ETIOLOGY OF SUBESTANCE DEPENDENCY

advertisement

ETIOLOGY OF

SUBESTANCE

DEPENDENCY

DR MOTAHARE MIRDAMADI psychiatrist

Substance abuse

 the excessive and compulsive use of substance

 for their effect on the mind.

 tolerance to the drug, an increasingly higher dose of the drug is needed.

 withdrawal : it will cause physical problems.

How Drugs & Alcohol Work

 They interact with nerve circuits, centers, and chemical messengers Results;

I Feel Good – Euphoria & Reward

I Feel “Better” – Reduce negative feelings

 This Feels “Normal”

 I’m craving it, tolerating its effects, withdrawing and feeling sick

Common Characteristics of People Who are Addicted

 Unemployed or employed

 Multiple or no criminal justice contacts

 Difficulty coping with stress or anger

Highly influenced by social peer group or a loner

 Difficulty handling high-risk relapse situations or craves excitement

conscious decision or a chronic, relapsing illness

 changes that occur in the brain can turn drug abuse into a chronic, relapsing illness.

First, there is an activation of the brain's "pleasure pathway.

More specifically, genetic factors contribute 40% to 60% to the risk for alcoholism addicts who become dependent early in life are the most genetically predisposed to the disease

MULTI FACTORIAL

major questions concern the etiology of addiction, including the relative roles of genetic and environmental factors, neurochemical and neuroanatomic changes, and the course of the illness

initial drug use

Environmental factors:

 family's beliefs and attitudes

 exposure to a peer group that encourages drug use

Risk factors:

Biologic factor

 Enviroment

 psychologic

Environmental correlates

 influences of family, peers, and availability

 children and adolescents. favorable attitudes or actual use of drugs by parents

 absence of parental support, chaotic living conditions, divorce or separation, and inconsistent parenting styles

 coherent and consistent parenting styles are "protective" against substance abuse

 Have easy access to drugs

environmental factors

 Peer group :modeling and social reinforcement

Availability: For example, living in college dormitories versus living with parents

 gender :male; Although males and females selfreport similar reasons for using drugs

 18 and 44 years of age

 unmarried

 lower socioeconomic status.

environmental factors

 woman's risks for problem drinking include:

 the influence of her partner's drinking,

 her degree of depression,

 her sexual history (including sexual orientation and sexual dysfunction),

 a history of violent victimization (physical and sexual)

alcohol

Genes may influence traits such as impulsivity, which can make a person more likely to become alcoholic.

 Genes may also influence the level of dopamine in the brain

COMMUNITY

Availability of Drugs

Community Laws and Norms Favorable

Toward Drug Use

Transitions and Mobility

Low Neighborhood Attachment and

Community Disorganization

Extreme Economic Deprivation

INDIVIDUAL / PEER

Alienation and Rebelliousness

Friends Who Engage in the Problem

Behavior

Favorable Attitudes Toward the Problem

Behavior

Early Initiation of the Problem Behavior

Constitutional Factors

FAMILY SCHOOL

Family History of the Problem Behavior Early and Persistent Antisocial Behavior

Family Management Problems

Academic Failure Beginning in Late

Elementary School

Lack of Commitment to School Family Conflict

Favorable Parental Attitudes and

Involvement in the Problem Behavior

Peer group

PSYCHOLOGIC FACTORS:

 Have depression, bipolar disorder, anxiety disorders, and schizophrenia,PTSD

 Have low self-esteem, or problems with relationships

 Live a stressful lifestyle, economic or emotional

 Live in a culture where there is a high social acceptance of drug use

Risk factor

Family history of addiction. the effects of many genes

Being male. twice

Having another psychological problem. depression, attentiondeficit/hyperactivity disorder or post-traumatic stress disorder

Peer pressure. young people ;strong factor in starting to abuse drugs.

Lack of family involvement. A lack of attachment and lack of parental supervision.

Anxiety, depression and loneliness. coping with painful psychological feelings.

Taking a highly addictive drug heroin and cocaine

More Common Characteristics

Emotional and psychological immaturity

 Difficulty relating to family

Difficulty sustaining long-term relationships

 Educational and vocational deficits

Co-Occurring Disorders

 Mood Disorder+: 24-40% have a co-occurring substance abuse disorder

 Alcoholism+: 65% of females and 44% of male alcoholics have co-occurring mental health disorder(s)

 THE MAJOR ONE = DEPRESSION

19% of female alcoholics, 4x the rate for men

 antisocial personality

nature of the substance

 crack, heroin or cocaine can bring about addiction more rapidly if a group of people were to take crack every day for six months, versus another take alcohol, the number of crack addicts would be a lot higher than the number of alcoholics.

For some people trying a substance even once can be enough to spark an addiction. Crack, also known as crack cocaine or rock, is a freebase form of cocaine that can be smoked.

start consuming a drug earlier in life have a higher risk of addiction

How the body metabolizes (processes) the substance - in cases of alcohol

Classical conditioning

 physiological positive reinforcement (euphoria) social positive reinforcement (enhanced peer status)

 Physiological negative reinforcement :in warding off a withdrawal reaction

 Social negative reinforcement :escaping from a noxious home, school, or vocational life.

 peer cluster theory

• conditioned stimuli

environmental cues are present during drug use-> drug’s behavioral and physiological effects. With repetition the cues become conditioned stimuli, experiences as drug craving.

Sensitization

Withdrawal creates a craving or desire for the drug and plays a very strong role in recurrent patterns of relapse

Sensitization occurs when the effects of a given dose of a drug increase after repeated administration.

 repeated presentation of the environmental cues, absent the drug, should extinguish the conditioned association.

 he emergence of withdrawal symptoms as a result of exposure to conditioned

 cues can contribute to drug use relapse

cognitive

It has been argued, that substance abusers differ from others:

 beliefs about potential benefits of the drug

 ability to cope with the stress of everyday life

Cognitive

 self-reported motivations

 reasons for which type of substance use:

 motivations for alcohol and marijuana abuse include

"getting away from problems,“

 cocaine and amphetamines involve "staying alert and awake.“

 "self-medicating" motives increase with consumption ,pain relive

Cognitive Deficits

 Memory problems – short-term loss

Impaired abstraction

 failed problem-solving strategies

 Loss of impulse control

 These deficits are similar to those with brain damage

pleasure pathway

The mesocorticolimbic pathway from the ventral tegmental area to the nucleus accumbens and the frontal cortex is a key component of the brain reward system for drug reinforcement

Front of Brain

Amygdala is not lit up

Amygdala is activated

Back of Brain

Nature Video Cocaine Video

Personality

 no evidence for "addictive personality“ distinct personality syndrome: interpersonal alienation, poor impulse control, manifest emotional distress childhood and the quality of parenting received

Sensation seeking

Depressed mood

Low self steem

RF versus protective

Risk Factors Domain

Early Aggressive Behavior Individual

Lack of Parental

Supervision

Family

Substance Abuse

Drug Availability

Peer

School

Poverty Community

Protective Factors

Self-Control

Parental Monitoring

Academic Competence

Anti-drug Use Policies

Strong Neighborhood

Attachment

prevention efforts

Family Management Problems

 Favorable Attitudes Toward the Problem

Behavior

 Social Skills (protective)

 Bonding (protective)

Adolescence

Persons

Individual

Risk Factors Protective factors

Behavioral disengagement coping

Negative emotionality

Conduct disorder

Favorable attitudes toward drugs

Rebelliousness

Early substance use

Antisocial behavior

Positive physical development

Emotional self-regulation

High self-esteem

Good coping skills and problem-solving skills

Engagement and connections in two or more of the following contexts: at school, with peers, in athletics, employment, religion, culture

Infancy/Early Childhood

Individual

Family

Persons

School, Peers, Community

Risk Factors

Difficult temperament

Protective factors

Self-regulation

Secure attachment

Mastery of communication and language skills

Ability to make friends and get along with others

Cold and unresponsive mother behavior

Parental modeling of drug/alcohol use

Reliable support and discipline from caregivers

Responsiveness

Protection from harm and fear

Opportunities to resolve conflict

Adequate socioeconomic resources for the family

Support for early learning

Access to supplemental services such as feeding, and screening for vision and hearing

Stable, secure attachment to childcare provider

Low ratio of caregivers to children

Regulatory systems that support high quality of care

Family Substance use among parents

Lack of adult supervision

Family provides structure, limits, rules, monitoring, and predictability

Supportive relationships with family members

Poor attachment with Clear expectations for behavior and parents values

School, Peers,

Community

School failure

Low commitment to school

Associating with drugusing peers

Not college bound

Aggression toward peers

Norms (e.g., advertising) favorable

Presence of mentors and support for development of skills and interests

Opportunities for engagement within school and community

Positive norms

Clear expectations for behavior

Physical and psychological safety toward alcohol use

Accessibility/ availability

Age of onset

Alcohol and drug use tends to begin in mid-to-late adolescence, though it is greater among individuals who experience early puberty .. A delay in drinking until 20- to 21-years-old reduces the risk of developing alcohol-related problems Youth perception that parents approve of their alcohol or drug use

One of the most consistent risk factors for adolescent drinking is perceived parental approval

(Donovan, 2004). Reported maternal care perception has been shown to be significantly lower among alcohol and those who use multiple drugs (Gerra et al, 2004).

Peers engaging in problem behavior

Associating with drug- or alcohol-using peers, or being rejected by peers, can create problem behaviors and influence attitudes and norms related to substance use (O'Connell et al, 2009).

Exposure to peer problem behavior is correlated with increased alcohol and other substance use in the same month (Dishion et al, 2000). Those who drink in a social setting, or who have peers who do so, are more likely to abuse alcohol later in life (Beck et al, 1996).

Early and persistent problem behaviors, risk-taking, and high sensation-seeking

Early aggressiveness or antisocial behavior persisting into early adolescence predicts later adolescent aggressiveness, drug abuse, and alcohol problems (Hawkins et al, 1995).

Parental monitoring (or perception of monitoring)

Adolescents who report low parental monitoring are significantly more likely to use a variety of substances (Shillington et al, 2005). Positive parental style and close monitoring by parents are proven protective factors for adolescent’s use of alcohol and other drugs (Stewart, 2002).

Parent or older sibling drug use (or perception of use)

Familial alcohol-using behaviors are strong predictors of adolescent alcohol use

(Birckmayer et al, 2004). In a 2003 study, alcohol initiation most often occurred during family gatherings. Moreover, a family history of alcoholism was a significant risk factor for the development of adolescent problem drinking (Warner et al,

2003).

Low perception of harm

Low perception of harm towards alcohol and drug use is a risk factor for use

(Henry et al, 2005). Individuals with attitudes or values favorable to alcohol or drugs are more likely to initiate substance use

Strong parent and adolescent relationship and family cohesion

Adolescents who have a close relationship with their parents are less likely to become alcohol involved (Birckmayer et al, 2004).

Youth access and availability

The majority of alcohol consumed by youth is obtained through social sources, such as parents and friends, at underage parties and at home (Birckmayer et al, 2004). Availability of alcohol or illegal drugs leads to increased use

(Hawkins et al, 1995).

Poor school achievement and low school bonding

Adolescents who have a low commitment to school or do poorly are more likely to become alcohol involved

Download