CENTER FOR BIOLOGICAL SEQUENCE ANALYSIS Brief Introduction to the Theory of Evolution Anders Gorm Pedersen Molecular Evolution Group Center for Biological Sequence Analysis gorm@cbs.dtu.dk CENTER FOR BIOLOGICAL SEQUENCE ANALYSIS Classification: Linnaeus Carl Linnaeus 1707-1778 CENTER FOR BIOLOGICAL SEQUENCE ANALYSIS Classification: Linnaeus • Hierarchical system – – – – – – – Kingdom Phylum Class Order Family Genus Species (Rige) (Række) (Klasse) (Orden) (Familie) (Slægt) (Art) CENTER FOR BIOLOGICAL SEQUENCE ANALYSIS Classification depicted as a tree CENTER FOR BIOLOGICAL SEQUENCE ANALYSIS Classification depicted as a tree Species Genus Family Order Class CENTER FOR BIOLOGICAL SEQUENCE ANALYSIS Theory of evolution Charles Darwin 1809-1882 CENTER FOR BIOLOGICAL SEQUENCE ANALYSIS Phylogenetic basis of systematics • Linnaeus: Ordering principle is God. • Darwin: Ordering principle is shared descent from common ancestors. • Today, systematics is explicitly based on phylogeny. CENTER FOR BIOLOGICAL SEQUENCE ANALYSIS Darwin’s four postulates I. II. III. IV. More young are produced each generation than can survive to reproduce. Individuals in a population vary in their characteristics. Some differences among individuals are based on genetic differences. Individuals with favorable characteristics have higher rates of survival and reproduction. Evolution by means of natural selection Presence of ”design-like” features in organisms: quite often features are there “for a reason” CENTER FOR BIOLOGICAL SEQUENCE ANALYSIS Theory of evolution as the basis of biological understanding ”Nothing in biology makes sense, except in the light of evolution. Without that light it becomes a pile of sundry facts some of them interesting or curious but making no meaningful picture as a whole” T. Dobzhansky