DISTRIBUTION
plasma-protein binding,
volume of distribution,
barriers (blood- brain and
placental), obesity and
receptor combination
METABOLISM
oral medicines, age, nutrition
and hormones
EXCRETION
renal excretion, drugs affecting elimination of other
drugs, blood concentration levels
II. GENERAL
PRINCIPLES OF DRUG
ADMINISTRATION
&
SAFETY GUIDELINES
GIVING MEDICATIONS
General Principles of Drug Administration
and Safety Guidelines Giving Medications
1. Confirm client diagnosis and appropriateness of
medicines
2. Identify all concurrent medicines and any potential C/I
and allergies
3. Research drug compatibilities, action, purpose, route,
C/I, S/E
4. Calculate dosage accurately especially for pediatric
clients
5. Check for expiration date of medicines
General Principles of Drug Administration
and Safety Guidelines Giving Medications
6. Confirm client’s identity
7. Provide client teachings
8. Stay with client until medicines is gone; do not leave at
bedside
9. After giving medicines, leave client in position of
comfort
10.Give medicines within 30 minutes of prescribed time
General Principles of Drug Administration
and Safety Guidelines Giving Medications
11. To ensure safety do not give a medication that
someone else prepared
12. Know the policies of your office regarding the
administration of medication.
13. Give only the medication(s) that the physician has
order in writing. Do not accept verbal order.
14. Check with the physician if you have any doubt about
a medication or an order.
15. Avoid conversations or other distractions while
drawing up and administering medication. It is
important to remain attentive during this task.
General Principles of Drug Administration
and Safety Guidelines Giving Medications
16. Work in quiet, well lighted area.
17. Check the label when taking the medication from the
shelf, when pouring it, and when replacing it on the
shelf. This is known as the “three checks” for safe
medication administration.
18. Place the order and the medication side by side to
compare its accuracy.
19. Check strengths of the medication (eg. 250 mg versus
500 mg) and the routes (eg. ophthalmic, otic, topical).
20. Read labels carefully. Do not scan labels or orders.
General Principles of Drug Administration
and Safety Guidelines Giving Medications
21. Check the patient’s chart for allergies to components of
the medication.
22. Check the medication’s expiration date.
23. Be alert for color changes, precipitation, odor, or any
indication that the medication’s properties have changed
(especially insulin, nitroglycerin & phenytoin).
24. Measure exactly; there should be no bubbles.
25. Have sharps containers as close to the area of use as
possible.
General Principles of Drug Administration
and Safety Guidelines Giving Medications
26. Put on gloves for all procedures that might result in
contact with blood or body fluids.
27. Stay with the patient while oral medication is being
taken. Watch for any reaction and record the patient’s
response.
28. Never return a medication to the container.
29. Never recap, bend, or break a used needle.
30. Never give a medication poured or drawn up by someone
else.
31. Never leave the medication cabinet unlocked when not in
use.
32. Never give the keys of the medication cabinet to an
unauthorized person. Limit access to the medication
cabinet by limiting access to the cabinet keys.
Even if you are extremely careful, you may make
an error when administering a medication. It is
imperative that you report the error to the physician
and that intervention measures start immediately.
The error and all corrective actions must be
documented thoroughly on the patient’s chart. An
incident report must be completed for the error and
filed in the patient’s chart as verification that all
possible precautions were taken for the patient.
Errors made in charting medications must be
corrected using a standard procedure. If you discover
a charting error, mark it with one line. Then mark the
correction above the error and sign it.
THERAPEUTIC SERUM MEDICATION LEVEL
Acetaminophen
Carbamazepine
Digoxin
Gentamycin
Lithium
Magnesium SO4
Phenytoin
Theophylline
10 – 20 ug/ml
5 – 12 ug/ml
5 – 2 ng/ml
5 – 10 ug/ml
5 – 1.3 mEq/L
4 – 7 mg/dl
10 – 20 ug/ml
10 – 20 ug/ml
Right Client
Right Drug
Right Dose
Right Route
Right Time
Right Documentation
Right Drug Preparation and Administration
IV. GENERAL CONSIDERATIONS FOR
ORAL MEDICINES
1. Assess oral cavity and ability to swallow medicines
2. Enteric-coated medicines must not be crushed. Only scored
tablets can be broken
3. Do not administer alcohol-based products like elixirs to alcohol
dependent persons
4. Have patients swallow medicines except for sublingual and
buccal route. Do not allow fluids 30 minutes after giving
medicines. Give iron preparation using straw to prevent teeth
staining.
5. When giving medicines via NGT, do not mix with food. Give
before or after meals and flush tubing with 30 ml of H2O.
Check for tube patency before giving medications.
V. GENERAL CONSIDERATIONS FOR
PARENTERAL MEDICINES
•Select appropriate needle size and syringe for ID, SQ, IM ROUTES
•Use tuberculin syringe for medicines less than 1 ml
•Draw up air equal to amount of medicines needed
•Inject air to vial to prevent negative pressure and aid in aspirating
medicines
•Ampule: place needle into ampule to draw medicines and use filter
needle to avoid glass shards
•Select and rotate sites avoiding bruised or tender areas
•Insert needle quickly with bevel side up. Aspirate to check for blood
except heparin. If blood is present, remove needle and start again.
For giving IV medicines, blood return is desired
•Apply gentle pressure after giving injections except for heparin and
Z-track.
a. Use 25g to 27g, ½ to 1 inch needle
b. Maximum volume of 1.5 ml
c. Pinch skin to form SC fold and insert at 45
degrees in thigh or arm and 90 degrees in
abdomen
d. Possible sites: lateral aspect of upper arm,
anterior thigh, abdomen…1 inch from
umbilicus and scapular area
EXAMPLES:
Heparin,
Insulin,
MMR,
Enoxaparin (Lovenox)
a.
Use 26g to 27g, 1" needle on a 1 ml or
tuberculin syringe (vol. approximately 0.1 ml)
b. Insert needle at 10-15 angle with 1-2 mm
depth with needle bevel upward
c. When wheal appears, do not massage,
mark
d. Possible sites: ventral forearm, scapula,
upper chest
EXAMPLES:
BCG,
PPD (Purified Protein Derivative)/
Mantoux test
a. Use 18 g to 23 g, 1-2 inch needle, maximum volume is
5ml
b. Stretch skin taut
c. Insert at 90 degrees angle. 45 degrees for infants and
children
d. Possible sites: gluteus medius (ventrogluteal and
dorsogluteal, vastus lateralis (anterior thigh), rectus femoris
(medial thigh) and deltoid
e. For Z-track: 20-22 g, 2-3 inches long with a different
needle to draw medicines; draw skin laterally with nondominant hand to ensure that medicines enter muscle; wait
10 sections before removing injection; do not massage to
lock irritating substances in place
EXAMPLES:
Vit.K, Hep. B, DPT, Iron dextran (Z-track)
a. Check site for complications (redness, swelling,
tenderness)
b. Check blood return
c. Prepare medicines according to manufacturer’s
specifications
d. Prepare tubing according to requirement: micro or
macro tubing
e. Change tubing and dress site every 24-72 days
depending on hospital policy and label appropriately
f. Never hang solutions more than 24 hours
g. Use syringe infusers and infusion pumps
EXAMPLES:
vancomycin (Vancocin), amphoterecin B, cisplatin
(Platinol), fluorouracil (5-FU), Oxytocin, Mannitol
a. Monitor the risk for fluid overload
especially in patients with respiratory, cardiac,
renal and liver diseases. Elderly clients and
very young clients cannot tolerate excessive
fluid volume
b. Clients with CHF cannot tolerate solutions
containing sodium
c. Clients with diabetes mellitus does not
typically receive dextrose (glucose) solutions
d. Lactated Ringer’s Solution contain
potassium and should not be given to clients
with renal failure
A. INFECTION
• LOCAL: redness, swelling and drainage at site
• SYSTEMIC: fever, chills, HA, tachycardia, malaise
The longer the site, the higher the risk
At risk are HIV/Aids patients and those
receiving chemotherapy
Assess for the S/Sx of infection, maintain strict
asepsis in IV site care, monitor WBC, check the
integrity of solutions, change tubings and
dressings q 24-72 hrs, prepare to obtain blood
culture from venipuncture device
B. PHLEBITIS/THROMBOPHLEBITIS
• PHLEBITIS: Redness, heat and tenderness at
site, sluggish IV
• THROMBOPHLEBITIS: Hard and cordlike vein
Use IV cannula smaller than vein
Avoid lower extremities and areas of
flexion as the site
C. INFILTRATION
• Edema, pain and coolness at the site d/t seepage
of IV fluid outside vein and into the interstitial space;
• May or may not have blood return
Caused when devise dislodged or perforates
vein or when vein backs up pressure d/t venospasm
Infiltrated if no backflow of blood upon
lowering fluid container or after occluding the
vein proximal to site and IV continues to flow
Remove infiltrated IV, elevate extremity and
apply cold or warm compress based on MD’s
order
D. CIRCULATORY OVERLOAD
• Increased BP, distended jugular veins, rapid
breathing dyspnea, moist cough and crackles
Use infusion pump esp. for clients at risk of
overload and time tape
If it occurs, KVO rate, elevate head of bed,
assess for edema and inform MD
If these occurs, remove and restart in
opposite extremity apply warm and moist
compress; inform doctor
E. AIR EMBOLISM
• Increased BP, distended jugular veins, rapid
breathing dyspnea, moist cough and crackles
Occurs when air bolus enters vein through
inadequately primed IV line, from loose connection,
tubing change and IV removal
If S/Sx occur, clamp the tubing, turn the
patient on the left side with the head lowered
(Trendelenburg position) to trap area in the right
atrium, call MD right away
VI. CONSIDERATIONS IN GIVING
OPTHALMIC MEDICINES
1. Have patient lie on back or sit with head turned to the
affected side to facilitate gravitational flow.
2. Cleanse eyelids and eyelashes with sterile gauze pads
soaked with physiologic saline.
3. Keep eye open by pulling down on cheekbone with thumb
and pointer finger to expose lower conjunctiva.
4. Place the necessary drops near the outer canthus and away
from cornea.
5. If using ointment, squeeze into lower conjunctiva and
move from inner to outer canthus. Do not touch tip to the eye
and twist tube to break medication stream.
VI. CONSIDERATIONS IN GIVING
OPTHALMIC MEDICINES
6. Let patient blink 2-3 times
7. Press on nasolacrimal glands (to prevent systemic
absortion, a perfect example is atropinr sulfate)
8. Wipe excess medicines starting from inner canthus
9. Droppers and ointments are for individual clients and
never shared.
VII. CONSIDERATIONS IN GIVING
OTIC MEDICINES
1. Clean outer ear using wet gauze pad.
2. Straighten ear canal:
Pull pinna up and back for adults
Pull pinna down and back for children under 3
3. Instill necessary number of drops along side of canal
without touching ear with dropper. Maintain ear position
until medicines has totally entered canal
4. Have client remain on side for 5-10 minutes to allow
medicines to reach to reach inner ear.
VIII. CONSIDERATIONS IN GIVING
TOPICAL MEDICINES
1. Cleanse area to remove old medicines using gauze with
soap and warm water
2. Spread medication evenly and thinly wearing gloves if the
skin is broken
3. When applying nitroglycerin ointment, take the client’s BP
5 minutes before and after application
4. Wash hands after applying to prevent self-absorption
5. For transderm patches, wear gloves to prevent self
absorption and place in an area with little hair. Press down
edges to secure patch
IX. CONSIDERATIONS IN GIVING
VAGINAL MEDICINES
1. Let client void
2. Drape to provide privacy and wear gloves
3. Place client on bedpan in a dorsal recumbent position with
hips and knees flexed
4. Cleanse perineum with warm, soapy water working from
inner to outer
IX. CONSIDERATIONS IN GIVING
VAGINAL MEDICINES
5. Moisten suppository with water-soluble lubricant
6. Separate labia and insert 2 inches…angled downward and
backward
7. Provide pillow under buttocks and let patient remain in that
position for 15-20 minutes (no sphincter to hold
suppository in place)
8. Provide with pads
X. CONSIDERATIONS IN GIVING
RECTAL MEDICINES
1. Check patient’s bowel function/ability to retain the enema
or suppository
2. Store suppositories in the refrigerator
3. Provide privacy and position client left laterally
4. Don gloves and moisten suppository with water-soluble
lubricant
5. Insert suppository tapered end 1st and insert 2 inches to
pass the internal sphincter
6. Hold buttocks together.
7. Encourage patient to retain:
Suppositories for 10-20 minutes
Enema for 20-30 minutes
XI. NEUROLOGIC MEDICINES
Nervous System
CNS
Brain
Spinal Cord
PNS
Somatic
Automatic
Adrenergic
1. Alpha
2. Beta
Cholinergic
XI. NEUROLOGIC MEDICINES
1. ANALGESICS
A. Narcotic Analgesics
Actions: Combines with opiate receptors in CNS. Reduces stimuli
from sensory nerve endings; pain threshold is increased.
DON’T GIVE TO PATIENT’S WITH: Alcoholism, respiratory, renal
or hepatic disease, increased intracranial pressure, severe heart
disease.
AVOID MIXING WITH THIS DRUGS: Alcohol and/ or CNS
depressants, barbiturates, anxiolytics, any products with alcohol.
MAOIs may result in a fatal reaction.
XI. NEUROLOGIC MEDICINES
1. ANALGESICS
A. Narcotic Analgesics
Interventions: Monitor RR, bowel sounds, VS, and pain for type
location, intensity, and duration. Dilute and administer IV solution
slowly to prevent CNS depression and possible cardiac arrest.
Hold medication if respirations <12/min. with the adult or <20/min.
with the child. Have Narcan available.
Education: No ambulating without assistance; no driving. Instruct
to take before pain is too severe. Dependence on drug is not likely
for short –term medical needs. Do not abruptly withdraw
medication.
MAJOR SIDE EFFECTS OF NARCOTICS
(this is according to prioritization):
#1. Respiratory Depression
(check the respiratory rate first!)
#2. Orthostatic Hypotension
(check the blood pressure before and
after taking the drug)
#3. Constipation decreases peristalsis)
MORPHINE-LIKE DERIVATIVES
Morphine (roxanol)- the best drug for MI
NEVER GIVE TO PANCREATITIS AND
CHOLELITHIASIS because it will contract the
SPHINCTER of ODDI.
= Codeine (Codeine SO4) & Hydrocodone
(hycodan) COMMONLY USED AS AN ANTITUSSIVE (cough suppressant)
= Levorphanol (Levodromoran)
MEPERIDINE-LIKE DERIVATIVES
• Meperidine (Demerol) never give to patients
with increase ICP. It masks the symptoms of
respiratory depression!
• Fentanyl (Sublimaze)
METHADONE-LIKE DERIVATIVES
• Methadone( Dolophine) the #1
preferred drug of choice for heroin
withdrawal. Propoxyphene (Darvon)
contains aspirin NEVER give to
hemorrhagic shock.
a. Others Narcotics:
Code: morphone/ codone
hydrocodone (Hycodan); hydromorphone
(Dilaudid);
oxycodone (Roxicodone); oxymorphone
(Numorphan);
Others: Dezocine (Dalgan); fentanyl
(Sublimaze), levomethadyl (ORLAAM);
levorphanol (Levo-Dromoran); remifentanil
(Ultiva); sufentanil (Sufenta). Butorphanol
Tartrate (Stadol), Nalbuphine, Pentazocine
b. Narcotic Antagonists
(Antidote for Narcotic poisoning)
• Naloxone (Narcan)
• Naltrexone (Trexan, Revia)
• Nalmefene (Revex)
c. Non-Steroidal Anti-Inflammatory
A. NSAIDS
1. ASA (Aspirin) – anti-platelet aggregator, antiinflammatory and analgesic
* the best drug for rheumatoid arthritis
*always with meals (causes Peptic ulcer)
*used in strokes and MI
*ototoxic (early side effect: tinnitus and
vertigo)
*be careful in giving to individuals with Viral
illness such as chicken pox because there is a
risk for REYES SYNDROME (liver damage is
evident)
* avoid giving to individuals with bleeding
tendencies and potential for blood dyscrasia
such as thrombolytics , anticoagulants, ginko
biloba, and phenytoin.
A. NSAIDS
2. Para – chlorobenzoic Acid (Indoles)
Indomethacin (Indocin)
Sulindac (Clinoril)
Tolmetin (Tolectin)
3. Pyrazolone derivatives: Phenylbutazone
(Butazolidin)
A. NSAIDS
Proprionic Acid Derivatives
Ibuprofen (Motrin, Advil, Nuprin)
Fenoprofen Calcium (Nalfon)
Naproxen (Naprosyn)
Flurbiprofen Sodium (Ansaid, Ocufen)
Ketoprofen (Orudis)
Oxaprozin (Daypro)
7.
Phenylacetic Acid Derivatives
Ethodolac (Lodine)
Diclofenac Sodium (Voltaren)
Ketorolac tromethamine (Toradol)
8.
COX-2 INHIBIOTORS
Celecoxib (Celebrex)
Meloxicaqm (Mobic)
Rofecoxib (Vioxx)
9. Miscellaneous Analgesic Agents
Acetaminophen (Tylenol)
1. Acetaminophen (Tylenol)
*hepatotoxic ( monitor SGPT/ALT)
*with food
A. NSAIDS
ANXIOLYTICS/ANTI-ANXIETY
Another word: Sedatives/Hypnotics/Minor Tranquilizer
For: Delirium, anti-anxiety, insomnia
ACTION: Increases GABA (gamma amino butyric acid)
USES:
Major Use
to reduce anxiety; also induce sedation, relax muscles,
inhibit convulsion; Used in neuroses, psychosomatic
disorders, functional psychiatric disorders.
DO NOT modify psychotic behavior.
Most commonly prescribed drugs in medicine
Greatest harm: When combined with ALCOHOL
ANXIOLYTICS/ANTI-ANXIETY
I. BENZODIAZEPINE
Code: ZEPAM / ZOLAM
Action:
Anticonvulsant, muscle relaxant & anxiolytic
Diazepam (Valium)* best for: Status epilepticus ,
the best for delirium tremens (alcohol &
cocaine withdrawal
ANXIOLYTICS/ANTI-ANXIETY
I. BENZODIAZEPINE
Estazolam (Prosom)
Alprazolam (Xanax)
Chlorazepate (Tranxene)
Oxazepam (Serax)*
The best in sundown syndrome
(seen in Alzheimers)
Advantage: Not hepatotoxic
ANXIOLYTICS/ANTI-ANXIETY
I. BENZODIAZEPINE
Lorazepam (Ativan)* 2nd drug for sundown syndrome
Triazolam (Halcion)* Anti-insomnia
Temazepam (Restoril)* Anti-insomnia
Flurazepam (Dalmane)*
Anti-insomnia; do not stop abruptly 
because of rebound grand mal seizure
Midazolam (Dormicum)
Prazepam (Centrax)
ANXIOLYTICS/ANTI-ANXIETY
I. BENZODIAZEPINE
Chlordiazepoxide (Librium)* 2nd drug of choice for
delirium tremens
Chlordiazepoxide (Librium), multivitamins, thiamine and
folic acid help decrease withdrawal symptoms of
alcohol withdrawal. Positive outcome of Librium in
alcoholic depressed woman includes an observation
that client can pick an object on floor w/ smooth
coordination
Clonazepam (Klonopin)
Halazepam (Paxipam)
ANXIOLYTICS/ANTI-ANXIETY
I. BENZODIAZEPINE
Side Effects #1: Vital sign to be monitored:
Respiratory Rate due to its Lethal Side Effect;
Respiratory Depression
1. Early Side effects  decrease LOC 
Lethargic Late/Fatal side effects decrease RR 
Respiratory Depression  RR below 12
Avoid strenuous activities
Antidote for Benzodiazepine intoxication:
FLUMAZENIL (ROMAZICON); an anxiolytic
antagonist
ANXIOLYTICS/ANTI-ANXIETY
II. BARBITURATES
Action:
Used as an anticonvulsant besides
being a sedative
Code: TAL / AL
Secobarbital (seconal)
Phenobarbital (luminal)*
commonly used anticonvulsant barbiturate
Methohexital (Brevital)
Amobarbital (Amital)
Methobarbital (Methalba)
ANXIOLYTICS/ANTI-ANXIETY
III. A TYPICAL ANXIOLYTICS
Meprobamate (Equanil, Milltown)
Chloral Hydrate (Noctec)
Hydroxyzine (Atarax, Iterax, Vistaril)*
anti emetic & antihistamine
Diphenhydramine (Benadryl)*
Antiparkinsons, Antihistamine,and an
Anxiolytic (addictive)
Zolpidem (Ambien, Stillnox) sleeping aid
Doxylamine (Unisom) sleeping aid
Buspirone (Buspar)* will take 1 week
before the effect could be seen
a. Barbiturates (given above)
b. Benzodiazepines (given above)
c. Hydantoins (code: toin)
Phenytoin (Dilantin)  best anticonvulsant
petit mal seizures for children
SE: Gingival hyperplasia & pinkish urine,
alopecia, hyperglycemia, Intervention:
Massage the gums & use soft bristle
toothbrush
Hydantoins
Adverse Effect: Blood dyscrasia- thrombocytopenia
S/SX: Bleeding of the gums
Lab test: Platelet count = 150,000-400,000;
if ↓100,000-active bleeding
Special Considerations:
The only COMPATIBLE I.V. Solution for Phenytoin
(dilantin) is NSS (Normal Saline Solution)
• Ethotoin (Peganone)
• Mephenetoin (Mesantoin)
d. Miscellaneous
e. Carbamazepine (Tegretol)  trigeminal neuralgia
(tic douloureux) A/E: Agranulocytosis –
S/Sx: Sore throat
MgSO4
The best tocolytic for premature labor, also
efficient as an anti-convulsant for Eclampsia or PIH.
Early side effects: decrease deep tendon reflex
and oliguria (renal failure).
Fatal/Late Side Effect: Respiratory Depression
(assess the RR if it is below 12 /min).
Valproic Acid (Depakene) therapeutic serum level:
40-100 mcg
Adverse Reaction: Hepatotoxic (assess SGPT or ALT)
e.Succinimides (code: suximide)
Ethosuximide (Zarantoin)
Methoximide (Celontin)
Phensuximide (Milontin)
ANTIPSYCHOTICS
Another word: Neuroleptic / Major Tranquilizers
USES: Schizophrenia, acute mania, depression
and organic conditions; Non-psychiatric cases:
Nausea and vomiting, pre-anesthesia, intractable
hiccups.
Antipsychotics can only decrease the positive
symptoms of schizophrenia, but not the negative
symptom such as ambivalence.
Action:↓ delusion, hallucinations, looseness of
association to decrease levels of dopamine in the
ANTIPSYCHOTICS
I. PHENOTHIAZINE
Code: AZINE
Fluphenazine (Prolixin)*
Acetophenazine (Tindal)
Pherphenazine (Trilafon)
Promazine (Sparine)
Chlorpromazine (Thorazine)*#1 that causes
photosensitivity/photophobia;
Side effects: Causes also red orange urine. In liquid
form is usually put in a chaser  Chaser: 60-100ml
juice (prone or tomato); to prevent constipation &
contact dermatitis; taken with straw
(bite straw & sip)
ANTIPSYCHOTICS
MESORIDAZINE (SERENTIL)
Thioridazine (Mellaril)*
ceiling dose/day: 800 mg 
Adverse Effect:
Retinitis pigmentosa
Prochlorperazine (Compazine)*
#1 commonly used anti emetic
Trifluoperazine (Stelazine)
ANTIPSYCHOTICS
II. BUTYROPHENONES
Code: PERIDOL
Haloperidol (Haldol, Serenase)* #1 drug used
for extreme violent behavior
Instruct patient taking Haldol to wear
sunscreen
Droperidol (Inapsine)
III. THIOXANTHENES
Code: THIXENE
Chlorprothixene (Taractan)
Thiothixene (Navane)
ANTIPSYCHOTICS
IV. ATYPICAL ANTIPSYCHOTICS
Code: DONE / ZAPINE or APINE
Olanzapine (Zyprexia)
Clozapine (Clozaril) #1 that causes Agranulocytosis &
Blood Dyscrasia
“I will need to monitor my blood level to continue my
medication.” shows a correct understanding of a patient
while taking Clozaril.
Loxapine (Loxitane)
Risperidone (Risperidone) #1 drug for
Korsakoff’s psychosis
Molindone (Moban)
Aripiprazole (Abilify) newest antipsychotic drug
SIX COMMON
ANTICHOLINERGIC SIDE EFFECTS
OF ANTIPSYCHOTICS
(Anticholinergic effects are drug actions of
antipsychotic drugs because they BLOCK
MUSCARINIC CHOLINERGIC RECEPTORS)
CODE: BUCO PanDan – anticholinergic S/Es
CODE: BUCO PanDan – anticholinergic S/Es
1. Blurring of Vision - ↑ sympathetic reaction
(don’t operate machinery);
Mydriatic – pupil dilate  sympa  ↑ IOP 
don’t use in glaucoma
2. Urinary Retention –
Nursing Interventions:
1. Provide Privacy – give bed pan
2. Sounds of dripping water – faucet
3. Intermittent cold & warm compress
CODE: BUCO PanDan – anticholinergic S/Es
3. Constipation
Nursing Interventions:
1. Prevent constipation ↑ fiber
(residue) roughage, prune/pineapple/papaya
juice/ fruits.
2. ↑ OFI
3. ↑exercise
CODE: BUCO PanDan – anticholinergic S/Es
4. Orthostatic Hypotension/Postural Hypotension
Difference of BP 15-20 mm Hg above the
diastole after sudden changing of position
S/Sx: Pallor, dizziness
Nursing consideration:
Slowly change position
Told patient to dangle feet first before
standing
CODE: BUCO PanDan – anticholinergic S/Es
5. Pan Photosensitivity (photophobia)
Nursing Intervention:
1. Use sun glasses, sun block, long
sleeves or/and umbrella. Patients taking
antipsychotic should be instructed to wear
wide brimmed hat when going outside
6. Dan Dry mouth/ Xerostomia
Prioritized Nursing Intervention:
Give (1) ice chips, (2) chewing gum,
(3) sips of water
ANTIDEPRESSANTS
or
THYMOLEPTICS
ANTIDEPRESSANTS or THYMOLEPTICS
I. SELECTIVE SEROTONIN REUPTAKE
INHIBITORS (SSRIs)
Usually the FIRST LINE of drug.
RATIONALE: FEWER SIDE EFFECTS
Action: Balance Serotonin – gradual effect
(usually 2 weeks)
Effect: 2 wks.
ANTIDEPRESSANTS or THYMOLEPTICS
I.
SELECTIVE SEROTONIN REUPTAKE INHIBITORS (SSRIs)
Code: XETINE/ODONE
Fluoxetine HCl (Prozac) – causes too much
dry mouth (xerostomia)
Paroxetine HCl (Paxil)
Trazodone (Desyrel)) – adverse effect:
Priapism (prolonged use)
Nefazodone (Serzone)
Fluvoxamine (Luvox)
Sertraline (Zoloft) – causes GI upset
(diarrhea, insomnia): always with meals
Venlafaxine (Effexor)
Citalopram (Celexia)
COMMON SIDE EFFECTS:
1. Weight Loss
2. Insomnia (single am dose)
Nursing Considerations:
1. For insomnia:
a. Induce sleep thru:
1. Warm bath (systemic effect)
2. Warm milk/banana (active
substance: tryptophan)
3. Massage
b. Give meds in single AM dose
Antidepressants are best taken after meals
ANTIDEPRESSANTS or THYMOLEPTICS
II. SECOND GENERATION TRICYCLIC ANTI DEPRESSANT
Action: Increases norepinephrine and/or
serotonin levels in CNS by blocking their
uptake by presynaptic neurons or it
balances Serotonin & Epinephrine levels.
Effect: 2-4 wks.
ANTIDEPRESSANTS or THYMOLEPTICS
II. SECOND GENERATION TRICYCLIC ANTI DEPRESSANT
Code: PRAMINE/TRYPTILLINE
Clomipramine HCl (Anaframil) #1 for OCD*
Imipramine (Tofranil)* the best drug for
enuresis
Amitryptilline (Elavil)
Protryphilline (Vivactil)
Maprotilline (Ludiomil)
Norpramine (Desipramine) #1
antidepressant for elderly depression.
RATIONALE: Fewer anticholinergic S/E
ANTIDEPRESSANTS or THYMOLEPTICS
II. SECOND GENERATION TRICYCLIC ANTI DEPRESSANT
Code: PRAMINE/TRYPTILLINE
Nortryptilline (Pamelor, Aventyl)
Trimipramine ( Surmontil)
Buproprion (Wellbutrin) 400 mg/day*(ceiling dose)
EXCESS INTAKE:
Grand mal seizure
Doxepine (Sinequan)
Amoxapine (Asendin)
COMMON SIDE EFFECTS:
1. Sedation (best given at night)
2. Weight gain
Nursing Consideration:
1. Give meds at night
#1 adverse effect – cardiac dysrhythmias
#1 screening test before taking TCA – ECG
When a depressed client taking TCA shows no
improvement in the symptoms, the nurse must
anticipate the physician to discontinue TCA after two
weeks and start on Parnate.
Nursing intervention before giving the drug
includes checking the BP to assess for orthostatic
hypotension.
ANTIDEPRESSANTS or THYMOLEPTICS
III. MAOI – MONO AMINE OXIDESE INHIBITOR
ACTION: Psychomotor stimulator or psychic
energizers; block oxidative deamination of naturally
occurring monoamines (epinephrine,
NOREPINEPHRINE, serotonin) → CNS
stimulation
Effect: 2 weeks
CODE: PAMMANA
Parnate (tranylcypromine)
Marplan (Isocarboxacid)
Mannerix (Moclobemide) *the newest MAOI
Nardil (Phenelzine SO4)
ANTIDEPRESSANTS or THYMOLEPTICS
III. MAOI – MONO AMINE OXIDESE INHIBITOR
CONTAINDICATIONS: TYRAMINE + MAOI =
HYPERTENSIVE CRISIS
1. Tyramine rich-food, high in Na & cholesterol
Hypertensive Crisis
1. Aged cheese (except cottage cheese, cream
cheese), Cheddar cheese and Swiss cheese are
high in tyramine and should be avoided.
2. Canned foods such as sardines, soy sauce &
catsup
3. Organ meats (chicken gizzard & liver) & Process
foods (salami/bacon) ↑ Na
4. Red wine (alcohol)
ANTIDEPRESSANTS or THYMOLEPTICS
III. MAOI – MONO AMINE OXIDESE INHIBITOR
5. Soy sauce
6. Cheese burger
7. Banana, papaya, avocado, raisins (all over ripe
fruits except apricot)
8. Yogurt, sour cream, margarine;
9. Mayonnaise
10. OTC decongestants
11. Pickled foods, Pickled herring
12. Other Foods contraindicated in MAOI therapy
includes figs, bologna, chicken liver, meat
tenderizer, , sausage, chocolate, licorice, yeast,
sauerkrauts.
ANTIDEPRESSANTS or THYMOLEPTICS
III. MAOI – MONO AMINE OXIDESE INHIBITOR
Antidote for Hypertensive Crisis: CALCIUM
CHANNEL BLOCKERS (-DIPINE)
1. Verapamil (Calan)
2. Phentolamine (Regitine) 
also the #1drug for Pheochromocytoma
(tumor in the medulla)
ANTICOAGULANTS
ANTICOAGULANTS
CODE: PARIN, RIN
Indication: to prevent clot formation. Used
in MI, cardiac catheterization, pulmonary
embolism.
Warfarin (Coumadin)
Heparin , Enoxaparin (Lovenox), Ardeparin,
Dalteparin
COMPARISON OF CHARACTERISTICS OF
ANTICOAGULANT DRUGS
Heparin
Coumadin
Immediate
Slow (24-48hrs)
Parenteral
Oral
Duration of Action:
Short (<4hrs)
Long (approximately 2-5 days)
Lab Test:
PTT or APTT
PT
Antidote:
Protamine SO4
Vitamin K or aquamephyton
Cost
Expensive
Inexpensive
Onset of Action:
Route of
Administration:
1. WARFARIN
Action:
 Interferes with the hepatic synthesis of
vitamin K-clotting factors (II, VII, IX,
and X)
Indication:
 Prevents or slow extension of a blood
clot
Undesirable
Effects:
 Anorexia, nausea, diarrhea; rash;
bleeding, hematuria, thrombocytopenia,
hemorrhage
Warnings:
 Pregnancy; hemorrhagic tendencies
such as hemophilia, thromb-ocytopenia
purpura, leukemia; peptic ulcer; cerebral
vascular accident (CVA); severe renal.
 DIC, Blood dyscrasia, liver & kidney
diseases
Other Specific
AVOID THE FOLLOWING !!!!
Information H2 blockers , Aspirin, Phenytoin, Oral
:
Hypoglycemics & NSAIDS ( avoid
HAPON!)
Foods: Green leafy vegetables (Vitamin K)
decrease Effectiveness (i.e. asparagus,
cabbage, cauliflower, turnip greens, and
other green leafy vegetables)
 Drugs: decrease Effectiveness - Phenytoin
Oral contraceptives, Rifampin,Estrogen
(PORE). Increase Risk of bleeding with
chamomile, garlic, ginger, ginkgo, and
ginseng therapy. There are numerous
interactions.
Interventions:
A Warfarin’s antidote is Vitamin K
(Aquamephytoin). Laboratory test is PT
 Check all drugs for potential drug-drug
interactions.
Education:
Evaluation of PT/INR will be required to regulate
dosage. Report any unusual bleeding. Review a diet
low in vitamin K. Wear a medical identification card
or jewelry. No strenuous activities (skydiving, long
distance running, football). Review bleeding protocol
(i.e., electronic razors, soft toothbrushes, etc.)
Medical Alert:
Always advise other providers (i.e., dentists, surgeon,
etc.) of medication.
No OTC medication without provider approval.
Evaluation:
PT will have a value of 1.5 to 2.5 times the control
value in seconds; the INR will be 2-3. Normal PT is
9-11 seconds times 1.5 to 2.5 times the normal value.
The client will have no signs or symptoms of
bleeding.
2. HEPARIN SODIUM
Action:
 Combines with antithrombin III to retard
thrombin activity.
 Low molecular-weight heparin blocks factor Xa,
factor IIa.
Indications:




Undesirable
Effects:
 Hemorrhagic tendencies: hematuria, bleeding
gums, frank hemorrhage
Other Specific
Informatio:
 Risk of bleeding with chamomile, garlic, ginger,
ginkgo, and ginseng therapy.
Thrombosis
Reduces risk of myocardial infraction (MI)
CVA
Clots associated with atrial fibrillation: pulmonary
embolism
Interventions:
Monitor PTT (usually 1.5- 2.5 times control
values) and platelet count.
Monitor for signs of unusual bleeding
(petechiae, hematuria. GI bleeding, gum
bleeding).
Initiate bleeding protocol measures (use
electric razors, hold pressure for 5 minutes
with venipunctures, soft toothbrushes).
Monitor IV site carefully.
Heparin has short half life, therefore, with
discontinuation, PTT will usually return to
baseline within 1-2 hours.
Have protamine sulfate available as an
antidote.
*Monitor clotting time; normal is 8-15 minutes;
maintain
clotting time 15-20 minutes
Education:
Inject SQ into the abdomen with 25-28g at 90
degrees
 angle; don’t aspirate or rub injection site
 Explain bleeding protocol precautions.
 Explain the need of several PTT
evaluation.
 Teach signs of unusual bleeding.
 Avoid activities with risk of injury.
 Caution with sharp utensils while cooking
or eating.
 Avoid salicylates or any OTC medication
without approval from provider.
 Wear identification that notes
anticoagulant therapy.
 Inform provider of therapy prior to
surgical procedure.
Evaluation:
Heparin’s antidote is Protamine
Sulfate. Laboratory test is aPTT.
Normal PTT is 60-70 seconds
Normal aPTT is 20-36 seconds times
1.5 to 2.5 times the normal value.
Drugs:
 Heparin Sodium (Hyperlin)
 Low
Molecular
Weight
Ardeparin
(Normiflo);
(Frafmin);
Danaparoid
Enoxaparin (Lovenox)
Heparins:
Dalteparin
(Organ);
THROMBOLYTIC MEDICINES
CODE: ASE / KINASE
Example: Alteplase / Urokinase/ Streptokinase/
Reteplase/ Retavase
Salteplase (Activase, t-PA tissue plasminogen activator);
Abbokinase, Streptase, Kabikinase)
THROMBOLYTIC MEDICINES
Action:
Binds with plasminogen causing
conversion to plasmin which dissolves
blood clots. Activates plasminogen
which generates plasmin .
 The best drug to DISSOLVE clot ,
such as pulmonary embolism &
myocardial infarction
Indications:  Dissolves blood clots due to coronary
artery thrombi, deep vein thrombosis,
and pulmonary embolism.
. Used 4-6 hrs after MI to restore blood
flow, limit myocardial damage, and
preserve left ventricular function.
THROMBOLYTIC MEDICINES
Warnings:
 Active internal bleeding; recent CVA;
aneurysm, hypertension; anticoagulant
therapy; ulcerative colitis.
 Severe allergic reactions to either
anistreplase or streptokinase.
Other
Specific
Information:
Monitor for bleeding, hypotension &
tachycardia .Handle clients minimally & let
clients use electric razors & brush teeth
gently.
 Effects of drug disappear within a few hours
after discontinuing but the systemic effect of
coagulation and the risk of bleeding may
persist for 24 hours.
 Increase in risk for bleeding with heparin,
oral anticoagulants, antiplatelet drugs and
NSAIDs.
THROMBOLYTIC MEDICINES
Interventions  Apply direct pressure over a puncture
site for 20 – 30 minutes
:
 Monitor CBC especially hgb/hct, coagulation
tests.
 Evaluate bleeding at a sutured wound,
arterial site, central line.
 Monitor vital signs during and after infusion.
 Monitor EKG for re-perfusion dysrhythmias.
 Watch for unusual bleeding disturbance (GI,
GU)
 Initiate bleeding protocol measures for
several hours (e.g., no venipunctures,
repetitive manual blood pressure, or removal
of IV lines or catheters).
Antidote:
Aminocaproic Acid (Amicar)
ANTIPLATELET: ASPIRIN
Action:
 Platelet aggregation inhibitor; inhibitis
platelet synthesis of thromboxane A2, a
vasoconstrictor and inducer of platelet
aggregation. This occurs at low doses and
lasts for 8 days (life of the platelet).
Indications:
 TIAs, CVAs with a history of TIA due to fibrin
platelet emboli.
 Reduces risk of death from MI in clients with
a history of infarction or unstable angina.
Warnings:
 Allergy to salicylates or NSAIDs.
 Bleeding disorders, renal or hepatic
disorders, chickenpox, influenza (risk
of Reye’s in syndrome in children),
pregnancy, lactation.
ANTIPLATELET: ASPIRIN
Warnings:
 Allergy to salicylates or NSAIDs.
 Bleeding disorders, renal or hepatic
disorders, chickenpox, influenza (risk
of Reye’s in syndrome in children),
pregnancy, lactation.
Undesirable
Effects:
 GI discomfort, bleeding, dizziness,
tinnitus
Other
Specific
Information:
  Risk of bleeding with anticoagulants,
thrombolytics
  Risk of GI ulceration with alcohol,
NSAIDs, phenylbutazone, steroids.
ANTIPLATELET: ASPIRIN
Interventions:
 Monitor liver and renal function tests, CBC,
clotting times, stool guaiac, blood drug
levels, and vital signs.
Education:
 Instruct to take drug with food and a full glass of
water.
 Do not crush and do not chew sustained-release
preparations.
Drugs:
COMMON DRUGS: Code: D CAT
Dipyridamole(persantine)
Clopidogrel(plavix)
Aspirin(ASA)
Ticlopidine(Ticlid)
 Aspirin (Bayer, Bufferin, Ecotrin)
 Other antiplatelet drugs are listed below,
however, there are numerous differences
between each drug : Abciximab (Reopro);
Cilostazol (Pletal); Eptifibatide (Integrilin);
Sulinpyrazone (Anturane); Tirofiban (Aggrastat)
CARDIOVASCULAR DRUGS
CARDIOVASCULAR DRUGS
ANTIHYPERTENSIVES
CODE NAME: AAABCCD (short cut for anti-hypertensi
Angiotensin Converting Enzyme Inhibitor or Antagonist
(ACE Inhibitor)
Angiotensin II Receptor Blocker (ARBS)
Alpha Adrenergic Blockers
Beta Adrenergic Blockers
Calcium Channel Blockers
Central Acting Sympatholytics /Adrenergic Blockers
Direct Acting Vasodilators
Angiotensin Converting Enzyme Inhibitor or Antagonist
(ACE Inhibitor)
Angiotensin Converting Enzyme Inhibitor or
Antagonist (ACE Inhibitor)
ACTION: prevent vasoconstriction by blocking
angiotensin 1 to angiotensin 2
USE: hypertension, adjunctive therapy in CHF,
PREVENTS SEVERE HEART FAILURE following
M.I. in clients with
IMPAIRED LEFT VENTRICULAR FUNCTION
and prevents kidney failure in Type 2 Diabetes.
EXAMPLES: Captopril (Capoten)
ONE HOUR BEFORE MEALS
Enalapril (Vasotec)
Ramipril (Altace)
Side Effects: CHIT – B
C: cough persistent
H: Hyperkalemia and
Hypoglycemia
I: Impotence and Insomnia
T: Taste decreases
B: Bleeding
Angiotensin II Receptor Blocker
(ARBS)
ACTION: blocks the binding of angiotensin II
to the Angiotensin 1 , and also blocks the
release of aldosterone resulting in a decrease
BP.
USE: Hypertension
Code: SARTAN
Examples: Losartan (Cozaar)
Eprosartan (Teveten)
Candesartan (Atacand)
Side Effects: Upper Respiratory Infection
(cough); Diarrhea
Adverse Effect: Nephrotoxic / Hepatotoxic
ALPHA ADRENERGIC BLOCKERS
ACTION: blocks the alpha 1 adrenergic
receptors resulting in vasodilation of arteries
and veins, decreases peripheral resistance and
relaxes smooth muscle of bladder and prostate.
USE: Hypertension, Prazocin used in CHF and
Doxazocin used in BPH.
Code: ZOCIN
Examples:
Doxazocin (Cardura)
Prazocin (Minipress)
Terazocin (Hytrin)
ALPHA ADRENERGIC BLOCKERS
SIDE EFFECTS: SI – DUD
Syncope
Impotence
Depression
Urination
Dry mouth
ADVERSE EFFECTS:
Nephrotoxicity
BETA ADRENERGIC BLOCKERS
ACTION: binds to beta 1 (cardiac) and beta 2
(lungs) adrenergic receptors sites that prevents
the release of catecholamine.
USE: Angina, Hypertension, anxiety disorders,
as a Group II anti dysrhythmias
CODE: OLOL
BETA ADRENERGIC BLOCKERS
SIDE EFFECTS:
P - BBNDAH
Psychotic Features
Bradycardia
Bronchoconstriction
Nightmares
Depression
Agranulocytosis
Hypoglycemia
NEVER USED IN PATIENTS WITH COPD, CVA,
CHF, HEPATIC DISEASE, GRAVES, and
BRADYCARDIA
CALCIUM CHANNEL BLOCKERS
ACTION: Decrease contractility (negative
inotropic effect by relaxing the smooth
muscle) and the workload of the heart thus
decreasing the need for oxygen. It also
causes coronary and peripheral
vasodilation.
USE: Group IV antidysrythmia, vasodilator
and anti hypertensive drug.
CALCIUM CHANNEL BLOCKERS
CODE: DIPINE
except Verapamil (Calan) and Diltiazem
(Cardizem)
SIDE EFFECTS: CAP
Constipation
AV block
(therefore never give it to patients with CHF)
Peripheral Edema
ADVERSE EFFECTS:
Hepatotoxic and Nephrotoxic
CENTRAL ACTING SYMPTHOLYTICS /
ADNEGERNIC BLOCKERS
ACTION: Decreases the release of adrenergic
hormones from the brain resulting in decrease
peripheral vascular resistance and blood
pressure.
MC G
Methyldopa (Aldomet)
Clonidine (Catapress)
Guanabenz (Wytensin)
CENTRAL ACTING SYMPTHOLYTICS /
ADNEGERNIC BLOCKERS
SIDE EFFECTS: DIES
Depression
Impotence
Edema (if more than 4 lbs/week)
Sodium & Water retention
ADVERSE EFFECT:
Hepatotoxic
DIRECT ACTING VASODILATORS
ACTION: uses arterial vasodilatation
Nitroglycerin causes DECREASE LAV M
DECREASE Left Ventricular
Workload
DECREASE Arterial BP
DECREASE Venous return
DECREASE Myocardial O2
Consumption
DIRECT ACTING VASODILATORS
SIDE EFFECTS:
HEN G
Headaches (orthostatic Hypotension)
Edema
Nasal Congestion
GI Bleeding
Examples: D MANN
Diazoxide (Hyperstat)
Minoxidil (Lomiten)
Apresoline (Hydralazine)
Nitropruside (Nipride)
NITROGLYCERIN (Nitrobid, Nitrostat)
Action:
 Relaxes the vascular smooth system.
 ↓ Myocardial demand for oxygen.
 ↓ Left ventricular preload by dilating
veins thus indirectly ↓ afterload.
Undesirable
Effects:
 Headache (most common),
hypotension, postural hypotension,
syncope, dizziness, weakness, reflex
tachycardia, paradoxical bradycardia.
 Sublingual: burning, tingling sensation
in mouth.
 Ointment erythematous, vesicular and
pruritic lesions.
NITROGLYCERIN (Nitrobid, Nitrostat)
Interventions:  Record characteristics and precipitating
factors of anginal pain.
 Monitor BP and apical pulse before
administration and periodically after
dose.
 Have client sit or lie down if taking drug
for the first time.
 Client must have continuing EKG
monitoring for IV administration.
 Cardioverter / defibrillator must not be
discharged through paddle electrode
overlying Nitro-Bid ointment or the
Transderm-Nitro patch (may cause burns
on client).
 Assist with ambulating if dizzy.
NITROGLYCERIN (Nitrobid, Nitrostat)
Education:
 Avoid alcohol.
 Teach to recognize symptoms of hypotension.
 Advise to make position changes slowly and to
avoid prolonged standing.
 Teach about the form of nitroglycerin prescribed.
 Oral: Instruct to take on an empty stomach with
a full glass of water. Do not chew tablet
 Sublingual: Instruct to take at first sign of anginal
pain. May be repeated every 5 minutes to a
maximum of 3 doses. If the client doesn’t
experience relief, advise to seek medical
assistance immediately.
 A stinging or biting sensation may indicate the
tablet is fresh. With newer SL nitroglycerin, the
biting sensation may not be present.
 Protect drug from light moisture, and heat.
 Instruct to apply Transderm-Nitro patch once a
day, usually in the morning.
 Rotation of sites is necessary.
NITROGLYCERIN (Nitrobid, Nitrostat)
Drugs:
 Nitroglycerin intravenous
(Nitro-Bid IV, Tridil)
 Sublingual (Nitrostat)
 Sustained-release
(Nitroglyn, Nitrong, Nitro-Time)
 Topical
(Nitro-Bid, Nitrol, Nitrong, Nitrostat)
 Transdermal (Deponit, Minitran,
Nitro-Dur, Nitrodisc, Transderm-Nitro,
Nitro-Derm)
 Translingual (Nitrolingual)
 Transmucosal (Nitrogard)
CARDIAC GLYCOSIDES
Code:
Dig
Example:
Digoxin (lanoxin)
Digitoxin (Crystodigin)
CARDIAC GLYCOSIDES
Action:
 Inhibits the sodium-potassium ATPase,
resulting in cardiac construction.
 Effect: Positive Inotropic
(increase Contraction of the heart)
Negative Chronotropic (slows Cardiac ratedepresses SA node- bradycardia)
Negative Dromotropic (slows conduction
velocity)
Indication:
 THE BEST DRUG OF CHOICE FOR CHF
 for CHF, atrial tachycardia, atrial fibrillation &
atrial flutter.
CARDIAC GLYCOSIDES
Side Effects:
1st / Initial: Nausea & Vomiting(adult)
Confusion(elderly)
2nd: Bradycardia
3rd: Hypokalemia (highest in K rich food is
apricot and avocado, next is potato and
raisins)
Adverse Rxn/ Late: Yellow & Green Vision
Special Consideration: Never give with
FOOD. Check the pulse before & after
giving. Compare the apical and the radial
pulse in a FULL minute. Check the
therapeutic serum level which is .5- 2
ng/ml
Contraindicated: MI, heart blocks & PVC
CARDIAC GLYCOSIDES
Other
Significant
Information:
 ↓ K; ↓ Mg”, and ↑ Ca “may be associated with
digitalis toxicity.
 Administer separately from antacids (1 to 2 hours
apart).
 Use cautiously with calcium channel blockers or
beta blockers.
Interventions:
 Monitor K+, Mg++, ECG, liver/renal function tests,
drug level (therapeutic level 0.5-2.0 ng/ml. toxity
is > 2.0 ng/mL).
 Before each dose, assess apical pulse for full
minute; record and report changes in rate or
rhythm.
 Withhold drug and contact provider if pulse is <
60/minute or > 100 (adults) or <1 10 minute
(children) unless provider has outlined specific
parameters.
 Weigh daily, monitor I O, and signs has CHF.
CARDIAC GLYCOSIDES
Education:
 Teach to take pulse correctly and report
if pulse is out of parameter.
 Weigh every other day and record.
 Restrict alcohol, sodium and smoking.
 Eat food rich in potassium.
 Wear medical alert tag. Emphasize
importance of regular checkups.
Evaluation:  Normal sinus rhythm on ECG. Clinical
improvement as evidenced by no S3,
edema, etc.
 Cardiomegaly decreased.
Antidote
Antidote: Digibind Fab
ANTIHYPERTENSIVE
ANTIHYPERTENSIVE
STEP 1. Diuretic
(1st step for younger clients with tachycardia and marked liability of BP)
STEP 2. Beta-Blocking Agent
Beta 1 Adrenergic (Cardioselective) Blocking Agents:
Acetabulol (Sectral); Atenolol (Tenormin); Metoprolol
(Betaloc)
Beta 1 and 2 (Nonselective) Blocking Agents:
Nadolol (Corgard), Pindolol (Visken), Propranolol
(Inderal, Novopranol), Timolol
Adrenergic Inhibiting Agent
Clonidine, Methyldopa, Reserpine, Prazoline
Usually diuretic added to prevent fluid retention
STEP 3. Vasodilator Agent
Hydralazine
Added with adrenergic blocking agent and diuretic decrease
workload
STEP 4. Guanethedine, Minoxidil or Angiotensin Inhibitors
Captopril or Analapril
ANTIDYSRHYTHMIC
ANTIDYSRHYTHMIC
GROUP 1 - Generally inhibit the fast sodium
channel in cardiac muscle resulting in an
increased refractory period
a.Disopyramide phosphate (Norpace);
Procainimide HCl (Procan); Quinidine
(Quinidex)
b.Lidocaine (Xylocaine)
c. Flecainide
ANTIDYSRHYTHMIC
GROUP 2-Beta blockers that decrease stimulation of the heart
•Beta 1 Selective Antagonists
Cardiogenic Blockers; Block Beta 1 cardiac receptors
Atelonol (Ternonim), Acebutolol Sectral, Metoprolol
(Betaloc)
•Beta 2 Selective Antagonists
Mucolytics and Bronchodilators
•Nonseletive Beta Adrenergic Blocking Agents; (Beta 1 and
Beta 2 Blockers)
Nadolol (Corgard); Oxyprenelol (Trasicor); Pindolol (Visken);
ANTIDYSRHYTHMIC
Group 3 - Generally do not affect depolarization but
work by prolonging cardiac repolarization
• Anti adrenergic; Positive inotropic action
• Bretylium, Amiodarone HCl (Cordarone)
Group 4
• Calcium antagonist action - Depression of heart
and smooth muscle contraction, decreased
atomaticity and decreased conduction velocity
• Verapamil
RESPIRATORY AGENTS
1. BRONCHODILATORS
Respiratory Agents
a. Breathing and Coughing Techniques: This will
facilitate the removal of respiratory secretions and
optimize oxygen exchange.
b. Relation Techniques: Since anxiety may result in
respiratory difficulty, review ways to alleviate anxiety
such as music and relaxation techniques.
c. Evaluate Heart Rate and BP: Teach client to monitor
heart rate and BP since an undesirable effect of these
medications may be tachycardia, cardiac arrthymias, and
a change in blood pressure. (Beta2, Adrenergic Agonists
can cause hypertension; methylxanthines can cause
hypotension at theophylline levels > 30-35 mcg/ml.)
1. BRONCHODILATORS
Respiratory Agents
d. Arm Identification: Recommend clients having
asthmatic attacks to wear an ID bracelet or tag.
e. Tremors: Evaluate client for tremors from these
medications.
Have 8 or more glasses of fluids. Fluid will assist in
decreasing the viscosity of the respiratory secretions.
f. Emphasize No Smoking: Encourage the client to stop
smoking under medical supervision.
2. ANTIHISTAMINES
Respiratory Agents
CODE: tadine, amine, ramine
Action:
Blocks histamine at H, receptors
Indications:
Upper respiratory allergic disorders,
anaphylactic reactions; blood transfusion
reactions; acute urticaria; motion sickness.
Warnings:
Allergies, acute asthmatic attack,
respiratory disease, hepatic disorder,
narrow-angle glaucoma, symptomatic
prostatic hypertrophy, pregnancy,
lactation.
CODE: BUCO PD
Blurring of Vision, Urinary Retention,
Constipation, Orthostatic Hypotension,
Photosensitivity & Dry Mouth
Side Effects:
2. ANTIHISTAMINES
Respiratory Agents
Interventions:  Monitor vital signs, intake and output. If
secretions are thick, use a humidifier.
Education:
 Instruct client to take with food; drink
minimum of 8 glasses of fluid per day.
 Advise to do frequent mouth care; may use
sugarless gum, lozenges, or candy.
 Notify provider if confusion or other
undesirable effects occur.
 Instruct client not to drive or operate
machinery if drowsiness occurs or until
response to drug has been determined.
 For prophylaxis of motion sickness,
recommend taking 30-60 minutes before
traveling. Avoid alcohol and other CNS
depressants.
2. ANTIHISTAMINES
Drugs:
Respiratory Agents
Loratadine, Azatadine, Cyproheptadine,
Cyproheptadine (Periactin),
Diphenhydramine, Chlorpheniramine,
Dexchlorpheniramine (Polaramine),
Doxylamine, Phenylpropanolamine,
Brompheniramine
 Others: Azelastine (Astelin); Buclizine
(Bucladin-S); Cetirizine (Zyrtec);
Clemastine (Tavist); Cyclizine (Mazerine);
Dimenhydrinate (Dramamine);
Fexofenadine (Allegra); Hydroxyzine
(Atarax, Vistaril); Loratidine (Claritin);
Meclizine (Antivert); Promethazine
(Phenergan); Tripelen-namine (PBZ)
3. BRONCHODILATOR
Respiratory Agents
CODE: terol, terenol, phrine, phylline
Action:
 Stimulates beta receptors in lung.
Relaxes bronchial smooth muscle.
 Increases vital capacity, decreases
airway resistance.
Indications:  the best drug for COPD or CAL
(chronic airflow limitation)
 Asthma, bronchitis, emphysema, relief
of bronchospasm occurring during
anesthesia, exercised-induced
bronchospasm.
Warnings:
 Hypersensitivity, angina, tachycardia,
cardiac arrhythmias, hypertension,
cardiac disease, narrow-angle
glaucoma, hepatic disease.
3. BRONCHODILATOR
Respiratory Agents
Side effects:
 Sympathetic Side Effects such as
palpitation, tachycardia, restlessness,
nervousness, Hyperglycemia,
hypertension, cardiac dysrhythmias.
 Caution with clients with glaucoma & HPN
Other
Specific
Information:
Special Consideration: Avoid Upperscaffeine, cola & tea. Be careful in
giving bronchodilators with DIABETES
(hypoglycemia). Remember that the
therapeutic serum level of theophylline
is 10-20mcg/ml. Theophylline when
given intravenously should be given
SLOWLY. If not sympathetic reactions
will occur.
3. BRONCHODILATOR
Respiratory Agents
Interventions:
 Check for cardiac dysrhythmias.
Education:
 Notify provider taking other medicines or if
symptoms are not relieved. Watch our for status
asthmaticus.
 Demonstrate correct use of inhalers or nebulizers.
Teach about metered-dose inhalers (MDI). When
two puffs are needed, 1-3 minutes should lapse
between two puffs. A spacer may be used to
increase the delivery of the medication. Always
prioritized using FIRST the bronchodilator before
using steroids or another drug such as a
mucolytic.
* Avoid caffeine products
Drugs:
Albuterol, Isoproterenol, Formoterol, Bitolterol,
Levalbuterol, Epinephrine,
Aminophylline,Theophylline, Oxtriphylline
4. STEROIDS
Respiratory Agents
CODE: sone, one, solone
Action:
 Synthesized by adrenal cortex.
 Exhibits antiinflamatory properties
suppress the normal immune response.
 Increases carbohydrate, fat and protein
metabolism.
Indications:  Adrenal replacement therapy,
immunosuppressant and increases fat
& carbohydrate metabolism
 Antiinflammatory, immunosuppressant
dermatological disorders
 Replacement in adrenal cortical
insufficiency.
4. STEROIDS
Respiratory Agents
Undesirable
Effects:
Code name: GO CHAT!!!
G.I. upset, Osteoporosis, Cushing like
symptoms & Calcium is decrease, High
glucose & Sodium, Addisonian Crisis (if
abruptly withdrawn) , Tachycardia .
 Initial Side Effect: Hyperglycemia
 Late Side Effect: Immunocompromised
Other
Specific
Information:
 Always with food may cause Peptic Ulcer,
monitor BP for Hypertension, do not
abruptly discontinue the drug ,may cause
Addisonian Crisis, Moon Face, Cushing
like Symptoms
Interventions:
 Monitor VS, BP, weight, blood glucose,
electrolytes, EKG, and TB skin test
results.
4. STEROIDS
Education:
Respiratory Agents
 Special Considerations: Always With Food. Gradually
Taper. Do not receive vaccination .High Calcium diet &
Vitamin D. Steroids mask the symptoms of Infection.
Avoid Potassium wasting diuretics – it increases
HYPOKALEMIA.
Anticoagulants decrease the effects of Steroids.
 Instruct to administer oral drugs with food or milk
early in the morning, withdraw medication slowly or
taper off gradually under medical supervision.
 Follow-up visits and lab tests are essential.
 Avoid infection.
 Wounds may heal slowly.
 Do not receive vaccination.
 Do not take aspirin or any medication without
consulting provider.
 Discuss a diet low in sodium, high in vitamin D, protein
and potassium.
 Avoid sun light on treated area.
 Recommend wearing a medical alert tag.
4. STEROIDS
Drugs:





Respiratory Agents
CODE: SONE, ONE, SOLONE
Common Medications: (Baby) Bethamethasone (Celestone)
usually given to premature infants, to increase Lung maturity),
Dexamethasone (Decadron), Prednisone(Deltasone),
Hydrocortisone (Solu-cortef), Prednisolone (Prelone),
Triamcinolone (Azmacort, Kenalog, Nasacort-O)
Topical: Alclometasone (Acolvate); Amcinonide (Cylocort); Clobetasol
(Ternovate); Cortisone (Cortone-O); Desoride (Tridesilone);
Desoximetasone (Topicort);
IM, IV, OP, IN, IH); Fluocinolone (Synalar, Synemol); Flurandrenolide
(Cordran); Fluocasone (Cutivate, Flonase-IN); Halcmonide (Halog);
Halobetasol (Ultravate); Hydrocortisone (Cort-Dome, Cortef,
Hydrocortone, Solu-Cortef – mO, IM, IV, SubQ, R); Mometasone
(Elocon); ; Prednicarbate (Dermatop);
Inhalation, intranasal: Beclomethasone (Beclovent, Vanceril,
Benconase, Vancenase); Budesonide (Rhinocort-IN only); Flunisolide
(Aerobid, Nasalide);; Oral; Fludrocortisone (Florinef);
Methylprednisolone (Medrol, Solu-Medrol – IM, IV); Prednisolone
(Delta-Cortef, Hydeltra, Hydeltrasol – IM, IV, Il, IA); Prednisone
(Deltasone, Meticorten, Orasone).
Ophthalmic: Fluorometholone (FML); Nmexolone (Vexol).
GIT MEDICINES
1. ANTACIDS AND MUCOSAL PROTECTIVES
GIT Medicines
react with gastric acid to produce neutral salts or salts of low
acidity
inactivate pepsin and enhance mucosal protection but do not
coat ulcer to protect from acid & pepsin
used for patients with PUD & GRF (gastroesophageal
reflex disease)
antacid tablets should be chewed and followed with
glass of H2O or milk
administer 1 hour – 2 hours apart from other meds to
minimize the chance of drug interactions
1. ANTACIDS AND MUCOSAL PROTECTIVES
GIT Medicines
 Sucralfate (Carafate)
CODE:
Sucralfate (S for STOMACH EMPTY!)
Carafate (CONSTIPATION IS THE SIDE EFFECT!)
creates a protective barrier against acid &
pepsin
given po & on an empty stomach
A/R: constipation, impede absorption of
warfarin Na,phenytoin, theophylline, digoxin &
some antibiotics…
Administer 2 hours apart from these meds
1. ANTACIDS AND MUCOSAL PROTECTIVES
GIT Medicines
 Magnesium Hydroxide (Milk of Magnesia)
rapid acting & A/R is diarrhea
usually combined with aluminum hydroxide to
counter diarrhea
1. ANTACIDS AND MUCOSAL PROTECTIVES
GIT Medicines
 Alumni Hydroxide (Amphoiel, Alu-Cap)
slow acting & A/R: constipation
with significant Na content…caution in clients
with HPN & Heart failure; reduce effect of
tetracyclines, warfarin Na & digoxin
reduce phosphate absorption (USED IN
CRF- Chronic Renal Failure)
1. ANTACIDS AND MUCOSAL PROTECTIVES
GIT Medicines
 Sodium Bicarbonate
rapid onset
A/R: liberates CO2 & increases intraabdominal pressure causing flatulence,
caution in clients with HPN & heart
failure, systemic alkalosis in clients with
renal failure
 Calcium Carbonate (Tums)
rapid acting & A/R: constipation
2. H2 BLOCKERS
•suppress secretion of gastric acid
•indicated for PUD & heart burn & for GRF
( gastro esophageal reflux disease)
CODE: TIDINE
Cimetidine (Tagamet)
Ranitidine (Zantac)
Famotidine (Pepcid)
GIT Medicines
2. H2 BLOCKERS
GIT Medicines
cimetidine (Tagamet)
*taken on an empty stomach
*administered 1 hour apart from antacids
*crosses the blood-brain barrier & may cause mental
confusion, agitation, anxiety & disorientation
*dosages of these meds are reduced when taken
together: warfarin Na, phenytoin, theophyllin &
lidocaine
ranitidine (Zantac)
*not affected by food
*S/E are uncommon & does not cross blood-brain barrier
3. PANCREATIC ENZYME REPLACEMENT
GIT Medicines
CODE: PREFIX is PANCREA
Pancreatin (Creon)
Pancrelipase (Cotazym, Viokase, Pancrease)
*used to supplement pancreatic enzymes
*taken with meals or snacks
*interacts with calcium carbonate & magnesium
hydroxide
4. MEDICINES FOR HEPATIC
ENCEHALOPATHY
GIT Medicines
LACTULOSE (CEPHULAC)
*reduces the ammonia level
*given p.o. in the form of a syrup
*improves CHON tolerance in clients with
advanced liver cirrhosis
*lowers colonic pH from 7 to 5; acidification pulls ammonia
into the bowel to be excreted in the feces thus decreasing the
ammonia level
NEOMYCIN (MYCIFRADIN)
*reduces the number of colonic bacteria that normally
convert urea & amino acids into ammonia
*given p.o. or via NGT
*used with caution in clients with kidney impairment
5. LAXATIVES
GIT Medicines
BULK FORMING LAXATIVES
psyllium hydrophillic mucilloid (Metamucil)
*absorbs water into the feces & increase bulk to form large and
soft stools
*C/I bowel obstruction
*A/R: dehydration, electrolyte imbalance & dependent
STOOL SOFTENERS
docusate calcium (Surfak), docusate sodium (Colace)
*inhibit the absorption of H2O so fecal mass remains large &
soft
*used to avoid straining
*Commonly used in CVA, MI, post op head surgeries,
glaucoma and post op eye injuries so as to decrease
straining and chances of complications.
5. LAXATIVES
GIT Medicines
LUBRICANTS
Mineral oil
*soften stools, ease strain of passing stools;
lessen the rritation of hemorrhoids
*interferes with absorption of fat-soluble
vitamins A, D, E, K
*Never use in pregnant women, may trigger
premature labor
6. STIMULANTS CATHARTICS
GIT Medicines
biscodyl (Dulcolax): give 1 hour before/after
antacids & milk cascara
(Castor Oil): effect 2-6 hours; give with juice
*stimulate motility of large intestine
SALINE CATHARTICS
Glycerin suppositories (Senokot); Mg hydroxide
*Attract H2O to large intestine to produce bulk,
stimulate peristalsis & effect begins in 2-6 hours