Paul D. Soloway, Ph.D.
Curriculum Vitae
ADDRESS
Cornell University
College of Agriculture and Life Sciences
Division of Nutritional Sciences
211 Weill Hall
Ithaca, NY 14853-6301
Phone:
607-254-6444
E-mail:
soloway@cornell.edu
PERSONAL
Citizenship:
USA
EDUCATION/TRAINING
1975-1979
Cornell University, Dept. of Biochemistry, Ithaca, NY; BA Awarded 1979
1981
Purdue University, Dept. of Chemical Engineering, W. Lafayette, IN
1982-1984
SUNY Stonybrook, Dept. of Microbiology, Stonybrook, NY
1984-1989
Princeton University, Dept. of Molecular Biology, Princeton, NJ;
Thomas E. Shenk, Advisor; Ph.D. Awarded 1989
1989-1990
Post-doctoral Fellow, MIT, Dept. of Biology, Cambridge, MA;
Malcolm Gefter, Advisor
1990-1994
Post-doctoral Fellow, Whitehead Institute, Cambridge, MA;
Rudolf Jaenisch, Advisor
EMPLOYMENT
1979-1981
Lab Technician, Cornell University, Dept. of Agricultural Engineering, Ithaca, NY
1994-1998
Cancer Research Scientist III, Assistant Member, Dept. of Molecular and Cellular
Biology, Roswell Park Cancer Institute, Buffalo, NY
1998-1999
Cancer Research Scientist IV, Assistant Member, Dept. of Molecular and Cellular
Biology, Roswell Park Cancer Institute, Buffalo, NY
1999-2002
Cancer Research Scientist IV, Associate Member, Dept. of Molecular and Cellular
Biology; Director, Transgenic and Gene Targeting Facility, Roswell Park Cancer Institute,
Buffalo, NY
2002-2005
Adjunct Member, Dept. of Molecular and Cellular Biology, Roswell Park Cancer Institute,
Buffalo, NY
2002-2005
Associate Professor, Division of Nutritional Sciences, Cornell University,
Ithaca, NY
2005-pres.
Professor, Division of Nutritional Sciences, Cornell University,
Ithaca, NY
PUBLICATIONS:
Original Reports
1. Soloway, A.H., P.D. Soloway, and V.D. Warner, Chemical Initiators of Cognitive Dysfunction in
Phenylketonuria. Med Hypotheses, 2013. 81: 690–694.
2. Murphy, P.J., B.R. Cipriany, C.M. Wallin, K. Szeto, J.J. Benitez, H.G. Craighead, and P.D. Soloway, Singlemolecule Analysis of Combinatorial Epigenomic States in Normal and Tumor Cells. Proc Natl Acad Sci U S
A, 2013. 110(19): 7772.
3. Hagarman, J.A., M.P. Motley, K. Kristjansdottir, and P.D. Soloway, Coordinate regulation of DNA methylation
and H3K27me3 in mouse embryonic stem cells. PLoS One, 2013. 8(1): p. e53880.
4. Zou, H., R. Li, Y. Jia, X. Yang, Y. Ni, R. Cong, P.D. Soloway, and R. Zhao, Breed-Dependent Transcriptional
Regulation of 5′-Untranslated GR (NR3C1) Exon 1 mRNA Variants in the Liver of Newborn Piglets. PLoS
ONE, 2012. 7(7): p. e40432.
5. Park, Y.J., H. Herman, Y. Gao, A.M. Lindroth, B.Y. Hu, P.J. Murphy, J.R. Putnam, and P.D. Soloway,
Sequences sufficient for programming imprinted germline DNA methylation defined. PLoS One, 2012. 7(3): p.
e33024. (PMC3293921)
6. Cipriany, B.R., P.J. Murphy, J.A. Hagarman, A. Cerf, D. Latulippe, S.L. Levy, J.J. Benitez, C.P. Tan, J.
Topolancik, P.D. Soloway, and H.G. Craighead, Real-time analysis and selection of methylated DNA by
fluorescence-activated single molecule sorting in a nanofluidic channel. Proc Natl Acad Sci U S A, 2012.
109(22): p. 8477-82. (PMC3365150)
7. Benitez, J.J., J. Topolancik, H.C. Tian, C.B. Wallin, D.R. Latulippe, K. Szeto, P.J. Murphy, B.R. Cipriany, S.L.
Levy, P.D. Soloway, and H.G. Craighead, Microfluidic extraction, stretching and analysis of human
chromosomal DNA from single cells. Lab Chip, 2012.
8. Watanabe, T., S. Tomizawa, K. Mitsuya, Y. Totoki, Y. Yamamoto, S. Kuramochi-Miyagawa, N. Iida, Y. Hoki,
P.J. Murphy, A. Toyoda, K. Gotoh, H. Hiura, T. Arima, A. Fujiyama, T. Sado, T. Shibata, T. Nakano, H. Lin, K.
Ichiyanagi, P.D. Soloway, and H. Sasaki, Role for piRNAs and noncoding RNA in de novo DNA methylation
of the imprinted mouse Rasgrf1 locus. Science, 2011. 332(6031): p. 848-52. (PMC3368507)
9. Wang, X., P.D. Soloway, and A.G. Clark, A Survey for Novel Imprinted Genes in the Mouse Placenta by
mRNA-seq. Genetics, 2011. 189(1): p. 109-22. (PMC3176116)
10. Drake, N.M., L.M. Devito, T.A. Cleland, and P.D. Soloway, Imprinted Rasgrf1 expression in neonatal mice
affects olfactory learning and memory. Genes Brain Behav, 2011. 10: p. 392-403. (PMC3091993)
11. Wang, X., P.D. Soloway, and A.G. Clark, Paternally biased X inactivation in mouse neonatal brain. Genome
Biol, 2010. 11(7): p. R79. (PMC2926790)
12. Kandalam, V., R. Basu, T. Abraham, X. Wang, P.D. Soloway, D.M. Jaworski, G.Y. Oudit, and Z. Kassiri,
TIMP2 Deficiency Accelerates Adverse Post-Myocardial Infarction Remodeling Because of Enhanced MT1MMP Activity Despite Lack of MMP2 Activation. Circ Res, 2010. 106(4): p. 796-808.
13. Cipriany, B.R., R. Zhao, P.J. Murphy, S.L. Levy, C.P. Tan, H.G. Craighead, and P.D. Soloway, Single
Molecule Epigenetic Analysis in a Nanofluidic Channel. Anal Chem, 2010. 82: p. 2480–2487. (PMC2839087)
14. Brideau, C.M., K.P. Kauppinen, R. Holmes, and P.D. Soloway, A Non-Coding RNA Within the Rasgrf1 Locus
in Mouse Is Imprinted and Regulated by Its Homologous Chromosome in Trans. PLoS ONE, 2010. 5(11): p.
e13784. (PMC2970558)
15. Brideau, C.M., K.E. Eilertson, J.A. Hagarman, C.D. Bustamante, and P.D. Soloway, Successful
Computational Prediction of Novel Imprinted Genes From Epigenomic Features. Mol Cell Biol, 2010. 30(13):
p. 3357–3370. (PMC2897571)
16. Fasano, S., A. D'Antoni, P.C. Orban, E. Valjent, E. Putignano, H. Vara, T. Pizzorusso, M. Giustetto, B. Yoon,
P. Soloway, R. Maldonado, J. Caboche, and R. Brambilla, Ras-guanine nucleotide-releasing factor 1 (RasGRF1) controls activation of extracellular signal-regulated kinase (ERK) signaling in the striatum and longterm behavioral responses to cocaine. Biol Psychiatry, 2009. 66(8): p. 758-68. (PMC2910545)
17. Drake, N.M., Y.J. Park, A.S. Shirali, T.A. Cleland, and P.D. Soloway, Imprint switch mutations at Rasgrf1
support conflict hypothesis of imprinting and define a growth control mechanism upstream of IGF1. Mamm
Genome, 2009. 20(9-10): p. 654-63. (PMC2919583)
18. Wang, X., Q. Sun, S.D. McGrath, E.R. Mardis, P.D. Soloway, and A.G. Clark, Transcriptome-wide
identification of novel imprinted genes in neonatal mouse brain. PLoS ONE, 2008. 3(12): p. e3839.
(PMC2585789)
19. Lluri, G., G.D. Langlois, P.D. Soloway, and D.M. Jaworski, Tissue inhibitor of metalloproteinase-2 (TIMP-2)
regulates myogenesis and beta1 integrin expression in vitro. Exp Cell Res, 2008. 314(1): p. 11-24.
20. Lindroth, A.M., Y.J. Park, C.M. McLean, G.A. Dokshin, J.M. Persson, H. Herman, D. Pasini, X. Miro, M.E.
Donohoe, J.T. Lee, K. Helin, and P.D. Soloway, Antagonism between DNA and H3K27 Methylation at the
Imprinted Rasgrf1 Locus. PLoS Genetics, 2008. 4(8): p. e1000145. (PMC2475503)
21. Slape, C., Y.J. Chung, P.D. Soloway, L. Tessarollo, and P.D. Aplan, Mouse embryonic stem cells that
express a NUP98-HOXD13 fusion protein are impaired in their ability to differentiate and can be
complemented by BCR-ABL. Leukemia, 2007. 21(6): p. 1239-48.
22. Lluri, G., G.D. Langlois, B. McClellan, P.D. Soloway, and D.M. Jaworski, Tissue inhibitor of
metalloproteinase-2 (TIMP-2) regulates neuromuscular junction development via a beta1 integrin-mediated
mechanism. J Neurobiol, 2006. 66(12): p. 1365-1377.
23. Jaworski, D.M., P. Soloway, J. Caterina, and W.A. Falls, Tissue inhibitor of metalloproteinase-2(TIMP-2)deficient mice display motor deficits. J Neurobiol, 2006. 66(1): p. 82-94.
24. Holmes, R., Y. Chang, and P.D. Soloway, Timing and Sequence Requirements Defined for Embryonic
Maintenance of Imprinted DNA Methylation at Rasgrf1. Mol Cell Biol, 2006. 26(24): p. 9564-70.
(PMC1698547)
25. English, J.L., Z. Kassiri, I. Koskivirta, S.J. Atkinson, M. Di Grappa, P.D. Soloway, H. Nagase, E. Vuorio, G.
Murphy, and R. Khokha, Individual Timp deficiencies differentially impact pro-MMP-2 activation. J Biol Chem,
2006. 281(15): p. 10337-46.
26. Crocker, S.J., J.K. Whitmire, R.F. Frausto, P. Chertboonmuang, P.D. Soloway, J.L. Whitton, and I.L.
Campbell, Persistent macrophage/microglial activation and myelin disruption after experimental autoimmune
encephalomyelitis in tissue inhibitor of metalloproteinase-1-deficient mice. Am J Pathol, 2006. 169(6): p.
2104-16.
27. Chaillan, F.A., S. Rivera, E. Marchetti, J. Jourquin, Z. Werb, P.D. Soloway, M. Khrestchatisky, and F.S.
Roman, Involvement of tissue inhibition of metalloproteinases-1 in learning and memory in mice. Behav
Brain Res, 2006. 173: p. 191-198.
28. Yoon, B.-J., H. Herman, B. Hu, Y.J. Park, A.M. Lindroth, A. Bell, A.G. West, Y. Chang, A. Stablewski, J.C.
Piel, D.I. Loukinov, V. Lobanenkov, and P.D. Soloway, Rasgrf1 Imprinting is Regulated by a CTCFdependent Methylation-Sensitive Enhancer Blocker. Mol Cell Biol, 2005. 25(24): p. 11184–11190.
(PMC1316951)
29. Ogier, C., R. Creidy, J. Boucraut, P.D. Soloway, M. Khrestchatisky, and S. Rivera, Astrocyte reactivity to Fas
activation is attenuated in TIMP-1 deficient mice: an in vitro study. BMC Neurosci, 2005. 6(1): p. 68.
30. Mohammed, F.F., C.J. Pennington, Z. Kassiri, J.S. Rubin, P.D. Soloway, U. Ruther, D.R. Edwards, and R.
Khokha, Metalloproteinase inhibitor TIMP-1 affects hepatocyte cell cycle via HGF activation in murine liver
regeneration. Hepatology, 2005. 41(4): p. 857-67.
31. Lee, M.M., B.J. Yoon, K. Osiewicz, M. Preston, B. Bundy, A.M. van Heeckeren, Z. Werb, and P.D. Soloway,
Tissue inhibitor of metalloproteinase 1 regulates resistance to infection. Infect Immun, 2005. 73(1): p. 661-5.
32. Kim, K.H., K. Burkhart, P. Chen, C.W. Frevert, J. Randolph-Habecker, R.C. Hackman, P.D. Soloway, and
D.K. Madtes, Tissue Inhibitor of MP-1 Deficiency Amplifies Acute Lung Injury in Bleomycin Exposed Mice. Am
J Respir Cell Mol Biol, 2005.
33. Jourquin, J., E. Tremblay, A. Bernard, G. Charton, F.A. Chaillan, E. Marchetti, F.S. Roman, P.D. Soloway, V.
Dive, A. Yiotakis, M. Khrestchatisky, and S. Rivera, Tissue inhibitor of metalloproteinases-1 (TIMP-1)
modulates neuronal death, axonal plasticity, and learning and memory. Eur J Neurosci, 2005. 22(10): p.
2569-2578.
34. Jaworski, D.M., J. Boone, J. Caterina, P. Soloway, and W.A. Falls, Prepulse inhibition and fear-potentiated
startle are altered in tissue inhibitor of metalloproteinase-2 (TIMP-2) knockout mice. Brain Res, 2005. 1051(12): p. 81-9.
35. Zhao, H., M.M. Bernardo, P. Osenkowski, A. Sohail, D. Pei, H. Nagase, M. Kashiwagi, P.D. Soloway, Y.A.
DeClerck, and R. Fridman, Differential Inhibition of MT3-MMP and MT1-MMP by TIMP-2 and TIMP-3
regulates Pro-MMP-2 activation. J Biol Chem, 2004. 279: p. 8592-8601.
36. Sabeh, F., I. Ota, K. Holmbeck, H. Birkedal-Hansen, P. Soloway, M. Balbin, C. Lopez-Otin, S. Shapiro, M.
Inada, S. Krane, E. Allen, D. Chung, and S.J. Weiss, Tumor cell traffic through the extracellular matrix is
controlled by the membrane-anchored collagenase MT1-MMP. J Cell Biol, 2004. 167(4): p. 769-81.
37. Worley, J.R., P.B. Thompkins, M.H. Lee, M. Hutton, P. Soloway, D.R. Edwards, G. Murphy, and V. Knauper,
Sequence motifs of tissue inhibitor of metalloproteinases 2 (TIMP-2) determining progelatinase A (proMMP-2)
binding and activation by membrane-type metalloproteinase 1 (MT1-MMP). Biochem J, 2003. 372(Pt 3): p.
799-809.
38. Wiseman, B.S., M.D. Sternlicht, L.R. Lund, C.M. Alexander, J. Mott, M.J. Bissell, P. Soloway, S. Itohara, and
Z. Werb, Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland
branching morphogenesis. J Cell Biol, 2003. 162(6): p. 1123-33.
39. Lemaitre, V., P.D. Soloway, and J. D'Armiento, Increased medial degradation with pseudo-aneurysm
formation in apolipoprotein E-knockout mice deficient in tissue inhibitor of metalloproteinases-1. Circulation,
2003. 107(2): p. 333-8.
40. Herman, H., M. Lu, M. Anggraini, A. Sikora, Y. Chang, B.J. Yoon, and P.D. Soloway, Trans allele methylation
and paramutation-like effects in mice. Nat Genet, 2003. 34(2): p. 199-202. (PMC2744043)
41. Appenheimer, M.M., R.Y. Huang, E.V. Chandrasekaran, M. Dalziel, Y.P. Hu, P.D. Soloway, S.A. Wuensch,
K.L. Matta, and J.T. Lau, Biologic contribution of P1 promoter-mediated expression of ST6Gal I
sialyltransferase. Glycobiology, 2003. 13(8): p. 591-600.
42. Yoon, B.J., H. Herman, A. Sikora, L.T. Smith, C. Plass, and P.D. Soloway, Regulation of DNA methylation of
Rasgrf1. Nat Genet, 2002. 30(1): p. 92-6. (PMC2756564)
43. Knauper, V., L. Bailey, J.R. Worley, P. Soloway, M.L. Patterson, and G. Murphy, Cellular activation of
proMMP-13 by MT1-MMP depends on the C-terminal domain of MMP-13. FEBS Lett, 2002. 532(1-2): p. 12730.
44. Fitzpatrick, G.V., P.D. Soloway, and M.J. Higgins, Regional loss of imprinting and growth deficiency in mice
with a targeted deletion of KvDMR1. Nat Genet, 2002. 32: p. 426 - 431.
45. de la Puente, A., J. Hall, Y.Z. Wu, G. Leone, J. Peters, B.J. Yoon, P. Soloway, and C. Plass, Structural
characterization of Rasgrf1 and a novel linked imprinted locus. Gene, 2002. 291(1-2): p. 287-97.
46. Yamada, E., T. Tobe, H. Yamada, N. Okamoto, D.J. Zack, Z. Werb, P.D. Soloway, and P.A. Campochiaro,
TIMP-1 promotes VEGF-induced neovascularization in the retina. Histol Histopathol, 2001. 16(1): p. 87-97.
47. Vaillant, B., M.G. Chiaramonte, A.W. Cheever, P.D. Soloway, and T.A. Wynn, Regulation of hepatic fibrosis
and extracellular matrix genes by the th response: new insight into the role of tissue inhibitors of matrix
metalloproteinases. J Immunol, 2001. 167(12): p. 7017-26.
48. Morrison, C.J., G.S. Butler, H.F. Bigg, C.R. Roberts, P.D. Soloway, and C.M. Overall, Cellular activation of
MMP-2 (gelatinase A) by MT2-MMP occurs via a TIMP-2-independent pathway. J Biol Chem, 2001. 276(50):
p. 47402-10.
49. Kim, H., T. Oda, J. Lopez-Guisa, D. Wing, D.R. Edwards, P.D. Soloway, and A.A. Eddy, TIMP-1 deficiency
does not attenuate interstitial fibrosis in obstructive nephropathy. J Am Soc Nephrol, 2001. 12(4): p. 736-48.
50. Johnson, M.T., S. Mahmood, S.L. Hyatt, H.S. Yang, P.D. Soloway, R.W. Hanson, and M.S. Patel,
Inactivation of the murine pyruvate dehydrogenase (Pdha1) gene and its effect on early embryonic
development. Mol Genet Metab, 2001. 74(3): p. 293-302.
51. Ho, A.T., E.B. Voura, P.D. Soloway, K.L. Watson, and R. Khokha, MMP inhibitors augment fibroblast
adhesion through stabilization of focal adhesion contacts and up-regulation of cadherin function. J Biol
Chem, 2001. 276(43): p. 40215-24.
52. Hernandez-Barrantes, S., Y. Shimura, P.D. Soloway, Q.A. Sang, and R. Fridman, Differential roles of TIMP-4
and TIMP-2 in pro-MMP-2 activation by MT1-MMP. Biochem Biophys Res Commun, 2001. 281(1): p. 12630.
53. Bigg, H.F., C.J. Morrison, G.S. Butler, M.A. Bogoyevitch, Z. Wang, P.D. Soloway, and C.M. Overall, Tissue
inhibitor of metalloproteinases-4 inhibits but does not support the activation of gelatinase A via efficient
inhibition of membrane type 1-matrix metalloproteinase. Cancer Res, 2001. 61(9): p. 3610-8.
54. Wang, Z., R. Juttermann, and P.D. Soloway, TIMP-2 is required for efficient activation of proMMP-2 in vivo. J
Biol Chem, 2000. 275(34): p. 26411-5.
55. Toth, M., M.M. Bernardo, D.C. Gervasi, P.D. Soloway, Z. Wang, H.F. Bigg, C.M. Overall, Y.A. DeClerck, H.
Tschesche, M.L. Cher, S. Brown, S. Mobashery, and R. Fridman, Tissue inhibitor of metalloproteinase
(TIMP)-2 acts synergistically with synthetic matrix metalloproteinase (MMP) inhibitors but not with TIMP-4 to
enhance the (Membrane type 1)-MMP-dependent activation of pro-MMP-2. J Biol Chem, 2000. 275(52): p.
41415-23.
56. Roten, L., S. Nemoto, J. Simsic, M.L. Coker, V. Rao, S. Baicu, G. Defreyte, P.J. Soloway, M.R. Zile, and F.G.
Spinale, Effects of gene deletion of the tissue inhibitor of the matrix metalloproteinase-type 1 (TIMP-1) on left
ventricular geometry and function in mice. J Mol Cell Cardiol, 2000. 32(1): p. 109-20.
57. Pozzi, A., P.E. Moberg, L.A. Miles, S. Wagner, P. Soloway, and H.A. Gardner, Elevated matrix
metalloprotease and angiostatin levels in integrin alpha 1 knockout mice cause reduced tumor
vascularization. Proc Natl Acad Sci U S A, 2000. 97(5): p. 2202-7.
58. Eddy, A.A., H. Kim, J. Lopez-Guisa, T. Oda, and P.D. Soloway, Interstitial fibrosis in mice with overload
proteinuria: deficiency of TIMP-1 is not protective. Kidney Int, 2000. 58(2): p. 618-28.
59. Wang, Z. and P.D. Soloway, TIMP-1 and TIMP-2 perform different functions in vivo. Ann N Y Acad Sci,
1999. 878: p. 519-21.
60. Osiewicz, K., M. McGarry, and P.D. Soloway, Hyper-resistance to infection in TIMP-1-deficient mice is
neutrophil dependent but not immune cell autonomous. Ann N Y Acad Sci, 1999. 878: p. 494-6.
61. Lijnen, H.R., P. Soloway, and D. Collen, Tissue inhibitor of matrix metalloproteinases-1 impairs arterial
neointima formation after vascular injury in mice. Circ Res, 1999. 85(12): p. 1186-91.
62. Nothnick, W.B., P.D. Soloway, and T.E. Curry, Jr., Pattern of messenger ribonucleic acid expression of tissue
inhibitors of metalloproteinases (TIMPs) during testicular maturation in male mice lacking a functional TIMP-1
gene. Biol Reprod, 1998. 59(2): p. 364-70.
63. Nothnick, W.B. and P.D. Soloway, Novel implications in the development of endometriosis: biphasic effect of
macrophage activation on peritoneal tissue expression of tissue inhibitor of metalloproteinase-1. Am J
Reprod Immunol, 1998. 40(5): p. 364-9.
64. d'Audiffret, A., P. Soloway, R. Saadeh, C. Carty, P. Bush, J.J. Ricotta, and M. Dryjski, Endothelial
dysfunction following thrombolysis in vitro. Eur J Vasc Endovasc Surg, 1998. 16(6): p. 494-500.
65. Nothnick, W.B., P. Soloway, and T.E. Curry, Jr., Assessment of the role of tissue inhibitor of
metalloproteinase-1 (TIMP-1) during the periovulatory period in female mice lacking a functional TIMP-1
gene. Biol Reprod, 1997. 56(5): p. 1181-8.
66. Soloway, P.D., C.M. Alexander, Z. Werb, and R. Jaenisch, Targeted mutagenesis of Timp-1 reveals that lung
tumor invasion is influenced by Timp-1 genotype of the tumor but not by that of the host. Oncogene, 1996.
13(11): p. 2307-14.
67. Carty, C.S., P.D. Soloway, S. Kayastha, J. Bauer, B. Marsan, J.J. Ricotta, and M. Dryjski, Nicotine and
cotinine stimulate secretion of basic fibroblast growth factor and affect expression of matrix
metalloproteinases in cultured human smooth muscle cells. J Vasc Surg, 1996. 24(6): p. 927-34; discussion
934-5.
68. Soloway, P., S. Fish, H. Passmore, M. Gefter, R. Coffee, and T. Manser, Regulation of the immune response
to peptide antigens: differential induction of immediate-type hypersensitivity and T cell proliferation due to
changes in either peptide structure or major histocompatibility complex haplotype. J Exp Med, 1991. 174(4):
p. 847-58.
69. Kamradt, T., P.D. Soloway, D.L. Perkins, and M.L. Gefter, Pertussis toxin prevents the induction of peripheral
T cell anergy and enhances the T cell response to an encephalitogenic peptide of myelin basic protein. J
Immunol, 1991. 147(10): p. 3296-302.
70. Soloway, P.D. and T. Shenk, The adenovirus type 5 i-leader open reading frame functions in cis to reduce
the half-life of L1 mRNAs. J Virol, 1990. 64(2): p. 551-8.
71. Hasson, T.B., P.D. Soloway, D.A. Ornelles, W. Doerfler, and T. Shenk, Adenovirus L1 52- and 55-kilodalton
proteins are required for assembly of virions. J Virol, 1989. 63(9): p. 3612-21.
Invited Reviews and Book Chapters
72. Soloway, P.D., Analysis of Combinatorial Epigenomic States. ACS Chem Biol, 2016. In
press.
73. Taylor, D.H., E.T.-J. Chu, R. Spektor, and P.D. Soloway, Long Non-Coding RNA Regulation
of Reproduction and Development. Mol Reprod Dev, 2015. 82: 932-956.
74. Hyun, B.R., J.L. McElwee, and P.D. Soloway, Single molecule and single cell epigenomics.
Methods, 2015. 72: p. 41–50.
75. Hagarman, J.A. and P.D. Soloway, Epigenomics - One molecule at a time. Cell Cycle, 2013. 12 p. 1-2..
76. Brideau, C. and P. Soloway, Data mining as a discovery tool for imprinted genes. Methods Mol Biol, 2012.
925: p. 89-134.
77. Flax, J.D. and P.D. Soloway, Methylation on the mind. Nat Neurosci, 2011. 14(12): p. 1494-6.
78. Soloway, P.D., Gene nutrient interactions and evolution. Nutr Rev, 2006. 64(5 Pt 2): p. S52-4; discussion
S72-91.
79. Soloway, P.D., Paramutable Possibilities. Nature, 2006. 441: p. 413-414.
80. Holmes, R. and P.D. Soloway, Regulation of imprinted DNA methylation. Cytogenet Genome Res, 2006.
113(1-4): p. 122-9.
81. Plass, C. and P.D. Soloway, DNA methylation, imprinting and cancer. Eur J Hum Genet, 2002. 10(1): p. 616.
82. Coussens, L.M., S.D. Shapiro, P.D. Soloway, and Z. Werb, Models for gain-of-function and loss-of-function of
MMPs. Transgenic and gene targeted mice. Methods Mol Biol, 2001. 151: p. 149-79.
83. Osiewicz, K., M.J. Preston, G.B. Pier, and P.D. Soloway, Elevated Antibacterial Activity in TIMP-1-deficient
Mice, in Tissue Inhibitors in Development and Disease, S.P. Hawkes, D.R. Edwards, and R. Khokha, Editors.
2000, Harwood Academic Publishers: Amsterdam. p. 159-162.
84. Campochiaro, P.A., P. Soloway, S.J. Ryan, and J.W. Miller, The pathogenesis of choroidal
neovascularization in patients with age-related macular degeneration. Mol Vis, 1999. 5: p. 34.
PATENTS
Craighead, H.G., B.R. Cipriany, S. Levy, and P.D Soloway, Device and methods for epigenetic analysis.
US 8,735,065 Issued May 27, 2014; WO 2011017681; EP 2462442.
PEER REVIEWED EXTERNAL FUNDING
Current
2/25/2003-3/31/2017
NIH 9R01GM98596-10
Total Costs:
$1,283,136
Title:
Epigenetic Control of a Ras Activator
Role:
Principal Investigator
Effort:
2.0 months
8/21/2012-6/30/2016
NIH R01 HG006850-01
Total Costs:
$1,731,684
Title:
Tools for Single Molecule and Single Cell Epigenomic
Analysis
Role:
Principal Investigator (Harold Craighead, Co-PI)
Effort:
1.5 months
Past
1. 1989-1992
Leukemia Society of America Post-doctoral Fellowship
2. 1992-1993
NIH 1-F32-GM015325 Post-doctoral Fellowship
3. 3/1/96-1/31/99
NIH 1-R01-EY11279-03
Direct Costs:
$339,881
Title:
Keratitis: The Role of the TIMPs and IL-6
Role:
Principal Investigator
Effort:
45%
4. 2/1/99-1/31/05
NIH 2-R01-EY11279
Direct Costs:
$943,748
Title:
Keratitis: The Role of the TIMPs
Role:
Principal Investigator
Effort:
40%
5. 6/1/02-5/31/06
US Army DAMD17-02-1-0652
Direct Costs:
$298,837
Title:
The Role of RASGRF1 in Neurofibromatosis
Validating a Potential Therapeutic Target
Role:
Principal Investigator
Effort:
15%
6. 2/25/03-2/24/08
NIH 1R01CA98596
Direct Costs:
Title:
Role:
Effort:
7. 4/1/06-3/31/09
8. 9/1/08-7/31/12
$1,112,500
Epigenetic Control of a Ras Activator
Principal Investigator
25%
NIH 1R01 CA120870
Direct Costs:
$285,000
Title:
Nutrient Genome Interactions Affecting Colon Cancer
Role:
Principal Investigator
Effort:
1.2 months
NIH 2R01CA98596
Direct Costs: $760,000
Title:
Epigenetic Control of a Ras Activator
Role:
Principal Investigator
Effort:
3.0 months
9. 9/15/08-7/31/12
NIH 1R01 DA025722
Direct Costs:
$1,000,000
Title:
Epigenomic analysis on a nanoscale device
Role:
Principal Investigator (Harold Craighead, Co-PI)
Effort:
1.2 months