PhenX Obesity Community Outreach Response Report June 19, 2015 The PhenX Obesity Community Outreach was available between June 4 and June 18, 2015. 8 people responded to the outreach e-mail. 6 respondents completed the value section of the measures table. There were 32 visits to the PhenX Portal page that included the full datasheets for each measure and protocol. The table below provides the measures and the votes received from respondents. General and specific comments are included after the table. I. Protocol Rankings Proposed PhenX Obesity Measures Measure Description of Measurement Protocol The Eating Disorder Examination© (EDE) (Edition 17.0D) is a clinical interview assessment of eating disorder psychopathology. The interview includes items related to the respondent behaviors which are potentially indicative of 1. an eating disorder over the past four weeks (28 days). Psychopathology The Eating Disorders Examination Questionnaire © (EDEof Eating Q) is a self-report questionnaire based on the Eating Disorders Disorders Examination Interview. The questionnaire includes twenty-eight questions related to the respondent behaviors over the past four weeks (28 days) which may be indicative of an eating disorder and with height and weight. The Three Factor Eating Questionnaire - TFEQ-18 is an 18 2. Dietary item self-administered questionnaire with Likert style Restraint questions. The Dietary Screener Questionnaire (DSQ) is a 30 item questionnaire. It was administered by interviewers in the National Health and Nutrition Examination Survey 3. Dietary Intake (NHANES) 2009-2010 series. The self-report questionnaire includes items about frequency of intake of various food items (per month, daily, etc.). A SAS scoring program is included. The Night Eating Questionnaire© (NEQ) is a selfadministered 14-item questionnaire with Likert style 4. Night Eating responses to assess night eating behaviors and identify Night Eating Syndrome (NES). 5. Weight This is a single item measure of an individual’s weight Change Goals change goals. This is a single item, three part measure taken from the 6. Use of Growing Up Today Study (GUTS) that assesses use and Creatine Growth frequency of various products (e.g., creatine, growth Hormone and hormone, steroids) to improve muscle mass or strength in Steroids the past year. 7. Free Fatty This protocol provides instructions for drawing, processing, Acids and storing blood according to the National Health and Yes No Did Not Respond 5 0 3 5 1 2 4 1 3 5 1 2 3 3 2 6 0 2 4 1 3 4 0 4 Nutrition Examination Survey (NHANES) and uses capillary gas chromatography with flame ionization or electron ionization to capture negative chemical ionization mass spectrometry to measure the plasma sample. This protocol provides instructions for drawing, processing, and storing blood from the National Health and Nutrition 8. Gut and Examination Survey (NHANES) 2007–2008 protocol. Pancreatic Analysis of the following gut and pancreatic peptides is Peptides recommended: Amylin, Ghrelin, PPY (3-36), PPY (total), GIP (total), GPL-1 (active), and Pancreatic polypeptide PP. 3 This is a bioassay to measure Leptin and High Molecular Weight (HMW) Adiponectin (primary bioactive form with insulin-sensitizing activity whose circulating levels negatively correlate with obesity, insulin resistance, and coronary artery disease). This measure utilizes the National Health 9. Adipocytokine and Nutrition Examination Study (NHANES) protocol instructions for drawing, processing, and storing blood and commercial specimen collection kits and ELIZA methods to quantify protein levels of human leptin in serum, plasma, supernatant, and other biological fluids. 3 Adult: The Eating Disorder Examination© (EDE) (14th 10. edition) Version 14.3 – Bariatric Surgery Version (EDE-BSV) Psychopathology is a clinical interview assessment of eating disorder of Eating psychopathology for individuals considering bariatric Disorders surgery or with a history of bariatric surgery. The interview Bariatric Surgery includes items related to the respondent behaviors which - Adult are potentially indicative of an eating disorder over the past four weeks (28 days). 2 The protocol requires extracting data for percent free or reduced price lunch from the Digest of Education Statistics. 11. Free or Researchers can use these freely available datasets to Reduced Price obtain additional information for enhanced analysis and School Lunch research on education-related outcomes and treatment services in specific communities. 4 This Metabolomic Studies protocol provides general sample collection recommendations for metabolomic studies, giving 12. input on quantity, preparation and handling of specimens. It Metabolomics also includes the general procedure for cell treatment for metabolomic analysis. 4 This 30-40 minute process (not including the 30-minute rest period required prior to the start of the measure) for measuring basal and resting metabolic rates using indirect 13. Basal calorimetry, a measure of resting energy expenditure. Using Metabolic and an indirect calorimeter or similar instrument, investigators Resting measure the concentrations of oxygen and carbon dioxide Metabolic Rate in air streams entering and exiting a clear plastic hood placed over the participant’s head. Oxygen consumption and carbon dioxide production are calculated from the change in concentration and flow rate. 4 II. General Comments Family history related questions about obesity are also important. 1 4 1 4 1 5 0 4 0 4 0 4 The measures in the table below all seem fine. However, I find it troubling that this is an “Obesity Research Measures” toolkit, and there are no measures of lifetime physical activity (recall), enjoyment of physical activity, self-efficacy for physical activity, current physical activity, or cardiorespiratory fitness. Perhaps these are in a different toolkit, but if not, I would strongly consider adding them. I as someone who has published a number of studies using objective physical activity/fitness, and subjective (i.e., self-report) physical activity its psychosocial correlates, I would be happy to provide suggestions if you’re interested in more input. I have general feedback: o o o Distributing CRFs as PDF is good for printing but may not be for importing into my electronic data capture software that I am using for clinical trials. For each CRF (questionnaire), some indication of how heavy use there is of that CRF. E.g., SF36 vs. night eating CRF (case report form). If a question is using some standard valueset for answers – it would be useful to know. E.g.: 1 [ ] Yes 2 [ ] No 3 [ ] Refused 4 [ ] Don’t Know III. Outreach Measure Comments 1. Psychopathology of Eating Disorders: Y/N depends on use; likely a bit burdensome to train interviewers when most of the information can be obtained in the EDE-Q. 3. Dietary Intake: No, will not provide additional information above that obtained with the EDE restraint scale 11. Free or Reduced Price School Lunch: Not yet, data are just emerging for this one.