain (a)Eleg1n b NA (a) (b) (b)Eleg01 (c)Eleg09 1 0.9 The equivalent circuit of individual electrode (c) 3.Materials and Methods The verification experiment —Analog circuit experiment ① —Active electrode experiments Each electrode effect of cloth thickness ② (Ⅰ)0.0mm (Ⅱ)0.2mm (Ⅲ) 0.4mm (Ⅳ)0.6mm Each electrode Effect of electrode area ③ 144 cm² 2 3 0.1Hz~100Hz 正弦波 1 0.01Hz~1kHz Sin signal (Ⅰ) 45 cm² (Ⅱ) 100 cm² (Ⅲ) 3.Materials and Methods The verification experiment —ECG simulation experiment ④ SNR 3.Materials and Methods • Analog circuit experiment ① —Use the NI USB-6356 to capture entity circuit output voltage and integrate the data in Matlab —Use the PSpice simulate the analog circuit and compare with captured data then show the frequency response graph 3.Materials and Methods Permittivity A C r 0 d C: Capacitance A: Area d: Distance εr : Relative permittivity (εr= 1 ,almost air) ε0: vacuum permittivity (ε0≈8.854×10−12F m–1) http://zh.wikipedia.org/wiki/%E7%94%B5%E5%AE%B9%E7%8E%87#mediaviewer/File:Diel.gif 3.Materials and Methods • Active electrode experiments Each electrode effect of cloth thickness The actual figure ② —Cotton cloths with thicknesses of (Ⅰ)0.0 mm、(Ⅱ)0.2 mm、 (Ⅲ) 0.4 mm and (Ⅳ)0.6 mm were inserted between the electrode and the copper plate 3.Materials and Methods • Active electrode experiments Each electrode Effect of electrode area ③ —The cloth thickness was selected as 0.2 mm —Three active electrodes with different areas (Ⅰ) 45 cm²、 (Ⅱ) 100 cm²、 (Ⅲ) 144 cm² were examined (Ⅰ) 45 cm² (Ⅱ) 100 cm² (Ⅲ) 144 cm² 3.Materials and Methods • ECG simulation experiment ④ — The cloth thickness was selected as 0.2 mm and active electrodes was selected as 144 cm² — FLUKE MPS450 simulat the ECG signal,output voltage is 2 mv The definition of SNR:Noise is defined before 0.5Hz , 60 Hz and after 100 Hz, signal is defined 0.5 Hz~59 Hz and 61 Hz~100 Hz SNR = 10log 𝑃0.5𝐻𝑧~59𝐻𝑧 + 𝑃61𝐻𝑧~100𝐻𝑧 𝑃<0.5𝐻𝑧 + 𝑃60𝐻𝑧 + 𝑃>100𝐻𝑧 4. Results • Analog circuit experiment ◦The actual circuit diagram 4. Results • Analog circuit experiment ◦All filter and preamplifier ◦PSpice circuit simulation frequency response 4. Results • Analog circuit experiment ◦ All filter and preamplifier circuit Bode 4. Results Analog circuit experiment ◦ Combined the actual circuit result and Pspice result 4. Results • Active electrode experiments ◦ The actual circuit diagram (Eleg1nb) 4. Results • Active electrode experiments ◦ The actual circuit diagram (Eleg01) 4. Results • Active electrode experiments ◦ The actual circuit diagram (Eleg09) 4. Results • Active electrode experiments — Each electrode effect of cloth thickness ② (b) Eleg01 (a) Eleg1nb (c) Eleg09 4. Results • Active electrode experiments —Each electrode Effect of electrode area ③ (b) Eleg01 (a) Eleg1nb (c) Eleg09 4. Results • ECG simulation experiment ④(Area 144 cm², cloth thickness0.2 mm) (a) Eleg1nb (b) Eleg01 (c) Eleg09 SNR Electrode (a)Eleg1n (b)Eleg01 (c)Eleg09 b 訊雜比 12.36 26.56 26.87 4. Results • NI/LabWindows GUI 5.Conclusions and Future Work More simulation and analysis of the electrode Combined with Android References [1] Electrostatic Interference in Contactless Biopotential Measurements Óscas Casas,2007 [2] Triboelectricity in Capacitive Biopotential Measurements , Tobias Wartzek,2010 [3] Effective Coupling Impedance for Power Line Interference in CapacitiveCoupled ECG Measurement System, Ko Keun Kim and Kwang Suk Park, 2008 [4] The Stability Analysis of a Biopotential Measurement System Equipped With Driven-Right-Leg and Shield-Driver Circuits , Emad Alnasser , 2014 [5] Common Mode Noise Cancellation for Electrically Non-Contact ECG Measurement System on a Chair, Ko Keun Kim, 2005 [6] Thin and flexible active electrodes with shield for capacitive electrocardiogram measurement, Seung Min Lee , 2010 Thank you for your attention