Abstract
Genetics
Comprehensive Review: WormBook
WormBase: An Information Resource for Research of Caenorhabditis
elegans and related nematodes. Raymond Lee and WormBase Consortium.
Division of Biology, California Institute of Technology, Pasadena, CA 91125
and www.wormbase.org.
The goal of WormBase is to provide a knowledge environment to facilitate
further research with C. elegans and related nematodes. We maintain a
database, extract information from the literature, and disseminate integrated
knowledge via the WWW. Information includes complete genome sequences,
developmental cell lineages, neural circuit maps, and extensive genetic
analyses that make functional connections between the genome,
development, anatomy, and physiology.
To allow rapid and easy access of available content, WormBase provides
Web pages that focus on special topics, e.g. Gene page, which contains
summaries of everything that is known about a gene. Also, users can
synthesize complex queries using tools such as WormMart, an interface
based on BioMart. For power users, we offer FTP downloads of all of our data
and software, and we provide directions for building local mirrors. To keep up
with the rapid growth of research literature, we update our database every
three weeks. But to ensure comparability between large-scale analyses, we
maintain a stable version every ten releases.
Sequence Homology
Literature Query Tool: Textpresso
Completing its functionality as a knowledge portal, WormBase integrates with
related services: Textpresso, a primary literature search engine, and
WormBook, a collection of expert-written chapters about C. elegans biology.
Since its inception in 2000, WormBase has become an indispensable
resource for C. elegans researchers. Going forward, a new focus will be on
comparative genomics as several other nematode genomes are being
sequenced.
Gene Page: Summary of a Gene
Database Query Tool - WormMart
Comparative Genomics (Future)
(Being) Sequenced
Genome
Documentation & User Feedback
www.wormbase.org/wiki
People and Funding
California Institute of Technology
Igor Antoshechkin
Carol Bastiani
Juancarlos Chan
Wen Chen
Ranjana Kishore
Raymond Lee
Hans-Michael Mueller
Cecilia Nakamura
Andrei Petcherski
Gary Schindelman
Erich Schwarz
Paul Sternberg
Kimberly Van Auken
Daniel Wang
Washington University at St. Louis
Tamberlyn Bieri
Darin Blasiar
Phil Ozersky
John Spieth
Wellcome Trust Sanger Institute
Paul Davis
Richard Durbin
Michael Han
Anthony Rogers
Mary Ann Tuli
Gary Williams
Cold Spring Harbor Laboratory
Payan Canaran
Jack Chen
Tristan Fiedler
Todd Harris
Sheldon McKay
Will Spooner
Lincoln Stein
Support by National Human Genome Research Institute at the US National Institutes
of Health and the British Medical Research Council