Total Fat and Breast Cancer Publications
Hunter, D.J., et al. Cohort studies of fat intake and the
risk of breast cancer -- a pooled analysis. New England
Journal of Medicine. 1996; 334: 356-361.
Hunter, D.J., et al. Non-dietary factors as risk factors for
breast cancer, and as effect modifiers of the association
of fat intake and risk of breast cancer. Cancer Causes
and Control. 1997; 8: 49-56.
Hunter, D.J., et al. Dietary fat and breast cancer (letter).
Journal of the National Cancer Institute. 1998; 90: 13031305.
Cohort Studies Included in the Pooled
Analyses of Total Fat
Canadian National Breast
Screening Study
Nurses’ Health Study
Sweden
Mammography
Cohort
Netherlands
Cohort Study
New York
State Cohort
Adventist
Health Study
Total = 337,819
# cases = 4,980
Iowa Women’s
Health Study
Cohort Studies Included in
the Pooled Analyses of Total Fat
Study
Total
Cohort
Adventist Health
Canadian National
Iowa Women’s
Netherlands Cohort
New York State
Nurses’ Health (a)
Nurses’ Health (b)
Sweden Mammography
TOTAL
# of
Cases
15,172
153
56,837
514
34,406
723
62,412
434
18,475
376
89,046 1,094
68,817
911
61,471
775
337,819 4,980
Hunter, et al. 1996
Fat and Breast Cancer: Pooled Analysis
Pooled RR for Categories of Intake
1.5
1.0
0.5
45
45
-<
40
40
-<
35
35
-<
30
30
-<
25
20
-<
25
0.0
<2
0
Relative Risk
2.0
% of Energy from Fat
Hunter, et al. 1996
Pooled Multivariate Relative Risks of Breast
Cancer and Total Fat by Menopausal
Status and Benign Breast Disease
Multi. RR (95% CI)
p-for(increment=25g/d) interaction
Menopausal Status
Premeno.
0.98 (0.85-1.13)
Postmeno.
0.96 (0.86-1.08)
0.95
History of Benign Breast Disease
No
0.95 (0.87-1.05)
Yes
1.29 (0.96-1.72)
0.05
Hunter, et al. 1997
Pooled Multivariate Relative Risks of Breast
Cancer and Total Fat by Family History
Multi. RR (95% CI)
(Increment =25g/d)
p-forinteraction
History of breast cancer in mother
Yes
No
1.00 (0.77-1.29)
1.02 (0.90-1.15)
0.94
History of breast cancer in sister
Yes
No
1.02 (0.74-1.42)
1.05 (0.94-1.18)
0.86
Hunter, et al. 1997
Pooled Multivariate Relative Risks of Breast
Cancer and Total Fat by Alcohol Intake
Alcohol
(g/d)
Multi. RR (95% CI)
(increment=25g/d)
0
1.09 (0.93-1.28)
>0-<1.5
1.03 (0.84-1.27)
1.5-<5
0.97 (0.81-1.17)
5-<15
1.00 (0.83-1.19)
15-<30
1.20 (0.93-1.55)
>30
0.77 (0.47-1.28)
p-forinteraction
0.95
Hunter, et al. 1997