Drug Name Date Ordered: 05/30/10 Indications Action Side Effects / Adverse Effects Treatment of fever and pain. Paracetamol produces analgesia by raising the threshold of the pain center in the brain and by obstructing impulses at the pain-mediating chemoreceptors. The drug produces antipyresis by an action on the hypothalamus; heat dissipation is increased as a result of vasodilation and increased peripheral blood flow. Skin eruption, hematological Toxicity (thrombocytopenia and leukopenia.), renal damage (long term use). Generic Name: Paracetamol Brand Name: Aeknil Classification: Antipyretic and analgesic Dosage: 1 ml prn T>38.7 Route: IV References: MIMS Pyrexia of unknown origin. Fever & pain a ssociated w/ common childhood disorders,tonsillitis, upper respirtory tract infections postimmunization reactions, after tonsillectomy & other conditions. Prevention of febrile convulsion. Headache, cold,sinusitis, muscle pain, arthritis & toothache. Nursing Consideration Paracetamol has rarely been found to produce any adverse effects in therapeutic doses and is usually well tolerated by aspirin-sensitive patients. Toxicity may result from a single toxic dose of the drug or from chronic ingestion. The following adverse reactions have been reported: Skin eruption, hematological toxicity eg, thrombocytopenia and leucopenia, methemoglobinaemia which can result in cyanosis, and on long-term use, renal damage can result. If to be given as analgesia, assess onset, type, location, duration of pain. Can be given without regards to meals. Assess temperature directly before and 1 hour after giving medication. If respirations are <12/min (<20/min in children), withhold the medication and contact the physician. Evaluate for therapeutic response: relief of pain, stiffness, swelling; increasing in joint mobility; reduced joint tenderness; improve grip strength. Patient Teachings Instruct patient’s guardian to take with meals. Drink plenty of water when taking this drug. Report ringing in ears and persistent GI pain. Severe, recurrent pain or high continuous fever may indicate serious illness.