PEROXISOMES
Haley Nathanson
WHAT ARE PEROXISOMES?
Peroxisomes are membrane-bound organelles
found in the cytoplasm of eukaryotic cells.
Peroxisomes contain enzymes that oxidize fatty
acids and amino acids.
Stained human
peroxisome
ANATOMY OF PEROXISOMES
FUNCTION
Peroxisomes are responsible for protecting the cell
from the production of hydrogen peroxide.
Peroxisomes contain an oxidation enzyme, known
as catalase.
Catalase breaks down the hydrogen peroxide to
form one oxygen molecule and two water
molecules.
BREAKDOWN OF HYDROGEN PEROXIDE
2H2O2
hydrogen
peroxide
→
catalase
2H2O + O2
2 water
molecules
1 oxygen
molecule
PEROXISOME BIOGENESIS DISORDERS
Zellweger Syndrome (ZS)
Most Severe
Neonatal Adrenoleukodystrophy (NALD)
Infantile Refsum Disease (IRD)
Least Severe
All of these disorders are caused by defective peroxisomes.
ZELLWEGER SYNDROME (ZS)
Facial features of a child with ZS
NEONATAL ADRENOLEUKODYSTROPHY
(NALD)
INFANTILE REFSUM DISEASE (IRD)
WORKS CITED
"Neonatal Adrenoleukodystrophy." Penn Medicine. The University of Pennsylvania Health
System,, 1 Dec. 2001. Web. 14 Mar. 2014.
<http://www.pennmedicine.org/encyclopedia/em_DisplayImage.aspx?gcid=17277&ptid=2>.
"INFANTILE REFSUM DISEASE." — Windows Of Hope. St. George's, University of London
and University of Arizona, n.d. Web. 14 Mar. 2014.
<http://www.wohproject.org/Disorders/a-z/infantile-refsum-disease-1/infantile-refsumdisease>.
"NINDS Infantile Refsum Disease Information Page." Infantile Refsum Disease Information
Page: National Institute of Neurological Disorders and Stroke (NINDS). N.p., n.d. Web. 14 Mar.
2014. <http://www.ninds.nih.gov/disorders/refsum
"Diseases &amp Conditions." <i>Cleveland Clinic</i>. Cleveland Clinic, n.d. Web. 14 Mar.
2014.
&lt;http://my.clevelandclinic.org/disorders/adrenoleukodystrophy/hic_what_is_adrenoleuk
odystrophy.aspx&gt;.
"Zellweger Syndrome." Indian Pediatrics - Editorial. Indian Pediatrics, n.d. Web. 14 Mar. 2014.
<http://www.indianpediatrics.net/july2003/july-682.htm>.
WORKS CITED (CONTINUED)
"Peroxisomes." Molecular Expressions Cell Biology: Animal Cell Structure - Peroxisomes. Michael
Davidson and The Florida State University, 10 May 2005. Web. 15 Mar. 2014.
<http://micro.magnet.fsu.edu/cells/peroxisomes/peroxisomes.html>.
Cooper, John. "peroxisome (biology)." <i>Encyclopedia Britannica Online</i>.
Encyclopedia Britannica, 12 June 2013. Web. 14 Mar. 2014.
&lt;http://www.britannica.com/EBchecked/topic/452457/peroxisome&gt;.
"The Human Protein Atlas." Vesicles (Peroxisomes). The Human Protein Atlas, n.d. Web. 14
Mar. 2014. <http://www.proteinatlas.org/dictionary/cell/vesicles+(peroxisome)+2>.
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