Material Safety Data Sheet
Epsilon-Caprolactam, 99+%
ACC# 96782
Section 1 - Chemical Product and Company Identification
MSDS Name: Epsilon-Caprolactam, 99+%
Catalog Numbers: AC108230000, AC108230010, AC108230050
Synonyms: 2-Oxohexamethyleneimine; 6-Aminocaproic acid lactam; 6-Aminohexanoic
acid cyclic lactam; 1-aza-2-cycloheptanone; Hexahydro-2H-azepin-2-one
Company Identification:
Acros Organics N.V.
One Reagent Lane
Fair Lawn, NJ 07410
For information in North America, call: 800-ACROS-01
For emergencies in the US, call CHEMTREC: 800-424-9300
Section 2 - Composition, Information on Ingredients
CAS#
105-60-2
Chemical Name
Percent
EINECS/ELINCS
99+%
203-313-2
epsilon-Caprolactam
Hazard Symbols: XI T+
Risk Phrases: 21/22 23 36/37/38 43
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Appearance: white. Hygroscopic. Danger! Causes eye and skin irritation. Causes
respiratory tract irritation. May cause digestive tract irritation. May be fatal if inhaled.
May be harmful if absorbed through the skin. May be harmful if swallowed. Skin
sensitizer.
Target Organs: Nervous system.
Potential Health Effects
Eye: Vapors cause eye irritation.
Skin: Causes skin irritation. May be absorbed through the skin in harmful amounts. May
cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure
to this material. May cause dermatitis.
Ingestion: May cause gastrointestinal irritation with nausea, vomiting and diarrhea.
May be harmful if swallowed.
Inhalation: Causes respiratory tract irritation. Toxic if inhaled.
Chronic: Chronic ingestion may cause neurological symptoms.
Section 4 - First Aid Measures
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally
lifting the upper and lower eyelids. Get medical aid immediately.
Skin: Get medical aid immediately. Immediately flush skin with plenty of soap and water
for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion: Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of
milk or water. Never give anything by mouth to an unconscious person. Get medical aid
immediately.
Inhalation: Get medical aid immediately. Remove from exposure to fresh air
immediately. If not breathing, give artificial respiration. If breathing is difficult, give
oxygen.
Notes to Physician: Treat symptomatically and supportively.
Section 5 - Fire Fighting Measures
General Information: As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
During a fire, irritating and highly toxic gases may be generated by thermal
decomposition or combustion.
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or appropriate
foam.
Section 6 - Accidental Release Measures
General Information: Use proper personal protective equipment as indicated in Section
8.
Spills/Leaks: Wash area with soap and water. Clean up spills immediately, observing
precautions in the Protective Equipment section. Sweep up, then place into a suitable
container for disposal. Avoid generating dusty conditions. Provide ventilation.
Section 7 - Handling and Storage
Handling: Wash thoroughly after handling. Avoid breathing dust, vapor, mist, or gas.
Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation. Use only in a
chemical fume hood.
Storage: Store in a cool, dry place. Store in a tightly closed container.
Section 8 - Exposure Controls, Personal Protection
Engineering Controls: Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use only under a chemical fume hood.
Exposure Limits
Chemical Name
ACGIH
epsilon-Caprolactam
(1 mg/m3) TWA
(particulate); (5 ppm)
TWA (vapor); (10ppm)
STEL (vapor); (3
mg/m3) STEL
(particulate)
NIOSH
OSHA - Final PELs
dust: 1 mg/m3 TWA;
vapor: 0.22 ppm TWA,
1 mg/m3 TWA
none listed
OSHA Vacated PELs: epsilon-Caprolactam: dust: 1 mg/m3 TWA; vapor: 5 ppm TWA;
20 mg/m3 TWA; dust: 3 mg/m3 STEL; vapor: 10 ppm STEL; 40 mg/m3 STEL
Personal Protective Equipment
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described
by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: Follow the OSHA respirator regulations found in 29CFR 1910.134 or
European Standard EN 149. Always use a NIOSH or European Standard EN 149
approved respirator when necessary.
Section 9 - Physical and Chemical Properties
Physical State: Crystals
Appearance: white
Odor: Unpleasant odor.
pH: Not available.
Vapor Pressure: 6.0 mm Hg @ 120C
Vapor Density: Not available.
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: 180 deg C @ 50 mm Hg
Freezing/Melting Point:70-72 deg C
Autoignition Temperature: 374 deg C ( 705.20 deg F)
Flash Point: 125 deg C ( 257.00 deg F)
Decomposition Temperature:Not available.
NFPA Rating: Not published.
Explosion Limits, Lower:1.40 vol %
Upper: 8.00 vol %
Solubility: Soluble.
Specific Gravity/Density:Not available.
Molecular Formula:C6H11NO
Molecular Weight:113.16
Section 10 - Stability and Reactivity
Chemical Stability: Stable under normal temperatures and pressures.
Conditions to Avoid: Incompatible materials, dust generation, exposure to moist air or
water.
Incompatibilities with Other Materials: Strong oxidizing agents, strong bases.
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon
dioxide.
Hazardous Polymerization: Has not been reported
Section 11 - Toxicological Information
RTECS#:
CAS# 105-60-2: CM3675000
LD50/LC50:
CAS# 105-60-2:
Draize test, rabbit, eye: 20 mg/24H Moderate;
Draize test, rabbit, skin: 500 mg/24H Mild;
Inhalation, mouse: LC50 = 450 mg/m3;
Inhalation, rat: LC50 = 300 mg/m3/2H;
Oral, mouse: LD50 = 930 mg/kg;
Oral, rat: LD50 = 1210 mg/kg;
Skin, rabbit: LD50 = 1410 uL/kg;
Skin, rat: LD50 = >2 gm/kg;<BR.
Carcinogenicity:
CAS# 105-60-2:
ACGIH: particulate and vapor: (A4) - Not Classifiable as a Human Carcinogen
IARC: Group 4 carcinogen
Epidemiology: No data available.
Teratogenicity: No data available.
Reproductive Effects: No data available.
Neurotoxicity: No data available.
Mutagenicity: No data available.
Other Studies: No data available.
Section 12 - Ecological Information
Ecotoxicity: No data available. For further information, contact Acros.
Environmental: No information available.
Physical: No information available.
Other: No information available.
Section 13 - Disposal Considerations
Chemical waste generators must determine whether a discarded chemical is classified as
a hazardous waste. US EPA guidelines for the classification determination are listed in 40
CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous
waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.
Section 14 - Transport Information
US DOT
IATA
RID/ADR
IMO
No
Shipping Name: information
available.
Canada
TDG
No
information
available.
Hazard Class:
UN Number:
Packing Group:
Section 15 - Regulatory Information
US FEDERAL
TSCA
CAS# 105-60-2 is listed on the TSCA inventory.
Health & Safety Reporting List
CAS# 105-60-2: Effective Date: October 4, 1982; Sunset Date: October 4 , 1992
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
SARA
Section 302 (RQ)
None of the chemicals in this material have an RQ.
Section 302 (TPQ)
None of the chemicals in this product have a TPQ.
SARA Codes
CAS # 105-60-2: acute.
Section 313
No chemicals are reportable under Section 313.
Clean Air Act:
This material does not contain any hazardous air pollutants. This material does not
contain any Class 1 Ozone depletors. This material does not contain any Class 2 Ozone
depletors.
Clean Water Act:
None of the chemicals in this product are listed as Hazardous Substances under the
CWA. None of the chemicals in this product are listed as Priority Pollutants under the
CWA. None of the chemicals in this product are listed as Toxic Pollutants under the CWA.
OSHA:
None of the chemicals in this product are considered highly hazardous by OSHA.
STATE
CAS# 105-60-2 can be found on the following state right to know lists: California, New
Jersey, Florida, Pennsylvania, Minnesota, Massachusetts.
California No Significant Risk Level: None of the chemicals in this product are listed.
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
XI T+
Risk Phrases:
R 21/22 Harmful in contact with skin and if
swallowed.
R 23 Toxic by inhalation.
R 36/37/38 Irritating to eyes, respiratory system
and skin.
R 43 May cause sensitization by skin contact.
Safety Phrases:
S 22 Do not breathe dust.
S 24/25 Avoid contact with skin and eyes.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
S 46 If swallowed, seek medical advice immediately
and show this container or label.
WGK (Water Danger/Protection)
CAS# 105-60-2: 1
Canada
CAS# 105-60-2 is listed on Canada's DSL List. CAS# 105-60-2 is listed on Canada's DSL
List.
WHMIS: Not available.
CAS# 105-60-2 is listed on Canada's Ingredient Disclosure List.
Exposure Limits
CAS# 105-60-2: OEL-AUSTRALIA:TWA 1 mg/m3;STEL 3 mg/m3 (dust) OEL-AU
STRALIA:TWA 5 ppm (20 mg/m3);STEL 10 ppm (vapor) OEL-AUSTRIA:TWA 25 m
g/m3 (dust) OEL-BELGIUM:TWA 1 mg/m3;STEL 3 mg/m3 (dust) OEL-BELGIUM:
TWA 4.3 ppm (20 mg/m3);STEL 8.6 ppm (40 mg/m3) OEL-CZECHOSLOVAKIA:TWA
10 mg/m3;STEL 20 mg/m3 (vapor) OEL-CZECHOSLOVAKIA:TWA 5 mg/m3;STEL 1
0 mg/m3 (dust) OEL-DENMARK:TWA 1 mg/m3 JANUARY 1993 OEL-DENMARK:TWA
5 ppm (25 mg/m3) (dust) OEL-DENMARK:TWA 5 ppm (25 mg/m3) (vapor) OE
L-FINLAND:TWA 1 mg/m3;STEL 3 mg/m3 (dust) OEL-FINLAND:TWA 5 ppm (20 m
g/m3);STEL 10 ppm (46 mg/m3) (vapor) OEL-FRANCE:TWA 1 mg/m3 (dust) O
EL-FRANCE:TWA 5 ppm (20 mg/m3) (vapor) OEL-GERMANY:TWA 25 mg/m3 (dust
) OEL-GERMANY:TWA 25 mg/m3 (vapor) OEL-HUNGARY:TWA 1 mg/m3;STEL 2 mg
/m3 (dust) OEL-THE NETHERLANDS:TWA 1 mg/m3 (vapor) OEL-THE NETHERLAN
DS:TWA 5 ppm (20 mg/m3) (dust) OEL-POLAND:TWA 10 mg/m3 (dust) OEL-RU
SSIA:STEL 10 mg/m3 (dust) OEL-SWITZERLAND:TWA 4 ppm (20 mg/m3) (vapor
) JAN9 OEL-UNITED KINGDOM:TWA 1 mg/m3;STEL 3 mg/m3 (dust OEL-UNITED
KINGDOM:TWA 5 ppm (20 mg/m3);STEL 10 ppm (vapor) OEL IN BULGARIA, COL
OMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, V
IETNAM check ACGI TLV
Section 16 - Additional Information
MSDS Creation Date: 3/16/1998
Revision #2 Date: 8/02/2000
The information above is believed to be accurate and represents the best information currently available to us.
However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such
information, and we assume no liability resulting from its use. Users should make their own investigations to
determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any
claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or
exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.