Supplementary file 1a: PRISMA-E 2012 CHECKLIST Checklist of Items for Reporting Equity-Focused Systematic Reviews Section Item TITLE Title 1 Identify the report as a systematic review, meta-analysis, or both. Identify equity as a focus of the review, if relevant, using the term equity. 1 ABSTRACT Structured summary 2 Provide a structured summary including, as applicable: background; objectives; data sources; study eligibility criteria, participants, and interventions; study appraisal and synthesis methods; results; limitations; conclusions and implications of key findings; systematic review registration number. State research question(s) related to health equity. 2 2A Present results of health equity analyses (e.g., subgroup analyses or meta-regression). 2 2B Describe extent and limits of applicability to disadvantaged populations of interest. 2 3 Describe the rationale for the review in the context of what is already known. Describe assumptions about mechanism(s) by which the intervention is assumed to have an impact on health equity. 3,4 3A Provide the logic model/analytical framework, if done, to show the pathways through which the intervention is assumed to affect health equity and how it was developed. n/a 4 Provide an explicit statement of questions being addressed with reference to participants, interventions, comparisons, outcomes, and study design (PICOS). Describe how disadvantage was defined if used as criterion in the review (e.g., for selecting studies, conducting analyses, or judging applicability). 4,5,6 4A State the research questions being addressed with reference to health equity 4 5 Indicate if a review protocol exists, if and where it can be accessed (e.g., Web address), 4 INTRODUCTION Rationale Objectives METHODS Protocol and Standard PRISMA item Extension for Equity-Focused Reviews Page # 1 Checklist of Items for Reporting Equity-Focused Systematic Reviews Section Item registration Eligibility criteria Standard PRISMA item Extension for Equity-Focused Reviews and, if available, provide registration information including registration number. Page # 6 Specify study characteristics (e.g., PICOS, length of follow-up) and report characteristics (e.g., years considered, language, publication status) used as criteria for eligibility, giving rationale. Describe the rationale for including particular study designs related to equity research questions. 4,5,6 6A Describe the rationale for including the outcomes (e.g., how these are relevant to reducing inequity). 4 Information sources 7 Describe all information sources (e.g., databases with dates of coverage, contact with study authors to identify additional studies) in the search and date last searched. Describe information sources (e.g., health, non-health, and grey literature sources) that were searched that are of specific relevance to address the equity questions of the review. 4,5,6 Search 8 Present full electronic search strategy for at least one database, including any limits used, such that it could be repeated.Describe the broad search strategy and terms used to address equity questions of the review. Supplemen tary file 1a Study selection 9 State the process for selecting studies (i.e., screening, eligibility, included in systematic review, and, if applicable, included in the meta-analysis). 4,5,6, figure 2 Data collection process 10 Describe method of data extraction from reports (e.g., piloted forms, independently, in duplicate) and any processes for obtaining and confirming data from investigators. 6 Data items 11 List and define all variables for which data were sought (e.g., PICOS, funding sources) and any assumptions and simplifications made. List and define data items related to equity, where such data were sought (e.g., using PROGRESS-Plus or other criteria, context). 6 Risk of bias in individual studies 12 Describe methods used for assessing risk of bias of individual studies (including specification of whether this was done at the study or outcome level), and how this information is to be used in any data synthesis. 6, supplement ary file 1f Summary measures 13 State the principal summary measures (e.g., risk ratio, difference in means). 6 2 Checklist of Items for Reporting Equity-Focused Systematic Reviews Section Item Standard PRISMA item Extension for Equity-Focused Reviews Describe the methods of handling data and combining results of studies, if done, including measures of consistency (e.g., I 2) for each meta-analysis.Describe methods of synthesizing findings on health inequities (e.g., presenting both relative and absolute differences between groups). Page # Synthesis of results 14 Risk of bias across studies 15 Specify any assessment of risk of bias that may affect the cumulative evidence (e.g., publication bias, selective reporting within studies). 6 Additional analyses 16 Describe methods of additional analyses (e.g., sensitivity or subgroup analyses, metaregression), if done, indicating which were pre-specified.Describe methods of additional synthesis approaches related to equity questions, if done, indicating which were pre-specified n/a RESULTS Study selection 17 Give numbers of studies screened, assessed for eligibility, and included in the review, with reasons for exclusions at each stage, ideally with a flow diagram. 7, figure 1 Study characteristics 18 For each study, present characteristics for which data were extracted (e.g., study size, PICOS, follow-up period) and provide the citations.Present the population characteristics that relate to the equity questions across the relevant PROGRESS-Plus or other factors of interest. 7,8, supplement ary file 1g Risk of bias within studies 19 Present data on risk of bias of each study and, if available, any outcome-level assessment (see Item 12). 7, Supplemen tary file 1f Results of individual studies 20 For all outcomes considered (benefits or harms), present, for each study: (a) simple summary data for each intervention group and (b) effect estimates and confidence intervals, ideally with a forest plot. 7-12 Synthesis of results 21 Present results of each meta-analysis done, including confidence intervals and measures of consistency.Present the results of synthesizing findings on inequities (see 14). 7-12, table 2, supplement ary file 1g 5,6 3 Checklist of Items for Reporting Equity-Focused Systematic Reviews Section Item Risk of bias across studies 22 Additional analysis 23 Give results of additional analyses, if done (e.g., sensitivity or subgroup analyses, meta-regression) (see Item 16).Give the results of additional synthesis approaches related to equity objectives, if done, (see 16). DISCUSSION Summary of evidence 24 Summarize the main findings including the strength of evidence for each main outcome; consider their relevance to key groups (e.g., health care providers, users, and policy makers). 7-12 Limitations 25 Discuss limitations at study and outcome level (e.g., risk of bias), and at review level (e.g., incomplete retrieval of identified research, reporting bias). 13 Conclusions 26 Provide a general interpretation of the results in the context of other evidence, and implications for future research.Present extent and limits of applicability to disadvantaged populations of interest and describe the evidence and logic underlying those judgments. 13,14 26A Provide implications for research, practice, or policy related to equity where relevant (e.g., types of research needed to address unanswered questions). 13,14 27 Describe sources of funding for the systematic review and other support (e.g., supply of data); role of funders for the systematic review. 14 FUNDING Funding Standard PRISMA item Extension for Equity-Focused Reviews Present results of any assessment of risk of bias across studies (see Item 15). Page # 7, Supplemen tary file 1f n/a 4 Supplementary file 1b: searches Electronic searches Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations and Ovid MEDLINE(R) 1946 to May 04 2012, search date 09/05/2012; also Ovid MEDLINE(R) 1946 to January week 3, 2013, search date 23/01/2013; also Ovid MEDLINE(R) 1946 to September Week 3 2013, search date 01/10/2013. 1. smoking/ 2. smoking cessation/ 3. tobacco/ 4. "Tobacco Use Disorder"/ 5. nicotine/ 6. tobacco, smokeless/ 7. tobacco use, cessation/ 8. (smokers or smoker).ti,ab. 9. cigar$.mp. 10. smoking.ti,ab. 11. or/1-10 12. smoking cessation/ 13. tobacco use, cessation/ 14. tobacco use, cessation products/ 15. smoking/pc 16. smoking/dt 17. smoking/th 18. ((smok$ or anti smok$ or tobacco or cigarette$) adj3 (ban or bans or prohibit$ or restrict$ or discourage$)).ti,ab. 19. ((smok$ or anti smok$ or tobacco or cigarette$) adj3 (workplace or work place or work site or worksite)).ti,ab. 20. ((smok$ or anti smok$ or tobacco or cigarette$) adj3 (public place$ or public space$ or public area$ or office$ or school$ or institution$)).ti,ab. 21. ((smok$ or anti smok$ or tobacco or cigarette$) adj3 (legislat$ or government$ or authorit$ or law or laws or bylaw$ or byelaw$ or bye law$ or regulation$)).ti,ab. 22. ((tobacco free or smoke free) adj3 (hospital or inpatient or outpatient or institution$)).ti,ab. 23. ((tobacco-free or smoke-free) adj3 (facilit$ or zone$ or area$ or site$ or place$ or environment$ or air)).ti,ab. 24. ((tobacco or smok$ or cigarette$) adj3 (campaign$ or advertis$ or advertiz$)).ti,ab. 25. ((billboard$ or advertis$ or advertiz$ or sale or sales or sponsor$) adj3 (restrict$ or limit$ or ban or bans or prohibit$)).ti,ab. 26. (tobacco control adj3 (program$ or initiative$ or policy or policies or intervention$ or activity or activities or framework)).ti,ab. 27. ((smok$ or tobacco) adj (policy or policies or program$)).ti,ab. 28. ((retailer$ or vendor$) adj3 (educat$ or surveillance$ or prosecut$ or legislat$)).ti,ab. 29. test purchas$.ti,ab. 30. voluntary agreement$.ti,ab. 31. health warning$.ti,ab. 5 32. ((tobacco or cigarette$) adj3 (tax or taxes or taxation or excise or duty free or duty paid or customs)).ti,ab. 33. ((cigarette$ or tobacco) adj3 (packaging or packet$)).ti,ab. 34. ((cigarette$ or tobacco) adj3 (marketing or marketed)).ti,ab. 35. ((cigarette$ or tobacco) adj3 (price$ or pricing)).ti,ab. 36. point of sale.ti,ab. 37. vending machine$.ti,ab. 38. (trade adj (restrict$ or agreement$)).ti,ab. 39. (contraband$ or smuggl$ or bootleg$ or cross border shopping).ti,ab. 40. (tobacco control act or clean air or clean indoor air).ti,ab. 41. ((reduce$ or prevent$) adj3 (environmental tobacco smoke or passive smok$ or secondhand smok$ or second hand smok$ or SHS)).ti,ab. 42. ((population level or population based or population orientated or population oriented) adj3 (intervention$ or prevention or policy or policies or program$ or project$)).ti,ab. 43. (community adj3 (intervention$ or prevention or policy or policies or program$ or project$)).ti,ab. 44. ((sale or sales or retail$ or purchas$) adj3 (minors or teenage$ or underage$ or underage$ or child$)).ti,ab. 45. (youth access adj3 restrict$).ti,ab. 46. (smoking cessation or cessation support).ti,ab. 47. (smokefree or smoke-free or smoke free).ti,ab. 48. ((stop$ or quit$ or reduc$ or give up or giving up) adj3 (cigarette$ or tobacco or smoking)).ti,ab. 49. quit attempt$.ti,ab. 50. tobacco quit.ti,ab. 51. quit rate$.ti,ab. 52. (quitline$ or quit line$ or quit-line$).ti,ab. 53. ((smok$ or tobacco or nicotine or cigarette$) adj2 (abstinence or cessation)).ti,ab. 54. or/12-53 55. (socioeconomic or socio economic or socio-economic).ti,ab. 56. inequalit$.ti,ab. 57. depriv$.ti,ab. 58. disadvantage$.ti,ab. 59. educat$.ti,ab. 60. (social adj (class$ or group$ or grade$ or context$ or status)).ti,ab. 61. (employ$ or unemploy$).ti,ab. 62. income.ti,ab. 63. poverty.ti,ab. 64. SES.ti,ab. 65. demographic$.ti,ab. 66. (uninsur$ or insur$).ti,ab. 67. minorit$.ti,ab. 68. poor.ti,ab. 69. affluen$.ti,ab. 70. equity.ti,ab. 71. (underserved or under served or under-served).ti,ab. 72. occupation$.ti,ab. 73. (work site or worksite or work-site).ti,ab. 74. (work place or workplace or work-place).ti,ab. 6 75. (work force or workforce or work-force).ti,ab. 76. (high risk or high-risk or at risk).ti,ab. 77. (marginalised or marginalized).ti,ab. 78. (social$ adj (disadvant$ or exclusion or excluded or depriv$)).ti,ab. 79. exp socioeconomic factors/ 80. exp public assistance/ 81. exp social welfare/ 82. vulnerable populations/ 83. or/55-82 84. 11 and 54 85. 83 and 84 86. limit 85 to (abstracts and english language and yr="1990 -Current") Embase; Excerpta Medica Database Guide, 1980 to 2012 Week 18, search date 09/05/2012; also 1980 to 2013 week 3, search date 23/01/2013; also Embase 1980 to 2013 Week 39, search date 01/10/2013. 1. smoking/ 2. smoking cessation/ 3. tobacco/ 4. nicotine/ 5. tobacco, smokeless/ 6. "smoking and smoking related phenomena"/ 7. cigarette smoking/ 8. cigarette smoke/ 9. tobacco smoke/ 10. (smokers or smoker).ti,ab. 11. cigar$.mp. 12. smoking.ti,ab. 13. or/1-12 14. smoking cessation program/ 15. ((smok$ or anti smok$ or tobacco or cigarette$) adj3 (ban or bans or prohibit$ or restrict$ or discourage$)).ti,ab. 16. ((smok$ or anti smok$ or tobacco or cigarette$) adj3 (workplace or work place or work site or worksite)).ti,ab. 17. ((smok$ or anti smok$ or tobacco or cigarette$) adj3 (public place$ or public space$ or public area$ or office$ or school$ or institution$)).ti,ab. 18. ((smok$ or anti smok$ or tobacco or cigarette$) adj3 (legislat$ or government$ or authorit$ or law or laws or bylaw$ or byelaw$ or bye law$ or regulation$)).ti,ab. 19. ((tobacco free or smoke free) adj3 (hospital or inpatient or outpatient or institution$)).ti,ab. 20. ((tobacco-free or smoke-free) adj3 (facilit$ or zone$ or area$ or site$ or place$ or environment$ or air)).ti,ab. 21. ((tobacco or smok$ or cigarette$) adj3 (campaign$ or advertis$ or advertiz$)).ti,ab. 22. ((billboard$ or advertis$ or advertiz$ or sale or sales or sponsor$) adj3 (restrict$ or limit$ or ban or bans or prohibit$)).ti,ab. 23. (tobacco control adj3 (program$ or initiative$ or policy or policies or intervention$ or activity or activities or framework)).ti,ab. 7 24. ((smok$ or tobacco) adj (policy or policies or program$)).ti,ab. 25. ((retailer$ or vendor$) adj3 (educat$ or surveillance$ or prosecut$ or legislat$)).ti,ab. 26. test purchas$.ti,ab. 27. voluntary agreement$.ti,ab. 28. health warning$.ti,ab. 29. ((tobacco or cigarette$) adj3 (tax or taxes or taxation or excise or duty free or duty paid or customs)).ti,ab. 30. ((cigarette$ or tobacco) adj3 (packaging or packet$)).ti,ab. 31. ((cigarette$ or tobacco) adj3 (marketing or marketed)).ti,ab. 32. ((cigarette$ or tobacco) adj3 (price$ or pricing)).ti,ab. 33. point of sale.ti,ab. 34. vending machine$.ti,ab. 35. (trade adj (restrict$ or agreement$)).ti,ab. 36. (contraband$ or smuggl$ or bootleg$ or cross border shopping).ti,ab. 37. (tobacco control act or clean air or clean indoor air).ti,ab. 38. ((reduce$ or prevent$) adj3 (environmental tobacco smoke or passive smok$ or secondhand smok$ or second hand smok$ or SHS)).ti,ab. 39. ((population level or population based or population orientated or population oriented) adj3 (intervention$ or prevention or policy or policies or program$ or project$)).ti,ab. 40. (community adj3 (intervention$ or prevention or policy or policies or program$ or project$)).ti,ab. 41. ((sale or sales or retail$ or purchas$) adj3 (minors or teenage$ or underage$ or underage$ or child$)).ti,ab. 42. (youth access adj3 restrict$).ti,ab. 43. (smoking cessation or cessation support).ti,ab. 44. (smokefree or smoke-free or smoke free).ti,ab. 45. ((stop$ or quit$ or reduc$ or give up or giving up) adj2 (cigarette$ or tobacco or smoking)).ti,ab. 46. tobacco quit.ti,ab. 47. quit attempt$.ti,ab. 48. quit rate$.ti,ab. 49. (quit line$ or quitline$ or quit-line$).ti,ab. 50. ((smok$ or tobacco or nicotine or cigarette$) adj2 (abstinence or cessation)).ti,ab. 51. or/14-50 52. (socioeconomic or socio economic or socio-economic).ti,ab. 53. inequalit$.ti,ab. 54. depriv$.ti,ab. 55. disadvantage$.ti,ab. 56. educat$.ti,ab. 57. (social adj (class$ or group$ or grade$ or context$ or status)).ti,ab. 58. (employ$ or unemploy$).ti,ab. 59. income.ti,ab. 60. poverty.ti,ab. 61. SES.ti,ab. 62. demographic$.ti,ab. 63. (uninsur$ or insur$).ti,ab. 64. minorit$.ti,ab. 65. poor.ti,ab. 66. affluen$.ti,ab. 8 67. equity.ti,ab. 68. (underserved or under served or under-served).ti,ab. 69. occupation$.ti,ab. 70. (work site or worksite or work-site).ti,ab. 71. (work place or workplace or work-place).ti,ab. 72. (work force or workforce or work-force).ti,ab. 73. (high risk or high-risk or at risk).ti,ab. 74. (marginalised or marginalized).ti,ab. 75. (social$ adj (disadvant$ or exclusion or excluded or depriv$)).ti,ab. 76. exp socioeconomics/ 77. public assistance/ 78. welfare, social/ 79. exp social status/ 80. social security/ 81. vulnerable population/ 82. or/52-81 83. 13 and 51 84. 82 and 83 85. limit 84 to (abstracts and english language and yr="1990 -Current") PsycInfo (OVID) 1987 to May Week 1 2012, search date 10/05/2012; also 1987 to January week 3 2013, search date 23/01/2013; also PsycINFO 1806 to September Week 4 2013, search date 01/10/2013. 1. exp tobacco smoking/ 2. exp smoking cessation/ 3. nicotine/ 4. tobacco, smokeless/ 5. (smokers or smoker).ti,ab. 6. tobacco.ti,ab. 7. nicotine.ti,ab. 8. cigar$.mp. 9. smoking.ti,ab. 10. or/1-9 11. exp smoking cessation/ 12. ((smok$ or anti smok$ or tobacco or cigarette$) adj3 (ban or bans or prohibit$ or restrict$ or discourage$)).ti,ab. 13. ((smok$ or anti smok$ or tobacco or cigarette$) adj3 (workplace or work place or work site or worksite)).ti,ab. 14. ((smok$ or anti smok$ or tobacco or cigarette$) adj3 (public place$ or public space$ or public area$ or office$ or school$ or institution$)).ti,ab. 15. ((smok$ or anti smok$ or tobacco or cigarette$) adj3 (legislat$ or government$ or authorit$ or law or laws or bylaw$ or byelaw$ or bye law$ or regulation$)).ti,ab. 16. ((tobacco free or smoke free) adj3 (hospital or inpatient or outpatient or institution$)).ti,ab. 17. ((tobacco-free or smoke-free) adj3 (facilit$ or zone$ or area$ or site$ or place$ or environment$ or air)).ti,ab. 18. ((tobacco or smok$ or cigarette$) adj3 (campaign$ or advertis$ or advertiz$)).ti,ab. 9 19. ((billboard$ or advertis$ or advertiz$ or sale or sales or sponsor$) adj3 (restrict$ or limit$ or ban or bans or prohibit$)).ti,ab. 20. (tobacco control adj3 (program$ or initiative$ or policy or policies or intervention$ or activity or activities or framework)).ti,ab. 21. ((smok$ or tobacco) adj (policy or policies or program$)).ti,ab. 22. ((retailer$ or vendor$) adj3 (educat$ or surveillance$ or prosecut$ or legislat$)).ti,ab. 23. test purchas$.ti,ab. 24. voluntary agreement$.ti,ab. 25. health warning$.ti,ab. 26. ((tobacco or cigarette$) adj3 (tax or taxes or taxation or excise or duty free or duty paid or customs)).ti,ab. 27. ((cigarette$ or tobacco) adj3 (packaging or packet$)).ti,ab. 28. ((cigarette$ or tobacco) adj3 (marketing or marketed)).ti,ab. 29. ((cigarette$ or tobacco) adj3 (price$ or pricing)).ti,ab. 30. point of sale.ti,ab. 31. vending machine$.ti,ab. 32. (trade adj (restrict$ or agreement$)).ti,ab. 33. (contraband$ or smuggl$ or bootleg$ or cross border shopping).ti,ab. 34. (tobacco control act or clean air or clean indoor air).ti,ab. 35. ((reduce$ or prevent$) adj3 (environmental tobacco smoke or passive smok$ or secondhand smok$ or second hand smok$ or SHS)).ti,ab. 36. ((population level or population based or population orientated or population oriented) adj3 (intervention$ or prevention or policy or policies or program$ or project$)).ti,ab. 37. (community adj3 (intervention$ or prevention or policy or policies or program$ or project$)).ti,ab. 38. ((sale or sales or retail$ or purchas$) adj3 (minors or teenage$ or underage$ or underage$ or child$)).ti,ab. 39. (youth access adj3 restrict$).ti,ab. 40. (smoking cessation or cessation support).ti,ab. 41. (smokefree or smoke-free or smoke free).ti,ab. 42. ((stop$ or quit$ or reduc$ or give up or giving up) adj3 (cigarette$ or tobacco or smoking)).ti,ab. 43. quit attempt$.ti,ab. 44. tobacco quit.ti,ab. 45. quit rate$.ti,ab. 46. (quitline$ or quit line$ or quit-line$).ti,ab. 47. ((smok$ or tobacco or nicotine or cigarette$) adj2 (abstinence or cessation)).ti,ab. 48. or/11-47 49. (socioeconomic or socio economic or socio-economic).ti,ab. 50. inequalit$.ti,ab. 51. depriv$.ti,ab. 52. disadvantage$.ti,ab. 53. educat$.ti,ab. 54. (social adj (class$ or group$ or grade$ or context$ or status)).ti,ab. 55. (employ$ or unemploy$).ti,ab. 56. income.ti,ab. 57. poverty.ti,ab. 58. SES.ti,ab. 59. demographic$.ti,ab. 10 60. (uninsur$ or insur$).ti,ab. 61. minorit$.ti,ab. 62. poor.ti,ab. 63. affluen$.ti,ab. 64. equity.ti,ab. 65. (underserved or under served or under-served).ti,ab. 66. occupation$.ti,ab. 67. (work site or worksite or work-site).ti,ab. 68. (work place or workplace or work-place).ti,ab. 69. (work force or workforce or work-force).ti,ab. 70. (high risk or high-risk or at risk).ti,ab. 71. (marginalised or marginalized).ti,ab. 72. (social$ adj (disadvant$ or exclusion or excluded or depriv$)).ti,ab. 73. exp socioeconomic status/ 74. poverty/ 75. disadvantaged/ 76. or/49-75 77. 10 and 48 78. 76 and 77 79. limit 78 to (english language and abstracts and yr="1990 - 2012") Cochrane Library 2012 (Cochrane Database of Systematic Reviews; Database of Abstracts of Reviews of Effects; Cochrane Central Register of Controlled Trials; Health Technology Assessment Database), search date 10/05/12; also January 2012 to December 2012, search date 29/04/13; also January 2013 to December 2013, search date 01/10/2013. #1 MeSH descriptor Smoking, this term only #2 MeSH descriptor Tobacco Use Cessation explode all trees #3 MeSH descriptor Tobacco explode all trees #4 MeSH descriptor Tobacco Use Disorder, this term only #5 MeSH descriptor Nicotine, this term only #6 (smoking or smokers or smoker or tobacco or cigar* or nicotine) #7 (#1 OR #2 OR #3 OR #4 OR #5 OR #6) #8 (smok* or anti-smok* or tobacco or cigarette*) near3 (ban or bans or prohibit* restrict* or discourage*) #9 (smok* or anti-smok* or tobacco or cigarette*) near3 (workplace or work place worksite) #10 (smok* or anti-smok* or tobacco or cigarette*) near3 (public next place*) #11 (smok* or anti-smok* or tobacco or cigarette*) near3 (public next space) #12 (smok* or anti-smok* or tobacco or cigarette*) near3 (public next area*) #13 (smok* or anti-smok* or tobacco or cigarette*) near3 (office* or school* institution*) #14 (smok* or anti-smok* or tobacco or cigarette*) near3 (legislat* or government* authorit* or law or laws or bylaw* or byelaw* or bye-law* or regulation*) #15 (tobacco-free or smoke-free) near3 (hospital* or inpatient* or outpatient* institution*) #16 (tobacco-free or smoke-free) near3 (facility* or zone* or area* or site* or place* environment* or air) or or or or or or 11 #17 (tobacco or smok* or cigarette*) near3 (campaign* or advertis* or advertiz*) #18 (billboard* or advertis* or advertiz* or sale or sales or sponsor*) near3 (restrict* or limit* or ban or bans or prohibit*) #19 (tobacco next control) near3 (program* or initiative* or policy or policies or intervention* or activity or activities or framework) #20 (smok* or tobacco) next (policy or policies or program*) #21 (retailer* or vendor*) near3 (educat* or surveillance or prosecut* or legslat*) #22 test next purchas* in All Fields or (voluntary next agreement*) #23 (sale or sales or retail* or purchas*) near3 (minors or teenage* or underage* or underage* or child*) #24 (youth near3 access) near3 restrict* #25 health next warning* #26 (tobacco or cigarette*) near3 (tax or taxes or taxation or excise or duty-free or dutypaid or customs) #27 (cigarette* or tobacco) near3 (packaging or packet*) #28 (cigarette* or tobacco) near3 (marketing or marketed) #29 (cigarette* or tobacco) near3 (price* or pricing) #30 "point of sale" #31 vending next machine* #32 trade near3 (restrict* or agreement*) #33 contraband* or smuggl* or bootleg* or (cross-border next shopping) #34 "tobacco control act" or "clean air" or "clean indoor air" #35 reduce* near3 "environmental tobacco smoke" or (passive next smok*) or (secondhand next smok*) or (second next hand next smok*) or SHS #36 prevent* near3 "environmental tobacco smoke" or (passive next smok*) or (secondhand next smok*) or (second next hand next smok*) or SHS #37 (population next level) near3 (intervention* or prevention or policy or policies or program* or project*) #38 (population next based) near3 (intervention* or prevention or policy or policies or program* or project*) #39 (population next orientated) near3 (intervention* or prevention or policy or policies or program* or project*) #40 (community next level) near3 (intervention* or prevention or policy or policies or program* or project*) #41 (community next based) near3 (intervention* or prevention or policy or policies or program* or project*) #42 (community next orientated) near3 (intervention* or prevention or policy or policies or program* or project*) #43 (community next oriented) near3 (intervention* or prevention or policy or policies or program* or project*) #44 smoking next cessation or cessation next support #45 smokefree or smoke-free or smoke next free #46 (stop* or quit* or reduc* or give next up or giving next up) near3 (cigarette* or tobacco or smoking) #47 quit next attempt* #48 tobacco next quit #49 quit next rate* #50 quitline* or quit-line* or quit next line* #51 (smok* or tobacco or nicotine or cigarette*) near2 (abstinence or cessation) 12 #52 (#8 OR #9 OR #10 OR #11 OR #12 OR #13 OR #14 OR #15 OR #16 OR #17 OR #18 OR #19 OR #20 OR #21 OR #22 OR #23 OR #24 OR #25 OR #26 OR #27 OR #28 OR #29 OR #30 OR #31 OR #32 OR #33 OR #34 OR #35 OR #36 OR #37 OR #38 OR #39 OR #40 OR #41 OR #42 OR #43 OR #44 OR #45 OR #46 OR #47 OR #48 OR #49 OR #50 OR #51) #53 socioeconomic or socio next economic or socio-economic #54 inequalit* #55 depriv* #56 disadvantage* #57 educat* #58 social next (class* or group* or grade* or context* or status) #59 employ* or unemploy* #60 income #61 poverty #62 SES #63 demographic* #64 insur* or uninsur* #65 minorit* #66 poor #67 affluen* #68 equity #69 underserved or under next served or under-served #70 occupation* #71 work next site or worksite or work-site #72 work next place or workplace or work-place #73 work next force or workforce or work-force #74 high next risk or high-risk or at next risk #75 marginalised or marginalized #76 social* next (disadvant* or exclusion or excluded or depriv*) #77 MeSH descriptor Socioeconomic Factors explode all trees #78 MeSH descriptor Public Assistance, this term only #79 MeSH descriptor Social Welfare, this term only #80 MeSH descriptor Vulnerable Populations, this term only #81 (#53 OR #54 OR #55 OR #56 OR #57 OR #58 OR #59 OR #60 OR #61 OR #62 OR #63 OR #64 OR #65 OR #66 OR #67 OR #68 OR #69 OR #70 OR #71 OR #72 OR #73 OR #74 OR #75 OR #76 OR #77 OR #78 OR #79 OR #80) #82 (#7 AND #52) #83 (#81 and #82), from 1990 to 2012 Science Citation Index Expanded, Social Sciences Citation Index, Conference Proceedings Citation Index (Science, and Social Science & Humanities), in Web of Science hosted on ISI Web of Knowledge, search date 10/05/12; also 1st May 2012 to 31st December 2012, search date 29/04/13; also 1st January 2013 to 1st October 2013. (TS=(smoking or smokers or smoker or tobacco or cigar* or nicotine) AND TS=(abstinence or cessation or quit*) AND TS=(socioeconomic or socio economic or socio-economic)) AND Language=(English), Timespan=1990-2012 BIOSIS Previews hosted on ISI Web of Knowledge, search date 10/05/12 13 (TS=(smoking or smokers or smoker or tobacco or cigar* or nicotine) AND TS=(abstinence or cessation or quit*) AND TS=(socioeconomic or socio economic or socio-economic)) AND Language=(English), Timespan=1990-2012; also January 2012 to December 2012, search date 29/04/13; also Timespan = 2013, search date 01/10/2013. CINAHL Plus (EBSCO host) search date 10/05/12; also 1st May 2012 to 31st December 2012, search date 29/04/13, also 1st January 2013 to 31st December 2013, search date 01/10/2013. S8 S5 AND S9, Limiters - Published Date from: 19900101-20121231 S9 S6 OR S7 OR S8 S8 TX social* W1 (disadvantage* or exclusion or excluded or depriv*) S7 TX social W1 (class* or group* or grade* or context* or status) S6 (MH "Socioeconomic Factors") OR "SOCIOECONOMIC" OR (MH "Poverty") OR "POVERTY" OR "EQUITY" S5 S1 OR S2 OR S3 OR S4 S4 TX (stop* or quit* or reduc* or give up or giving up) W3 (cigarette* or tobacco or smoking) S3 TX Smoking W1 cessation S2 (MH "Tobacco, Smokeless") OR (MH "Tobacco Abuse Control (Saba CCC)") OR (MH "Risk Control: Tobacco Use (Iowa NOC)") OR (MH "Passive Smoking") S1 (MH "Smoking Cessation Programs") OR (MH "Smoking Cessation") OR (MH "Smoking Cessation Assistance (Iowa NIC)") ERIC (EBSCO Host) search date 11/05/12; also 1st May 2012 to 31st December 2012, search date 29/04/13, also 1st January 2013 to 31st December 2013, search date 01/10/2013. S10 S8 and S9 S9 S4 or S5 or S6 or S7 S8 S1 or S2 or S3 S7 AB Socioeconomic OR AB Poverty OR AB equity S6 ((DE "Socioeconomic Background" OR DE "Socioeconomic Influences" OR DE "Socioeconomic Status") OR (DE "Poverty")) AND (DE "Disadvantaged Environment" OR DE "Economically Disadvantaged" OR DE "Socioeconomic Influences") S5 TX social* W1 (disadvantage* or exclusion or excluded or depriv*) S4 TX social W1 (class* or group* or grade* or context* or status) S3 TX (stop* or quit* or reduc* or give up or giving up) W3 (cigarette* or tobacco or smoking) S2 TX Smoking W1 cessation S1 DE SMOKING Handsearching: 1. Addiction 2012 volume 107 issues 1 to 8 (August 2012) and Early View, search date 31/7/12; also ‘Accepted Articles’, ‘Early View’, search date 14/2/13 and 2012 volume 107 issues 12 and S2, volume 108 issues 1 to 2 search date 18/2/13. Volume 108 issues 10 and 11, ‘Accepted Articles’ and ‘Early View’, search date 01/10/13. 14 2. Nicotine and Tobacco Research 2012, volume 14, issues 1 to 6, search date 30/7/12; also 2013 volume 15 issues 1 to 3 and ‘Advance Access’ search date 18/2/13. Volume 15 issues 10 and 11 and ‘Advance Access’, search date 01/10/13. 3. Social Science and Medicine 2012, volume 74 issues 1 to 12, volume 75 issues 1 to 7, articles ‘in press’ search date 31/7/12; also 2013 volumes 74 to 82 ‘in progress’, and ‘articles in press’, search date 18/2/13. Volumes 94 to 99 ‘in progress’ and ‘articles n press’, search date 01/1013. 4. Tobacco Control 2012, volume 21, issues 1 to 4, ‘online first’ search date 31/7/12; also volume 21 issue 6, volume 22 issues 1 to 2 and ‘online first’, search date 18/2/13. Volume 22 issues 5 and 6, and ‘online first’ search date 01/10/13. 15 Supplementary file 1c. WHO European countries and other stage 4 countries (source: http://www.euro.who.int/en/home) Albania Andorra Armenia Austria Azerbaijan Belarus Belgium Bosnia and Herzegovina Bulgaria Croatia Cyprus Czech Republic Denmark Estonia Finland France Georgia Germany Greece Hungary Iceland Ireland Israel Italy Kazakhstan Kyrgyzstan Latvia Lithuania Luxembourg Malta Monaco Montenegro Netherlands Norway Poland Portugal Republic of Moldova Romania Russian Federation San Marino Serbia Slovakia Slovenia Spain Sweden Switzerland 16 Tajikistan The Former Yugoslav Republic of Macedonia Turkey Turkmenistan Ukraine United Kingdom of Great Britain and Northern Ireland Uzbekistan 17 Supplementary file 1d: Included studies Bauld L, Chesterman J, Judge K, Pound E, Coleman T, English Evaluation of Smoking Cessation Services (EESCS). Impact of UK National Health Service smoking cessation services: variations in outcomes in England. Tobacco Control 2003; 12(3):296-301. Bauld L, Judge K, Platt S. Assessing the impact of smoking cessation services on reducing health inequalities in England: observational study. Tobacco Control 2007; 16(6):400-404. Bauld L, Chesterman J, Ferguson J, Judge K. A comparison of the effectiveness of group-based and pharmacy-led smoking cessation treatment in Glasgow. Addiction 2009; 104(2):308-316. Bauld L, Ferguson J, McEwen A, Hiscock R. Evaluation of a drop-in rolling-group model of support to stop smoking. Addiction 2012. Bernard P, Ninot G, Guillaume S, Fond G, Courtet P, Christine PM et al. Physical activity as a protective factor in relapse following smoking cessation in participants with a depressive disorder. American Journal on Addictions 2012; 21(4):348-355. Brown J, Michie S, Geraghty AWA, Miller S, Yardley L, Gardner B et al. A pilot study of StopAdvisor: A theory-based interactive internet-based smoking cessation intervention aimed across the social spectrum. Addictive Behaviors 2012; 37(12):1365-1370. Cosnes J, Beaugerie L, Carbonnel F, Gendre JP. Smoking cessation and the course of Crohn's disease: an intervention study. Gastroenterology 2001; 120(5):1093-1099. De Vries H, Bakker M, Mullen PD, van BG. The effects of smoking cessation counseling by midwives on Dutch pregnant women and their partners. Patient Education and Counseling 2006; 63:177-187. De Vries H, Kenward MG, Free CJ. Preventing Smoking Relapse Using Text Messages: Analysis of Data From the txt2stop Trial. Nicotine and Tobacco Research 2012; Advance Access published April 19, 2012 Edwards R, McElduff P, Jenner D, Heller RF, Langley J. Smoking, smoking cessation, and use of smoking cessation aids and support services in South Derbyshire, England. Public Health 2007; 121(5):321-332. Ferguson J, Bauld L, Chesterman J, Judge K. The English smoking treatment services: one-year outcomes. Addiction 2005; 100 (Suppl 2): 59-69. Fernandez E, Schiaffino A, Borrell C, Benach J, Ariza C, Ramon JM et al. Social class, education, and smoking cessation: Long-term follow-up of patients treated at a smoking cessation unit. Nicotine and Tobacco Research 2006; 8(1):29-36. Galbraith L, Hecht G (Information Services Division, Scotland). NHS Smoking Cessation Service Statistics (Scotland) 1st January to 31st December 2011. 1-40. 2012. Scottish Public Health Observatory. 18 Hiscock R, Judge K, Bauld L. Social inequalities in quitting smoking: what factors mediate the relationship between socioeconomic position and smoking cessation? Journal of Public Health 2011; 33(1):39-47. Hiscock R, Murray S, Brose LS, McEwen A, Bee JL, Dobbie F, et al. Behavioural therapy for smoking cessation: The effectiveness of different intervention types for disadvantaged and affluent smokers. Addictive Behaviors 2013;38(11):2787-2796. Johnstone E, Hey K, Drury M, Roberts S, Welch S, Walton R et al. Zyban for smoking cessation in a general practice setting: the response to an invitation to make a quit attempt. Addiction Biology 2004; 9(3-4):227-232. Judge K, Bauld L, Chesterman J, Ferguson J. The English smoking treatment services: short-term outcomes. Addiction 2005; 100 (Suppl 2):46-58. Low A, Unsworth L, Low A, Miller I. Avoiding the danger that stop smoking services may exacerbate health inequalities: building equity into performance assessment. BMC Public Health 2007; 7:198. Lowey H, Lowey HH. Smoking cessation services are reducing inequalities. Journal of Epidemiology and Community Health 2003; 57(8). Mason D, Gilbert H, Sutton S. Effectiveness of web-based tailored smoking cessation advice reports (iQuit): a randomized trial. Addiction 2012;107, 2183-2190. McEwen A, West R. Do implementation issues influence the effectiveness of medications? The case of nicotine replacement therapy and bupropion in UK Stop Smoking Services. BMC Public Health 2009; 9:28. Neumann T, Rasmussen M, Ghith N, Heitman BL, Tonnesen H. 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American Journal of Epidemiology Conference: 3rd North American Congress of Epidemiology Montreal, QC Canada Conference Start: 20110621 Conference End: 20110624 Conference Publication: (var pagings) 2011; 173(pp S104):01. Judit BJ, Simon E, Lukacs M, Csapo E. Psychosocial factors influencing smoking cessation in patients with coronary artery disease. European Journal of Cardiovascular Prevention and Rehabilitation Conference: EuroPRevent 2011 Geneva Switzerland Conference Start: 20110414 Conference End: 20110416 Conference Publication: (var pagings) 2011; 18(1 SUPPL.#1):April. Ling AC, Elward DD, Barry S. A retrospective cohort study of the long term effectiveness of smoking cessation counselling. Thorax Conference: British Thoracic Society Winter Meeting 2011 London United Kingdom Conference Start: 20111207 Conference End: 20111209 Conference Publication: (var pagings) 2011; 66(pp A116A117):December. Mcgorrian CM, Lonergan M, Kelleher CC, Daly L, Fitzpatrick P. 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(Turkish) 31 Supplementary file 1f: QUALITY ASSESSMENT Attrition rate†† 1.1 Yes n/a n/a yes n/a yes national Bauld 2007 25 1.2 yes n/a n/a yes yes yes national Bauld 2009 26 1.1 yes n/a n/a yes n/a national 1.3 n/a n/a yes yes 2.1 n/a n/a yes yes 1.1 n/a n/a yes n/a yes n/a n/a yes n/a yes 1.1 n/a n/a yes n/a 1.1 n/a n/a yes n/a Johnstone 2004 2.1 n/a n/a yes Judge 200532 1.1 n/a n/a yes n/a 1.2 n/a n/a yes yes 1.1 n/a n/a yes n/a n/a yes yes yes yes Generalisability+ Credibility of data collection instruments† Bauld 200324 Attributability to intervention††† Comparability*** Quality of execution Randomisation** study design + Representativeness* Study Behavioural & pharmacological Bauld 201227 Bernard 2012 39 Edwards 200728 Ferguson 2005 29 Hiscock 201130 38 Hiscock 2013 31 33 Low 2007 Lowey 200334 35 1.1 yes yes yes yes Neumann 201236 1.3 n/a n/a yes yes yes 2.1 n/a n/a yes yes yes n/a yes yes yes yes yes yes yes yes yes yes yes yes yes Behavioural Cosnes 200140 2.2 41 De Vries 2006 Pisinger 200842 Polanska 2004 43 van der Aalst 201244 yes 3.1 3.1 yes 3.3 yes 3.1 yes yes yes 2.1 n/a n/a yes national yes 2.2 Sperber 2000 national yes McEwen 2009 37 yes yes national national national yes yes national Pharmacological Fernandez 200645 yes Brief interventions 32 Randomisation** Comparability*** 3.1 yes yes yes yes yes yes yes yes Generalisability+ Representativeness* Yilmaz 200646 Attributability to intervention††† Quality of execution Attrition rate†† study design + Credibility of data collection instruments† Study regional Mass media – Quitlines and Quit & Win campaigns Owen 200047 1.3 n/a n/a Wisniewska 200548 1.3 n/a n/a 3.1 yes Brown 201250 2.1 n/a n/a yes yes yes 51 3.1 yes yes yes yes Text-based Devries 201249 yes Internet-based Mason 2012 # Typology of study designs Code Study design 1.0 1.1 1.2 1.3 1.4 2.0 2.1 2.2 2.3 3.0 3.1 3.2 3.3 4.0 4.1 4.2 4.3 Population-based observational Cross-sectional Repeat cross-sectional Cohort longitudinal Econometric analyses (cross-sectional data) Intervention-based observational Single intervention (before and after, same participants) Single intervention with internal comparison Comparison between different types of intervention Intervention-based experimental Randomised controlled trial (individual or cluster) Non-randomised controlled trial Quasi-experimental trial Qualitative Cross-sectional Repeat cross-sectional Longitudinal 33 ## Quality of execution *Representativeness: Were the study samples randomly recruited from the study population with a response rate of at least 60% or were they otherwise shown to be representative of the study population? **Randomisation: Were participants, groups or areas randomly allocated to receive the intervention or control condition? ***Comparability: Were the baseline characteristics of the comparison groups comparable or if there were important differences in potential confounders were these appropriately adjusted for in the analysis? If there is no comparison group this criterion cannot be met. †Credibility of data collection instruments: Were data collection tools shown to be credible, e.g. shown to be valid and reliable in published research or in a pilot study, or taken from a published national survey, or recognized as an acceptable measure (such as biochemical measures of smoking). ††Attrition Rate: Were outcomes studied in a panel of respondents with an attrition rate of less than 30% or were results based on a cross-sectional design with at least 200 participants included in analysis in each wave? †††Attributability to intervention: Is it reasonably likely that the observed effects were attributable to the intervention under investigation? This criterion cannot be met if there is evidence of contamination of a control group in a controlled study. Equally, in all types of study, if there is evidence of a concurrent intervention that could also have explained the observed effects and was not adjusted for in analysis, this criterion cannot be met. + Generalisability: Is the study generalisable at National, State/Regional, or Local level? A study cannot be generalisable if not representative or representativeness is unclear. Randomisation is not applicable (N/A) for all study designs except trials coded 3.1. Attrition rate is N/A to cross-sectional studies coded 1.1. 34 Supplementary file 1g: EQUITY IMPACT TABLE Author, SES variable Intervention Study design, Country Behavioural & Pharmacological Bauld Health action zones, NHS Smoking 200324 Index of Multiple Cessation 1.1 deprivation Services, England N=132,500 Outcome Bauld 200725 1.2 England Reach, Quit rates (selfreported at 4 weeks and estimated at one year) Index of Multiple Deprivation NHS Smoking Cessation Services, N=1.5 million Reach, Number quit at 4 weeks, Cessation rate Equity impact Cessation services based in health action zones reached 140% more smokers compared to other more affluent areas, and the number of people who reported quitting at four weeks was 90% greater in HAZ areas. However, there was an inverse relationship between reach and cessation rates. Cessation rates were lower in deprived areas compared with more advantaged areas. Typically the cessation rate in an area with an upper quartile deprivation score was 6% lower than that in an area in the lower quartile. Services operating in deprived areas were more likely to lose clients between setting a quit date and reporting outcomes at four weeks. The study did not assess the overall equity impact of the services (i.e. whether the higher reach in deprived areas compensated for lower quit rates). Although disadvantaged groups had proportionately lower quitting success rates than their more affluent neighbours, services were treating many more clients in disadvantaged communities. Overall, therefore, the net effect of service intervention was to achieve a greater proportion of quitters among smokers living in the most disadvantaged areas and a slight narrowing effect on inequalities in smoking prevalence. Summary for quits Negative Negative 35 Author, SES variable Intervention Outcome Equity impact Study design, Country Behavioural & Pharmacological Bauld Scottish Index of NHS Smoking Carbon A high proportion of clients in both groups were from 200926 Multiple Deprivation, Cessation monoxide disadvantaged areas, with 58.0% of pharmacy-based clients in the 1.1 Socio-economic Services: validated 4bottom Scottish deprivation quintile, compared with 45.5% in Scotland group score pharmacy week quit rates, group-based community support. (summary measure based vs number of Users who accessed the group-based services were almost twice as based on education group-based service users in likely (OR 1.980; CI 1.50 to 2.62) as those who used pharmacyfinished by 16, single community each type of based support to have quit smoking at 4-week follow-up. parent, rented services, service In multivariate analysis low SES was significantly associated with housing, unemployed N=1785 lower 4 week quit rates (OR 0.677, p=0.015). or permanently sick/disabled, eligible for free prescriptions and aged under 60, lowest Scottish deprivation decile. Bauld Composite measure: NHS Smoking 52-week In a region of high economic and social disadvantage the service 201227 home ownership; Cessation carbon reached a significant proportion of the smoking population however 1.3 managerial, Services: drop- monoxide long-term validated quit rates were significantly associated with England professional or in rolling validated quit SES: higher SES was a predictor of quitting. intermediate group service rate occupation; and ‘Fag Ends’ in resident in the most Liverpool, affluent half of N=2585 Liverpool postcode area neighbourhoods Summary for quits Negative Negative 36 Author, SES variable Intervention Study design, Country Behavioural & Pharmacological Bernard Education Brief 201239 counselling 2.1 and France pharmacothera py, hospitalbased, N=133 Outcome Smoking abstinence, relapse rates up to 3 years Equity impact Level of education was significantly associated with relapse (relapse rate=0.80, 95% CI: 0.64 to 0.99, p = 0.04). Lower SES more likely to relapse. Summary for quits Negative 37 Author, SES variable Study design, Country Behavioural & Pharmacological Edwards Area-level: 200728 ‘disadvantaged areas’ 1.1 included three England ‘Neighbourhood Renewal Areas’ and a small ‘New Deal for Communities’ area and areas within rural PCTs, designated as ‘Communities in Need’. Individual-level: low SES defined as one or more: no access to a car; leaving school before 17th birthday (not used for 65–74year age group); living in Local Authority/Housing Association rented accommodation; receiving one mean tested benefit or more; or being currently unemployed (not used for 65–74-year age group). Intervention Outcome NHS Smoking Cessation Services ‘Fresh Start’ in Derbyshire, N=8328 Reach, Quitting in the last year, Self-reported motivation to quit, Awareness and use of NHS Smoking Cessation Services Equity impact Quit rates were generally lower among low SES smokers, but only significantly so for men aged 25–44 years. Motivation to quit did not vary by SES. Awareness varied little by SES but accessing services was generally higher among smokers of lower SES. Reach is unclear because split by age. Numbers were small (n=79) and differences were not significant. Summary for quits Neutral 38 Author, SES variable Study design, Country Behavioural & Pharmacological Ferguson Composite measure: 200529 education finished by 1.1 16, single parent, England rented housing, unemployed or permanently sick/disabled, eligible for free prescriptions and aged under 60, lowest deprivation decile. Galbraith Scottish Index of 201223 Multiple Deprivation 1.1 Scotland Intervention Outcome NHS Smoking Cessation Services, N=2069 52-week carbon monoxide validated quit rate NHS Smoking Reach, Cessation Self-report Services, week quit Scotland N=108,269 Equity impact 14.6% validated quit rate at 52-weeks, 17.7% when self-report cases were included. Relapse rates between 4 and 52 weeks were about 75% and were most likely to occur in the first 6 months. Service users with lower SES were less likely to be quitters at 52weeks (OR 0.86; CI 0.78–0.96). 52-week cessation rate ranged from 17.4% for group 1 (relatively advantaged) to just 8.7% for group 6 (relatively disadvantaged). Summary for quits Negative Those living in the most deprived communities (equivalent to SIMD Negative 4- 1-2) accounted for an estimated 31% of adult smokers in Scotland and for 37% of quit attempts made in NHS SSSs in 2011. One month quit outcomes by SIMD revealed that the lowest quit rates were in the most deprived areas (1-2) and the highest quit rates in the least deprived areas (9-10). However, in terms of overall numbers of quitters the most deprived areas (1-2) still accounted for the largest numbers of quitters of all the deprivation deciles. Combining reach with quit rates at one month, showed that the percentage of successful quitters was greater in the most deprived SIMD area 1 (4.2%) compared with least deprived SIMD area 10 (3.4%). 39 Author, SES variable Intervention Study design, Country Behavioural & Pharmacological Hiscock Composite measure: NHS Smoking 201130 education finished by Cessation 1.1 16, single parent, Services, EnglandS rented housing, N=2397 cotland unemployed or permanently sick/disabled, eligible for free prescriptions and aged under 60, lowest deprivation decile. Hiscock 201338 1.1 England Outcome Equity impact Summary for quits 52-week carbon monoxide validated quit rate Continuous abstinence rates at 1 year were higher in England Negative (average 14%) than Glasgow (average 3%). At 52-week follow-up, 14.3% of the most affluent smokers remained quit compared with only 5.1% of the most disadvantaged. After adjustment for demographic factors, the most advantaged clients at the North Cumbria and Nottingham sites and the Glasgow one-to-one programme (but not the group intervention) were significantly more likely to have remained abstinent than those who were most disadvantaged (OR 2.5, 95% CI 1.4 to 4.7; and OR 7.5, 95% CI 1.4 to 40.3 respectively). During the study period relatively few smokers from disadvantaged backgrounds attended the group service. Index of Multiple NHS Smoking 4-week carbon Overall CO validated quit rate was 34%. 80% of service clients Negative Deprivation, Cessation monoxide received one-to-one counselling but open group forms of Occupational social Services, validated quit behavioural therapy were more successful (main effect OR 1.26 class (National N= 132,586 rate (1.12 to 1.41). Statistics Area deprivation did not predict quitting. Affluent clients (those Socio-Economic with managerial, professional and intermediate occupations) were Classification) significantly more likely to quit than clients with routine and manual occupations. All but the most affluent clients were less likely to be successful if treated by a nurse compared with other types of advisers, including smoking cessation specialists. 40 Author, SES variable Intervention Study design, Country Behavioural & Pharmacological Johnston Deprivation score (no Zyban plus e 200431 further details), behavioural 2.1 Occupatinal social support from England class nurse in general practice setting, N=239 Outcome Judge 200532 1.1 England 4-week selfreport and also carbon monoxide validated quit rate Composite measure: education finished by 16, single parent, rented housing, unemployed or permanently sick/disabled, eligible for free prescriptions and aged under 60, lowest deprivation decile. NHS Smoking Cessation Services, N=6959 Point prevalence, continuous abstinence at 6 and 12 months Equity impact 54 of 239 (23%) made an attempt to stop smoking on the agreed quit date. At 6 months, 21/54 (39%) claimed to be abstinent, and 16/54 (30%) had biochemically verified abstinence. At 12 months, 14/54 (26%) claimed to be abstinent and 12/54 (22%) were biochemically-validated continuously abstinent at 12 months. When those who attempted to quit were stratified by deprivation score, females had significantly less deprivation than males (p = 0.03). This difference in deprivation score persisted among the successful quitters (mean deprivation score at 12 months in females =6.7, in males= 12.1). There were no significant differences between participants and nonparticipants for SES. 42.4% of adults invited to join the study were in manual work and 44% of those who accepted were in manual work. There were slightly higher numbers of manual workers among the successful quitters (55.6% at six months and 46.2% at 12 months), than among the quit attempters (42.6%). However these differences were not statistically significant and the numbers were relatively small. More than one-half of clients (53%) were CO-validated as quitters at 4 weeks, rising to 60.7% when self-reported cases not receiving a CO validation test, were included. Users with lower SES were less likely to quit at four weeks (OR 0.92; CI 0.88–0.95). The COvalidated rate ranging from 59.8% for group 1 (least deprived areas) to 43.1% for group 6 (most deprived areas, P<0.001). The study authors emphasise that the majority of users in this study were relatively disadvantaged. Summary for quits Neutral Negative 41 Author, SES variable Intervention Study design, Country Behavioural & Pharmacological Low Index of Multiple NHS Smoking 200733 Deprivation Cessation 1.2 Services, England N=5495 Outcome Lowey 200334 1.1 England Index of Multiple Deprivation NHS Smoking Cessation Services, N=22,753 Reach, Setting a quit date, 4-week quit rate McEwen 200935 2.2 England Education NHS Smoking Cessation Services, N=2626 Carbon monoxide validated 3-4 week abstinence Reach, Quit rates, Prevalence rates, up to 5 years Equity impact The equity analysis suggests that the Derwentside Stop Smoking Service is operating at a position between equity of access and equity of outcome. Between 2001/02 and 2004/05 there has been some movement towards equity of outcome, but equity of outcome is not yet being achieved i.e. quit rates remained lower in more deprived wards. The gap in quit rates per adult between affluent and deprived areas is lower than the gap in smoking prevalence means that the Stop Smoking Service in Derwentside is not contributing to a reduction of inequality in smoking prevalence between deprived and affluent areas. Disproportionately more people living in deprived areas were contacting smoking cessation services. The relative proportion of the total population quitting smoking increased as deprivation increased. In the least deprived quintile, only 0.05% of the total population quit smoking compared with 0.25% in the most deprived areas. No clear trend on quits by SES. 3–4 week abstinence rate was 41% (865/2129); for clients using bupropion it was 34% (129/377) and for those using NRT it was 42% (736/1752) (p = .005). There were no differences in abstinence rates according to the level of education. Summary for quits Negative Unclear Neutral 42 Author, SES variable Intervention Outcome Equity impact Study design, Country Behavioural & Pharmacological Neumann Education Six-week Continuous Continuous abstinence of the 16 377 responders was 34% (of all 20 201236 ‘Gold Standard abstinence at 6- 588 smokers: continuous abstinence was 27%, when all non1.3 Programme’ of months responders were considered to be smokers). Denmark behaviour Of the 16 377 responding to follow-up, 27% had a lower level of change plus education compared with 37% in the Danish population. Continuous Nicotine abstinence was lower in 5738 smokers with a lower educational ReplacementT level (30% of responders, 23% of all) compared with those with a herapy, higher education level (35% of responders, 28% of all). The overall N=16,377 difference in continuous abstinence between disadvantaged and non-disadvantaged patients was 5% (with respect to education). Sperber Education Smoking Self-reported Thirty-three percent reported that they did not smoke at follow-up 200037 cessation and breath-test and there was 95% agreement rate with carbon monoxide breath 2.1 groups based smoking status tests. There was no difference between quitters and nonquitters in Israel on behaviour at 1-3 years use of NRT and in years of education. modification and peer support, N=89 Summary for quits Negative Neutral 43 Author, Study design, Country Behavioural Cosnes 200140 2.2 France SES variable Intervention Outcome Equity impact Summary for quits ‘Low-moderate SES, Moderate-high SES, High SES’ no further details Behavioural counselling with opportunity to join smoking cessation programme, could include nicotine patches and fluoxetine but no further details, N=177 One year biochemically verified abstinence, Disease course and therapy for Crohn’s disease, median 29 months follow-up Risk of flare-up of Crohn’s disease in quitters did not differ from that in non-smokers and was less than in continuing smokers (P <0.001). Need for steroids and for introduction or reinforcement of immunosuppressive therapy, respectively, were similar in quitters and non-smokers and increased in continuing smokers. The risk of surgery was not significantly different in the 3 groups. Fifty-nine (12%) participants remained abstinent for more than one year. Independent factors associated with smoking cessation included high SES (adjusted odds ratio, 2.84; 95% CI, 1.43–5.62). Negative 44 Author, SES variable Study design, Country Behavioural De Vries Education 200641 3.1 Netherlan ds Intervention Outcome Equity impact Summary for quits Brief health counselling, self-help materials on smoking cessation during pregnancy and early postpartum, and a partner booklet vs routine care, delivered by midwives, N=318 Self-reported quit attempts, 7-day point prevalence, approximately 34 weeks follow-up When all dropouts were included as smokers, 19% of the Negative experimental group reported 7-day abstinence compared to 7% of the control group at 6 weeks post-intervention, and 21% and 12%, respectively, at 6 weeks postpartum. For continuous abstinence (defined as reporting 7-day abstinence at both time points) these percentages were 12% in the experimental group and 3% in the control group. When dropouts were excluded from the analysis these percentages for the experimental group and the control group were not markedly different. The intervention had no effect on the smoking behaviour of the partner as reported by the pregnant women (72% of partners smoked). Having a higher education level was predictive of quit attempts but not 7-day point prevalence abstinence at 6 weeks post-intervention and was predictive of quit attempts and 7-day point prevalence at 6 weeks postpartum using intention-to-treat analysis. 45 Author, SES variable Study design, Country Behavioural Pisinger Education 200842 3.1 Denmark Intervention Outcome Equity impact Behaviour change: individual face-to-face lifestyle counselling, N=2408 Self-reported point abstinence at 1, 3 and 5 years Polanska 200443 3.3 Poland Behaviour change delivered by midwives, N=386 Self-reported smoking status shortly after delivery (approximatel y 20 weeks follow-up) When baseline differences between the groups were Negative adjusted for, the difference in self-reported point abstinence group A (OR: 2.19; 95% CI: 1.7 to 2.8; p=0.001) and group B (OR: 1.71; 95% CI: 1.1 to 2.6; p=0.016) were significant when compared separately with group C. The validated point abstinence rates at 5-year follow-up were 11.6% in group A and 9.2% in group B. Smoking status could not be validated in group C. Logistic analyses, adjusted for baseline differences, showed a significant effect of the intervention, even when compared validated point abstinence in groups AB with the selfreported point abstinence in group C (OR: 1.38; 95% CI: 1.1–1.8; p=0.014). Vocational training predicted abstinence at 5-year follow-up in the combined intervention groups AB: OR 1.77 (95% CI: 1.2 to 2.6, p=0.003). The chance of quitting smoking was significantly higher Neutral in the intervention group than in the control group when including participants, those lost to follow-up, spontaneous quitters and refusals (OR = 2.5; 95% CI 1.8– 3.7). No statistically significant differences were found in the efficacy of the intervention with regard to the level of education whether including just participants and those lost to follow-up or also including spontaneous quitters and refusals. Education Summary for quits 46 Author, SES variable Study design, Country Behavioural Van der Education Aalst44 3.1 Netherlan ds, Belgium Intervention Outcome Equity impact Summary for quits Computerised individually tailored smoking cessation advice in sub cohort of current male smokers (with long-term smoking history) who participated in lung cancer screening (NELSON trial), N=1284 Self-reported quit attempts, Point prevalent abstinence, Prolonged abstinence, Continued abstinence, 2 year followup 47.6% (301/633) of the brochure group and 48.8% (309/633) of the tailored information group – were lower educated (primary, lower secondary general or lower vocational education). Twenty-three percent of the male smokers in the tailored information group returned a completed questionnaire and received the tailored advice. The prolonged smoking abstinence was slightly, but not statistically significant, lower amongst those randomised in the tailored information group (12.5%) compared with the brochure group (15.6%) (OR = 0.77 (95%-CI: 0.56–1.06) as was the continued smoking abstinence (OR=0.78; 95% CI: 0.56 to 1.07). Multivariate analysis showed that those who were higher educated and motivated to quit smoking were more likely to quit smoking at follow-up. Negative 47 Author, SES variable Study design, Country Pharmacological Fernand Education, ez Occupational 45 2006 social class 2.1 Spain Intervention Specialised smoking clinic in a university teaching hospital, N=1516 Outcome 1 year and 8 year abstinence probabilities and hazard ratios for relapse at 8 years (median follow-up 52 months) Equity impact Summary for quits Both men and women in affluent social classes or with Negative higher educational levels had a higher probability of abstinence at 1 year and 8 years. Overall abstinence probability was 0.412 (95% CI 0.387 to 0.437) at 1-year and 0.277 (95%CI 0.254 to 0.301) at 8 years. Lower SES was associated with a higher rate of relapse. This association persisted after adjustment for confounders and despite motivation to quit being equal among all social groups. Men and women in social classes IV–V had significant hazard ratios of relapse after 8 years follow-up (men: 1.36, 95% CI 1.07 to 1.72; women: 1.60, 95% CI 1.24 to 2.06), as compared with patients in social classes I– II. The same independent effect was observed for education: men and women with primary or less than primary education had higher hazard ratios of relapse (men: 1.75, 95% CI 1.35 to 2.25; women: 1.92, 95% CI 1.51 to 2.46), as compared with patients with a university degree. 48 Author, Study design, Country SES variable Brief intervention Yilmaz Monthly income 200646 3.1 Turkey Intervention Brief advice from nurse focussed either on health risks of smoking to the child or to the mother compared with control (general personal health information), N=363 Outcome Self-reported smoking status at six-months, change in smoking location, knowledge scores Equity impact Summary for quits The percentage reporting quitting smoking was 24.3%, 13% and 0.8% of the child intervention, mother intervention and control at six months, respectively and the three groups were statistically significantly different from each other. When the rates of smoking cessation were controlled for monthly family income there were statistically significant differences for both income levels. The percentage reporting quitting smoking was 25%, 8.1% and 1.5% of the child intervention, mother intervention and control at six months, respectively for ‘low income’ and 23.6%, 17.4% and 0% of the child intervention, mother intervention and control at six months, respectively for ‘high income’. Family income was an independent factor significantly influencing smoking location change and post intervention knowledge, but not smoking cessation. Higher income families had less location change than lower income families but greater improvement in knowledge scores at six months follow-up. Neutral 49 Author, SES variable Intervention Outcome Study design, Country Mass media – Quitlines and Quit & Win campaigns Owen Occupational 3-month Characteristic 200047 social class hard-hitting s of helpline 1.3 testimonial callers, England TV and smoking advertising status at one (radio/magazi year ne) campaign targeted at young smokers (1624 years) encouraging calls to free Quitline plus additional support (written information), N=730 Equity impact The social class distribution of callers to the helpline reflected the social class distribution of smoking in the population, with nearly two thirds of callers being in manual occupations or unemployed. However, 25% social classes ABC1 stopped smoking at one year, compared to 21% social class C2DE which was not statistically significant. Summary for quits Neutral 50 Author, SES variable Intervention Outcome Study design, Country Mass media – Quitlines and Quit & Win campaigns Wisniew Education Quit & Win Self-report ska campaign, smoking 48 2005 N=296 status two 1.3 years after 5 Poland years abstinence (total 7 years) Text-based Devries Education, 201249 occupation 3.1 England Intervention arm of ‘txt2stop’, an RCT of an automated, mobile phone text messagebased smoking cessation intervention to prevent smoking relapse, N=2915 Use of text functions ‘lapse’ and/or ‘crave’, quit attempts, relapse, 6month followup Equity impact Summary for quits In 2003, 284 of 296 respondents (92.6%) reported that they were still abstinent, during the two years following a five year period of abstinence (seven years after the Quit & Win competition). The maintenance of nicotine abstinence was associated with having a higher than elementary education level: there was a greater percentage of non-smoking adults with ‘other’ levels of education (94.8%) compared with non-smoking adults with elementary education (84.2%). Negative Both education and occupation did not predict relapse following a quit attempt. Both education and occupation did not predict using the text lapse function amongst those who did lapse. Higher SES participants appeared more likely to text crave or lapse but the relationship between these outcomes and smoking outcomes appears complex. Neutral 51 Author, SES variable Study design, Country Internet-based UK Education, Occupation (National Statistics Socio-Economic Classification) Mason 201251 3.1 UK Composite measure: rented home; no car; no educational qualifications; manual occupation; unemployed or full-time student. Intervention Internet-based ‘StopAdvisor’ recommends a structured quit plan and a variety of behaviour change techniques for smoking cessation, N=204 Internet-based ‘iQuit’ tailored smoking cessation advice, N=1758 Outcome Equity impact Summary for quits Self-report of at least 1 month continuous abstinence verified by saliva cotinine or anabasine. Usage, Satisfaction, 8-weeks follow-up At 8 weeks post-enrolment, 19.6% (95% CI: 14.1 to 25.1) of participants (40/204) were abstinent. Participants viewed a mean of 133.5 pages (median=71.5) during 6.4 log-ins (median=3). A majority of respondents rated the website positively on each of the four satisfaction ratings measured by helpfulness, personal relevance, recommendation and use in future. There was no evidence of an effect of SES on cessation (OR=0.99, CI: 0.48–2.02), usage or satisfaction, using both an occupational and an educational measure of SES. Neutral Self-report 1month and 3month prolonged abstinence, 7-day and 24hour point prevalence, 6months follow-up The intervention group did not differ from the control group on self-reported three month prolonged abstinence (9.1% versus 9.3%; OR = 1.02, 95% CI: 0.73 to 1.42) or on any of the secondary outcomes. There were no significant moderating effects of deprivation on the intervention effect for any of these four outcomes. Neutral 52