Chapter Four Anatomy of the Nervous System Starring… Your Brain Research Methods Injection of dye into blood allows CAT (computerized axial tomography) scanner to take images of the brain Intentional brain damage points to behavioral impairment, e.g., damage to Broca’s area associated with inability to speak intense magnetic field temporarily inactivates area electrode or chemicals used to damage specific area but, brain damage may not solely produce behavior; impairment may be due to many factors Figure 4.1 Computerized axial tomography (CT scanning). (a) A person’s head is placed into the device and than a rapidly rotating source sends x-rays through the head while detectors on the opposite side make photographs. A computer than constructs an image of the brain. (b) A CT scan of a normal human brain. (Source: Dan McCoy/Rainbow). Research Methods cont. Brain stimulation can evoke sensations, e.g., flashes of light less intense magnetic fields stimulate an area injected chemicals stimulate specific receptors but, sensations are in isolation and behaviors depend on coordination across brain areas Research Methods cont. Recording brain activity identifies area of brain associated with behavior PET (positron emission tomography) detects radioactive chemicals absorbed by most active cells rCBF (regional cerebral blood flow) measures increased blood flow by monitoring inert radioactive chemical fMRI (functional magnetic resonance imaging) detects release of oxygen in active cell - replaces PET and rCBF but, brain is always active and interpreting changing activity is a challenge also, different people use different areas for same task New Brain Research; CNN Today: Biological Psychology, Volume I Research Methods cont. Correlating brain anatomy with behavior extensive practice on string instrument correlated with enlarged area of brain receiving sensations from left hand experienced taxi drivers have enlarged area of hippocampus related to spatial memory Albert Einstein had one area of brain larger than normal and had unusually high ratio of glia to neurons Caution: samples are small & correlation is not causation Structure of the Vertebrate Nervous System CNS: brain & spinal cord PNS: nerves outside brain &spinal cord somatic: nerves that convey messages from sense organs to CNS & from CNS to muscles and glands autonomic: set of neurons that control heart, intestines, & other organs sympathetic: arousal, “fight or flight”, emergency parasympathetic: “relax and digest”, nonemergency Figure 4.5 The human nervous system. Both the central nervous system and the peripheral nervous system have major subdivisions. The closeup of the brain shows the right hemisphere as seen from the midline. Anatomical Terms for Directions Road map of nervous system uses technical terms to describe a three dimensional structure basic terms include, e.g., ventral, dorsal, lateral and medial permits clear communication among investigators Figure 4.6 Terms for anatomical directions in the nervous system. In four-legged animals dorsal and ventral point in the same direction for the head as they do for the rest of the body. However, human’s upright position has tilted the head relative to the spinal cord, so the dorsal and ventral directions of the head are not parallel to the dorsal and ventral directions of the spinal cord. The Spinal Cord Bell-Magendie Law: the entering dorsal roots carry sensory info to brain and, the exiting ventral roots carry motor info to muscles and glands Dorsal root ganglia: clusters of neurons outside, but near, the spinal cord on dorsal roots carrying sensory info Cut the spinal cord and brain loses motor control over parts of body served by that segment and below Figure 4.7 Diagram of a cross section through the spinal cord. The dorsal root on each side conveys sensory information to the spinal cord; the ventral root conveys motor commands to the muscles. Autonomic Nervous System Sympathetic: prepares body for arousal increased breathing, increased heart rate, decreased digestive activity form chain of ganglia just outside spinal cord act as a single system; in “sympathy” with one another short preganglionic axons and long postganglionic axons both release norepinephrine Autonomic Nervous System cont. Parasympathetic: facilitates vegetative, nonemergency responses by the body’s organs increases digestive activity, activities opposing sympathetic system consists of cranial nerves and nerves from sacral spinal cord long preganglionic axons extend from the spinal cord to parasympathetic ganglia close to each internal organ shorter postganglionic fibers then extend from the parasympathetic ganglia in the organs; release acetylcholine The Hindbrain (rhombencephalon) Medulla: controls vital reflexes, e.g., breathing, heart beat Pons: area where many axons cross from one side of the brain to the other Reticular formation: controls motor areas of the spinal cord; output to cerebral cortex increasing arousal and attention Raphe system: sends axons to much of the forebrain, increasing or decreasing the brain’s readiness to respond Cerebellum: controls movement, balance and coordination damage impairs timing and difficulty shifting attention between auditory and visual stimuli The Midbrain (mesencephalon) Tectum (“roof”): includes superior colliculus and inferior colliculus, important routes for sensory information Tegmentum (”covering, carpet”) includes: nuclei for third and fourth cranial nerves (eye movements) parts of reticular formation extensions of the pathways between the forebrain and the spinal cord or hindbrain Substantia nigra gives rise to dopamine path that deteriorates in Parkinson’s disease Figure 4.12 The human brain stem. This composite structure extends from the top of the spinal cord into the center of the forebrain. The pons, pineal gland, and colliculi are ordinarily surrounded by the cerebral cortex. The Forebrain (prosencephalon) Cerebral cortex: outer portion of brain Thalamus: center of forebrain and relay station for sensory info to/from cerebral cortex (except olfactory) Hypothalamus: small area with widespread connections damage here affects sexual behavior temperature regulation, fighting, feeding, activity level sends messages to attached pituitary gland, altering release of hormones into bloodstream Limbic system borders the brain stem and mediates eating, drinking, sexual activity, anxiety and aggression Figure 4.14 The limbic system is a set of subcortical structures that form a border (or limbus) around the brain stem. The Forebrain cont. Basal ganglia: includes caudate nucleus, putamen, globus pallidus Basal forebrain many connections with frontal cortex, where planning, memory and emotional expression arise here the nucleus basalis is key part of brain’s system for arousal, wakefulness, and attention (intermediary between hypothalamus and cerebral cortex) Hippocampus located between thalamus and cerebral cortex critical for the formation of new memory connected to the hypothalamus by the fornix Figure 4.18 Figure 4.18 The basal ganglia. The thalamus is in the center, the basal ganglia are lateral to it, and the cerebral cortex is on the outside. (Source After Nieuwenhuys Voogd & vanHuijzen, 1988) Cerebral Spinal Fluid and the Ventricles Cerebral spinal fluid assists in cushioning the brain fills the central canal, channel in the center of the spinal cord fills the ventricles, four cavities within the brain fills space between brain and meninges (membranes that surround the brain and spinal cord) meningitis is inflammation of meninges Cerebral Spinal Fluid and the Ventricles cont. Cerebral spinal fluid is clear fluid similar to blood plasma formed in choroid plexus flows from lateral to third to fourth ventricle to central canal or between meninges reabsorbed in arachnoid apace between meninges and brain and spinal cord Cerebral Spinal Fluid and the Ventricles cont. Hydrocephalus is blockage of flow of CFS increases pressure on the brain in infants this spreads the skull bones and is associated with mental retardation Figure 4.20 The cerebral ventricles. (a) Diagram showing positions of the four ventricles. (b) Photo of a human brain, viewed from above, with a horizontal cut through one hemisphere to show the position of the lateral ventricles. Note that the two parts of this figure are seen from different angles. (Source: After Woolf, 1991) Cerebral Cortex Contains grey matter, the outer surface of cerebral hemispheres White matter is formed by axons extending inward from cortex Neurons from each hemisphere communicate with each other through the corpus callosum and anterior commissure Cerebral Cortex cont. Contains six distinct layers of cells parallel to surface of cortex (laminae I - VI) a layer may be missing in a region, e.g., lamina IV is absent from the motor cortex lamina V is thickest in motor cortex Organized into columns of cells arranged perpendicular to the laminae cells within a given column have similar or related properties, e.g., may all respond to touch on palm of hand or foot Lobes of Cortex Occipital lobe: posterior end of cortex contains primary visual cortex damage in one hemisphere causes blindness in opposite visual field Parietal lobe: between occipital lobe and the central sulcus contains the primary somatosensory cortex which receives touch sensation, muscle-stretch and joint position information postcentral gyrus includes four bands of cells; two receive light-touch information, one receives deeppressure and one a combination of both Lobes of Cortex cont. Temporal lobe: lateral portion of each hemisphere, near the temples essential for understanding spoken language contributes to perception of movement and face recognition damage may lead to Külver-Bucy syndrome Frontal lobe extends from the central sulcus to the anterior limit of the brain primary motor cortex controls fine movements prefrontal cortex important for working memory, delayed response tasks, planning of appropriate behavior for context How Do the Parts Work Together A brain area functions like a word in a sentence damage the amygdala and diminish fear (delete a word and you lose something) but, fear intensifies with pain and diminishes with a trusted friend (a word has richer meaning in context) no single brain area where information is integrated How Do the Parts Work Together Unified experience emerges from “binding” of separate parts Simultaneous areas neural activity may bind brain recognition of Mooney faces produced gamma waves 30-80/second in various brain areas when cat sees and hears bird it has synchronized neural activity in occipital, parietal, and frontal areas Einstein’s brain had larger than normal inferior parietal cortex, an area known to bind different aspects of perception, e.g., damage prevents binding color to shape How Do the Parts Work Together cont. But, why does synchronous activity produce binding? Overall, the cerebral cortex serves to elaborate sensory material