Author(s): Michael Hortsch, Ph.D., 2010
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Histology of the Liver and Gallbladder Second Look
Michael Hortsch, Ph.D.
Department of Cell and Developmental Biology
University of Michigan
© 2010 Michael Hortsch
The white lines indicate what kind of liver subdivision ?
How is it defined ?
Starting at the bottom portal triad, indicate how blood is
distributed in this liver lobule. Name the different vessels that
participate in blood supply and drainage.
Identify the
vessels that are
marked by the
colored arrows.
Name the vessels that are
encircled by the different
dashed lines.
How many portal triads do you see in this image ?
Name the
structure
indicated by
the arrow.
How many central veins do you see in this image ?
Identify the opening that
is encircled by the red
dashed line.
Identify the opening that
is encircled by the green
dashed line.
What is the arrangement
of liver cells called that is
indicated by the blue
dashed lines ?
*
*
Identify the cells
that are marked by
the different
colored asterisks.
* *
*
*
*
Identify the cell outlined in this
electron micrograph.
Use this opportunity to review the
appearance of cell organelles in
high power electron micrographs
(this micrograph is not the best for this purpose).
List as many functions of this cell
type as you can remember.
Image courtesy of Dorothy Sorenson,
University of Michigan
Name the cell that is
outlined by the blue
dashed lines.
Name the area that is
outlined by the red
dashed lines.
What cells, cellular structures and proteins do you expect to find in
the space of Disse ?
*
Name the cell that
is marked by the
red asterisk. What
general type of cell
is this and what is
its main function in
the liver ?
Find some
Kupffer cells
in the image
on the left.
Name some
visible
features that
will help you
to identify
Kupffer cells.
Identify the cells that are indicated by the arrows.
This section of liver tissue was stained using the PAS method.
The red stain in the hepatocyte cells is indicative of what substance ?
What is the
area of liver
tissue called
that is
indicated by
the lines ?
I
II
III
Which area represents the location of hepatocytes that are
most resistant to malnutrition ?
How is it
defined and
why is it a
useful
concept ?
Central
vein
What is this pathological change called that is
depicted in the image above ?
This is a special
silver-stained
section of a liver.
Name the dark
brown/black lines.
*
Identify the structure that is
indicated by the red circle.
Identify the two cells marked by the
blue asterisks.
*
Name the cellular
structure that is
found in the liver
tissue and
depicted in this
electron
micrograph.
What does the
dark stain between
the cells, which is
indicated by the
red arrows,
represent ?
Identify the organ outlined by the green dashed line.
What is the main function of the gallbladder ?
The gallbladder
is lined by
which type of
epithelium ?
Masson trichrome stained
Identify the tissue type in the
insert.
Name a substance that controls
the activity of the gallbladder
muscularis externa.
Attributions by Slide
Slide 3:
Michigan Histology 001_HISTO_40X.svs
Slide 4:
Michigan Histology 001_HISTO_40X.svs
Slide 5:
Michigan Histology 001_HISTO_40X.svs
Slide 6:
Michigan Histology 223 - Liver_001.svs portal triad 12%
Slide 7:
Michigan Histology 001_HISTO_40X.svs
Slide 8:
Michigan Histology 001_HISTO_40X.svs
Slide 9:
Michigan Histology 001_HISTO_40X.svs
Slide 10:
Michigan Histology 219 - Liver_001.svs central vein 12%
Slide 11:
Michigan Histology 220 - Liver_001.svs sinusoids 12%
Slide 12:
Michigan Histology 220 - Liver_001.svs Hepatocyte 55%
Slide 13:
Image courtesy of Dorothy Sorenson, University of Michigan
Slide 14:
Michigan Histology 220 - Liver_001.svs Kupffer cell 40%
Slide 15:
Michigan Histology 194_HISTO_40X.svs
Slide 16:
Michigan Histology 001_HISTO_40X.svs
Slide 17:
Image courtesy of Don McCallum
Slide 18:
Michigan Histology 001_HISTO_40X.svs
Slide 19:
Image courtesy of Don MacCallum (malaria infected hamster liver)
Slide 20:
Michigan Histology 198-1_HISTO_20X.svs
Slide 21:
Michigan Histology 223 - Liver_001.svs bile canaliculus 26% and 49%
Slide 22:
Michigan Histology 223 - Liver_001.svs bile duct 40%
Slide 23:
Michigan Histology 194_HISTO_40X.svs gall bladder appr 5%
Slide 24:
Michigan Histology Slide Collection Slide 195 trichrome 40x
Slide 25:
Michigan Histology 194_HISTO_40X.svs gallbladder wall 22% and 79%
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